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Volumn 3, Issue 9, 2006, Pages 515-526

Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways

Author keywords

Apoptosis; Machine learning; Mechanistic modelling; Signalling pathways; Systems biology

Indexed keywords

FAS ANTIGEN;

EID: 33747603487     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2005.0109     Document Type: Article
Times cited : (53)

References (32)
  • 1
    • 0036645099 scopus 로고    scopus 로고
    • Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men
    • Adam, B. L. et al. 2002 Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. Cancer Res. 62, 3609-3614.
    • (2002) Cancer Res. , vol.62 , pp. 3609-3614
    • Adam, B.L.1
  • 4
    • 0036718393 scopus 로고    scopus 로고
    • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis
    • doi:10.1038/sj.cdd.4401069
    • Bratton, S. B., Lewis, J., Butterworth, M., Duckett, C. S. & Cohen, G. M. 2002 XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell Death Differ. 9, 881-892. (doi:10.1038/sj.cdd.4401069)
    • (2002) Cell Death Differ. , vol.9 , pp. 881-892
    • Bratton, S.B.1    Lewis, J.2    Butterworth, M.3    Duckett, C.S.4    Cohen, G.M.5
  • 5
    • 0035478854 scopus 로고    scopus 로고
    • Random forests
    • doi:10.1023/A:1010933404324
    • Breiman, L. 2001a Random forests. Mach. Learn. 45, 5-32. (doi:10.1023/A:1010933404324)
    • (2001) Mach. Learn. , vol.45 , pp. 5-32
    • Breiman, L.1
  • 6
    • 0000245743 scopus 로고    scopus 로고
    • Statistical modelling: The two cultures
    • doi:10.1214/ss/1009213726
    • Breiman, L. 2001b Statistical modelling: the two cultures. Stat. Sci. 16, 199-231. (doi:10.1214/ss/1009213726)
    • (2001) Stat. Sci. , vol.16 , pp. 199-231
    • Breiman, L.1
  • 8
    • 24744472075 scopus 로고    scopus 로고
    • A validated mathematical model of cell-mediated immune response to tumor growth
    • de Pillis, L. G., Radunskaya, A. E. & Wiseman, C. L. 2005 A validated mathematical model of cell-mediated immune response to tumor growth. Cancer Res. 65, 7950-7958.
    • (2005) Cancer Res. , vol.65 , pp. 7950-7958
    • De Pillis, L.G.1    Radunskaya, A.E.2    Wiseman, C.L.3
  • 10
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: Playing dirty
    • doi:10.1038/437942a
    • Frantz, S. 2005 Drug discovery: playing dirty. Nature 437, 942-943. (doi:10.1038/437942a)
    • (2005) Nature , vol.437 , pp. 942-943
    • Frantz, S.1
  • 11
    • 0033925842 scopus 로고    scopus 로고
    • A mathematical model of caspase function in apoptosis
    • doi:10.1038/81208
    • Fussenegger, M., Bailey, J. E. & Varner, J. 2000 A mathematical model of caspase function in apoptosis. Nat. Biotechnol. 18, 768-774. (doi:10.1038/81208)
    • (2000) Nat. Biotechnol. , vol.18 , pp. 768-774
    • Fussenegger, M.1    Bailey, J.E.2    Varner, J.3
  • 12
    • 0041421151 scopus 로고    scopus 로고
    • Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro
    • doi:10.1073/pnas.1632587100
    • Gunther, E. C., Stone, D. J., Gerwien, R. W., Bento, P. & Heyes, M. P. 2003 Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro. Proc. Natl Acad. Sci. USA 100, 9608-9613. (doi:10.1073/pnas.1632587100)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 9608-9613
    • Gunther, E.C.1    Stone, D.J.2    Gerwien, R.W.3    Bento, P.4    Heyes, M.P.5
  • 13
    • 18744404266 scopus 로고    scopus 로고
    • Modelling of signal-response cascades using decision tree analysis
    • doi:10.1093/bioinformatics/bti278
    • Hautaniemi, S., Kharait, S., Iwabu, A., Wells, A. & Lauffenburger, D. A. 2005 Modelling of signal-response cascades using decision tree analysis. Bioinformatics 21, 2027-2035. (doi:10.1093/bioinformatics/bti278)
    • (2005) Bioinformatics , vol.21 , pp. 2027-2035
    • Hautaniemi, S.1    Kharait, S.2    Iwabu, A.3    Wells, A.4    Lauffenburger, D.A.5
  • 14
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signalling module: Temporal control and selective gene activation
    • doi:10.1126/science.1071914
    • Hoffmann, A., Levchenko, A., Scott, M. L. & Baltimore, D. 2002 The IkappaB-NF-kappaB signalling module: temporal control and selective gene activation. Science 298, 1241-1245. (doi:10.1126/science.1071914)
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 15
    • 23244462491 scopus 로고    scopus 로고
    • Effects of Bcl-2 levels on Fas signalling-induced caspase-3 activation: Molecular genetic tests of computational model predictions
    • Hua, F., Cornejo, M. G., Cardone, M. H., Stokes, C. L. & Lauffenburger, D. A. 2005 Effects of Bcl-2 levels on Fas signalling-induced caspase-3 activation: molecular genetic tests of computational model predictions. J. Immunol. 175, 985-995.
    • (2005) J. Immunol. , vol.175 , pp. 985-995
    • Hua, F.1    Cornejo, M.G.2    Cardone, M.H.3    Stokes, C.L.4    Lauffenburger, D.A.5
  • 16
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: Tumour resistance to apoptosis
    • doi:10.1038/nrc776
    • Igney, F. H. & Krammer, P. H. 2002 Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer 2, 277-288. (doi:10.1038/nrc776)
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 17
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • doi:10.1038/40657
    • Irmler, M. et al. 1997 Inhibition of death receptor signals by cellular FLIP. Nature 388, 190-195. (doi:10.1038/40657)
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1
  • 18
    • 0033570090 scopus 로고    scopus 로고
    • Quantification of short term signalling by the epidermal growth factor receptor
    • doi:10.1074/jbc.274.42.30169
    • Kholodenko, B. N., Demin, O. V., Moehren, G. & Hoek, J. B. 1999 Quantification of short term signalling by the epidermal growth factor receptor. J. Biol. Chem,. 274, 30 169-30 181. (doi:10.1074/jbc.274.42.30169)
    • (1999) J. Biol. Chem. , vol.274 , pp. 30169-30181
    • Kholodenko, B.N.1    Demin, O.V.2    Moehren, G.3    Hoek, J.B.4
  • 20
    • 0034641898 scopus 로고    scopus 로고
    • CD95's deadly mission in the immune system
    • doi:10.1038/35037728
    • Krammer, P. H. 2000 CD95's deadly mission in the immune system. Nature 407, 789-795. (doi:10.1038/35037728)
    • (2000) Nature , vol.407 , pp. 789-795
    • Krammer, P.H.1
  • 21
    • 0030715354 scopus 로고    scopus 로고
    • Mutations in the Fas antigen in patients with multiple myeloma
    • Landowski, T. H., Qu, N., Buyuksal, L, Painter, J. S. & Dalton, W. S. 1997 Mutations in the Fas antigen in patients with multiple myeloma. Blood 90, 4266-4270.
    • (1997) Blood , vol.90 , pp. 4266-4270
    • Landowski, T.H.1    Qu, N.2    Buyuksal, L.3    Painter, J.S.4    Dalton, W.S.5
  • 22
    • 14044278251 scopus 로고    scopus 로고
    • Death receptor signalling
    • doi:10.1242/jcs.01610
    • Lavrik, I., Golks, A. & Krammer, P. H. 2005 Death receptor signalling. J. Cell Sci. 2, 265-267. (doi:10.1242/jcs.01610)
    • (2005) J. Cell Sci. , vol.2 , pp. 265-267
    • Lavrik, I.1    Golks, A.2    Krammer, P.H.3
  • 23
    • 20544474049 scopus 로고    scopus 로고
    • Toward predictive models of mammalian cells
    • doi:10.1146/annurev.biophys.34.040204.144415
    • Ma'ayan, A., Blitzer, R. D. & Iyengar, R. 2005 Toward predictive models of mammalian cells. Annu. Rev. Biophys. Biomol. Struct. 34, 319-349. (doi:10.1146/ annurev.biophys.34.040204.144415)
    • (2005) Annu. Rev. Biophys. Biomol. Struct. , vol.34 , pp. 319-349
    • Ma'Ayan, A.1    Blitzer, R.D.2    Iyengar, R.3
  • 24
    • 27544446579 scopus 로고    scopus 로고
    • Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
    • doi:10.1186/1472-6904-5-3
    • Mencher, S. K. & Wang, L. G. 2005 Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin. Pharmacol. 5, 3. (doi:10.1186/1472-6904-5-3)
    • (2005) BMC Clin. Pharmacol. , vol.5 , pp. 3
    • Mencher, S.K.1    Wang, L.G.2
  • 25
    • 0033396491 scopus 로고    scopus 로고
    • Fas ligand-induced apoptosis
    • doi:10.1146/annurev.genet.33.1.29
    • Nagata, S. 1999 Fas ligand-induced apoptosis. Annu. Rev. Genet. 33, 29-55. (doi:10.1146/annurev.genet.33.1.29)
    • (1999) Annu. Rev. Genet. , vol.33 , pp. 29-55
    • Nagata, S.1
  • 26
    • 0036778479 scopus 로고    scopus 로고
    • Decision trees: An overview and their use in medicine
    • doi:10.1023/A:1016409317640
    • Podgorelec, V., Kokol, P., Stiglic, B. & Rozman, I. 2002 Decision trees: an overview and their use in medicine. J. Med. Syst. 26, 445-463. (doi:10.1023/A:1016409317640)
    • (2002) J. Med. Syst. , vol.26 , pp. 445-463
    • Podgorelec, V.1    Kokol, P.2    Stiglic, B.3    Rozman, I.4
  • 27
    • 0037142053 scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • doi:10.1056/NEJMoa012914
    • Rosenwald, A. et al. 1947 The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 1937 1937. (doi:10.1056/NEJMoa012914)
    • (1947) N. Engl. J. Med. , vol.346 , pp. 19371937
    • Rosenwald, A.1
  • 28
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • doi:10.1038/nrd1346
    • Roth, B. L., Sheffler, D. J. & Kroezc, W. K. 2004 Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat. Rev. Drug Discov. 3, 353-359. (doi:10.1038/nrd1346)
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroezc, W.K.3
  • 30
    • 0036212767 scopus 로고    scopus 로고
    • Computational modelling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • doi:10.1038/nbt0402-370
    • Schoeberl, B., Eichler-Jonsson, C., Gilles, E. D. & Muller, G. 2002 Computational modelling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 20, 370-375. (doi:10.1038/nbt0402-370)
    • (2002) Nat. Biotechnol. , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 31
    • 0037941585 scopus 로고    scopus 로고
    • Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data
    • Segal, E., Shapira, M., Regev, A., Pe'er, D., Botstein, D., Koller, D. & Friedman, N. 2003 Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat. Genet. 34, 166-176.
    • (2003) Nat. Genet. , vol.34 , pp. 166-176
    • Segal, E.1    Shapira, M.2    Regev, A.3    Pe'er, D.4    Botstein, D.5    Koller, D.6    Friedman, N.7
  • 32
    • 0037213006 scopus 로고    scopus 로고
    • Computational modelling of the EGF-receptor system: A paradigm for systems biology
    • doi:10.1016/S0962-8924(02)00009-0
    • Wiley, H. S., Shvartsman, S. Y. & Lauffenburger, D. A. 2003 Computational modelling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 13, 43-50. (doi:10.1016/S0962-8924(02)00009-0)
    • (2003) Trends Cell Biol. , vol.13 , pp. 43-50
    • Wiley, H.S.1    Shvartsman, S.Y.2    Lauffenburger, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.