Dose-response modeling of cytochrome P450 induction in rats by octamethylcyclotetrasiloxane

Toxicological Sciences

Volumn 67, Issue 2, 2002, Pages 159-172

  Sarangapani, Ramesh ^a   Teeguarden, Justin ^a   Plotzke, Kathleen P ^b   McKim Jr , James M ^b   Andersen, Melvin E ^c  

^a ICF Consulting   (United States)

^b DOW CORNING CORPORATION   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Enzyme induction; Inhalation; Modeling; Pharmacodynamic; Siloxane

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; LIVER PROTEIN; OCTAMETHYLCYCLOTETRASILOXANE; PHENOBARBITAL; SILOXANE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; COMPARTMENT MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME INDUCTION; EXPOSURE; FEMALE; HEPATOMEGALY; LIVER LEVEL; LIVER WEIGHT; NONHUMAN; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RAT; TISSUE DISTRIBUTION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INHALATION; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; IMMUNOHISTOCHEMISTRY; LIVER; MODELS, BIOLOGICAL; RATS; SILOXANES; STEROID HYDROXYLASES;

ANIMALIA;

EID: 0036300635     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/67.2.159     Document Type: Article

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