Nuclear hormone receptors and gene expression

Physiological Reviews

Volumn 81, Issue 3, 2001, Pages 1269-1304

  Aranda, Ana ^a,b   Pascual, Angel ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL DERIVATIVE; FATTY ACID; HISTONE DEACETYLASE; HORMONE RECEPTOR; LIGAND; PROSTAGLANDIN; RETINOID; RETINOID X RECEPTOR; STEROID RECEPTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; VITAMIN D RECEPTOR;

CHROMATIN; CONFORMATIONAL TRANSITION; DEACETYLATION; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; HUMAN; LIGAND BINDING; LIPID METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; REVIEW; TRANSCRIPTION INITIATION;

EID: 0034957480     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.3.1269     Document Type: Review

References (324)

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96. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
97. How chromatin changes its shape
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99. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone signaling in reproduction and stress
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101. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat
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103. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
104. Af-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors
105. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins
106. The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements
107. Grip1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
108. Grip1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
109. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
110. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
111. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
112. Acetylation of general transcription factors by histone acetyltransferases
113. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
114. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
115. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
116. Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor
117. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
118. Steroid receptor induction of gene transcription: A two-step model
119. Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity
120. The vitamin D receptor binds in a transcriptionally inactive form and without a defined polarity on a retinoic acid response element
121. Vitamin D represses retinoic acid-dependent transactivation of the retinoic acid receptor-beta2 promoter: The AF-2 domain of the vitamin D receptor is required for transrepression
122. The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta
123. Rip 140 enhances nuclear receptor-dependent transcription in vivo in yeast
124. Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain
125. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
126. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
127. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
128. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
129. Genetic analysis of RXR alpha developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
130. Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development
131. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
132. Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors
133. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation
134. Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations
135. 3 signalling
136. Sin meets NuRD and other tails of repression
137. Syndrome of resistance to thyroid hormone: Insights into thyroid hormone action
138. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
139. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
140. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
141. Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers
142. Nuclear protein CBP is a coactivator for the transcription factor CREB
143. Sap30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
144. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex
145. Evolution of the nuclear receptor superfamily: Early diversification from an ancestral orphan receptor
146. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors
147. Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter
148. Structure of the retinoid X receptor alpha DNA binding domain: A helix required for homodimeric DNA binding
149. Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53
150. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
151. 3 receptor- and retinoid X receptor-mediated gene activation in vivo
152. Rac3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
153. p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption
154. A conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor release
155. Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers
156. Role of the histone deacetylase complex in acute promyelocytic leukaemia
157. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin
158. Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
159. Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo
160. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
161. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins
162. Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors
163. The RXR heterodimers and orphan receptors
164. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR
165. H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes
166. Regulation of E2F1 activity by acetylation
167. The N-terminal domain of transcription factor IIB is required for direct interaction with the vitamin D receptor and participates in vitamin D-mediated transcription
168. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
169. Nuclear receptor coregulators: Cellular and molecular biology
170. P/Caf associates with cyclin D1 and potentiates its activation of the estrogen receptor
171. 3, and thyroid hormone receptors in mammalian cells
172. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells
173. Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor
174. Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression
175. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
176. Retinoid receptors in health and disease: Co-regulators and the chromatin connection
177. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
178. The nuclear receptor ligand-binding domain: Structure and function
179. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor
180. FHL2, a novel tissue-specific coactivator of the androgen receptor
181. Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein
182. Composite co-activator ARC mediates chromatin-directed transcriptional activation
183. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors
184. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and historic deacetylase
185. Mechanism of corepressor binding and release from nuclear hormone receptors
186. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
187. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
188. Ski is a component of the histone deacetylase complex required for transcriptional repression by mad and thyroid hormone receptor
189. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators
190. The transcriptional coactivators p300 and CBP are histone acetyltransferases
191. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors
192. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
193. Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex
194. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
195. A direct protein-protein interaction is involved in the cooperation between thyroid hormone and retinoic acid receptors and the transcription factor GHF-1
196. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors: Extended isoform that is more related to the nuclear receptor corepressor
197. Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells
198. Differentiation of neuroblastoma cells by phorbol esters and insulin-like growth factor 1 is associated with induction of retinoic acid receptor β gene expression
199. An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells
200. Molecular determinants of nuclear receptor-corepressor interaction
201. Determinants for selective RAR and TR recognition of direct repeat HREs
202. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
203. Nuclear receptor/AP-1 interaction
204. Association of an X-chromosome dodecamer insertional variant allele with mental retardation
205. Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter
206. Activation of PPARgamma coactivator-1 through transcription factor docking
207. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
208. Androgen receptor defects: Historical, clinical, and molecular perspectives
209. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes
210. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
211. 3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
212. Structural determinants of nuclear receptor assembly on DNA direct repeats
213. Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1
214. DNA binding of the glucocorticoid receptor is not essential for survival
215. Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: Induction leads to a reversible disruption of nucleosomes over an enhancer
216. Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid
217. Therapeutic potential of selective modulators of nuclear receptor action
218. Chromatin structure. The nucleosome core all wrapped up
219. Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors
220. Nuclear hormone receptor coregulators in action: Diversity for shared tasks
221. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand
222. Stimulation of RAR alpha activation function AP-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
223. Retinoic acid receptor-beta: Immunodetection and phosphorylation on tyrosine residues
224. The role of general initiation factors in transcription by RNA polymerase II
225. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
226. A novel cis element mediating ligand-independent activation by c-ErbA: Implications for hormonal regulation
227. Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein
228. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone
229. The thyroid hormone response element is required for activation of the growth hormone gene promoter by nicotinamide analogs
230. Negative regulation of expression of the pituitary-specific transcription factor GHF-1/ Pit-1 by thyroid hormones through interference with promoter enhancer elements
231. 3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
232. Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product
233. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
234. Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene
235. 3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation
236. Many transcription factors interact synergistically with steroid receptors
237. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation
238. The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor
239. The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements
240. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors
241. Novel receptor interaction and repression domains in the orphan receptor SHP
242. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR
243. Modulating nuclear receptor function: May the phos be with you
244. Interdomain communication regulating ligand binding by PPAR-gamma
245. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
246. Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT)
247. The p300/CBP family: Integrating signals with transcription factors and chromatin
248. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
249. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription
250. 3-dependent signal transduction by phosphorylating human retinoid X receptor alpha
251. Acetylation regulates transcription factor activity at multiple levels
252. Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins
253. Steroid receptor coactivator-1 is a histone acetyltransferase
254. Histone acetylation and transcriptional regulatory mechanisms
255. Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone
256. Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor
257. Tram-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
258. Abnormal skeletal patterning in embryos lacking a single CBP allele: A partial similarity with Rubinstein-Taybi syndrome
259. Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment
260. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
261. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
262. Activation of the prolactin gene by peroxisome proliferator-activated receptor-alpha appears to be DNA binding-independent
263. Transcriptional silencing by unliganded thyroid hormone receptor beta requires a soluble corepressor that interacts with the ligand-binding domain of the receptor
264. Co-activators and corepressors in the integration of transcriptional responses
265. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
266. Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1
267. A regulatory role for RIP140 in nuclear receptor activation
268. SMRTer, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development
269. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): Coming of age
270. The "dark side" of chromatin remodeling: Repressive effects on transcription
271. Retinoic acid and thyroid hormone induce gene expression through a common responsive element
272. 3 receptors
273. Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma
274. Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations
275. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit anti-inflammatory activity in vivo
276. ATP-dependent chromatin-remodeling complexes
277. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
278. Tif2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
279. Transcriptional regulation: Switching circuitry
280. A structural role for hormone in the thyroid hormone receptor
281. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
282. Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone
283. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
284. The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility
285. Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine
286. Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR
287. LXR, a nuclear receptor that defines a distinct retinoid response pathway
288. RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling
289. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction
290. Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors
291. Distinct domains of the RelA NF-kappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor
292. Targeting chromatin disruption: Transcription regulators that acetylate histones
293. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
294. A canonical structure for the ligand-binding domain of nuclear receptors
295. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
296. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
297. Coactivator and corepressor complexes in nuclear receptor function
298. Signal-specific co-activator domain requirements for Pit-1 activation
299. Nurd, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
300. Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
301. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
302. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
303. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
304. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
305. 3 receptors and transcriptional corepressors
306. Roles of SW11, SW12, and SW13 proteins for transcriptional enhancement by steroid receptors
307. RXR beta: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
308. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
309. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex
310. Stoichiometric and steric principles governing repression by nuclear hormone receptors
311. Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements
312. The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats
313. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA
314. Proteasomal regulation of nuclear receptor corepressor-mediated repression
315. A novel role for helix 12 of retinoid X receptor in regulating repression
316. A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor
317. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
318. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid
319. Sap30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
320. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins
321. Amplification and over-expression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer
322. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
323. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1
324. Cdk-independent activation of estrogen receptor by cyclin D1