Regulatory network of lipid-sensing nuclear receptors: Roles for CAR, PXR, LXR, and FXR

Archives of Biochemistry and Biophysics

Volumn 433, Issue 2, 2005, Pages 387-396

  Handschin, Christoph ^a   Meyer, Urs A ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Bile acids; CAR; Cholesterol; Cytochrome P450; Drug induction; FXR; Lipids; LXR; Nuclear receptors; PXR

Indexed keywords

BILE ACID; BILIRUBIN; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; FARNESOID X RECEPTOR; FLUINDOSTATIN; HYBRID PROTEIN; LIPID; LIVER X RECEPTOR; MEVINOLIN; PHENOBARBITAL; PREGNANE X RECEPTOR; RETINOID X RECEPTOR; SQUALESTATIN; VITAMIN D RECEPTOR;

CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONFERENCE PAPER; DRUG DETOXIFICATION; DRUG METABOLISM; HOMEOSTASIS; HUMAN; HYDROPHILICITY; LIVER; LIVER PROTECTION; MOLECULAR CLOCK; MOLECULE; NONHUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SPECIES DIFFERENCE; STEROID METABOLISM;

ANIMALS; BILE ACIDS AND SALTS; BILIRUBIN; CELL NUCLEUS; CHOLESTEROL; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DNA-BINDING PROTEINS; HUMANS; LIPID METABOLISM; LIVER; MODELS, BIOLOGICAL; PHYLOGENY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 9944265844     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2004.08.030     Document Type: Conference Paper

References (157)

1. D.R. Nelson, L. Koymans, T. Kamataki, J.J. Stegeman, R. Feyereisen, D.J. Waxman, M.R. Waterman, O. Gotoh, M.J. Coon, R.W. Estabrook, I.C. Gunsalus, and D.W. Nebert Pharmacogenetics 6 1996 1 42
2. H. Remmer Naturwissenschaften 46 1958 580 581
3. P. Honkakoski, I. Zelko, T. Sueyoshi, and M. Negishi Mol. Cell. Biol. 18 1998 5652 5658
4. S.A. Kliewer, J.T. Moore, L. Wade, J.L. Staudinger, M.A. Watson, S.A. Jones, D.D. McKee, B.B. Oliver, T.M. Willson, R.H. Zetterstrom, T. Perlmann, and J.M. Lehmann Cell 92 1998 73 82
5. J.M. Lehmann, D.D. McKee, M.A. Watson, T.M. Willson, J.T. Moore, and S.A. Kliewer J. Clin. Invest. 102 1998 1016 1023
6. B. Blumberg, W. Sabbagh Jr., H. Juguilon, J. Bolado Jr., C.M. van Meter, E.S. Ong, and R.M. Evans Genes Dev. 12 1998 3195 3205
7. G. Bertilsson, J. Heidrich, K. Svensson, M. Asman, L. Jendeberg, M. Sydow-Baeckman, R. Ohlsson, H. Postlind, P. Blomquist, and A. Berkenstam Proc. Natl. Acad. Sci. USA 95 1998 12208 12213
8. W. Xie, J.L. Barwick, M. Downes, B. Blumberg, C.M. Simon, M.C. Nelson, B.A. Neuschwander-Tetri, E.M. Brunt, P.S. Guzelian, and R.M. Evans Nature 406 2000 435 439
9. P. Wei, J. Zhang, M. Egan-Hafley, S. Liang, and D.D. Moore Nature 407 2000 920 923
10. L.B. Moore, D.J. Parks, S.A. Jones, R.K. Bledsoe, T.G. Consler, J.B. Stimmel, B. Goodwin, C. Liddle, S.G. Blanchard, T.M. Willson, J.L. Collins, and S.A. Kliewer J. Biol. Chem. 275 2000 15122 15127
11. W. Xie, J.L. Barwick, C.M. Simon, A.M. Pierce, S. Safe, B. Blumberg, P.S. Guzelian, and R.M. Evans Genes Dev. 14 2000 3014 3023
12. P. Wei, J. Zhang, D.H. Dowhan, Y. Han, and D.D. Moore Pharmacogenomics J. 2 2002 117 126
13. J.M. Maglich, C.M. Stoltz, B. Goodwin, D. Hawkins-Brown, J.T. Moore, and S.A. Kliewer Mol. Pharmacol. 62 2002 638 646
14. J.T. Moore, L.B. Moore, J.M. Maglich, and S.A. Kliewer Biochim. Biophys. Acta 1619 2003 235 238
15. S.A. Kliewer, B. Goodwin, and T.M. Willson Endocr. Rev. 23 2002 687 702
16. H. Wang, and M. Negishi Curr. Drug Metab. 4 2003 515 525
17. P. Honkakoski, T. Sueyoshi, and M. Negishi Ann. Med. 35 2003 172 182
18. S. Kakizaki, Y. Yamamoto, A. Ueda, R. Moore, T. Sueyoshi, and M. Negishi Biochim. Biophys. Acta 1619 2003 239 242
19. C. Handschin, M. Podvinec, and U.A. Meyer Drug News Perspect. 16 2003 423 434
20. C. Handschin, and U.A. Meyer Pharmacol. Rev. 55 2003 649 673
21. T.M. Willson, and S.A. Kliewer Nat. Rev. Drug Discov. 1 2002 259 266
22. J.M. Pascussi, S. Gerbal-Chaloin, L. Drocourt, P. Maurel, and M.J. Vilarem Biochim. Biophys. Acta 1619 2003 243 253
23. K. Swales, and M. Negishi Mol. Endocrinol. 18 2004 1589 1598
24. D.J. Waxman, and L. Azaroff Biochem. J. 281 1992 577 592
25. R.E. Watkins, G.B. Wisely, L.B. Moore, J.L. Collins, M.H. Lambert, S.P. Williams, T.M. Willson, S.A. Kliewer, and M.R. Redinbo Science 292 2001 2329 2333
26. R.E. Watkins, J.M. Maglich, L.B. Moore, G.B. Wisely, S.M. Noble, P.R. Davis-Searles, M.H. Lambert, S.A. Kliewer, and M.R. Redinbo Biochemistry 42 2003 1430 1438
27. Nuclear Receptors Nomenclature Committee, Cell 97 (1999) 161-163
28. L.B. Moore, J.M. Maglich, D.D. McKee, B. Wisely, T.M. Willson, S.A. Kliewer, M.H. Lambert, and J.T. Moore Mol. Endocrinol. 16 2002 977 986
29. F. Grün, R.N. Venkatesan, M.M. Tabb, C. Zhou, J. Cao, D. Hemmati, and B. Blumberg J. Biol. Chem. 277 2002 43691 43697
30. A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Science 294 2001 1866 1870
31. D.J. Mangelsdorf, and R.M. Evans Cell 83 1995 841 850
32. D.J. Mangelsdorf, C. Thummel, M. Beato, P. Herrlich, G. Schütz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R.M. Evans Cell 83 1995 835 839
33. D.P. McDonnell, D.J. Mangelsdorf, J.W. Pike, M.R. Haussler, and B.W. O'Malley Science 235 1987 1214 1217
34. B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf Nature 383 1996 728 731
35. H. Wang, J. Chen, K. Hollister, L.C. Sowers, and B.M. Forman Mol. Cell 3 1999 543 553
36. D.J. Parks, S.G. Blanchard, R.K. Bledsoe, G. Chandra, T.G. Consler, S.A. Kliewer, J.B. Stimmel, T.M. Willson, A.M. Zavacki, D.D. Moore, and J.M. Lehmann Science 284 1999 1365 1368
37. M. Makishima, A.Y. Okamoto, J.J. Repa, H. Tu, R.M. Learned, A. Luk, M.V. Hull, K.D. Lustig, D.J. Mangelsdorf, and B. Shan Science 284 1999 1362 1365
38. B. Blumberg, and R.M. Evans Genes Dev. 12 1998 3149 3155
39. B.M. Forman, I. Tzameli, H.S. Choi, J. Chen, D. Simha, W. Seol, R.M. Evans, and D.D. Moore Nature 395 1998 612 615
40. T. Kawamoto, S. Kakizaki, K. Yoshinari, and M. Negishi Mol. Endocrinol. 14 2000 1897 1905
41. A. Ueda, H.K. Hamadeh, H.K. Webb, Y. Yamamoto, T. Sueyoshi, C.A. Afshari, J.M. Lehmann, and M. Negishi Mol. Pharmacol. 61 2002 1 6
42. W. Xie, M.F. Yeuh, A. Radominska-Pandya, S.P. Saini, Y. Negishi, B.S. Bottroff, G.Y. Cabrera, R.H. Tukey, and R.M. Evans Proc. Natl. Acad. Sci. USA 100 2003 4150 4155
43. L. You Chem. Biol. Interact. 147 2004 233 246
44. M. Terzolo, G. Borretta, A. Ali, F. Cesario, G. Magro, A. Boccuzzi, G. Reimondo, and A. Angeli Horm. Metab. Res. 27 1995 148 150
45. C. Gupta, S.J. Yaffe, and B.H. Shapiro Science 216 1982 640 642
46. C. Gupta, B.R. Sonawane, S.J. Yaffe, and B.H. Shapiro Science 208 1980 508 510
47. C. Gupta, B.H. Shapiro, and S.J. Yaffe Pediatr. Pharmacol. (New York) 1 1980 55 62
48. A.B. Dessens, P.T. Cohen-Kettenis, G.J. Mellenbergh, N. vd Poll, J.G. Koppe, and K. Boer Arch. Sex Behav. 28 1999 31 44
49. A.B. Dessens, P.T. Cohen-Kettenis, G.J. Mellenbergh, J.G. Koppe, N.E. Poll, and K. Boer Teratology 64 2001 181 188
50. J.L. Staudinger, B. Goodwin, S.A. Jones, D. Hawkins-Brown, K.I. MacKenzie, A. LaTour, Y. Liu, C.D. Klaassen, K.K. Brown, J. Reinhard, T.M. Willson, B.H. Koller, and S.A. Kliewer Proc. Natl. Acad. Sci. USA 98 2001 3369 3374
51. W. Xie, A. Radominska-Pandya, Y. Shi, C.M. Simon, M.C. Nelson, E.S. Ong, D.J. Waxman, and R.M. Evans Proc. Natl. Acad. Sci. USA 98 2001 3375 3380
52. B. Goodwin, K.C. Gauthier, M. Umetani, M.A. Watson, M.I. Lochansky, J.L. Collins, E. Leitersdorf, D.J. Mangelsdorf, S.A. Kliewer, and J.J. Repa Proc. Natl. Acad. Sci. USA 100 2003 223 228
53. S.A. Jones, L.B. Moore, J.L. Shenk, G.B. Wisely, G.A. Hamilton, D.D. McKee, N.C. Tomkinson, E.L. LeCluyse, M.H. Lambert, T.M. Willson, S.A. Kliewer, and J.T. Moore Mol. Endocrinol. 14 2000 27 39
54. S.P. Saini, J. Sonoda, L. Xu, D. Toma, H. Uppal, Y. Mu, S. Ren, D.D. Moore, R.M. Evans, and W. Xie Mol. Pharmacol. 65 2004 292 300
55. G.L. Guo, G. Lambert, M. Negishi, J.M. Ward, H.B. Brewer Jr., S.A. Kliewer, F.J. Gonzalez, and C.J. Sinal J. Biol. Chem. 278 2003 45062 45071
56. M. Assem, E.G. Schuetz, M. Leggas, D. Sun, K. Yasuda, G. Reid, N. Zelcer, M. Adachi, S. Strom, R.M. Evans, D.D. Moore, P. Borst, and J.D. Schuetz J. Biol. Chem. 279 2004 22250 22257
57. W. Huang, J. Zhang, S.S. Chua, M. Qatanani, Y. Han, R. Granata, and D.D. Moore Proc. Natl. Acad. Sci. USA 100 2003 4156 4161
58. J.Y. Chiang J. Hepatol. 40 2004 539 551
59. J.Y. Chiang Am. J. Physiol. Gastrointest. Liver Physiol. 284 2003 G349 G356
60. J.Y. Chiang Endocr. Rev. 23 2002 443 463
61. R.A. Davis, J.H. Miyake, T.Y. Hui, and N.J. Spann J. Lipid Res. 43 2002 533 543
62. J.M. Lehmann, S.A. Kliewer, L.B. Moore, T.A. Smith-Oliver, B.B. Oliver, J.L. Su, S.S. Sundseth, D.A. Winegar, D.E. Blanchard, T.A. Spencer, and T.M. Willson J. Biol. Chem. 272 1997 3137 3140
63. D.J. Peet, S.D. Turley, W. Ma, B.A. Janowski, J.-M.A. Lobaccaro, R.E. Hammer, and D.J. Mangelsdorf Cell 93 1998 693 704
64. J.Y. Chiang, R. Kimmel, and D. Stroup Gene 262 2001 257 265
65. B. Goodwin, M.A. Watson, H. Kim, J. Miao, J.K. Kemper, and S.A. Kliewer Mol. Endocrinol. 17 2003 386 394
66. L.B. Agellon, V.A. Drover, S.K. Cheema, G.F. Gbaguidi, and A. Walsh J. Biol. Chem. 277 2002 20131 20134
67. J.Y. Chen, B. Levy-Wilson, S. Goodart, and A.D. Cooper J. Biol. Chem. 277 2002 42588 42595
68. J.D. Horton, J.L. Goldstein, and M.S. Brown J. Clin. Invest. 109 2002 1125 1131
69. T.A. Kocarek, and N.A. Mercer-Haines Mol. Pharmacol. 62 2002 1177 1186
70. S.D. Shenoy, T.A. Spencer, N.A. Mercer-Haines, M. Abdolalipour, W.L. Wurster, M. Runge-Morris, and T.A. Kocarek Mol. Pharmacol. 65 2004 1302 1312
71. B.M. Forman, B. Ruan, J. Chen, G.J. Schroepfer Jr., and R.M. Evans Proc. Natl. Acad. Sci. USA 94 1997 10588 10593
72. T.T. Lu, M. Makishima, J.J. Repa, K. Schoonjans, T.A. Kerr, J. Auwerx, and D.J. Mangelsdorf Mol. Cell 6 2000 507 515
73. B. Goodwin, S.A. Jones, R.R. Price, M.A. Watson, D.D. McKee, L.B. Moore, C. Galardi, J.G. Wilson, M.C. Lewis, M.E. Roth, P.R. Maloney, T.M. Willson, and S.A. Kliewer Mol. Cell 6 2000 517 526
74. T.A. Kerr, S. Saeki, M. Schneider, K. Schaefer, S. Berdy, T. Redder, B. Shan, D.W. Russell, and M. Schwarz Dev. Cell 2 2002 713 720
75. L. Wang, Y.K. Lee, D. Bundman, Y. Han, S. Thevananther, C.S. Kim, S.S. Chua, P. Wei, R.A. Heyman, M. Karin, and D.D. Moore Dev. Cell 2 2002 721 731
76. J.A. Holt, G. Luo, A.N. Billin, J. Bisi, Y.Y. McNeill, K.F. Kozarsky, M. Donahee, D.Y. Wang, T.A. Mansfield, S.A. Kliewer, B. Goodwin, and S.A. Jones Genes Dev. 17 2003 1581 1591
77. J. Staudinger, Y. Liu, A. Madan, S. Habeebu, and C.D. Klaassen Drug Metab. Dispos. 29 2001 1467 1472
78. M. Crestani, A. Sadeghpour, D. Stroup, G. Galli, and J.Y. Chiang J. Lipid Res. 39 1998 2192 2200
79. E. De Fabiani, N. Mitro, A.C. Anzulovich, A. Pinelli, G. Galli, and M. Crestani J. Biol. Chem. 276 2001 30708 30716
80. H.R. Kast, B. Goodwin, P.T. Tarr, S.A. Jones, A.M. Anisfeld, C.M. Stoltz, P. Tontonoz, S. Kliewer, T.M. Willson, and P.A. Edwards J. Biol. Chem. 277 2002 2908 2915
81. N.J. Cherrington, D.P. Hartley, N. Li, D.R. Johnson, and C.D. Klaassen J. Pharmacol. Exp. Ther. 300 2002 97 104
82. J.L. Staudinger, A. Madan, K.M. Carol, and A. Parkinson Drug Metab. Dispos. 31 2003 523 527
83. E.G. Schuetz, S. Strom, K. Yasuda, V. Lecureur, M. Assem, C. Brimer, J. Lamba, R.B. Kim, V. Ramachandran, B.J. Komoroski, R. Venkataramanan, H. Cai, C.J. Sinal, F.J. Gonzalez, and J.D. Schuetz J. Biol. Chem. 276 2001 39411 39418
84. G.A. Francis, E. Fayard, F. Picard, and J. Auwerx Annu. Rev. Physiol. 65 2003 261 311
85. J.J. Repa, and D.J. Mangelsdorf Annu. Rev. Cell Dev. Biol. 16 2000 459 481
86. J.M. Rosenfeld, R. Vargas Jr., W. Xie, and R.M. Evans Mol. Endocrinol. 17 2003 1268 1282
87. M. Makishima, T.T. Lu, W. Xie, G.K. Whitfield, H. Domoto, R.M. Evans, M.R. Haussler, and D.J. Mangelsdorf Science 296 2002 1313 1316
88. L. Drocourt, J.C. Ourlin, J.M. Pascussi, P. Maurel, and M.J. Vilarem J. Biol. Chem. 277 2002 25125 25132
89. M. Trauner Hepatology 40 2004 260 263
90. Z. Araya, and K. Wikvall Biochim. Biophys. Acta 1438 1999 47 54
91. C. Furster, and K. Wikvall Biochim. Biophys. Acta 1437 1999 46 52
92. J.C. Ourlin, C. Handschin, M. Kaufmann, and U.A. Meyer Biochem. Biophys. Res. Commun. 291 2002 378 384
93. C. Handschin, M. Podvinec, R. Amherd, R. Looser, J.C. Ourlin, and U.A. Meyer J. Biol. Chem. 277 2002 29561 29567
94. J.C. Ourlin, F. Lasserre, T. Pineau, J.M. Fabre, A. Sa-Cunha, P. Maurel, M.J. Vilarem, and J.M. Pascussi Mol. Endocrinol. 17 2003 1693 1703
95. C. Stedman, G. Robertson, S. Coulter, and C. Liddle J. Biol. Chem. 279 2004 11336 11343
96. K. Bodin, L. Bretillon, Y. Aden, L. Bertilsson, U. Broome, C. Einarsson, and U. Diczfalusy J. Biol. Chem. 276 2001 38685 38689
97. K. Bodin, U. Andersson, E. Rystedt, E. Ellis, M. Norlin, I. Pikuleva, G. Eggertsen, I. Bjorkhem, and U. Diczfalusy J. Biol. Chem. 277 2002 31534 31540
98. S.D. Shenoy, T.A. Spencer, N.A. Mercer-Haines, M. Alipour, M.D. Gargano, M. Runge-Morris, and T.A. Kocarek Drug Metab. Dispos. 32 2004 66 71
99. Z. Zhang, D. Li, D.E. Blanchard, S.R. Lear, S.K. Erickson, and T.A. Spencer J. Lipid Res. 42 2001 649 658
100. H. Wietholtz, H.U. Marschall, J. Sjovall, and S. Matern J. Hepatol. 24 1996 713 718
101. C. Song, R.A. Hiipakka, and S. Liao Steroids 65 2000 423 427
102. T.A. Kocarek, S.D. Shenoy, N.A. Mercer-Haines, and M. Runge-Morris J. Pharmacol. Toxicol. Methods 47 2002 177 187
103. J.J. Repa, G. Liang, J. Ou, Y. Bashmakov, J.M. Lobaccaro, I. Shimomura, B. Shan, M.S. Brown, J.L. Goldstein, and D.J. Mangelsdorf Genes Dev. 14 2000 2819 2830
104. R.A. DeBose-Boyd, J. Ou, J.L. Goldstein, and M.S. Brown Proc. Natl. Acad. Sci. USA 98 2001 1477 1482
105. S.B. Joseph, B.A. Laffitte, P.H. Patel, M.A. Watson, K.E. Matsukuma, R. Walczak, J.L. Collins, T.F. Osborne, and P. Tontonoz J. Biol. Chem. 277 2002 11019 11025
106. Y. Zhang, L.W. Castellani, C.J. Sinal, F.J. Gonzalez, and P.A. Edwards Genes Dev. 18 2004 157 169
107. M. Watanabe, S.M. Houten, L. Wang, A. Moschetta, D.J. Mangelsdorf, R.A. Heyman, D.D. Moore, and J. Auwerx J. Clin. Invest. 113 2004 1408 1418
108. K.S. Miyata, S.E. McCaw, H.V. Patel, R.A. Rachubinski, and J.P. Capone J. Biol. Chem. 271 1996 9189 9192
109. T. Yoshikawa, T. Ide, H. Shimano, N. Yahagi, M. Amemiya-Kudo, T. Matsuzaka, S. Yatoh, T. Kitamine, H. Okazaki, Y. Tamura, M. Sekiya, A. Takahashi, A.H. Hasty, R. Sato, H. Sone, J. Osuga, S. Ishibashi, and N. Yamada Mol. Endocrinol. 17 2003 1240 1254
110. T. Ide, H. Shimano, T. Yoshikawa, N. Yahagi, M. Amemiya-Kudo, T. Matsuzaka, M. Nakakuki, S. Yatoh, Y. Iizuka, S. Tomita, K. Ohashi, A. Takahashi, H. Sone, T. Gotoda, J. Osuga, S. Ishibashi, and N. Yamada Mol. Endocrinol. 17 2003 1255 1267
111. A. Kassam, C.J. Winrow, F. Fernandez-Rachubinski, J.P. Capone, and R.A. Rachubinski J. Biol. Chem. 275 2000 4345 4350
112. A. Columbano, G.M. Ledda-Columbano, M. Pibiri, D. Concas, J.K. Reddy, and M.S. Rao Hepatology. 34 2001 262 266
113. T. Shiraki, N. Sakai, E. Kanaya, and H. Jingami J. Biol. Chem. 278 2003 11344 11350
114. P. Puigserver, and B.M. Spiegelman Endocr. Rev. 24 2003 78 90
115. J.M. Maglich, J. Watson, P.J. McMillen, B. Goodwin, T.M. Willson, and J.T. Moore J. Biol. Chem. 279 2004 19832 19838
116. M. Qatanani, P. Wei, and D.D. Moore Pharmacol. Biochem. Behav. 78 2004 285 291
117. T.A. Kocarek, E.G. Schuetz, and P.S. Guzelian Toxicol. Appl. Pharmacol. 120 1993 298 307
118. T.A. Kocarek, J.M. Kraniak, and A.B. Reddy Mol. Pharmacol 54 1998 474 484
119. T.A. Kocarek, and A.B. Reddy Biochem. Pharmacol. 55 1998 1435 1443
120. E. Sudjana-Sugiaman, G. Eggertsen, and I. Bjorkhem J. Lipid Res. 35 1994 319 327
121. M. Andersson, J. Ericsson, E.L. Appelkvist, S. Schedin, T. Chojnacki, and G. Dallner Biochim. Biophys. Acta 1214 1994 79 87
122. N. Kiyosawa, K. Tanaka, J. Hirao, K. Ito, N. Niino, K. Sakuma, M. Kanbori, T. Yamoto, S. Manabe, and N. Matsunuma Arch. Toxicol. 78 2004 435 452
123. A. Plewka, and M. Kaminski Exp. Toxicol. Pathol. 48 1996 249 253
124. M. Watanabe, H. Nakura, T. Tateishi, H. Tanaka, T. Kumai, and S. Kobayashi Med. Sci. Res. 24 1996 257 259
125. R.A. Blouin, A.M. Bandyopadhyay, I. Chaudhary, L.W. Robertson, B. Gemzik, and A. Parkinson Arch. Biochem. Biophys. 303 1993 313 320
126. P.N. Zannikos, A.M. Bandyopadhyay, L.W. Robertson, and R.A. Blouin Drug Metab. Dispos. 21 1993 782 787
127. P.N. Zannikos, A.M. Bandyopadhyay, L.W. Robertson, and R.A. Blouin Int. J. Obes. Relat. Metab. Disord. 18 1994 369 374
128. K.D. Thomas Isr. J. Med. Sci. 20 1984 240 241
129. F.R. Heller, J.P. Desager, and C. Harvengt Int. J. Clin. Pharmacol. Ther. Toxicol. 26 1988 138 142
130. K. Bachmann, H. Patel, Z. Batayneh, J. Slama, D. White, J. Posey, S. Ekins, D. Gold, and L. Sambucetti Pharmacol. Res. 50 2004 237 246
131. J.M. Eiris, S. Lojo, M.C. Del Rio, I. Novo, M. Bravo, P. Pavon, and M. Castro-Gago Neurology 45 1995 1155 1157
132. F.M. Aynaci, F. Orhan, A. Orem, S. Yildirmis, and Y. Gedik J. Child Neurol. 16 2001 367 369
133. M. Schwaninger, P. Ringleb, A. Annecke, R. Winter, B. Kohl, E. Werle, W. Fiehn, P.A. Rieser, and I. Walter-Sack J. Neurol. 247 2000 687 690
134. A. Verrotti, S. Domizio, B. Angelozzi, G. Sabatino, G. Morgese, and F. Chiarelli J. Paediatr. Child Health 33 1997 242 245
135. E. Yilmaz, Y. Dosan, M.K. Gurgoze, and S. Gungor Acta Neurol. Belg. 101 2001 217 220
136. A. Verrotti, F. Basciani, S. Domizio, G. Sabatino, G. Morgese, and F. Chiarelli Pediatr. Neurol. 19 1998 364 367
137. T. Nikolaos, G. Stylianos, N. Chryssoula, P. Irini, M. Christos, T. Dimitrios, P. Konstantinos, and T. Antonis Med. Sci. Monit. 10 2004 MT50 MT52
138. M.J. Tutor-Crespo, J. Hermida, and J.C. Tutor J. Clin. Pharmacol. 44 2004 974 980
139. S.J. Yaffe, G. Levy, T. Matsuzawa, and T. Baliah N. Engl. J. Med. 275 1966 1461 1466
140. P. Back Pharmacol. Ther. 33 1987 153 155
141. W. Huang, J. Zhang, and D.D. Moore J. Clin. Invest. 113 2004 137 143
142. T.A. Kocarek, E.G. Schuetz, S.C. Strom, R.A. Fisher, and P.S. Guzelian Drug Metab. Dispos. 23 1995 415 421
143. F.P. Guengerich Annu. Rev. Pharmacol. Toxicol. 39 1999 1 17
144. S.C. Dogra, B.P. Davidson, and B.K. May Mol. Pharmacol. 55 1999 14 22
145. M.S. Denison, and J.P. Whitlock Jr. J. Biol. Chem. 270 1995 18175 18178
146. C. Handschin, M. Podvinec, J. Stöckli, K. Hoffmann, and U.A. Meyer Mol. Endocrinol. 15 2001 1571 1585
147. C. Handschin, and U.A. Meyer J. Biol. Chem. 275 2000 13362 13369
148. C. Handschin, M. Podvinec, R. Looser, R. Amherd, and U.A. Meyer Mol. Pharmacol. 60 2001 681 689
149. C. Handschin, M. Podvinec, and U.A. Meyer Proc. Natl. Acad. Sci. USA 97 2000 10769 10774
150. J.M. Maglich, J.A. Caravella, M.H. Lambert, T.M. Willson, J.T. Moore, and L. Ramamurthy Nucleic Acids Res. 31 2003 4051 4058
151. T.H. Lindblom, G.J. Pierce, and A.E. Sluder Curr. Biol. 11 2001 864 868
152. B. Hollanders, A. Mougin, F. N'Diaye, E. Hentz, X. Aude, and A. Girard Comp. Biochem. Physiol. B 84 1986 83 89
153. L.B. Moore, B. Goodwin, S.A. Jones, G.B. Wisely, C.J. Serabjit-Singh, T.M. Willson, J.L. Collins, and S.A. Kliewer Proc. Natl. Acad. Sci. USA 97 2000 7500 7502
154. J. Zhang, W. Huang, S.S. Chua, P. Wei, and D.D. Moore Science 298 2002 422 424
155. M.A. Lazar J. Clin. Invest. 113 2004 23 25
156. T.M. Willson, S.A. Jones, J.T. Moore, and S.A. Kliewer Med. Res. Rev. 21 2001 513 522
157. B. Goodwin, and J.T. Moore Trends Pharmacol. Sci. 25 2004 437 441