Role of Gadd45 in apoptosis

Biochemical Pharmacology

Volumn 59, Issue 1, 2000, Pages 43-45

  Sheikh, M Saeed ^a   Hollander, M Christine ^a   Fornace, Albert J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Brca1; c Myc; Gadd45; MAP kinases; p53

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; CELL CYCLE G2 PHASE; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; EXPRESSION VECTOR; FIBROBLAST; GENE CONTROL; GENOTOXICITY; HUMAN; HUMAN CELL; MITOSIS INHIBITION; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; REVIEW;

ANIMALS; APOPTOSIS; CELL CYCLE; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEINS;

EID: 0033990288     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00291-9     Document Type: Conference Paper

References (37)

1. Fornace A.J. Jr, Alamo I. Jr, Hollander M.C. DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci U S A. 85:1988;8800-8804.
2. Kastan M.B., Zhan Q., El-Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., Fornace A.J. Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell. 71:1992;587-597.
3. Fornace A.J. Jr, Nebert D.W., Hollander M.C., Luethy J.D., Papathanasiou M., Fargnoli J., Holbrook N.J. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol. 9:1989;4196-4203.
4. Kearsey J.M., Coates P.J., Prescott A.R., Warbrick E., Hall P.A. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Oncogene. 11:1995;1675-1683.
5. Smith M.L., Chen I.T., Zhan Q., Bae I., Chen C.Y., Gilmer T.M., Kastan M.B., O'Connor P.M., Fornace A.J. Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 266:1994;1376-1380.
6. WAF1/CIP1 . Oncogene. 12:1996;2579-2594.
7. Marhin W.W., Chen S., Facchini L.M., Fornace A.J. Jr, Penn L.Z. Myc represses the growth arrest gene gadd45. Oncogene. 14:1997;2825-2834.
8. Amundson S.A., Zhan Q., Penn L.Z., Fornace A.J. Jr. Myc suppresses induction of the growth arrest genes gadd34, gadd45 and gadd153 by DNA-damaging agents. Oncogene. 17:1998;2149-2154.
9. Bush A., Mateyak M., Dugan K., Obaya A., Adachi S., Sedivy J., Cole M. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes Dev. 12:1998;3797-3802.
10. Zhan Q., Antinore M.J., Wang X.W., Carrier F., Smith M.L., Harris C.C., Fornace A.J. Jr. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene. 18:1999;2892-2900.
11. 2 /M cell cycle checkpoint. Proc Natl Acad Sci U S A. 96:1999;3706-3711.
12. Hollander M.C., Alamo I., Jackman J., Wang M.G., McBride O.W., Fornace A.J. Jr. Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem. 268:1993;24385-24393.
13. Rishi A.K., Sun R.J., Gao Y., Hsu C.K., Gerald T.M., Sheikh M.S., Dawson M.I., Reichert U., Shroot B., Fornace A.J. Jr, Brewer G., Fontana J.A. Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437. Nucleic Acids Res. 27:1999;3111-3119.
14. Sakaue M., Adachi H., Jetten A.M. Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-(3-(1-adamantyl)-4-hydroxyphenyl)-2- naphthalene carboxylic acid-induced apoptosis. Mol Pharmacol. 55:1999;668-676.
15. Takekawa M., Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell. 95:1998;521-530.
16. Harkin P.D., Bean J.M., Miklos D., Song Y.-H., Truong V.B., Englert C., Christians F.C., Ellisen L.W., Maheswaran S., Oliner J.D., Haber D.A. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCAI. Cell. 97:1999;575-586.
17. Kyriakis J.M., Avruch J. Sounding the alarm Protein kinase cascades activated by stress and inflammation. J Biol Chem. 271:1996;24313-24316.
18. Karin M. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann N Y Acad Sci. 851:1998;139-146.
19. Davis R.J. Signal transduction by the c-Jun N-terminal kinase. Biochem Soc Symp. 64:1999;1-12.
20. Gerwins P., Blank J.L., Johnson G.L. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem. 272:1997;8288-8295.
21. Takekawa M., Posas F., Saito H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase knase kinase, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16:1997;4973-4982.
22. Liu Y., Gorospe M., Yang C., Holbrook N.J. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. J Biol Chem. 270:1995;8377-8380.
23. Liu Z.G., Baskaran R., Lea-Chou E.T., Wood L.D., Chen Y., Karin M., Wang J.Y. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 384:1996;273-276.
24. Chen Y.-R., Meyer C.F., Tan T.-H. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in radiation-induced apoptosis. J Biol Chem. 271:1996;631-634.
25. Chen Y.-R., Wang X., Templeton D., Davis R.J., Tan T.-H. The role of c-Jun N-terminal kinase (JNK1) in apoptosis induced by ultraviolet C and γ radiation Duration of JNK activation may determine cell death and proliferation. J Biol Chem. 271:1996;31929-31936.
26. Miki Y., Swensen J., Shattuck-Eidens D., Futreal P.A., Harshman K., Tavtigian S., Liu Q., Cochran C., Bennett L.M., Ding W., et al., A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 266:1994;66-71.
27. Somasundaram K., Zhang H., Zeng Y.X., Houvras Y., Peng Y., Zhang H., Wu G.S., Licht J.D., Weber B.L., El-Deiry W.S. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature. 389:1997;187-190.
28. Butterfield L., Storey B., Maas L., Heasley L.E. c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation. J Biol Chem. 272:1997;10110-10116.
29. Guo Y.-L., Baysal K., Kang B., Yang L.-J., Williamson J.R. Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells. J Biol Chem. 273:1998;4027-4034.
30. Basu S., Kolesnick R. Stress signals for apoptosis Ceramide and c-Jun kinase. Oncogene. 17:1998;3277-3285.
31. Fuchs S.Y., Adler V., Pincus M., Ronai Z. MEKKI/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci U S A. 95:1998;10541-10546.
32. Adler V., Pincus M.R., Minamotot T., Fuchs S.Y., Bluth M.J., Brandt-Rauf P.W., Friedman F.K., Robinson R.C., Chen J.M., Wang X.W., Harris C.C., Ronai Z. Conformation-dependent phosphorylation of p53. Proc Natl Acad Sci U S A. 94:1997;1686-1691.
33. Huang C., Ma W.Y., Maxiner A., Sun Y., Dong Z. p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J Biol Chem. 274:1999;12229-12235.
34. Kharbanda S., Yuan Z.M., Weichselbaum R., Kufe D. Determination of cell fate by c-Ab1 activation in response to DNA damage. Oncogene. 17:1998;3309-3318.
35. Salles-Passador I., Fotedar A., Fotedar R. Cellular response to DNA damage. Link between p53 and DNA-PK. C R Acad Sci III. 322:1999;113-120.
36. Hollander M.C., Sheikh M.S., Bulavin D., Lundgren K., Henmueller L., Shehee R., Molinaro T., Kim K., Tolosa E., Ashwell J.D., Rosenberg M., Zhan Q., Fernandez-Salgueros F., Morgan W.F., Deng C., Fornace A.J. Jr. Genomic instability in gadd45-deficient mice. Nat Genet. 23:1999;176-184.
37. Wang X., Gorospe M., Holbrook N.J. gadd45 is not required for activation of c-Jun N-terminal kinase and p38 during acute stress. J Biol Chem. 274:1999;29599-29602.