Dose-response modeling in reproductive toxicology in the systems biology era

Reproductive Toxicology

Volumn 19, Issue 3 SPEC. ISS., 2005, Pages 327-337

  Andersen, Melvin E ^a   Thomas, Russell S ^a   Gaido, Kevin W ^a   Conolly, Rory B ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Biological circuits; Cellular networks; Phthalates; Risk assessment; Signal transduction; Steroidogenesis; System biology; Testes malformations

Indexed keywords

2 PROPANOL; ACETONE; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID ESTER; XENOBIOTIC AGENT;

BIOINFORMATICS; CONGENITAL MALFORMATION; CYTOLOGY; DEVELOPMENTAL STAGE; EXAMINATION; EXPOSURE; GENE FUNCTION; GENE MAPPING; GENE TECHNOLOGY; GENETIC LINKAGE; GENETIC SCREENING; GENOME; HUMAN; LIVER CANCER; LIVER CARCINOGENESIS; MALE GENITAL TRACT MALFORMATION; MATHEMATICAL MODEL; METHODOLOGY; NONHUMAN; PREDICTION; PREGNANCY; PROTEIN MOTIF; PROTEIN TARGETING; REPRODUCTIVE TOXICITY; REVIEW; RISK ASSESSMENT; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TEAMWORK; TESTIS;

EID: 15944383395     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.12.004     Document Type: Review

References (54)

1. K.B. Bischoff, and R.H. Brown Drug distribution in mammals Chem Eng Prog Symp Ser 62 1966 33 45
2. H.W. Leung Development and utilization of physiologically based pharmacokinetic models for toxicological applications J Toxicol Environ Health 32 1991 247 267
3. P.R. Gentry, T.R. Covington, M.E. Andersen, and H.J. Clewell Application of a physiologically-based pharmacokinetic model for isopropanol in the derivation of an RfD/RfC Regul Toxicol Pharmacol 36 2002 51 68
4. R.A. Corley, T.J. Mast, E.W. Carney, J.M. Rogers, and G.P. Daston Evaluation of physiologically based models of pregnancy and lactation for their application in children's health risk assessment CRC Crit Rev Toxicol 33 2003 137 211
5. P.R. Gentry, T.R. Covington, and H.J. Clewell III Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation Regul Toxicol Pharmacol 38 2004 1 16
6. K.B. Bischoff, R.L. Dedrick, D.S. Zaharko, and J.A. Longstreth Methotrexate pharmacokinetics J Pharm Sci 60 1971 1128 1133
7. R.L. Dedrick Animal scale-up J Pharmacokinet Biopharm 1 1973 435 461
8. M.C. Kohn, G.W. Lucier, G.C. Clark, C. Sewall, A. Tritscher, and C.J. Portier A mechanistic model of the effects of dioxin on gene expression in the rat liver Toxicol Appl Pharmacol 120 1993 138 154
9. K. Krishnan, M.L. Gargas, T.R. Fennell, and M.E. Andersen A physiologically-based description of ethylene oxide dosimetry in the rat J Toxicol Ind Health 8 1992 121 140
10. M.L. Gargas, M.E. Andersen, S.K.O. Teo, R. Batra, T.R. Fennel, and G.L. Kedderis A physiologically-based dosimetry description of acrylonitrile and cyanoethyleneoxide in the rat Toxicol Appl Pharmacol 134 1995 185 194
11. M.E. Andersen Tissue dosimetry in risk assessment: what's the problem here any way? Drinking Water Health 8 1987 8 23
12. S.H. Moolgavkar, and G. Luebeck Two-event model for carcinogenesis: biological, mathematical and statistical considerations Risk Anal 10 1990 323 341
13. B.G. Leroux, W.M. Leisenring, S.H. Moolgavkar, and E.M. Faustman A biologically-based dose-response model for developmental toxicology Risk Anal 16 1996 449 458
14. S.Y. Whitaker, H.T. Tran, and C.J. Portier Development of a biologically-based controlled growth and differentiation model for developmental toxicology J. Math. Biol. 46 2003 1 16
15. R.W. Setzer, C. Lau, M.L. Mole, M.F. Copeland, J.M. Rogers, and R.J. Kavlock Toward a biologically based doe-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct Toxicol. Sci. 59 2001 49 58
16. C. Lau, M.L. Mole, M.F. Copeland, J.M. Rogers, R.J. Kavlock, and D.L. Shuey Toward a biologically based doe-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data Toxicol. Sci. 59 2001 37 48
17. R.J. Kavlock, and R.W. Setzer The road to embryologically based dose-response models Environ Health Perspect 104 1996 107 121
18. E.S. Lander, and R.A. Weinberg Genomics: journey to the center of biology Science 287 2000 1777 1782
19. C. Surridge Nature insight: computational biology Nature 420 2002 205
20. H. Kitano Computational systems biology Nature 420 2002 206 210
21. C.C. Guet, M.B. Elowitz, W. Hsing, and S. Seibler Combinatorial synthesis of genetic networks Science 296 2002 1466 1470
22. J.F. Hasty Designer gene networks: towards fundamental cellular control Chaos 11 2001 207 220
23. J. Hasty, D. McMillen, and J.J. Collins Engineered gene circuits Nature 420 2002 224 230
24. D. McMillen, N. Kopell, J. Hasty, and J.J. Collins Synchronizing genetic relaxation oscillators by intercell signalling PNAS 999 2002 679 684
25. J.J. Tyson Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell Curr Opin Cell Biol 15 2003 221 231
26. E. Alm, and A.P. Arkin Biological networks Curr Opin Struct Biol 13 2003 193 202
27. E.H. Davidson, J.P. Rast, P. Oliveri, A. Ransick, C. Calestani, and C.H. Yuh A genomic regulatory network for development Science 295 2002 1669 1678
28. J.E. Ferrell Jr. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability Curr Opin Chem Biol 6 2002 140 148
29. J.J. Tyson Models of cell cycle control J. Biotechnol. 71 1999 239 244
30. B. Novak, and J.J. Tyson Biochem Soc Trans 31 2003 1526 1529
31. L.B. Ray, E.M. Adler, and N.R. Gough Common signaling pathways Science 306 2004 1505
32. J. Schlessinger Common and distinct elements in cellular signaling via EGF and FGF receptors Science 306 2004 1506 1507
33. Scientific Frontiers in Developmental Toxicology and Risk Assessment. National Research Council. National Academy Press, 2101 Constitution Ave., N.W., Washington, DC 20418; 2000.
34. U.S. Bhalla, P.T. Ram, and R. Iyengar MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network Science 297 2002 1018 1023
35. A. Hoffmann, A. Levchenko, M.L. Scott, and D. Baltimore The IκB-NF-κB signaling module: temporal control and selective gene activation Science 298 2002 1241 1245
36. K.-H. Cho, S.-Y. Shin, H.-W. Lee, and O. Wolkenhauer Investigations into the analysis and modeling of the TNF-α-mediated NF-κB-signaling pathway Genome Res. 13 2003 2412 2422
37. H. Bolouri, and E.H. Davidson Modeling transcriptional regulatory networks Bioessays 24 2002 1118 11129
38. L.H. Hartwell, J.J. Hopfield, S. Leibler, and A.W. Murray From molecular to modular cell biology Nature 402 1999 C47 C52
39. E. Mylchreest, R.C. Cattley, and P.M. Foster Male reproductive tract malformations in rats following gestational and lactational exposures to di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol Sci 43 1998 47 60
40. V.D. Shultz, S. Phillips, M. Sar, P.M. Foster, and K.W. Gaido Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl)phthalate Toxicol Sci 64 2001 233 242
41. C.J. Thompson, S.M. Ross, and K.W. Gaido Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism Endocrinology 145 2004 1227 1237
42. K.P. Lehmann, S. Phillips, M. Sar, P.M.D. Foster, and K.W. Gaido Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di(n-butyl) phthalate Toxicol Sci 81 2004 60 68
43. K.C. Fertuck Identification of temporal patterns of gene expression in the uteri of immature, oviarectomized mice following exposure to ethynylestradiol Physiol Genom 15 2003 127 141
44. X. Wang, L.P. Walsh, and D.M. Stocco The role of arachidonic acid on LH-stimulated steroidogenesis and steroidogenic acute regulatory protein accumulation in MA-10 mouse Leydig tumor cells Endocrine 10 1999 7 12
45. X. Wang, L.P. Walsh, A.J. Reinhart, and D.M. Stocco The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression J Biol Chem 275 2000 20204 20209
46. S.K. Chanda, S. White, A.P. Orth, R. Reisdorph, L. Miraglia, and R.S. Thomas Genome-scale functional profiling of the mammalian AP-1 signaling pathway Proc Natl Acad Sci USA 100 2003 12153 12158
47. L. Lum, S. Yao, B. Mozer, A. Rovescalli, D. Von Kessler, and M. Nirenberg Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells Science 299 2003 2039 2045
48. K. Berns, E.M. Hijmans, J. Mullenders, T.R. Brummelkamp, A. Velds, and M. Heimerikx A large-scale RNAi screen in human cells identifies new components of the p53 pathway Nature 428 2004 431 437
49. F. Michiels, H. van Es, L. van Rompaey, P. Merchiers, B. Francken, and K. Pittois Arrayed adenoviral expression libraries for functional screening Nat Biotechnol 20 2002 1154 1157
50. Q. Huang, A. Raya, P. DeJesus, S.H. Chao, K.C. Quon, and J.S. Caldwell Identification of p53 regulators by genome-wide functional analysis Proc Natl Acad Sci USA 101 2004 3456 3461
51. T. Akutsu, S. Kuhara, O. Maruyama, and S. Miyano A system for identifying genetic regulatory networks from gene expression patterns produced by gene disruption and overexpressions Genome Inform Ser Workshop Genome Inform 9 1998 151 160
52. Andersen ME, Dennison JE, Thomas RS, Conolly RB. New directions in incidence-dose modeling. Trends Biotechnol, in press.
53. G. Weng, U.S. Bhalla, and R. Iyengar Complexity in biological signaling systems Science 284 1999 92 96
54. S. Chevalier, and R.A. Roberts Perturbations of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: mechanisms and lack of relevance for human health (review) Oncol Rep 5 1998 1319 1327