Toxic potential of materials at the nanolevel

Science

Volumn 311, Issue 5761, 2006, Pages 622-627

  Nel, Andre ^a,b   Xia, Tian ^a   Mädler, Lutz ^b   Li, Ning ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; CONTROLLED DRUG DELIVERY; FILLERS; MICROELECTRONICS; OPACIFIERS; TOXICITY;

BIOLOGICAL SYSTEMS; MARKETPLACE; NANOMATERIALS; OPTICAL SENSITIVITY;

NANOSTRUCTURED MATERIALS;

COSMETIC; DRUG CARRIER; FILLER; NANOPARTICLE;

NANOTECHNOLOGY;

CATALYST; CHEMICAL INTERACTION; CONDUCTANCE; ELECTRONICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SEMICONDUCTOR;

ANIMALS; CHEMISTRY, PHYSICAL; CONSUMER PRODUCT SAFETY; HUMANS; IMMUNE SYSTEM; INHALATION EXPOSURE; NANOSTRUCTURES; NANOTECHNOLOGY; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PARTICLE SIZE; SURFACE PROPERTIES; TISSUE DISTRIBUTION; TOXICITY TESTS;

EID: 31944451232     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1114397     Document Type: Review

References (41)

1. R. F. Service, Science 304, 1732 (2004).
2. V. L. Colvin, Nat. Biotechnol. 21, 1166 (2003).
3. K. Donaldson et al., Occup. Environ. Med. 58, 211 (2001).
4. G. Oberdörster et al., Environ. Health Perspect. 113, 823 (2005).
5. Royal Society, "Nanoscience and nanotechnologies: Opportunities and uncertainties" (Royal Society, London, 2004); available online at www.nanotec.org. uk/finalReport.htm.
6. K. Donaldson et al., Occup. Environ. Med. 61, 727 (2004).
7. K. Donaldson, C. L. Tran, Inhal. Toxicol. 14, 5 (2002).
8. A. Nel, Science 308, 804 (2005).
9. A. A. Shvedova et al., Am. J. Physiol. 289, L698 (2005).
10. A. T. Bell, Science 299, 1688 (2003).
11. B. Halliwell, J. M. C. Gutteridge, Free Radicals in Biology and Medicine (Oxford Univ. Press, Oxford, 1999).
12. G. G. Xiao et al., J. Biol. Chem. 278, 50781 (2003).
13. F. Gilliland et al., Lancet 363, 119 (2004).
14. W. S. Beckett et al., Am. J. Respir. Crit. Care Med. 171, 1129 (2005).
15. N. Li et al., Environ. Health Perspect. 111, 455 (2003).
16. L. L. Dugan et al., Proc. Natl. Acad. Sci. U.S.A. 94, 9434 (1997).
17. H. H. C. Chen et al., Toxicol. Path. 26, 143 (1998).
18. E. Oberdörster, Environ. Health Perspect. 112, 1058 (2004).
19. A. A. Shvedova et al., J. Toxicol. Environ. Health Part A 66, 1909 (2003).
20. N. A. Monteiro-Riviere et al., Toxicol. Lett 155, 377 (2005).
21. D. B. Warheit et al., Toxicol. Sci. 77, 117 (2004).
22. C. W. Lam et al., Toxicol. Sci. 77, 126 (2004).
23. M. D. Geller et al., Aerosol Sci. Technol. 36, 748 (2002).
24. A. A. Vertegel et al., Langmuir 20, 6800 (2004).
25. A. Nemmar et al., Circulation 105, 411 (2002).
26. J. S. Brown et al., Am. J. Respir. Crit. Care Med. 166, 1240 (2002).
27. J. Rejman et al., Biochem. J. 377, 159 (2004).
28. I. Raynal et al., Investig. Radiol. 39, 56 (2004).
29. J. S. Patton, Adv. Drug Deliv. Rev. 19, 3 (1996).
30. P. Somasundaran et al., J. Cosmet. Sci. 55, 51 (2004).
31. R. D. Brook et al., Circulation 109, 2655 (2004).
32. S. S. Tinkle et al., Environ. Health Perspect. 111, 1202 (2003).
33. S. Kim et al., Nat. Biotechnol. 22, 93 (2004).
34. A. Nel et al., J. Allergy Clin. Immunol. 102, 539 (1998).
35. B. Chen et al., Proc. Natl. Acad. Sci. U.S.A. 95, 10809 (1998).
36. W. Kreyling et al., J. Toxicol. Environ. Health Part A 65, 1513 (2002).
37. S. Yamago et al., Chem. Biol. 2, 385 (1995).
38. G. Oberdörster et al., Inhal. Toxicol. 16, 437 (2004).
39. More information is available online at http://ntp-server. niehs.nih.gov.
40. G. Oberdörster et al., Part. Fibre Toxicol. 2, 8 (2005).
41. We apologize for the many seminal contributions that have not been cited for lack of space. This work was supported by U.S. Public Health Service grants RO-1 E5105S3, RO1 E512053, RO1 ES013432, and PO1 AI50495 (UCLA Asthma and Immunology Disease Center), and by the U.S. EPA (STAR grant to the Southern California Particle Center and Supersite). This manuscript has not been subjected to the EPA's peer and policy review. L.M. was supported by the Parson's chair at UCLA.