Membrane lipids as signaling molecules

Current Opinion in Lipidology

Volumn 18, Issue 2, 2007, Pages 121-128

  Fernandis, Aaron Z ^a   Wenk, Markus R ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Eicosanoids; Endocannabinoids; Lipid oxidation; Lipidomics; Phosphoinositides; Sphingolipids

Indexed keywords

ANANDAMIDE; ARACHIDONIC ACID; CHOLINE; DIACYLGLYCEROL; DOCOSAHEXAENOIC ACID; ENDOCANNABINOID; EXODEOXYRIBONUCLEASE VIII; GLYCEROPHOSPHOLIPID; GUANOSINE TRIPHOSPHATASE; HYDROCARBON; ICOSANOID; MEMBRANE LIPID; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLSERINE; POLYUNSATURATED FATTY ACID; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE 1 PHOSPHATE; TOLL LIKE RECEPTOR;

CARDIOVASCULAR DISEASE; HUMAN; HYDROLYSIS KINETICS; INFLAMMATION; LIPID METABOLISM; LIPID PEROXIDATION; MEMBRANE TRANSPORT; METABOLOMICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

BIOLOGICAL MARKERS; HUMANS; HYDROCARBONS; LIPIDS; MEMBRANE LIPIDS; PHOSPHOLIPIDS; PHOSPHOPROTEINS; PROTEINS; SIGNAL TRANSDUCTION;

EID: 33947183899     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328082e4d5     Document Type: Review

References (48)

1. Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312:315-321.
2. Saiardi A, Bhandari R, Resnick AC, et al. Phosphorylation of proteins by inositol pyrophosphates. Science 2004; 306:2101-2105.
3. Wood CD, Marklund U, Cantrell DA. Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes. J Biol Chem 2005; 280:6245-6251.
4. Colon-Gonzalez F, Kazanietz MG. C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta 2006; 1761:827-837.
5. Loewen CJ, Gaspar ML, Jesch SA, et al. Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 2004; 304:1644-1647.
6. Han GS, Wu WI, Carman GM. The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. J Biol Chem 2006; 281:9210-9218. • Identification of phosphatidic acid phosphohydrolase-1 (PAH1), a GPA phosphatase, the yeast homologue of mammalian Lipin, a protein involved in fat regulation. Together with the study by Loewen et al. (Science 2004, 281:1644-1647), this work provides new evidence for a close regulatory coupling of glycerolipid and glycerophospholipid metabolism via levels of GPA.
7. Stace CL, Ktistakis NT. Phosphatidic acid- and phosphatidylserine-binding proteins. Biochim Biophys Acta 2006; 1761:913-926. • Excellent recent review addressing the important question of protein recognition of headgroups at membrane lipids other than phosphoinositides.
8. Ross EM, Mateu D, Gomes AV, et al. Structural determinants for phosphatidic acid regulation of phospholipase C-beta1. J Biol Chem 2006; 281:33087-33094.
9. Yeung T, Terebiznik M, Yu L, et al. Receptor activation alters inner surface potential during phagocytosis. Science 2006; 313:347-351. •• Study employing technically elaborate probes for membrane surface potential in combination with monitoring of phosphoinositide metabolism in living cells.
10. Burger KN, Demel RA, Schmid SL, de Kruijff B. Dynamin is membrane-active: lipid insertion is induced by phosphoinositides and phosphatidic acid. Biochemistry 2000; 39:12485-12493.
11. Roux A, Uyhazi K, Frost A, De Camilli P. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature 2006; 441:528-531.
12. Kolter T, Sandhoff K. Sphingolipid metabolism diseases. Biochim Biophys Acta 2006; 1758:2057-2079 [Epub ahead of print].
13. Zumbansen M, Stoffel W. Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease. Mol Cell Biol 2002; 22:3633-3638.
14. Stoffel W, Jenke B, Block B, et al. Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Proc Natl Acad Sci U S A 2005; 102:4554-4559.
15. Marchesini N, Osta W, Bielawski J, et al. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem 2004; 279:25101-25111.
16. Levy M, Castillo SS, Goldkorn T. nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Biochem Biophys Res Commun 2006; 344:900-905.
17. Grimm MO, Grimm HS, Patzold AJ, et al. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol 2005; 7:1118-1123.
18. Pettitt TR, Martin A, Horton T, et al. Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions: phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells. J Biol Chem 1997; 272:17354-17359.
19. Zimmerberg J, Kozlov MM. How proteins produce cellular membrane curvature. Nat Rev Mol Cell Biol 2006; 7:9-19.
20. Marsh D. Elastic curvature constants of lipid monolayers and bilayers. Chem Phys Lipids 2006; 144:146-159 [Epub ahead of print].
21. Gardell SE, Dubin AE, Chun J. Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med 2006; 12:65-75.
22. van Meeteren LA, Ruurs P, Stortelers C, et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol 2006; 26:5015-5022.
23. Oskouian B, Sooriyakumaran P, Borowsky AD, et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A 2006; 103:17384-17389 [Epub ahead of print].
24. Schwab SR, Pereira JP, Matloubian M, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005; 309:1735-1739.
25. Serhan CN. Resolution phases of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 2006 [Epub ahead of print]. • Excellent review on lipid mediators with instructive displays on experimental results with chemical structures and metabolic pathways.
26. Liu J, Wang L, Harvey-White J, et al. A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A 2006; 103:13345-13350. • Study providing new insights into biosynthetic pathways of anandamide.
27. Bari M, Battista N, Fezza F, et al. New insights into endocannabinoid degradation and its therapeutic potential. Mini Rev Med Chem 2006; 6:257-268.
28. Whitman M, Downes CP, Keeler M, et al. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 1988; 332:644-646.
29. Hawkins PT, Anderson KE, Davidson K, Stephens LR. Signalling through Class I PI3Ks in mammalian cells. Biochem Soc Trans 2006; 34:647-662.
30. Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006; 443:651-657.
31. Takenawa T, Itoh T. Membrane targeting and remodeling through phosphoinositide-binding domains. IUBMB Life 2006; 58:296-303.
32. Godi A, Di CA, Konstantakopoulos A, et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol 2004; 6:393-404.
33. Wenk MR, De Camilli P. Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals. Proc Natl Acad Sci U S A 2004; 101:8262-8269.
34. Akbar M, Calderon F, Wen Z, Kim HY. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci U S A 2005; 102:10858-10863.
35. Saad JS, Miller J, Tai J, et al. Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc Natl Acad Sci U S A 2006; 103:11364-11369. •• Structural study providing evidence that GPIns(4,5)P2 acts as a myristoyl switch trigger as well as a membrane anchor via headgroup and fatty acyl chains.
36. Wu Y, Tibrewal N, Birge RB. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol 2006; 16:189-197.
37. Rao V, Gao F, Chen B, et al. Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis-induced inflammation and virulence. J Clin Invest 2006; 116:1660-1667. • Elegant study using M. tuberculosis mutants defective in cyclopropanation of mycolic acids to study effects of subtle lipid modification during host response.
38. Cheng TY, Relloso M, Van RI, et al. Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J 2006; 25:2989-2999.
39. De Libero G, Mori L. How T lymphocytes recognize lipid antigens. FEBS Lett 2006; 580:5580-5587.
40. Oda K, Kitano H. A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol 2006; 2:2006.0015 [Epub ahead of print]. • Map on TLR signaling based on published work.
41. Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A. Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res 2006; 99:924-932.
42. Zmijewski JW, Landar A, Watanabe N, et al. Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium. Biochem Soc Trans 2005; 33:1385-1389.
43. Jessup W, Kritharides L, Stocker R. Lipid oxidation in atherogenesis: an overview. Biochem Soc Trans 2004; 32:134-138.
44. Stocker R, Keaney JF Jr. Role of oxidative modifications in atherosclerosis. Physiol Rev 2004; 84:1381-1478.
45. Bayir H, Fadeel B, Palladino MJ, et al. Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta 2006; 1757:648-659.
46. Kaddurah-Daouk R. Metabolic profiling of patients with schizophrenia. PloS Med 2006; 3:e363.
47. Wenk MR. The emerging field of lipidomics. Nat Rev Drug Discov 2005; 4:594-610.
48. Rapaka RS, Piomelli D, Spiegel S, et al. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins Other Lipid Mediat 2005; 77:223-234.