The IκB-NF-κB signaling module: Temporal control and selective gene activation

Science

Volumn 298, Issue 5596, 2002, Pages 1241-1245

  Hoffmann, Alexander ^a   Levchenko, Andre ^a   Scott, Martin L ^a   Baltimore, David ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPUTATIONAL METHODS; FEEDBACK; GENES; PROTEINS;

NUCLEAR LOCALIZATION;

BIOCHEMISTRY;

I KAPPA B; I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROTEIN; ALPHA CHEMOKINE; CXC CHEMOKINE IP 10; CXC CHEMOKINE IP-10; DNA BINDING PROTEIN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NFKBIE PROTEIN, HUMAN; NFKBIE PROTEIN, MOUSE; ONCOPROTEIN; RANTES; TUMOR NECROSIS FACTOR ALPHA;

GENE; PROTEIN;

ANIMAL CELL; ARTICLE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; KNOCKOUT GENE; MAMMAL CELL; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CELL NUCLEUS; COMPUTER SIMULATION; CYTOPLASM; FEEDBACK SYSTEM; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT;

ANIMALS; CELL LINE; CELL NUCLEUS; CHEMOKINES, CXC; COMPUTER SIMULATION; CYTOPLASM; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NF-KAPPA B; PROTO-ONCOGENE PROTEINS; RANTES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037044575     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1071914     Document Type: Article

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21. The authors thank T. L. Johnson, S. Sanjabi, S. Smale, R. Tanaka, and an anonymous reviewer for suggestions on the manuscript. A.H. gratefully acknowledges the Jane Coffin Child Foundation for Cancer Research for postdoctoral fellowship support.