Ochratoxin A: Potential epigenetic mechanisms of toxicity and carcinogenicity

Food Additives and Contaminants

Volumn 22, Issue SUPPL. 1, 2005, Pages 88-93

  Schilter, Benoǐt ^a   Marin Kuan, Maricel ^a   Delatour, Thierry ^a   Nestler, Sandra ^b,c   Mantle, Peter ^c   Cavin, Christophe ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Epigenetic mechanisms; Ochratoxin A; Oxidative stress; Signal transduction; Toxicogenomics

Indexed keywords

CALCIUM; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCHRATOXIN; TRANSCRIPTION FACTOR AP 1; CARCINOGEN;

APOPTOSIS; ARTICLE; BIOCHEMISTRY; CALCIUM HOMEOSTASIS; CARCINOGENICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG DNA BINDING; EPIGENETICS; GENE EXPRESSION REGULATION; GENOTOXICITY; HUMAN; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TOXICOGENETICS; ANIMAL; CELL TRANSFORMATION; DRUG EFFECT; MALE; METABOLISM; RAT; REVIEW;

ANIMALIA;

ANIMALS; APOPTOSIS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MALE; OCHRATOXINS; OXIDATIVE STRESS; RATS; SIGNAL TRANSDUCTION;

EID: 33645468875     PISSN: 0265203X     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/02652030500309319     Document Type: Article

References (31)

1. Marin-Kuan, M and Nestler, S and Verguet, C and Bezençon, C and Mansourian, R and Holzwarth, J and Mantle, P and Schilter, B and Cavin, C.(2004). Ochratoxin A rat chronic study: Comparison of kidney and liver gene expression profiles using Affymetrix approach. Joint specialty Symposium on renal toxicology and toxicologic pathology: An integration of mechanistic investigation and morphological evaluation LindauGermanySept 26-Oct 12004. In [pp. 25].
2. Creppy, EE and Baudrimont, I and Betbeder, A-M. (1995) Prevention of nephrotoxicity of ochratoxin A, a food contaminant Toxicology Letters, 82/83, pp. 869-877.
3. Dirheimer, G and Creppy, E.E.(1991) Mechanism of action of ochratoxin A. In Mycotoxins, endemic nephropathy and urinary tract tumours. (pp. 171-186). Lyon editors
4. Oka, H and Chatani, Y and Hoshino, R and Ogawa, O and Kakehi, Y and Terachi, Y and Okada, Y and Kawaishi, M and Kohno, M and Yoshida, O. (1995) Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma Cancer Research, 55, pp. 4182-4187.
5. Omar, RF and Hasinoff, BB and Mejilla, F and Rahimtula, AD. (1990) Mechanism of ochratoxin A-stimulated lipid peroxidation Biochemical Pharmacology, 40, pp. 1183-1191.
6. Omar, RF and Rahimtula, AD and Bartsch, H. (1991) Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation Journal of Biochemical Toxicology, 6(3), pp. 203-209.
7. Creppy, EE and Schlegel, M and Röschenthaler, R and Dirheimer, G. (1979) Phenylalanine prevents acute poisoning by ochratoxin A in mice Toxicology Letters, 6, pp. 77-80.
8. Petrik, J and Zanic-Grubisic, T and Barisic, K and Pepeljnjak, S and Radic, B and Ferencic, Z. (2003) Apoptosis and oxidative stress induced by ochratoxin A in rat kidney Archives of Toxicology, 77, pp. 685-693.
9. Dai Park, G and Wright, MW and Adams, M and Akman, SA and Manderville, RA. (2002) Detection and characterization of a glutathione conjugate of ochratoxin A. Chemical Research in Toxicology, 15, pp. 1581-1588.
10. Gekle, M and Sauvant, C and Schwerdt, G. (2005) Ochratoxin A at nanomolar concentrations: A signal modulator in renal cells Molecular Nutrition and Food Research, 49, pp. 118-130.
11. Gillman, IG and Clark, TN and Manderville, RA. (1999) Oxidation of ochratoxin A by an Fe-porphyrin system: Model for enzymatic activation and DNA cleavage Chemical Research in Toxicology, 12, pp. 1066-1076.
12. Grosse, Y and Chekir-Ghedira, L and Huc, A and Obrecht-Pflumio, S and Dirheimer, G and Bacha, H and Pfohl-Leszkowicz, A. (1997) Retinol, ascorbic acid and alpha-tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone Cancer Letters, 114, pp. 225-229.
13. Haubeck, HD and Lorkowski, G and Kölsch, E and Röschenthaler, R. (1981) Immunosuppression by ochratoxin A and its prevention by phenylalanine Applied and Environmental Microbiology, 41, pp. 1040-1042.
14. Jung, KY and Endou, H. (1989) Nephrotoxicity assessment by measuring cellular ATP content II Toxicology and Applied Pharmacology, 100, pp. 383-390. Intranephron site of ochratoxin A nephrotoxicity
15. Kamp, HG and Eisenbrand, G and Schlatter, J and Würth, K and Janzowski, C. (2005) Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells Toxicology, 206, pp. 413-425.
16. Klauning, JE and Kamendulis, LM. (2004) The role of oxidative stress in carcinogenesis Annual Review of Pharmacology and Toxicology, 44, pp. 239-267.
17. Manolova, Y and Manolov, G and Parvanova, L and Petkova-Bocharova, T and Castegnaro, M and Chernozemsky, IN. (1990) Induction of characteristic chromosomal aberrations, particularly x-trisomy, in cultured human lymphocytes treated by ochratoxin A; a mycotoxin implicated in Balkan endemic nephropathy Mutatation Research, 231(2), pp. 143-149.
18. Mantle, PG and Miljkovic, A and Udupa, V and Dobrota, M. (1998) Does apoptosis cause renal atrophy in Balkan endemic nephropathy? Lancet, 352, pp. 1118-1119.
19. Mayura, K and Parker, R and Berndt, WO and Philipps, TD. (1984) Ochratoxin A-induced teratogenesis in rats: Partial protection by phenylalanine Applied and Environmental Microbiology, 48, pp. 1186-1188.
20. Meki, A-RMA and Hussein, AAA. (2001) Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney Comparative Biochemistry and Physiology Part C, 130, pp. 305-313.
21. Miljkovic, A and Pfohl-Leszkowicz, A and Dobrota, M and Mantle, PG. (2003) Comparative responses to mode of oral administration and dose of ochratoxin A or nephrotoxic extract of Penicillium polonicum in rats Experimental Toxicological Pathology, 54(4), pp. 305-312.
22. O'Brien, E and Dietrich, DR. (2005) Ochratoxin A: The continuing enigma Critical Reviews in Toxicology, 35, pp. 33-60.
23. Rahimtula, A and Chong, X.(1991) Alterations in calcium homeostasis as a possible cause of ochratoxin A nephrotoxicity. In Mycotoxins, endemic nephropathy and urinary tract tumours. (pp. 207-214). Lyon editors
24. Sauvant, C and Holzinger, H and Gekle, M. (2005) The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells Cellular Physiology and Biochemistry, 15, pp. 125-134.
25. Schaaf, GJ and Nijmeijer, SM and Maas, RFM and Roestenberg, P and Groene, EM and Fink-Gremmels, J. (2002) The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells Biochimica et Biophysica Acta, 1588, pp. 149-158.
26. WHO. (2001) Ochratoxin A. In Safety assessment of certain mycotoxins in food. (pp. 281-415). Geneva: WHO.
27. Baudrimont, I and Betbeder, A and Creppy, E.E. (1997) Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame Archives of Toxicology, 71, pp. 290-298.
28. Wei, Y-H and Lu, C-Y and Lin, T-N and Wie, RD. (1985) Effect of ochratoxin A on rat liver mitochondrial respiration and oxidative phosphorylation Toxicology, 36, pp. 119-130.
29. Aleo, MD and Wyatt, RD and Schnellmann, RG. (1991) Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat proximal tubules Toxicology and Applied Pharmacology, 107, pp. 73-80.
30. Baudrimont, I and Betbeder, A and Gharbi, AM and Pfohl-Leszkowicz, A and Dirheimer, G and Creppy, E.E. (1994) Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats Toxicology, 89, pp. 101-111.
31. Benesic, A and Mildenberger, S and Gekle, M. (2000) Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney epithelial cells European Journal of Physiology, 439, pp. 278-287.