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Volumn 92, Issue 4, 2017, Pages 2046-2069

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

Author keywords

ageing; neurodegeneration; neuroinflammation; PPARs; SPPARM

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

EID: 85013371563     PISSN: 14647931     EISSN: 1469185X     Source Type: Journal    
DOI: 10.1111/brv.12320     Document Type: Article
Times cited : (84)

References (349)
  • 1
    • 79958286397 scopus 로고    scopus 로고
    • Molecular basis for gene-specific transactivation by nuclear receptors
    • Aagaard, M. M., Siersbæk, R. & Mandrup, S. (2011). Molecular basis for gene-specific transactivation by nuclear receptors. Biochimica et Biophysica Acta 1812, 824–835.
    • (2011) Biochimica et Biophysica Acta , vol.1812 , pp. 824-835
    • Aagaard, M.M.1    Siersbæk, R.2    Mandrup, S.3
  • 3
    • 84872491129 scopus 로고    scopus 로고
    • Overlapped metabolic and therapeutic links between alzheimer and diabetes
    • Ahmad, W. (2013). Overlapped metabolic and therapeutic links between alzheimer and diabetes. Molecular Neurobiology 47, 399–424.
    • (2013) Molecular Neurobiology , vol.47 , pp. 399-424
    • Ahmad, W.1
  • 6
    • 18144388677 scopus 로고    scopus 로고
    • Selective activation of PPARγ in breast, colon, and lung cancer cell lines
    • Allred, C. D. & Kilgore, M. W. (2005). Selective activation of PPARγ in breast, colon, and lung cancer cell lines. Molecular and Cellular Endocrinology 235, 21–29.
    • (2005) Molecular and Cellular Endocrinology , vol.235 , pp. 21-29
    • Allred, C.D.1    Kilgore, M.W.2
  • 7
    • 0033061409 scopus 로고    scopus 로고
    • Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver
    • Asayama, K., Sandhir, R., Sheikh, F. G., Hayashibe, H., Nakane, T. & Singh, I. (1999). Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver. Molecular and Cellular Biochemistry 194, 227–234.
    • (1999) Molecular and Cellular Biochemistry , vol.194 , pp. 227-234
    • Asayama, K.1    Sandhir, R.2    Sheikh, F.G.3    Hayashibe, H.4    Nakane, T.5    Singh, I.6
  • 8
    • 0029759110 scopus 로고    scopus 로고
    • Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR
    • Auwerx, J., Schoonjans, K., Fruchart, J. C. & Staels, B. (1996). Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR. Atherosclerosis 124, S29–37.
    • (1996) Atherosclerosis , vol.124 , pp. S29-37
    • Auwerx, J.1    Schoonjans, K.2    Fruchart, J.C.3    Staels, B.4
  • 9
    • 39349083915 scopus 로고    scopus 로고
    • Adapting proteostasis for disease intervention
    • Balch, W. E., Morimoto, R. I., Dillin, A. & Kelly, J. W. (2008). Adapting proteostasis for disease intervention. Science 319, 916–919.
    • (2008) Science , vol.319 , pp. 916-919
    • Balch, W.E.1    Morimoto, R.I.2    Dillin, A.3    Kelly, J.W.4
  • 10
    • 33646045898 scopus 로고    scopus 로고
    • Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases
    • Balint, B. L. & Nagy, L. (2006). Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocrine, Metabolic & Immune Disorders - Drug Targets 6, 33–43.
    • (2006) Endocrine, Metabolic & Immune Disorders - Drug Targets , vol.6 , pp. 33-43
    • Balint, B.L.1    Nagy, L.2
  • 12
    • 33846565429 scopus 로고    scopus 로고
    • 2+ signals and neuronal death in brain ischemia
    • 2+ signals and neuronal death in brain ischemia. Stroke 38, 674–676.
    • (2007) Stroke , vol.38 , pp. 674-676
    • Bano, D.1    Nicotera, P.2
  • 13
    • 0027180917 scopus 로고
    • Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro
    • Bars, R. G., Bell, D. R. & Elcombe, C. R. (1993). Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro. Biochemical Pharmacology 45, 2045–2053.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 2045-2053
    • Bars, R.G.1    Bell, D.R.2    Elcombe, C.R.3
  • 14
    • 84961683028 scopus 로고    scopus 로고
    • Recent advances in neuroinflammation therapeutics: PPARs/LXR as neuroinflammatory modulators
    • Bastías-Candia, S., Garrido, N. A., Zolezzi, J. M. & Inestrosa, N. C. (2016). Recent advances in neuroinflammation therapeutics: PPARs/LXR as neuroinflammatory modulators. Current Pharmaceutical Design 22, 1312–1323.
    • (2016) Current Pharmaceutical Design , vol.22 , pp. 1312-1323
    • Bastías-Candia, S.1    Garrido, N.A.2    Zolezzi, J.M.3    Inestrosa, N.C.4
  • 15
    • 0033544955 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures
    • Basu-modak, S., Braissant, O., Escher, P., Desvergne, B., Honegger, P. & Wahli, W. (1999). Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. Journal of Biological Chemistry 274, 35881–35888.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 35881-35888
    • Basu-modak, S.1    Braissant, O.2    Escher, P.3    Desvergne, B.4    Honegger, P.5    Wahli, W.6
  • 16
    • 25444474703 scopus 로고    scopus 로고
    • Mitochondria take center stage in aging and neurodegeneration
    • Beal, M. F. (2005). Mitochondria take center stage in aging and neurodegeneration. Annals of Neurology 58, 495–505.
    • (2005) Annals of Neurology , vol.58 , pp. 495-505
    • Beal, M.F.1
  • 17
    • 0029618368 scopus 로고
    • Steroid hormone receptors: many actors in search of a plot
    • Beato, M., Herrlich, P. & Schütz, G. (1995). Steroid hormone receptors: many actors in search of a plot. Cell 83, 851–857.
    • (1995) Cell , vol.83 , pp. 851-857
    • Beato, M.1    Herrlich, P.2    Schütz, G.3
  • 19
    • 0025939158 scopus 로고
    • Induction of acyl-CoA oxidase and cytochrome P450IVA1 RNA in rat primary hepatocyte culture by peroxisome proliferators
    • Bell, D. R. & Elcombe, C. R. (1991). Induction of acyl-CoA oxidase and cytochrome P450IVA1 RNA in rat primary hepatocyte culture by peroxisome proliferators. Biochemical Journal 280, 249–253.
    • (1991) Biochemical Journal , vol.280 , pp. 249-253
    • Bell, D.R.1    Elcombe, C.R.2
  • 20
    • 84879871501 scopus 로고    scopus 로고
    • Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model
    • Benjamin, S., Flotho, S., Börchers, T. & Spener, F. (2013). Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model. Journal of Zhejiang University. Science. B 14, 115–123.
    • (2013) Journal of Zhejiang University. Science. B , vol.14 , pp. 115-123
    • Benjamin, S.1    Flotho, S.2    Börchers, T.3    Spener, F.4
  • 21
    • 44049097234 scopus 로고    scopus 로고
    • Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists
    • Bernardo, A. & Minghetti, L. (2008). Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists. PPAR Research 2008, 864140–864150.
    • (2008) PPAR Research , vol.2008 , pp. 864140-864150
    • Bernardo, A.1    Minghetti, L.2
  • 22
    • 27244452751 scopus 로고    scopus 로고
    • Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, exerts neuroprotective effects in traumatic brain injury
    • Besson, V. C., Chen, X. R., Plotkine, M. & Marchand-Verrecchia, C. (2005). Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, exerts neuroprotective effects in traumatic brain injury. Neuroscience Letters 288, 7–12.
    • (2005) Neuroscience Letters , vol.288 , pp. 7-12
    • Besson, V.C.1    Chen, X.R.2    Plotkine, M.3    Marchand-Verrecchia, C.4
  • 24
    • 84901022738 scopus 로고    scopus 로고
    • Reversal apoE4-driven brain pathology and behavioral deficits by bexarotene
    • Boehm-Cagan, A. & Michaelson, D. M. (2014). Reversal apoE4-driven brain pathology and behavioral deficits by bexarotene. Journal of Neuroscience 34, 7293–7301.
    • (2014) Journal of Neuroscience , vol.34 , pp. 7293-7301
    • Boehm-Cagan, A.1    Michaelson, D.M.2
  • 25
    • 84902084909 scopus 로고    scopus 로고
    • Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy
    • Bomben, V., Holth, J., Reed, J., Cramer, P., Landreth, G. & Noebels, J. (2014). Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy. Neurobiology of Aging 35, 2091–2095.
    • (2014) Neurobiology of Aging , vol.35 , pp. 2091-2095
    • Bomben, V.1    Holth, J.2    Reed, J.3    Cramer, P.4    Landreth, G.5    Noebels, J.6
  • 26
    • 84887956934 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease--state of the art, 2013
    • Bonifati, V. (2014). Genetics of Parkinson's disease--state of the art, 2013. Parkinsonism & Related Disorders 20, S23–S28.
    • (2014) Parkinsonism & Related Disorders , vol.20 , pp. S23-S28
    • Bonifati, V.1
  • 29
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant, O., Foufelle, F., Scotto, C., Dauca, M. & Wahli, W. (1996). Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137, 354–366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 30
    • 0031788318 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptor –alpha, -beta, and -gamma during rat embryonic development
    • Braissant, O. & Wahli, W. (1998). Differential expression of peroxisome proliferator-activated receptor –alpha, -beta, and -gamma during rat embryonic development. Endocrinology 139, 2748–2754.
    • (1998) Endocrinology , vol.139 , pp. 2748-2754
    • Braissant, O.1    Wahli, W.2
  • 31
    • 84938717912 scopus 로고    scopus 로고
    • Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study
    • Brauer, R., Bhaskaran, K., Chaturvedi, N., Dexter, D. T., Smeeth, L. & Douglas, I. (2015). Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study. PLoS Medicine 12, e1001854.
    • (2015) PLoS Medicine , vol.12
    • Brauer, R.1    Bhaskaran, K.2    Chaturvedi, N.3    Dexter, D.T.4    Smeeth, L.5    Douglas, I.6
  • 32
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • Breidert, T., Callebert, J., Heneka, M. T., Landreth, G., Launay, J. M. & Hirsch, E. C. (2002). Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. Journal of Neurochemistry 82, 615–624.
    • (2002) Journal of Neurochemistry , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 34
    • 75949127362 scopus 로고    scopus 로고
    • Inflammation, microglia, and Alzheimer's disease
    • Cameron, B. & Landreth, G. E. (2010). Inflammation, microglia, and Alzheimer's disease. Neurobiology of Disease 37, 503–509.
    • (2010) Neurobiology of Disease , vol.37 , pp. 503-509
    • Cameron, B.1    Landreth, G.E.2
  • 35
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
    • Camp, H. S. & Tafuri, S. R. (1997). Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. Journal of Biological Chemistry 272, 10811–10816.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 36
    • 84860824001 scopus 로고    scopus 로고
    • FGF21 takes a fat bite
    • Cantó, C. & Auwerx, J. (2012). FGF21 takes a fat bite. Science 336, 675–676.
    • (2012) Science , vol.336 , pp. 675-676
    • Cantó, C.1    Auwerx, J.2
  • 37
    • 84877949532 scopus 로고    scopus 로고
    • Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?
    • Carta, A. R. & Pisanu, A. (2013). Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease? Neurotoxicity Research 23, 112–123.
    • (2013) Neurotoxicity Research , vol.23 , pp. 112-123
    • Carta, A.R.1    Pisanu, A.2
  • 38
    • 79959233784 scopus 로고    scopus 로고
    • Do PPAR-γ agonists have a future in Parkinson's disease therapy?
    • Carta, A. R., Pisanu, A. & Carboni, E. (2011). Do PPAR-γ agonists have a future in Parkinson's disease therapy? Parkinson's Disease 2011, 689181.
    • (2011) Parkinson's Disease , vol.2011 , pp. 689181
    • Carta, A.R.1    Pisanu, A.2    Carboni, E.3
  • 41
    • 34250312341 scopus 로고    scopus 로고
    • The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases
    • Cauwe, B., Van den Steen, P. E. & Opdenakker, G. (2007). The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases. Critical Reviews in Biochemistry and Molecular Biology 42, 113–185.
    • (2007) Critical Reviews in Biochemistry and Molecular Biology , vol.42 , pp. 113-185
    • Cauwe, B.1    Van den Steen, P.E.2    Opdenakker, G.3
  • 42
    • 45249108473 scopus 로고    scopus 로고
    • Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses
    • Cerpa, W., Dinamarca, M. C. & Inestrosa, N. C. (2008). Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Current Alzheimer Research 5, 233–243.
    • (2008) Current Alzheimer Research , vol.5 , pp. 233-243
    • Cerpa, W.1    Dinamarca, M.C.2    Inestrosa, N.C.3
  • 44
    • 84875679362 scopus 로고    scopus 로고
    • Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases
    • Chaturvedi, R. K. & Beal, M. F. (2013). Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases. Molecular and Cellular Neuroscience 55, 101–114.
    • (2013) Molecular and Cellular Neuroscience , vol.55 , pp. 101-114
    • Chaturvedi, R.K.1    Beal, M.F.2
  • 45
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: opening the X-files
    • Chawla, A., Repa, J. J., Evans, R. M. & Mangelsdorf, D. J. (2001). Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866–1870.
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 46
    • 34547118091 scopus 로고    scopus 로고
    • Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury
    • Chen, X. R., Besson, V. C., Palmier, B., Garcia, Y., Plotkinc, M. & Marchand-Leroux, C. (2007). Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury. Journal of Neurotrauma 24, 1119–1131.
    • (2007) Journal of Neurotrauma , vol.24 , pp. 1119-1131
    • Chen, X.R.1    Besson, V.C.2    Palmier, B.3    Garcia, Y.4    Plotkinc, M.5    Marchand-Leroux, C.6
  • 47
    • 0034805606 scopus 로고    scopus 로고
    • Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium
    • Chen, N. G. & Han, X. (2001). Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium. Biochemical and Biophysical Research Communications 282, 717–722.
    • (2001) Biochemical and Biophysical Research Communications , vol.282 , pp. 717-722
    • Chen, N.G.1    Han, X.2
  • 48
    • 84863620242 scopus 로고    scopus 로고
    • Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease
    • Chen, L. W., Horng, L. Y., Wu, C. L., Sung, H. C. & Wu, R. T. (2012). Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease. Neuropharmacology 63, 719–732.
    • (2012) Neuropharmacology , vol.63 , pp. 719-732
    • Chen, L.W.1    Horng, L.Y.2    Wu, C.L.3    Sung, H.C.4    Wu, R.T.5
  • 49
    • 84883053304 scopus 로고    scopus 로고
    • Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies
    • Chen, Z. & Zhong, C. (2012). Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Progress in Neurobiology 108, 21–43.
    • (2012) Progress in Neurobiology , vol.108 , pp. 21-43
    • Chen, Z.1    Zhong, C.2
  • 50
    • 84891898130 scopus 로고    scopus 로고
    • Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway
    • Chiang, M. C., Cheng, Y. C., Chen, H. M., Liang, Y. J. & Yen, C. H. (2014). Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway. Mitochondrion 14, 7–17.
    • (2014) Mitochondrion , vol.14 , pp. 7-17
    • Chiang, M.C.1    Cheng, Y.C.2    Chen, H.M.3    Liang, Y.J.4    Yen, C.H.5
  • 52
    • 41449112452 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells
    • Christianson, J. L., Nicoloro, S., Straubhaar, J. & Czech, M. P. (2008). Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells. Journal of Biological Chemistry 283, 2906–2916.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 2906-2916
    • Christianson, J.L.1    Nicoloro, S.2    Straubhaar, J.3    Czech, M.P.4
  • 54
    • 0034065822 scopus 로고    scopus 로고
    • Ubiquitin-mediated proteolysis: biological regulation via destruction
    • Ciechanover, A., Orian, A. & Schwartz, A. L. (2000). Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays 22, 442–451.
    • (2000) Bioessays , vol.22 , pp. 442-451
    • Ciechanover, A.1    Orian, A.2    Schwartz, A.L.3
  • 55
    • 41549107577 scopus 로고    scopus 로고
    • The basic biology of BACE1: a key therapeutic target for Alzheimer's disease
    • Cole, S. L. & Vassar, R. (2007). The basic biology of BACE1: a key therapeutic target for Alzheimer's disease. Current Genomics 8, 509–530.
    • (2007) Current Genomics , vol.8 , pp. 509-530
    • Cole, S.L.1    Vassar, R.2
  • 57
    • 0032528350 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1
    • Colville-Nash, P. R., Qureshi, S. S., Willis, D. & Willoughby, D. A. (1998). Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. Journal of Immunology 161, 978–984.
    • (1998) Journal of Immunology , vol.161 , pp. 978-984
    • Colville-Nash, P.R.1    Qureshi, S.S.2    Willis, D.3    Willoughby, D.A.4
  • 58
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B. & Landreth, G. E. (2000). Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. Journal of Neuroscience 20, 558–567.
    • (2000) Journal of Neuroscience , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 60
    • 84957558849 scopus 로고    scopus 로고
    • ABCB1 is necessary for bexarotene-mediated clearance of soluble amyloid beta from hippocampus of APP/PS1 mice
    • Corona, A. W., Kodoma, N., Casali, B. T. & Landreth, G. E. (2016). ABCB1 is necessary for bexarotene-mediated clearance of soluble amyloid beta from hippocampus of APP/PS1 mice. Journal of Neuroimmune Pharmacology 11, 61–72.
    • (2016) Journal of Neuroimmune Pharmacology , vol.11 , pp. 61-72
    • Corona, A.W.1    Kodoma, N.2    Casali, B.T.3    Landreth, G.E.4
  • 64
    • 11844278455 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury
    • Cuzzocrea, S. (2004). Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury. Vascular Pharmacology 41, 187–195.
    • (2004) Vascular Pharmacology , vol.41 , pp. 187-195
    • Cuzzocrea, S.1
  • 68
    • 84904255988 scopus 로고    scopus 로고
    • The intriguing complexities of mammalian gene regulation: how to link enhancers to regulated genes. Are we there yet?
    • Daniel, B., Nagy, G. & Nagy, L. (2014). The intriguing complexities of mammalian gene regulation: how to link enhancers to regulated genes. Are we there yet? FEBS Letters 588, 2379–2391.
    • (2014) FEBS Letters , vol.588 , pp. 2379-2391
    • Daniel, B.1    Nagy, G.2    Nagy, L.3
  • 70
    • 34748917549 scopus 로고    scopus 로고
    • Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha
    • Dasgupta, S., Roy, A., Jana, M., Hartley, D. M. & Pahan, K. (2007). Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. Molecular Pharmacology 72, 934–946.
    • (2007) Molecular Pharmacology , vol.72 , pp. 934-946
    • Dasgupta, S.1    Roy, A.2    Jana, M.3    Hartley, D.M.4    Pahan, K.5
  • 72
    • 84873395982 scopus 로고    scopus 로고
    • Alzheimer's disease and insulin resistance: translating basic science into clinical applications
    • De Felice, F. G. (2013). Alzheimer's disease and insulin resistance: translating basic science into clinical applications. Journal of Clinical Investigation 123, 531–539.
    • (2013) Journal of Clinical Investigation , vol.123 , pp. 531-539
    • De Felice, F.G.1
  • 73
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation
    • Dehmer, T., Heneka, M. T., Sastre, M., Dichgans, J. & Schulz, J. B. (2004). Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. Journal of Neurochemistry 88, 494–501.
    • (2004) Journal of Neurochemistry , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 74
    • 0037040253 scopus 로고    scopus 로고
    • PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    • Delerive, P., Wu, Y., Burris, T. P., Chin, W. W. & Suen, C. S. (2002). PGC-1 functions as a transcriptional coactivator for the retinoid X receptors. Journal of Biological Chemistry 277, 3913–3917.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 3913-3917
    • Delerive, P.1    Wu, Y.2    Burris, T.P.3    Chin, W.W.4    Suen, C.S.5
  • 75
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: nuclear control of metabolism
    • Desvergne, B. & Wahli, W. (1999). Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20, 649–688.
    • (1999) Endocrine Reviews , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 76
    • 33646384598 scopus 로고    scopus 로고
    • A novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation
    • Dhar, A., Gardner, J., Borgmann, K., Wu, L. & Ghorpade, A. (2006). A novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation. Journal of Neuroscience Research 83, 1271–1280.
    • (2006) Journal of Neuroscience Research , vol.83 , pp. 1271-1280
    • Dhar, A.1    Gardner, J.2    Borgmann, K.3    Wu, L.4    Ghorpade, A.5
  • 78
    • 84882670192 scopus 로고    scopus 로고
    • Postsynaptic receptors for amyloid-β oligomers as mediators of neuronal damage in Alzheimer's disease
    • Dinamarca, M. C., Ríos, J. A. & Inestrosa, N. C. (2012). Postsynaptic receptors for amyloid-β oligomers as mediators of neuronal damage in Alzheimer's disease. Frontiers in Physiology 3, 464.
    • (2012) Frontiers in Physiology , vol.3 , pp. 464
    • Dinamarca, M.C.1    Ríos, J.A.2    Inestrosa, N.C.3
  • 79
    • 14544272384 scopus 로고    scopus 로고
    • Phosphorylation of PPARs: from molecular characterization to physiological relevance
    • Diradourian, C., Girard, J. & Pégorier, J. P. (2005). Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 87, 33–38.
    • (2005) Biochimie , vol.87 , pp. 33-38
    • Diradourian, C.1    Girard, J.2    Pégorier, J.P.3
  • 80
    • 0026517010 scopus 로고
    • Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
    • Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G. & Wahli, W. (1992). Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68, 879–887.
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3    Givel, F.4    Helftenbein, G.5    Wahli, W.6
  • 81
    • 79955064893 scopus 로고    scopus 로고
    • Selective modulation of PPARg activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes
    • Dunn, F. L., Higgins, L. S., Fredrickson, J. & DePaolib, A. M. (2011). Selective modulation of PPARg activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes. Journal of Diabetes and its Complications 25, 151–158.
    • (2011) Journal of Diabetes and its Complications , vol.25 , pp. 151-158
    • Dunn, F.L.1    Higgins, L.S.2    Fredrickson, J.3    DePaolib, A.M.4
  • 84
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans, R. M. (1988). The steroid and thyroid hormone receptor superfamily. Science 240, 889–895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 85
    • 32644460092 scopus 로고    scopus 로고
    • From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    • Feige, J. N., Gelman, L., Michalik, L., Desvergne, B. & Wahli, W. (2006). From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Progress in Lipid Research 45, 120–159.
    • (2006) Progress in Lipid Research , vol.45 , pp. 120-159
    • Feige, J.N.1    Gelman, L.2    Michalik, L.3    Desvergne, B.4    Wahli, W.5
  • 86
    • 0037040272 scopus 로고    scopus 로고
    • Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes
    • Floyd, Z. E. & Stephens, J. M. (2002). Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. Journal of Biological Chemistry 277, 4062–4068.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 4062-4068
    • Floyd, Z.E.1    Stephens, J.M.2
  • 87
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman, B. M., Chen, J. & Evans, R. M. (1997). Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proceedings of the National Academy of Sciences of the United States of America 94, 4312–4317.
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 88
    • 84902252612 scopus 로고    scopus 로고
    • Impact of metabolic syndrome on cognitive decline in older age: protective or harmful, where is the pitfall?
    • Frisardi, V. (2014). Impact of metabolic syndrome on cognitive decline in older age: protective or harmful, where is the pitfall? Journal of Alzheimer's Disease 41, 163–167.
    • (2014) Journal of Alzheimer's Disease , vol.41 , pp. 163-167
    • Frisardi, V.1
  • 89
    • 84878349086 scopus 로고    scopus 로고
    • Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): the next generation of peroxisome proliferator-activated receptor α-agonists
    • Fruchart, J. C. (2013). Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): the next generation of peroxisome proliferator-activated receptor α-agonists. Cardiovascular Diabetology 12, 82.
    • (2013) Cardiovascular Diabetology , vol.12 , pp. 82
    • Fruchart, J.C.1
  • 91
    • 37549060702 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
    • Fuenzalida, K., Quintanilla, R., Ramos, P., Piderit, D., Fuentealba, R. A., Martinez, G., Inestrosa, N. C. & Bronfman, M. (2007). Peroxisome proliferator-activated receptor γ up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. Journal of Biological Chemistry 282, 37006–37015.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 37006-37015
    • Fuenzalida, K.1    Quintanilla, R.2    Ramos, P.3    Piderit, D.4    Fuentealba, R.A.5    Martinez, G.6    Inestrosa, N.C.7    Bronfman, M.8
  • 94
    • 78651322583 scopus 로고    scopus 로고
    • A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
    • Geldmacher, D. S., Fritsch, T., McClendon, M. J. & Landreth, G. (2011). A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. Archives of Neurology 68, 45–50.
    • (2011) Archives of Neurology , vol.68 , pp. 45-50
    • Geldmacher, D.S.1    Fritsch, T.2    McClendon, M.J.3    Landreth, G.4
  • 95
    • 19344375176 scopus 로고    scopus 로고
    • Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma
    • Genovese, T., Mazzon, E., Di Paola, R., Cannavo, G., Muia, C., Bramanti, P. & Cuzzocrea, S. (2005). Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma. Experimental Neurology 194, 267–278.
    • (2005) Experimental Neurology , vol.194 , pp. 267-278
    • Genovese, T.1    Mazzon, E.2    Di Paola, R.3    Cannavo, G.4    Muia, C.5    Bramanti, P.6    Cuzzocrea, S.7
  • 96
    • 0037050017 scopus 로고    scopus 로고
    • Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
    • Germain, P., Iyer, J., Zechel, C. & Gronemeyer, H. (2002). Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature 415, 187–192.
    • (2002) Nature , vol.415 , pp. 187-192
    • Germain, P.1    Iyer, J.2    Zechel, C.3    Gronemeyer, H.4
  • 99
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisns underlying inflammation in neurodegeneration
    • Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C. & Gage, F. H. (2010). Mechanisns underlying inflammation in neurodegeneration. Cell 140, 918–934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 101
    • 84893202518 scopus 로고    scopus 로고
    • Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain
    • Godoy, J. A., Zolezzi, J. M., Braidy, N. & Inestrosa, N. C. (2014b). Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain. Molecular Neurobiology 50, 744–756.
    • (2014) Molecular Neurobiology , vol.50 , pp. 744-756
    • Godoy, J.A.1    Zolezzi, J.M.2    Braidy, N.3    Inestrosa, N.C.4
  • 103
    • 84873060619 scopus 로고    scopus 로고
    • Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems
    • Gold, P. W., Licinio, J. & Pavlatou, M. G. (2013). Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems. Molecular Psychiatry 18, 154–165.
    • (2013) Molecular Psychiatry , vol.18 , pp. 154-165
    • Gold, P.W.1    Licinio, J.2    Pavlatou, M.G.3
  • 106
    • 33645562489 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1
    • Grau, R., Punzon, C., Fresno, M. & Iniguez, M. A. (2006). Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. Biochemical Journal 395, 81–88.
    • (2006) Biochemical Journal , vol.395 , pp. 81-88
    • Grau, R.1    Punzon, C.2    Fresno, M.3    Iniguez, M.A.4
  • 107
    • 0029609755 scopus 로고
    • PPAR: a mediator of peroxisome proliferator action
    • Green, S. (1995). PPAR: a mediator of peroxisome proliferator action. Mutation Research 333, 101–109.
    • (1995) Mutation Research , vol.333 , pp. 101-109
    • Green, S.1
  • 108
    • 2642609539 scopus 로고
    • The molecular mechanism of peroxisome proliferator action: a model for species differences and mechanistic risk assessment
    • Green, S., Tugwood, J. D. & Issemann, I. (1992). The molecular mechanism of peroxisome proliferator action: a model for species differences and mechanistic risk assessment. Toxicology Letters 64-65 Spec No, 131–139.
    • (1992) Toxicology Letters , vol.64-65 , pp. 131-139
    • Green, S.1    Tugwood, J.D.2    Issemann, I.3
  • 109
    • 34147154970 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial
    • Grey, A., Bolland, M., Gamble, G., Wattie, D., Horne, A., Davidson, J. & Reid, I. R. (2007). The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial. The Journal of Clinical Endocrinology and Metabolism 92, 1305–1310.
    • (2007) The Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 1305-1310
    • Grey, A.1    Bolland, M.2    Gamble, G.3    Wattie, D.4    Horne, A.5    Davidson, J.6    Reid, I.R.7
  • 111
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass, C. & Selkoe, D. J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews Molecular Cell Biology 8, 101–112.
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 112
    • 84898830649 scopus 로고    scopus 로고
    • The neurobiological basis of cognitive impairment in Parkinson's disease
    • Halliday, G. M., Leverenz, J. B., Schneider, J. S. & Adler, C. H. (2014). The neurobiological basis of cognitive impairment in Parkinson's disease. Movement Disorders 29(5), 634–650.
    • (2014) Movement Disorders , vol.29 , Issue.5 , pp. 634-650
    • Halliday, G.M.1    Leverenz, J.B.2    Schneider, J.S.3    Adler, C.H.4
  • 113
    • 0033968252 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma
    • Han, J., Hajjar, D. P., Tauras, J. M., Feng, J., Gotto, A. M. Jr. & Nicholson, A. C. (2000). Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma. Journal of Biological Chemistry 275, 1241–1246.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 1241-1246
    • Han, J.1    Hajjar, D.P.2    Tauras, J.M.3    Feng, J.4    Gotto, A.M.5    Nicholson, A.C.6
  • 115
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid pxidation determinaes the severity of hepatic steatosis in response to fasting
    • Hashimoto, T., Cook, W. S., Qi, C., Yeldani, A. V., Reddy, J. K. & Rao, M. S. (2000). Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid pxidation determinaes the severity of hepatic steatosis in response to fasting. Journal of Biological Chemistry 275, 28918–28928.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldani, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 116
    • 0034674567 scopus 로고    scopus 로고
    • Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation
    • Hauser, S., Adelmant, G., Sarraf, P., Wright, H. M., Mueller, E. & Spiegelman, B. M. (2000). Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation. Journal of Biological Chemistry 275, 18527–18533.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 18527-18533
    • Hauser, S.1    Adelmant, G.2    Sarraf, P.3    Wright, H.M.4    Mueller, E.5    Spiegelman, B.M.6
  • 118
    • 36148952124 scopus 로고    scopus 로고
    • Toward the development of rational therapies in multiple sclerosis: what is on the horizon?
    • Hemmer, B. & Hartung, H. P. (2007). Toward the development of rational therapies in multiple sclerosis: what is on the horizon? Annals of Neurology 62, 314–326.
    • (2007) Annals of Neurology , vol.62 , pp. 314-326
    • Hemmer, B.1    Hartung, H.P.2
  • 119
    • 0034666289 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
    • Heneka, M. T., Klockgether, T. & Feinstein, D. L. (2000). Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. Journal of Neuroscience 20, 6862–6867.
    • (2000) Journal of Neuroscience , vol.20 , pp. 6862-6867
    • Heneka, M.T.1    Klockgether, T.2    Feinstein, D.L.3
  • 121
    • 34548494847 scopus 로고    scopus 로고
    • Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders
    • Heneka, M. T., Landreth, G. E. & Hull, M. (2007). Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nature Clinical Practice Neurology 3, 496–504.
    • (2007) Nature Clinical Practice Neurology , vol.3 , pp. 496-504
    • Heneka, M.T.1    Landreth, G.E.2    Hull, M.3
  • 123
    • 74049159051 scopus 로고    scopus 로고
    • Selective peroxisome proliferator-activated receptor g (PPARg) modulation as a strategy for safer therapeutic PPARg activation
    • Higgins, L. S. & Depaoli, A. M. (2010). Selective peroxisome proliferator-activated receptor g (PPARg) modulation as a strategy for safer therapeutic PPARg activation. The American Journal of Clinical Nutrition 91, 267S–272S.
    • (2010) The American Journal of Clinical Nutrition , vol.91 , pp. 267S-272S
    • Higgins, L.S.1    Depaoli, A.M.2
  • 125
    • 84859416479 scopus 로고    scopus 로고
    • Metabolic health and nuclear-receptor sensitivity
    • Hollenberg, A. N. (2012). Metabolic health and nuclear-receptor sensitivity. New England Journal of Medicine 366, 1345–1347.
    • (2012) New England Journal of Medicine , vol.366 , pp. 1345-1347
    • Hollenberg, A.N.1
  • 126
    • 80355129688 scopus 로고    scopus 로고
    • PPARα and PPARγ protect against HIV-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
    • Huang, W., András, I. E., Rha, G. B., Hennig, B. & Toborek, M. (2011). PPARα and PPARγ protect against HIV-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. FASEB Journal 25, 3979–3988.
    • (2011) FASEB Journal , vol.25 , pp. 3979-3988
    • Huang, W.1    András, I.E.2    Rha, G.B.3    Hennig, B.4    Toborek, M.5
  • 127
    • 70349329335 scopus 로고    scopus 로고
    • PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junctions proteins by modulations of matrix metalloproteinase and proteasome activities
    • Huang, W., Eum, S. Y., András, I. E., Hennig, B. & Toborek, M. (2009). PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junctions proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB Journal 23, 1596–1606.
    • (2009) FASEB Journal , vol.23 , pp. 1596-1606
    • Huang, W.1    Eum, S.Y.2    András, I.E.3    Hennig, B.4    Toborek, M.5
  • 130
    • 13644271368 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
    • Inestrosa, N. C., Godoy, J. A., Quintanilla, R. A., Koenig, C. S. & Bronfman, M. (2005). Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Experimental Cell Research 304, 91–104.
    • (2005) Experimental Cell Research , vol.304 , pp. 91-104
    • Inestrosa, N.C.1    Godoy, J.A.2    Quintanilla, R.A.3    Koenig, C.S.4    Bronfman, M.5
  • 131
    • 1642268085 scopus 로고    scopus 로고
    • Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice
    • Inoue, H., Jiang, X. F., Katayama, T., Osada, S., Umesono, K. & Namura, S. (2003). Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice. Neuroscience Letters 352, 203–206.
    • (2003) Neuroscience Letters , vol.352 , pp. 203-206
    • Inoue, H.1    Jiang, X.F.2    Katayama, T.3    Osada, S.4    Umesono, K.5    Namura, S.6
  • 132
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I. & Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645–650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 136
    • 33749050855 scopus 로고    scopus 로고
    • Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study
    • Jekabsone, A., Mander, P. K., Tickler, A., Sharpe, M. & Brown, G. C. (2006). Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study. Journal of Neuroinflammation 3, 24.
    • (2006) Journal of Neuroinflammation , vol.3 , pp. 24
    • Jekabsone, A.1    Mander, P.K.2    Tickler, A.3    Sharpe, M.4    Brown, G.C.5
  • 137
    • 54049147721 scopus 로고    scopus 로고
    • Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines
    • Jennewein, C., Kuhn, A. M., Schmidt, M. V., Meilladec-Julling, V., von Knethen, A., Gonzales, F. J. & Brüne, B. (2008). Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. Journal of Immunology 181, 5646–5652.
    • (2008) Journal of Immunology , vol.181 , pp. 5646-5652
    • Jennewein, C.1    Kuhn, A.M.2    Schmidt, M.V.3    Meilladec-Julling, V.4    von Knethen, A.5    Gonzales, F.J.6    Brüne, B.7
  • 139
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., Ting, A. T. & Seed, B. (1998). PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82–86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 140
    • 84876665921 scopus 로고    scopus 로고
    • Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease
    • Jin, J., Albertz, J., Guo, Z., Peng, Q., Rudow, G., Troncoso, J. C., Ross, C. A. & Duan, W. (2013). Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. Journal of Neurochemistry 125, 410–419.
    • (2013) Journal of Neurochemistry , vol.125 , pp. 410-419
    • Jin, J.1    Albertz, J.2    Guo, Z.3    Peng, Q.4    Rudow, G.5    Troncoso, J.C.6    Ross, C.A.7    Duan, W.8
  • 141
    • 84869854776 scopus 로고    scopus 로고
    • PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes
    • Kanakasabai, S., Pestereva, E., Chearwae, W., Gupta, S. K., Ansari, S. & Bright, J. J. (2012). PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. PLoS One 7, e50500.
    • (2012) PLoS One , vol.7
    • Kanakasabai, S.1    Pestereva, E.2    Chearwae, W.3    Gupta, S.K.4    Ansari, S.5    Bright, J.J.6
  • 142
    • 38449085356 scopus 로고    scopus 로고
    • Mechanism of anti-inflammatory and neuroprotective actions of PPAR-gamma agonist
    • Kapadia, R., Yi, J. H. & Vemuganti, R. (2008). Mechanism of anti-inflammatory and neuroprotective actions of PPAR-gamma agonist. Frontiers in Bioscience 13, 1813–1826.
    • (2008) Frontiers in Bioscience , vol.13 , pp. 1813-1826
    • Kapadia, R.1    Yi, J.H.2    Vemuganti, R.3
  • 146
    • 33748489928 scopus 로고    scopus 로고
    • BCL-6: a possible missing link for anti-inflammatory PPAR-delta signaling in pancreatic beta cells
    • Kharroubi, I., Lee, C. H., Hekerman, P., Darville, M. I., Evans, R. M., Eizirik, D. L. & Cnop, M. (2006). BCL-6: a possible missing link for anti-inflammatory PPAR-delta signaling in pancreatic beta cells. Diabetologia 49, 2350–2358.
    • (2006) Diabetologia , vol.49 , pp. 2350-2358
    • Kharroubi, I.1    Lee, C.H.2    Hekerman, P.3    Darville, M.I.4    Evans, R.M.5    Eizirik, D.L.6    Cnop, M.7
  • 148
    • 33748447845 scopus 로고    scopus 로고
    • Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
    • Kim, Y. S. & Joh, T. H. (2006). Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Experimental & Molecular Medicine 38, 333–347.
    • (2006) Experimental & Molecular Medicine , vol.38 , pp. 333-347
    • Kim, Y.S.1    Joh, T.H.2
  • 149
    • 84875877935 scopus 로고    scopus 로고
    • Modulation of the transcriptional activity of peroxisome proliferator-activated receptor gamma by protein-protein interactions and post-translational modifications
    • Kim, T. H., Kim, M. Y., Jo, S. H., Park, J. M. & Ahn, Y. H. (2013). Modulation of the transcriptional activity of peroxisome proliferator-activated receptor gamma by protein-protein interactions and post-translational modifications. Yonsei Medical Journal 54, 545–559.
    • (2013) Yonsei Medical Journal , vol.54 , pp. 545-559
    • Kim, T.H.1    Kim, M.Y.2    Jo, S.H.3    Park, J.M.4    Ahn, Y.H.5
  • 150
    • 84872161392 scopus 로고    scopus 로고
    • PPAR could contribute to the pathogenesis of hepatocellular carcinoma
    • Kimura, O., Kondo, Y. & Shimosegawa, T. (2012). PPAR could contribute to the pathogenesis of hepatocellular carcinoma. PPAR Research 2012, 574180.
    • (2012) PPAR Research , vol.2012 , pp. 574180
    • Kimura, O.1    Kondo, Y.2    Shimosegawa, T.3
  • 151
    • 84869086473 scopus 로고    scopus 로고
    • Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats
    • Kishi, T., Hirooka, Y. & Sunagawa, K. (2012). Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats. Journal of Cardiology 60, 489–494.
    • (2012) Journal of Cardiology , vol.60 , pp. 489-494
    • Kishi, T.1    Hirooka, Y.2    Sunagawa, K.3
  • 152
    • 22144489808 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease
    • Klegeris, A. & McGeer, P. L. (2005). Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Current Alzheimer Research 2, 255–265.
    • (2005) Current Alzheimer Research , vol.2 , pp. 255-265
    • Klegeris, A.1    McGeer, P.L.2
  • 155
    • 84865191020 scopus 로고    scopus 로고
    • Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity
    • Kocalis, H. E., Turney, M. K., Printz, R. L., Laryea, G. N., Muglia, L. J., Davies, S. S., Stanwood, G. D., McGuinness, O. P. & Niswender, K. D. (2012). Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity. PLoS One 7, e42981.
    • (2012) PLoS One , vol.7
    • Kocalis, H.E.1    Turney, M.K.2    Printz, R.L.3    Laryea, G.N.4    Muglia, L.J.5    Davies, S.S.6    Stanwood, G.D.7    McGuinness, O.P.8    Niswender, K.D.9
  • 156
    • 17844385791 scopus 로고    scopus 로고
    • Interactions between Alzheimer's disease and cerebral ischemia—focus on inflammation
    • Koistinaho, M. & Koistinaho, J. (2005). Interactions between Alzheimer's disease and cerebral ischemia—focus on inflammation. Brain Research Reviews 48, 240–250.
    • (2005) Brain Research Reviews , vol.48 , pp. 240-250
    • Koistinaho, M.1    Koistinaho, J.2
  • 158
    • 0037245786 scopus 로고    scopus 로고
    • Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions
    • Kumar, R. & Thompson, E. B. (2003). Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions. Molecular Endocrinology 17, 1–10.
    • (2003) Molecular Endocrinology , vol.17 , pp. 1-10
    • Kumar, R.1    Thompson, E.B.2
  • 160
    • 84864693858 scopus 로고    scopus 로고
    • Preclinical success against Alzheimer's disease with an old drug
    • LaFerla, F. M. (2012). Preclinical success against Alzheimer's disease with an old drug. New England Journal of Medicine 367, 570–572.
    • (2012) New England Journal of Medicine , vol.367 , pp. 570-572
    • LaFerla, F.M.1
  • 161
    • 34648832073 scopus 로고    scopus 로고
    • Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomized clinical trials
    • Lago, R. M., Singh, P. P. & Nesto, R. W. (2007). Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomized clinical trials. Lancet 370, 1129–1136.
    • (2007) Lancet , vol.370 , pp. 1129-1136
    • Lago, R.M.1    Singh, P.P.2    Nesto, R.W.3
  • 162
    • 33745265189 scopus 로고    scopus 로고
    • PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease
    • Landreth, G. (2006). PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease. Experimental Neurology 199, 245–248.
    • (2006) Experimental Neurology , vol.199 , pp. 245-248
    • Landreth, G.1
  • 163
    • 34147102288 scopus 로고    scopus 로고
    • Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease
    • Landreth, G. (2007). Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease. Current Alzheimer Research 4, 159–164.
    • (2007) Current Alzheimer Research , vol.4 , pp. 159-164
    • Landreth, G.1
  • 164
    • 0035693506 scopus 로고    scopus 로고
    • Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease
    • Landreth, G. E. & Heneka, M. T. (2001). Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiology of Aging 22, 937–944.
    • (2001) Neurobiology of Aging , vol.22 , pp. 937-944
    • Landreth, G.E.1    Heneka, M.T.2
  • 165
    • 0036415838 scopus 로고    scopus 로고
    • Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
    • Lashuel, H. A., Petre, B. M., Wall, J., Simon, M., Nowak, R. J., Walz, T. & Lansbury, P. T. Jr. (2002). Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. Journal of Molecular Biology 322, 1089–1102.
    • (2002) Journal of Molecular Biology , vol.322 , pp. 1089-1102
    • Lashuel, H.A.1    Petre, B.M.2    Wall, J.3    Simon, M.4    Nowak, R.J.5    Walz, T.6    Lansbury, P.T.7
  • 166
    • 0034668147 scopus 로고    scopus 로고
    • Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases
    • Latruffe, N., Malki, M. C., Nicloas-Frances, V., Clemencet, M. C., Jannin, B. & Berlot, J. P. (2000). Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases. Biochemical Pharmacology 60, 1027–1032.
    • (2000) Biochemical Pharmacology , vol.60 , pp. 1027-1032
    • Latruffe, N.1    Malki, M.C.2    Nicloas-Frances, V.3    Clemencet, M.C.4    Jannin, B.5    Berlot, J.P.6
  • 169
    • 0036090467 scopus 로고    scopus 로고
    • Divergent effects of selective peroxisome proliferator-activated receptor-γ2 ligands on adipocyte versus osteoblast differentiation
    • Lecka-Czernik, B., Moerman, E. J., Grant, D. F., Lehmann, J. M., Manolagas, S. C. & Jilka, R. L. (2002). Divergent effects of selective peroxisome proliferator-activated receptor-γ2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 143, 2376–2384.
    • (2002) Endocrinology , vol.143 , pp. 2376-2384
    • Lecka-Czernik, B.1    Moerman, E.J.2    Grant, D.F.3    Lehmann, J.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 172
    • 84863154767 scopus 로고    scopus 로고
    • Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice
    • Lee, D. H., Huang, H., Choi, K., Mantzoros, C. & Kim, Y. B. (2012). Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice. American Journal of Physiology. Endocrinology and Metabolism 302, E552–560.
    • (2012) American Journal of Physiology. Endocrinology and Metabolism , vol.302 , pp. E552-560
    • Lee, D.H.1    Huang, H.2    Choi, K.3    Mantzoros, C.4    Kim, Y.B.5
  • 173
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H. & Gonzales, F. J. (1995). Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Molecular and Cellular Biology 15, 3012–3022.
    • (1995) Molecular and Cellular Biology , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzales, F.J.9
  • 174
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M. & Kliewer, S. A. (1997). Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. Journal of Biological Chemistry 272, 3406–3410.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 175
    • 85017328992 scopus 로고    scopus 로고
    • FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers
    • Leng, Y., Wang, Z., Tsai, L. K., Leeds, P., Fessler, E. B., Wang, J. & Chuang, D. M. (2014). FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers. Molecular Psychiatry 20, 215–223.
    • (2014) Molecular Psychiatry , vol.20 , pp. 215-223
    • Leng, Y.1    Wang, Z.2    Tsai, L.K.3    Leeds, P.4    Fessler, E.B.5    Wang, J.6    Chuang, D.M.7
  • 176
    • 0034121698 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene
    • Li, M., Pascual, G. & Glass, C. K. (2000). Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Molecular and Cellular Biology 20, 4699–4707.
    • (2000) Molecular and Cellular Biology , vol.20 , pp. 4699-4707
    • Li, M.1    Pascual, G.2    Glass, C.K.3
  • 177
    • 78149361157 scopus 로고    scopus 로고
    • How do soluble oligomers of amyloid beta-protein impair hippocampal synaptic plasticity?
    • Li, S., Shankar, G. M. & Selkoe, D. J. (2010). How do soluble oligomers of amyloid beta-protein impair hippocampal synaptic plasticity? Frontiers in Cellular Neuroscience 4, 5.
    • (2010) Frontiers in Cellular Neuroscience , vol.4 , pp. 5
    • Li, S.1    Shankar, G.M.2    Selkoe, D.J.3
  • 178
    • 84872150780 scopus 로고    scopus 로고
    • Effects of telmisartan on the level of Aβ1-42, interleukin-1β, tumor necrosis factor α and cognition in hypertensive patients with Alzheimer's disease
    • Li, W., Zhang, J. W., Lu, F. & Ma, M. M. (2012). Effects of telmisartan on the level of Aβ1-42, interleukin-1β, tumor necrosis factor α and cognition in hypertensive patients with Alzheimer's disease. Zhonghua Yi Xue Za Zhi 92, 2743–2746.
    • (2012) Zhonghua Yi Xue Za Zhi , vol.92 , pp. 2743-2746
    • Li, W.1    Zhang, J.W.2    Lu, F.3    Ma, M.M.4
  • 179
    • 79953186142 scopus 로고    scopus 로고
    • PGC-1 coactivators in the control of energy metabolism
    • Liu, C. & Lin, J. D. (2011). PGC-1 coactivators in the control of energy metabolism. Acta Biochimica et Biophysica Sinica 43, 248–257.
    • (2011) Acta Biochimica et Biophysica Sinica , vol.43 , pp. 248-257
    • Liu, C.1    Lin, J.D.2
  • 182
    • 84924863685 scopus 로고    scopus 로고
    • Activation of the nuclear receptor PPARdelta is neuroprotective in transgenic mouse model of Alzheimer's disease theough inhibition of inflammation
    • Malm, T., Mariani, M., Donovan, L. J., Neilson, L. & Landreth, G. E. (2015). Activation of the nuclear receptor PPARdelta is neuroprotective in transgenic mouse model of Alzheimer's disease theough inhibition of inflammation. Journal of Neuroinflammation 12, 7.
    • (2015) Journal of Neuroinflammation , vol.12 , pp. 7
    • Malm, T.1    Mariani, M.2    Donovan, L.J.3    Neilson, L.4    Landreth, G.E.5
  • 183
    • 33646152108 scopus 로고    scopus 로고
    • Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
    • Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J. & Reddy, P. H. (2006). Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Human Molecular Genetics 15, 1437–1449.
    • (2006) Human Molecular Genetics , vol.15 , pp. 1437-1449
    • Manczak, M.1    Anekonda, T.S.2    Henson, E.3    Park, B.S.4    Quinn, J.5    Reddy, P.H.6
  • 184
    • 84864249514 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
    • Mandrekar-Colucci, S., Karlo, J. C. & Landreth, G. E. (2012). Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. Journal of Neuroscience 32, 10117–10128.
    • (2012) Journal of Neuroscience , vol.32 , pp. 10117-10128
    • Mandrekar-Colucci, S.1    Karlo, J.C.2    Landreth, G.E.3
  • 186
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf, D. J. & Evans, R. M. (1995). The RXR heterodimers and orphan receptors. Cell 83, 841–850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 189
    • 79957509694 scopus 로고    scopus 로고
    • Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role of chromatin remodeling at the PGC-1-alpha promoter
    • Martin, E., Betuing, S., Pagès, C., Cambon, K., Auregan, G., Deglon, N., Roze, E. & Caboche, J. (2011). Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role of chromatin remodeling at the PGC-1-alpha promoter. Human Molecular Genetics 20, 2422–2434.
    • (2011) Human Molecular Genetics , vol.20 , pp. 2422-2434
    • Martin, E.1    Betuing, S.2    Pagès, C.3    Cambon, K.4    Auregan, G.5    Deglon, N.6    Roze, E.7    Caboche, J.8
  • 190
    • 84860365643 scopus 로고    scopus 로고
    • Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease
    • Martin, H. L., Mounsey, R. B., Mustafa, S., Sathe, K. & Teismann, P. (2012). Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease. Experimental Neurology 235, 528–538.
    • (2012) Experimental Neurology , vol.235 , pp. 528-538
    • Martin, H.L.1    Mounsey, R.B.2    Mustafa, S.3    Sathe, K.4    Teismann, P.5
  • 191
    • 84855851277 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress
    • Martín, A., Pérez-Girón, J. V., Hernanz, R., Palacios, R., Briones, A. M., Fortuño, A., Zalba, G., Salaices, M. & Alonso, M. J. (2012). Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress. Journal of Hypertension 30, 315–326.
    • (2012) Journal of Hypertension , vol.30 , pp. 315-326
    • Martín, A.1    Pérez-Girón, J.V.2    Hernanz, R.3    Palacios, R.4    Briones, A.M.5    Fortuño, A.6    Zalba, G.7    Salaices, M.8    Alonso, M.J.9
  • 192
    • 37649029200 scopus 로고    scopus 로고
    • Involvement of PPARs in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines
    • Martinasso, G., Oraldi, M., Tromabetta, A., Maggiora, M., Bertetto, O., Canuto, R. A. & Muzio, G. (2007). Involvement of PPARs in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines. PPAR Research 2007, 93416.
    • (2007) PPAR Research , vol.2007 , pp. 93416
    • Martinasso, G.1    Oraldi, M.2    Tromabetta, A.3    Maggiora, M.4    Bertetto, O.5    Canuto, R.A.6    Muzio, G.7
  • 193
    • 0031687071 scopus 로고    scopus 로고
    • On the role of the peroxisome in cell differentiation and carcinogenesis
    • Masters, C. & Crane, D. (1998). On the role of the peroxisome in cell differentiation and carcinogenesis. Molecular and Cellular Biochemistry 187, 85–97.
    • (1998) Molecular and Cellular Biochemistry , vol.187 , pp. 85-97
    • Masters, C.1    Crane, D.2
  • 195
    • 84888380533 scopus 로고    scopus 로고
    • Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson's disease
    • McFarland, K., Spalding, T. A., Hubbard, D., Ma, J. N., Olsson, R. & Burstein, E. S. (2013). Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson's disease. ACS Chemical Neuroscience 4, 1430–1438.
    • (2013) ACS Chemical Neuroscience , vol.4 , pp. 1430-1438
    • McFarland, K.1    Spalding, T.A.2    Hubbard, D.3    Ma, J.N.4    Olsson, R.5    Burstein, E.S.6
  • 196
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • McGeer, P. L. & McGeer, E. G. (2007). Glial reactions in Parkinson's disease. Movement Disorders 23, 474–483.
    • (2007) Movement Disorders , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 198
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • Minghetti, L. (2004). Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. Journal of Neurpathology and Experimental Neurology 63, 901–910.
    • (2004) Journal of Neurpathology and Experimental Neurology , vol.63 , pp. 901-910
    • Minghetti, L.1
  • 199
    • 34547557661 scopus 로고    scopus 로고
    • Role of COX-2 in inflammatory and degenerative brain diseases
    • Minghetti, L. (2007). Role of COX-2 in inflammatory and degenerative brain diseases. Subcellular Biochemistry 42, 127–141.
    • (2007) Subcellular Biochemistry , vol.42 , pp. 127-141
    • Minghetti, L.1
  • 200
    • 0027993220 scopus 로고
    • The peroxisome proliferator-activated receptor interacts with the retinoid X receptor in vivo
    • Miyata, K. S., McCaw, S. E., Marcus, S. L., Rachubinski, R. A. & Capone, J. P. (1994). The peroxisome proliferator-activated receptor interacts with the retinoid X receptor in vivo. Gene 148, 327–330.
    • (1994) Gene , vol.148 , pp. 327-330
    • Miyata, K.S.1    McCaw, S.E.2    Marcus, S.L.3    Rachubinski, R.A.4    Capone, J.P.5
  • 201
    • 0017861747 scopus 로고
    • The hepatic effects of hypolipidemic drugs (colfibrate, nafenopin, tibric acid, and, y-14,643) on hepatic peroxisomes and peroxisome-associated enzymes
    • Moody, D. E. & Reddy, J. K. (1978). The hepatic effects of hypolipidemic drugs (colfibrate, nafenopin, tibric acid, and, y-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. The American Journal of Pathology 90, 435–446.
    • (1978) The American Journal of Pathology , vol.90 , pp. 435-446
    • Moody, D.E.1    Reddy, J.K.2
  • 203
    • 0345118108 scopus 로고    scopus 로고
    • Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    • Moreno, S., Farioli-Vacchioli, S. & Ceru, M. P. (2004). Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience 123, 131–145.
    • (2004) Neuroscience , vol.123 , pp. 131-145
    • Moreno, S.1    Farioli-Vacchioli, S.2    Ceru, M.P.3
  • 204
    • 34250868282 scopus 로고    scopus 로고
    • Inflammation and dephosphorylation of the tight junction protein occluding in an experimental model of multiple sclerosis
    • Morgan, L., Shah, B., Rivers, L. E., Barden, L., Groom, A. J., Chung, R., Higazi, D., Desmond, H., Smith, T. & Staddon, J. M. (2007). Inflammation and dephosphorylation of the tight junction protein occluding in an experimental model of multiple sclerosis. Neuroscience 147, 664–673.
    • (2007) Neuroscience , vol.147 , pp. 664-673
    • Morgan, L.1    Shah, B.2    Rivers, L.E.3    Barden, L.4    Groom, A.J.5    Chung, R.6    Higazi, D.7    Desmond, H.8    Smith, T.9    Staddon, J.M.10
  • 205
    • 84866553780 scopus 로고    scopus 로고
    • Telmisartan at 80 mg/day increases high-molecular- weight adiponectin levels and improves insulin resistance in diabetic patients
    • Mori, H., Okada, Y., Arao, T., Nishida, K. & Tanaka, Y. (2012). Telmisartan at 80 mg/day increases high-molecular- weight adiponectin levels and improves insulin resistance in diabetic patients. Advances in Therapy 29, 635–644.
    • (2012) Advances in Therapy , vol.29 , pp. 635-644
    • Mori, H.1    Okada, Y.2    Arao, T.3    Nishida, K.4    Tanaka, Y.5
  • 208
    • 0030951143 scopus 로고    scopus 로고
    • Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists
    • Mukherjee, R., Jow, L., Croston, G. E. & Paterniti, J. R. Jr. (1997). Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists. Journal of Biological Chemistry 272, 8071–8076.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 8071-8076
    • Mukherjee, R.1    Jow, L.2    Croston, G.E.3    Paterniti, J.R.4
  • 209
    • 28844439793 scopus 로고    scopus 로고
    • Interaction of nuclear receptors with the Wnt/β-catenin/Tcf signaling axis: Wnt you like to know?
    • Mulholland, D. J., Dedhar, S., Coetzee, G. A. & Nelson, C. C. (2005). Interaction of nuclear receptors with the Wnt/β-catenin/Tcf signaling axis: Wnt you like to know? Endocrine Reviews 26, 898–915.
    • (2005) Endocrine Reviews , vol.26 , pp. 898-915
    • Mulholland, D.J.1    Dedhar, S.2    Coetzee, G.A.3    Nelson, C.C.4
  • 210
    • 84871849211 scopus 로고    scopus 로고
    • The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: abdominal fat depot intervention program of Okayama (ADIPO)
    • Murakami, K., Wada, J., Ogawa, D., Horiguchi, C. S., Miyoshi, T., Sasaki, M., Uchida, H. A., Nakamura, Y. & Makino, H. (2012). The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: abdominal fat depot intervention program of Okayama (ADIPO). Diabetes & Vascular Disease Research 10, 93–96.
    • (2012) Diabetes & Vascular Disease Research , vol.10 , pp. 93-96
    • Murakami, K.1    Wada, J.2    Ogawa, D.3    Horiguchi, C.S.4    Miyoshi, T.5    Sasaki, M.6    Uchida, H.A.7    Nakamura, Y.8    Makino, H.9
  • 211
    • 84858315888 scopus 로고    scopus 로고
    • New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury
    • Neher, M. D., Weckbach, S., Huber-Lang, M. S. & Stahel, P. F. (2012). New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury. PPAR Research 2012, 728461.
    • (2012) PPAR Research , vol.2012 , pp. 728461
    • Neher, M.D.1    Weckbach, S.2    Huber-Lang, M.S.3    Stahel, P.F.4
  • 212
    • 84930840553 scopus 로고    scopus 로고
    • Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARgamma agonism
    • Nenov, M. N., Tempia, F., Denner, L., Dineley, K. T. & Laezza, F. (2015). Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARgamma agonism. Journal of Neurophysiology 113, 1712–1726.
    • (2015) Journal of Neurophysiology , vol.113 , pp. 1712-1726
    • Nenov, M.N.1    Tempia, F.2    Denner, L.3    Dineley, K.T.4    Laezza, F.5
  • 213
    • 51349162561 scopus 로고    scopus 로고
    • Insights into PPARγ from structures with endogenous and covalently bound ligands
    • Nettles, K. W. (2008). Insights into PPARγ from structures with endogenous and covalently bound ligands. Nature Structural & Molecular Biology 15, 893–895.
    • (2008) Nature Structural & Molecular Biology , vol.15 , pp. 893-895
    • Nettles, K.W.1
  • 214
    • 0035149257 scopus 로고    scopus 로고
    • Control of glial immune function by neurons
    • Neumann, H. (2001). Control of glial immune function by neurons. Glia 36, 191–199.
    • (2001) Glia , vol.36 , pp. 191-199
    • Neumann, H.1
  • 215
    • 1942468955 scopus 로고    scopus 로고
    • Peroxisome proliferator activator receptors (PPAR), insulinresistance, and cardiomyopathy: friends or foes for the diabetic patient with heart failure?
    • Nikolaidis, L. A. & Levine, T. B. (2004). Peroxisome proliferator activator receptors (PPAR), insulinresistance, and cardiomyopathy: friends or foes for the diabetic patient with heart failure? Cardiology in Review 12, 158–170.
    • (2004) Cardiology in Review , vol.12 , pp. 158-170
    • Nikolaidis, L.A.1    Levine, T.B.2
  • 216
    • 84937520622 scopus 로고    scopus 로고
    • Pioglitazone in early Parkinson's disease: a phase 2, multicenter, double-blind, randomized trial
    • Ninds Exploratory Trials in Parkinsons Disease (NET-PD) FS-ZONE Investigators (2015). Pioglitazone in early Parkinson's disease: a phase 2, multicenter, double-blind, randomized trial. Lancet Neurology 14, 795–803.
    • (2015) Lancet Neurology , vol.14 , pp. 795-803
  • 217
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, S. E. & Wolski, K. (2007). Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. The New England Journal of Medicine 356, 2457–2471.
    • (2007) The New England Journal of Medicine , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 218
    • 84882827626 scopus 로고    scopus 로고
    • Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy
    • Noe, N., Dillon, L. l., Lellek, V. & Diaz, F. (2013). Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy. Mitochondrion 13, 417–426.
    • (2013) Mitochondrion , vol.13 , pp. 417-426
    • Noe, N.1    Dillon, L.L.2    Lellek, V.3    Diaz, F.4
  • 219
  • 220
    • 3142716146 scopus 로고    scopus 로고
    • Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification
    • Ohshima, T., Koga, H. & Shimotohno, K. (2004). Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification. Journal of Biological Chemistry 279, 29551–29557.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 29551-29557
    • Ohshima, T.1    Koga, H.2    Shimotohno, K.3
  • 222
    • 84892522551 scopus 로고    scopus 로고
    • Wnt signaling: role in LTP, neural networks and memory
    • Oliva, C. A., Vargas, J. Y. & Inestrosa, N. C. (2013). Wnt signaling: role in LTP, neural networks and memory. Ageing Research Reviews 12, 786–800.
    • (2013) Ageing Research Reviews , vol.12 , pp. 786-800
    • Oliva, C.A.1    Vargas, J.Y.2    Inestrosa, N.C.3
  • 223
    • 79955570315 scopus 로고    scopus 로고
    • Characteristics of drug-associated rhabdomyolysis: analysis of 8,610 cases reported to the U.S. Food and Drug Administration
    • Oshima, Y. (2011). Characteristics of drug-associated rhabdomyolysis: analysis of 8,610 cases reported to the U.S. Food and Drug Administration. Internal Medicine 50, 845–853.
    • (2011) Internal Medicine , vol.50 , pp. 845-853
    • Oshima, Y.1
  • 224
    • 0034086140 scopus 로고    scopus 로고
    • Origins and evolutionary diversification of the nuclear receptor superfamily
    • Owen, G. I. & Zelent, A. (2000). Origins and evolutionary diversification of the nuclear receptor superfamily. Cellular and Molecular Life Science 57, 809–827.
    • (2000) Cellular and Molecular Life Science , vol.57 , pp. 809-827
    • Owen, G.I.1    Zelent, A.2
  • 225
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Ref/NF-kappaB transcription factors
    • Pahl, H. L. (1999). Activators and target genes of Ref/NF-kappaB transcription factors. Oncogene 18, 6853–6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 227
    • 0030065322 scopus 로고    scopus 로고
    • Nuclear receptors spring into action
    • Parker, M. G. & White, R. (1996). Nuclear receptors spring into action. Nature Structural Biology 3, 113–115.
    • (1996) Nature Structural Biology , vol.3 , pp. 113-115
    • Parker, M.G.1    White, R.2
  • 229
    • 84873047729 scopus 로고    scopus 로고
    • Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
    • Paterniti, I., Impellizzeri, D., Crupi, R., Morabito, R., Campolo, M., Esposito, E. & Cuzzocrea, S. (2013). Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma. Journal of Neuroinflammation 10, 20.
    • (2013) Journal of Neuroinflammation , vol.10 , pp. 20
    • Paterniti, I.1    Impellizzeri, D.2    Crupi, R.3    Morabito, R.4    Campolo, M.5    Esposito, E.6    Cuzzocrea, S.7
  • 230
    • 79952417232 scopus 로고    scopus 로고
    • Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF
    • Paula-Lima, A. C., Adasme, T., Sanmartin, C., Sebollela, A., Hetz, C., Carrasco, M. A., Ferreira, S. T. & Hidalgo, C. (2011). Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF. Antioxidants & Redox Signaling 14, 1209–1223.
    • (2011) Antioxidants & Redox Signaling , vol.14 , pp. 1209-1223
    • Paula-Lima, A.C.1    Adasme, T.2    Sanmartin, C.3    Sebollela, A.4    Hetz, C.5    Carrasco, M.A.6    Ferreira, S.T.7    Hidalgo, C.8
  • 231
    • 0030885575 scopus 로고    scopus 로고
    • Thizolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
    • Peraldi, P., Xu, M. & Spiegelman, B. M. (1997). Thizolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. Journal of Clinical Investigation 100, 1863–1869.
    • (1997) Journal of Clinical Investigation , vol.100 , pp. 1863-1869
    • Peraldi, P.1    Xu, M.2    Spiegelman, B.M.3
  • 234
    • 75649135280 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease
    • Perl, D. P. (2010). Neuropathology of Alzheimer's disease. Mount Sinai Journal of Medicine 77, 32–42.
    • (2010) Mount Sinai Journal of Medicine , vol.77 , pp. 32-42
    • Perl, D.P.1
  • 235
    • 26044475136 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?
    • Peters, J. M., Cheung, C. & Gonzales, F. J. (2005). Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand? Journal of Molecular Medicine 83, 774–785.
    • (2005) Journal of Molecular Medicine , vol.83 , pp. 774-785
    • Peters, J.M.1    Cheung, C.2    Gonzales, F.J.3
  • 239
    • 84859762514 scopus 로고    scopus 로고
    • PPARγ and oxidative stress: con(β) catenating NRF2 and FOXO
    • Polvani, S., Tarocchi, M. & Galli, A. (2012). PPARγ and oxidative stress: con(β) catenating NRF2 and FOXO. PPAR Research 2012, 641087.
    • (2012) PPAR Research , vol.2012 , pp. 641087
    • Polvani, S.1    Tarocchi, M.2    Galli, A.3
  • 240
    • 77949878458 scopus 로고    scopus 로고
    • SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
    • Pourcet, B., Pineda-Torra, I., Derudas, B., Staels, B. & Gilneur, C. (2010). SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. Journal of Biological Chemistry 285, 5983–5992.
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 5983-5992
    • Pourcet, B.1    Pineda-Torra, I.2    Derudas, B.3    Staels, B.4    Gilneur, C.5
  • 241
    • 84883026047 scopus 로고    scopus 로고
    • Pioglitazone alleviates the mitochondrial apoptotic pathway and mito-oxidative damage in the d-galactose-induced mouse model
    • Prakash, A. & Kumar, A. (2013). Pioglitazone alleviates the mitochondrial apoptotic pathway and mito-oxidative damage in the d-galactose-induced mouse model. Clinical and Experimental Pharmacology and Physiology 40, 644–651.
    • (2013) Clinical and Experimental Pharmacology and Physiology , vol.40 , pp. 644-651
    • Prakash, A.1    Kumar, A.2
  • 242
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M. & Spiegelman, B. M. (1998). A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829–839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 243
    • 84946541570 scopus 로고    scopus 로고
    • PGC-1α silencing compunds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
    • Qi, Y., Yin, X., Wang, S., Jiang, H., Wang, X., Ren, M., Su, X. P., Lei, S. & Feng, H. (2015). PGC-1α silencing compunds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model. Frontiers in Aging Neuroscience 7, 204.
    • (2015) Frontiers in Aging Neuroscience , vol.7 , pp. 204
    • Qi, Y.1    Yin, X.2    Wang, S.3    Jiang, H.4    Wang, X.5    Ren, M.6    Su, X.P.7    Lei, S.8    Feng, H.9
  • 245
    • 40749103882 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes
    • Ramirez, S. H., Heilman, D., Morsey, B., Potula, R., Haorah, J. & Persidsky, Y. (2008). Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. Journal of Immunology 180, 1854–1865.
    • (2008) Journal of Immunology , vol.180 , pp. 1854-1865
    • Ramirez, S.H.1    Heilman, D.2    Morsey, B.3    Potula, R.4    Haorah, J.5    Persidsky, Y.6
  • 248
    • 36849000746 scopus 로고    scopus 로고
    • Inhibition of interleukin-1 beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
    • Ravaux, L., Denoyelle, C., Monne, C., Limon, I., Raymondjean, M. & El Hadri, K. (2007). Inhibition of interleukin-1 beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6. Molecular and Cellular Biology 27, 8374–8387.
    • (2007) Molecular and Cellular Biology , vol.27 , pp. 8374-8387
    • Ravaux, L.1    Denoyelle, C.2    Monne, C.3    Limon, I.4    Raymondjean, M.5    El Hadri, K.6
  • 249
    • 0016374920 scopus 로고
    • Hepatic microbody proliferation and catalase synthesis induced by methyl clofenapate, a hypilipidemic analog of CPIB
    • Reddy, J. K. (1974). Hepatic microbody proliferation and catalase synthesis induced by methyl clofenapate, a hypilipidemic analog of CPIB. American Journal of Pathology 75, 103–118.
    • (1974) American Journal of Pathology , vol.75 , pp. 103-118
    • Reddy, J.K.1
  • 250
    • 0018888058 scopus 로고
    • Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
    • Reddy, J. K., Azarnoff, D. L. & Hignite, C. E. (1980). Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature 283, 397–398.
    • (1980) Nature , vol.283 , pp. 397-398
    • Reddy, J.K.1    Azarnoff, D.L.2    Hignite, C.E.3
  • 251
    • 85011247002 scopus 로고
    • Nafenopin-induced hepatic microbody (peroxisome) proliferation and catalase synthesis in rats and mice. Absence of sex difference in response
    • Reddy, J. K., Azarnoff, D. L., Svoboda, D. J. & Prasad, J. D. (1974). Nafenopin-induced hepatic microbody (peroxisome) proliferation and catalase synthesis in rats and mice. Absence of sex difference in response. Journal of Cell Biology 61, 344–385.
    • (1974) Journal of Cell Biology , vol.61 , pp. 344-385
    • Reddy, J.K.1    Azarnoff, D.L.2    Svoboda, D.J.3    Prasad, J.D.4
  • 252
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline and Alzheimer's disease
    • Reddy, P. H. & Beal, M. F. (2008). Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline and Alzheimer's disease. Trends in Molecular Medicine 14, 45–53.
    • (2008) Trends in Molecular Medicine , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 254
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptative metabolic system
    • Reddy, J. K. & Hashimoto, T. (2001). Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptative metabolic system. Annual Review of Nutrition 21, 193–230.
    • (2001) Annual Review of Nutrition , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 255
    • 0032737858 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function
    • Ricote, M., Huang, J. T., Welch, J. S. & Glass, C. K. (1999). The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function. Journal of Leukocyte Biology 66, 733–739.
    • (1999) Journal of Leukocyte Biology , vol.66 , pp. 733-739
    • Ricote, M.1    Huang, J.T.2    Welch, J.S.3    Glass, C.K.4
  • 256
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J. & Glass, C. K. (1998). The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391, 79–82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 257
    • 84908397502 scopus 로고    scopus 로고
    • Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
    • Rios, J. A., Cisternas, P., Arrese, M., Barja, S. & Inestrosa, N. C. (2014). Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum. Progress in Neurobiology 121, 125–146.
    • (2014) Progress in Neurobiology , vol.121 , pp. 125-146
    • Rios, J.A.1    Cisternas, P.2    Arrese, M.3    Barja, S.4    Inestrosa, N.C.5
  • 258
    • 33745714392 scopus 로고    scopus 로고
    • PPARs and other nuclear receptors in inflammation
    • Rizzo, G. & Fiorucci, S. (2006). PPARs and other nuclear receptors in inflammation. Current Opinion in Pharmacology 6, 421–427.
    • (2006) Current Opinion in Pharmacology , vol.6 , pp. 421-427
    • Rizzo, G.1    Fiorucci, S.2
  • 259
    • 34547380204 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and Pakinson's disease: are microglia pathogenic in either disorder?
    • Rogers, J., Mastroeni, D., Leonard, B., Joyce, J. & Grover, A. (2007). Neuroinflammation in Alzheimer's disease and Pakinson's disease: are microglia pathogenic in either disorder? International Review of Neurobiology 82, 235–246.
    • (2007) International Review of Neurobiology , vol.82 , pp. 235-246
    • Rogers, J.1    Mastroeni, D.2    Leonard, B.3    Joyce, J.4    Grover, A.5
  • 262
    • 2142641833 scopus 로고    scopus 로고
    • Matrix metalloproteinases in neuroinflammation and cerebral ischemia
    • (eds. U. Dirnagl and B. Elger),, Ernst Schering Research Foundation Workshop
    • Rosenberg, G. A. & Mun-Bryce, S. (2004). Matrix metalloproteinases in neuroinflammation and cerebral ischemia. In Neuroinflammation in stroke (eds. U. Dirnagl and B. Elger), Ernst Schering Research Foundation Workshop 47, pp. 1–16.
    • (2004) Neuroinflammation in stroke , vol.47 , pp. 1-16
    • Rosenberg, G.A.1    Mun-Bryce, S.2
  • 263
    • 84868607245 scopus 로고    scopus 로고
    • Modulating peroxisome proliferator–activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects
    • Rosenson, R. S., Wright, R. S., Farkouh, M. & Plutzky, J. (2012). Modulating peroxisome proliferator–activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. American Heart Journal 164, 672–680.
    • (2012) American Heart Journal , vol.164 , pp. 672-680
    • Rosenson, R.S.1    Wright, R.S.2    Farkouh, M.3    Plutzky, J.4
  • 264
    • 0037447998 scopus 로고    scopus 로고
    • PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes
    • Roth, A. D., Leisewitz, A. V., Jung, J. E., Cassina, P., Barbeito, L., Inestrosa, N. C. & Bronfman, M. (2003). PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. Journal of Neuroscience Research 72, 425–435.
    • (2003) Journal of Neuroscience Research , vol.72 , pp. 425-435
    • Roth, A.D.1    Leisewitz, A.V.2    Jung, J.E.3    Cassina, P.4    Barbeito, L.5    Inestrosa, N.C.6    Bronfman, M.7
  • 265
  • 267
    • 84937643599 scopus 로고    scopus 로고
    • Nuclear receptor genes: evolution
    • In, John Wiley & Sons, Ltd, Chichester
    • Sáez, P. J., Lange, S., Pérez-Acle, T. & Owen, G. I. (2010). Nuclear receptor genes: evolution. In Encyclopedia of Life Sciences. John Wiley & Sons, Ltd, Chichester http://www.els.net [doi: 10.1002/9780470015902.a0006145.pub3].
    • (2010) Encyclopedia of Life Sciences
    • Sáez, P.J.1    Lange, S.2    Pérez-Acle, T.3    Owen, G.I.4
  • 268
    • 84869191121 scopus 로고    scopus 로고
    • Regulation of microglia and deactivation by nuclear receptors
    • Saijo, K., Crotti, A. & Glass, C. K. (2013). Regulation of microglia and deactivation by nuclear receptors. Glia 61, 104–111.
    • (2013) Glia , vol.61 , pp. 104-111
    • Saijo, K.1    Crotti, A.2    Glass, C.K.3
  • 269
    • 2442691703 scopus 로고    scopus 로고
    • Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor
    • Salma, N., Xiao, H., Mueller, E. & Imbalzano, A. N. (2004). Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. Molecular and Cellular Biology 24, 4651–4663.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 4651-4663
    • Salma, N.1    Xiao, H.2    Mueller, E.3    Imbalzano, A.N.4
  • 270
    • 60549115980 scopus 로고    scopus 로고
    • Neuropsychological assessment of dementia
    • Salmon, D. P. & Bondi, M. W. (2009). Neuropsychological assessment of dementia. Annual Review of Psychology 60, 257–282.
    • (2009) Annual Review of Psychology , vol.60 , pp. 257-282
    • Salmon, D.P.1    Bondi, M.W.2
  • 272
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., Van Leuven, F. & Heneka, M. T. (2003). Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. Journal of Neuroscience 23, 9796–9804.
    • (2003) Journal of Neuroscience , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5    Van Leuven, F.6    Heneka, M.T.7
  • 273
    • 33747785243 scopus 로고    scopus 로고
    • A novel membrane protein, encoded by the gene covering KIA A0233, is transcriptionally induced by senile plaque-associated astrocytes
    • Satoh, K., Hata, M., Takahara, S., Tsuzaki, H., Yokota, H., Akatsu, H., Yamamoto, T., Kosaka, K. & Yamada, T. (2006). A novel membrane protein, encoded by the gene covering KIA A0233, is transcriptionally induced by senile plaque-associated astrocytes. Brain Research 1108, 19–27.
    • (2006) Brain Research , vol.1108 , pp. 19-27
    • Satoh, K.1    Hata, M.2    Takahara, S.3    Tsuzaki, H.4    Yokota, H.5    Akatsu, H.6    Yamamoto, T.7    Kosaka, K.8    Yamada, T.9
  • 275
    • 34247611481 scopus 로고    scopus 로고
    • Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    • Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T. & Mufson, E. J. (2007). Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 68, 1501–1508.
    • (2007) Neurology , vol.68 , pp. 1501-1508
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    DeKosky, S.T.4    Mufson, E.J.5
  • 277
    • 84858972381 scopus 로고    scopus 로고
    • PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway
    • Schnegg, C. I., Kooshki, M., Hsu, F. C., Sui, G. & Robbins, M. E. (2012). PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway. Free Radical Biology and Medicine 52, 1734–1743.
    • (2012) Free Radical Biology and Medicine , vol.52 , pp. 1734-1743
    • Schnegg, C.I.1    Kooshki, M.2    Hsu, F.C.3    Sui, G.4    Robbins, M.E.5
  • 278
    • 84855281838 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of PPARδ: modulation of oxidative stress and inflammatory processes
    • Schnegg, C. I. & Robbins, M. E. (2011). Neuroprotective mechanisms of PPARδ: modulation of oxidative stress and inflammatory processes. PPAR Research 2011, 373560.
    • (2011) PPAR Research , vol.2011 , pp. 373560
    • Schnegg, C.I.1    Robbins, M.E.2
  • 282
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. Physiological Reviews 81, 741–766.
    • (2001) Physiological Reviews , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 284
    • 34249948005 scopus 로고    scopus 로고
    • Present concepts and future outlook: function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer
    • Sertzing, P., Seifert, M., Tilgen, W. & Reichrath, J. (2007). Present concepts and future outlook: function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer. Journal of Cellular Physiology 212, 1–12.
    • (2007) Journal of Cellular Physiology , vol.212 , pp. 1-12
    • Sertzing, P.1    Seifert, M.2    Tilgen, W.3    Reichrath, J.4
  • 285
    • 84894261400 scopus 로고    scopus 로고
    • Monitoring of neuronal loss in the hippocampus of Aβ-injected rat: autophagy, mitophagy, and mitochondrial biogenesis stand against apoptosis
    • Shaerzadeh, F., Motamedi, F., Minai-Tehrani, D. & Khodagholi, F. (2013). Monitoring of neuronal loss in the hippocampus of Aβ-injected rat: autophagy, mitophagy, and mitochondrial biogenesis stand against apoptosis. Neuromolecular Medicine 16, 175–190.
    • (2013) Neuromolecular Medicine , vol.16 , pp. 175-190
    • Shaerzadeh, F.1    Motamedi, F.2    Minai-Tehrani, D.3    Khodagholi, F.4
  • 286
    • 0029784760 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin
    • Shalev, A., Siegrist-Kaiser, C. A., Yen, P. M., Wahli, W., Burger, A. G., Chin, W. W. & Meier, C. A. (1996). The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology 137, 4499–4502.
    • (1996) Endocrinology , vol.137 , pp. 4499-4502
    • Shalev, A.1    Siegrist-Kaiser, C.A.2    Yen, P.M.3    Wahli, W.4    Burger, A.G.5    Chin, W.W.6    Meier, C.A.7
  • 287
    • 33847006604 scopus 로고    scopus 로고
    • Review: peroxisome proliferator-activated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism
    • Sharma, A. M. & Staels, B. (2007). Review: peroxisome proliferator-activated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism. Journal of Clinical Endocrinology & Metabolism 92, 386–395.
    • (2007) Journal of Clinical Endocrinology & Metabolism , vol.92 , pp. 386-395
    • Sharma, A.M.1    Staels, B.2
  • 288
    • 0037238924 scopus 로고    scopus 로고
    • Recent advances in peroxisome proliferator-activated receptor science
    • Shearer, B. G. & Hoekstra, W. J. (2003). Recent advances in peroxisome proliferator-activated receptor science. Current Medicinal Chemistry 10, 267–280.
    • (2003) Current Medicinal Chemistry , vol.10 , pp. 267-280
    • Shearer, B.G.1    Hoekstra, W.J.2
  • 292
  • 293
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with Rosiglitazone. A meta-analysis
    • Singh, S., Loke, Y. K. & Furberg, C. D. (2007). Long-term risk of cardiovascular events with Rosiglitazone. A meta-analysis. Journal of the American Medical Association 298, 1189–1195.
    • (2007) Journal of the American Medical Association , vol.298 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 294
    • 37049020205 scopus 로고    scopus 로고
    • The brain as a target for inflammatory processes and neuroprotective strategies
    • Skaper, S. D. (2007). The brain as a target for inflammatory processes and neuroprotective strategies. Annals of the New York Academy of Science 1122, 23–34.
    • (2007) Annals of the New York Academy of Science , vol.1122 , pp. 23-34
    • Skaper, S.D.1
  • 295
    • 84909635949 scopus 로고    scopus 로고
    • Nuclear receptors in neurodegenerative diseases
    • Skerrett, R., Malm, T. & Landreth, G. (2014). Nuclear receptors in neurodegenerative diseases. Neurobiology of Disease 72, 104–116.
    • (2014) Neurobiology of Disease , vol.72 , pp. 104-116
    • Skerrett, R.1    Malm, T.2    Landreth, G.3
  • 296
    • 84940703438 scopus 로고    scopus 로고
    • Combined liver X receptor/peroxisome proliferator-activated receptor γ agonist treatment reduces amyloid β levels and improves behavior in amyloid precursor protein/presenilin 1 mice
    • Skerrett, R., Pellegrino, M. P., Casali, B. T., Taraboanta, L. & Landreth, G. E. (2015). Combined liver X receptor/peroxisome proliferator-activated receptor γ agonist treatment reduces amyloid β levels and improves behavior in amyloid precursor protein/presenilin 1 mice. Journal of Biological Chemistry 290, 21591–21602.
    • (2015) Journal of Biological Chemistry , vol.290 , pp. 21591-21602
    • Skerrett, R.1    Pellegrino, M.P.2    Casali, B.T.3    Taraboanta, L.4    Landreth, G.E.5
  • 297
    • 43949146665 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: “key” regulators of neuroinflammation after traumatic brain injury
    • Stahel, P. F., Smith, W. R., Bruchis, J. & Rabb, C. H. (2008). Peroxisome proliferator-activated receptors: “key” regulators of neuroinflammation after traumatic brain injury. PPAR Research 2008, 538141.
    • (2008) PPAR Research , vol.2008 , pp. 538141
    • Stahel, P.F.1    Smith, W.R.2    Bruchis, J.3    Rabb, C.H.4
  • 298
    • 84899710827 scopus 로고    scopus 로고
    • Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers
    • Step, S. E., Lim, H.-W., Marinis, J. M., Prokesch, A., Steger, D. J., You, S.-H., Won, K.-J. & Lazar, M. A. (2014). Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers. Genes & Development 28, 1018–1028.
    • (2014) Genes & Development , vol.28 , pp. 1018-1028
    • Step, S.E.1    Lim, H.-W.2    Marinis, J.M.3    Prokesch, A.4    Steger, D.J.5    You, S.-H.6    Won, K.-J.7    Lazar, M.A.8
  • 299
    • 14844282813 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis
    • Storer, P. D., Xu, J., Chavis, J. & Drew, P. D. (2005). Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. Journal of Neuroimmunology 161, 113–122.
    • (2005) Journal of Neuroimmunology , vol.161 , pp. 113-122
    • Storer, P.D.1    Xu, J.2    Chavis, J.3    Drew, P.D.4
  • 300
    • 84863826404 scopus 로고    scopus 로고
    • The presynaptic active zone
    • Südhof, T. C. (2012). The presynaptic active zone. Neuron 75, 11–25.
    • (2012) Neuron , vol.75 , pp. 11-25
    • Südhof, T.C.1
  • 301
    • 84886998869 scopus 로고    scopus 로고
    • Neurotransmitter release: the last millisecond in the life of a synaptic vesicle
    • Südhof, T. C. (2013). Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron 80, 675–690.
    • (2013) Neuron , vol.80 , pp. 675-690
    • Südhof, T.C.1
  • 309
    • 84868702636 scopus 로고    scopus 로고
    • Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?
    • Tenenbaum, A. & Fisman, E. Z. (2012). Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention? Cardiovascular Diabetology 11, 140.
    • (2012) Cardiovascular Diabetology , vol.11 , pp. 140
    • Tenenbaum, A.1    Fisman, E.Z.2
  • 310
    • 0029588203 scopus 로고
    • From embryogenesis to metamorphosis: the regulation and function of Drosophila nuclear receptor superfamili members
    • Thummel, C. S. (1995). From embryogenesis to metamorphosis: the regulation and function of Drosophila nuclear receptor superfamili members. Cell 83, 871–877.
    • (1995) Cell , vol.83 , pp. 871-877
    • Thummel, C.S.1
  • 311
    • 0033772261 scopus 로고    scopus 로고
    • Proliferation of mitocondria and gene expression of carnitine plmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids
    • Totland, G. K., Madsen, L., Klementsen, B., Vaagenes, H., Kryvi, H., Frøyland, L., Hexeberg, S. & Berge, R. K. (2000). Proliferation of mitocondria and gene expression of carnitine plmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids. Biology of the Cell 92, 317–329.
    • (2000) Biology of the Cell , vol.92 , pp. 317-329
    • Totland, G.K.1    Madsen, L.2    Klementsen, B.3    Vaagenes, H.4    Kryvi, H.5    Frøyland, L.6    Hexeberg, S.7    Berge, R.K.8
  • 313
    • 84893494679 scopus 로고    scopus 로고
    • In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model
    • Vargas, J. Y., Fuenzalida, M. & Inestrosa, N. C. (2014). In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. Journal of Neuroscience 34, 2191–2202.
    • (2014) Journal of Neuroscience , vol.34 , pp. 2191-2202
    • Vargas, J.Y.1    Fuenzalida, M.2    Inestrosa, N.C.3
  • 315
    • 28544434439 scopus 로고    scopus 로고
    • Fos/AP-1 proteins in bone and the immune system
    • Wagner, E. F. & Eferl, R. (2005). Fos/AP-1 proteins in bone and the immune system. Immunological Reviews 208, 126–140.
    • (2005) Immunological Reviews , vol.208 , pp. 126-140
    • Wagner, E.F.1    Eferl, R.2
  • 316
    • 0029294531 scopus 로고
    • Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more…
    • Wahli, W., Braissant, O. & Desvergne, B. (1995). Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more…. Chemistry & Biology 2, 261–266.
    • (1995) Chemistry & Biology , vol.2 , pp. 261-266
    • Wahli, W.1    Braissant, O.2    Desvergne, B.3
  • 317
    • 0033278397 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors
    • Wahli, W., Devchand, P. R., Ijpenberg, A. & Desvergne, B. (1999). Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors. Advances in Experimental Medicine and Biology 447, 199–209.
    • (1999) Advances in Experimental Medicine and Biology , vol.447 , pp. 199-209
    • Wahli, W.1    Devchand, P.R.2    Ijpenberg, A.3    Desvergne, B.4
  • 318
    • 0035831494 scopus 로고    scopus 로고
    • Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes
    • Waite, K. J., Floyd, Z. E., Arbour-Reily, P. & Stephens, J. M. (2001). Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. Journal of Biological Chemistry 276, 7062–7068.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 7062-7068
    • Waite, K.J.1    Floyd, Z.E.2    Arbour-Reily, P.3    Stephens, J.M.4
  • 321
    • 0037221379 scopus 로고    scopus 로고
    • The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment
    • Watson, G. S. & Craft, S. (2003). The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 17, 27–45.
    • (2003) CNS Drugs , vol.17 , pp. 27-45
    • Watson, G.S.1    Craft, S.2
  • 322
    • 0034059821 scopus 로고    scopus 로고
    • Pharmacological induction of peroxisomes in peroxisome biogenesis disorders
    • Wei, H., Kemp, S., McGuinness, M. C., Moser, A. B. & Smith, K. D. (2000). Pharmacological induction of peroxisomes in peroxisome biogenesis disorders. Annals of Neurology 47, 286–296.
    • (2000) Annals of Neurology , vol.47 , pp. 286-296
    • Wei, H.1    Kemp, S.2    McGuinness, M.C.3    Moser, A.B.4    Smith, K.D.5
  • 323
    • 33947727192 scopus 로고    scopus 로고
    • Interleukins, inflammation, and mechanisms of Alzheimer's disease
    • Weisman, D., Hakimian, E. & Ho, G. J. (2006). Interleukins, inflammation, and mechanisms of Alzheimer's disease. Vitamins & Hormones 74, 505–530.
    • (2006) Vitamins & Hormones , vol.74 , pp. 505-530
    • Weisman, D.1    Hakimian, E.2    Ho, G.J.3
  • 324
    • 78649413837 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in cell life and death
    • Westermann, B. (2010). Mitochondrial fusion and fission in cell life and death. Nature Reviews Molecular Cell Biology 11, 872–884.
    • (2010) Nature Reviews Molecular Cell Biology , vol.11 , pp. 872-884
    • Westermann, B.1
  • 327
    • 34347357758 scopus 로고    scopus 로고
    • Inflammation in Parkinson's disease and other neurodegenerative diseases: cause and therapeutic implications
    • Wilms, H., Zecca, L., Rosenstiel, P., Sievers, J., Deuschl, G. & Lucius, R. (2007). Inflammation in Parkinson's disease and other neurodegenerative diseases: cause and therapeutic implications. Current Pharmaceutical Design 13, 1925–1928.
    • (2007) Current Pharmaceutical Design , vol.13 , pp. 1925-1928
    • Wilms, H.1    Zecca, L.2    Rosenstiel, P.3    Sievers, J.4    Deuschl, G.5    Lucius, R.6
  • 331
    • 33846221464 scopus 로고    scopus 로고
    • Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells
    • Xu, L., Han, C., Lim, K. & Wu, T. (2006). Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells. Cancer Research 66, 11859–11868.
    • (2006) Cancer Research , vol.66 , pp. 11859-11868
    • Xu, L.1    Han, C.2    Lim, K.3    Wu, T.4
  • 333
    • 84893957415 scopus 로고    scopus 로고
    • Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number
    • Xu, S., Liu, G., Bao, X., Wu, J., Li, S., Zheng, B., Anwyl, R. & Wang, Q. (2014). Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number. Journal of Alzheimer's Disease 39, 239–251.
    • (2014) Journal of Alzheimer's Disease , vol.39 , pp. 239-251
    • Xu, S.1    Liu, G.2    Bao, X.3    Wu, J.4    Li, S.5    Zheng, B.6    Anwyl, R.7    Wang, Q.8
  • 335
    • 84870226700 scopus 로고    scopus 로고
    • PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
    • Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P. & Heneka, M. T. (2012). PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. Journal of Neuroscience 32, 17321–17331.
    • (2012) Journal of Neuroscience , vol.32 , pp. 17321-17331
    • Yamanaka, M.1    Ishikawa, T.2    Griep, A.3    Axt, D.4    Kummer, M.P.5    Heneka, M.T.6
  • 336
    • 0001297403 scopus 로고    scopus 로고
    • Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT
    • Yang, X. Y., Wang, L. H., Chen, T., Hodge, D. R., Resau, J. H., DaSilva, L. & Farrar, W. L. (2000). Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT. Journal of Biological Chemistry 275, 4541–4544.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 4541-4544
    • Yang, X.Y.1    Wang, L.H.2    Chen, T.3    Hodge, D.R.4    Resau, J.H.5    DaSilva, L.6    Farrar, W.L.7
  • 337
    • 84857716778 scopus 로고    scopus 로고
    • Selective peroxisome proliferator-activated receptor-γ modulation to reduce cardiovascular risk in patients with insulin resistance
    • Yew, T., Toh, S. A. & Millar, J. S. (2012). Selective peroxisome proliferator-activated receptor-γ modulation to reduce cardiovascular risk in patients with insulin resistance. Recent Patents on Cardiovascular Drug Discovery 7, 33–41.
    • (2012) Recent Patents on Cardiovascular Drug Discovery , vol.7 , pp. 33-41
    • Yew, T.1    Toh, S.A.2    Millar, J.S.3
  • 338
    • 34547597709 scopus 로고    scopus 로고
    • PPPARalpha in atherosclerosis and inflammation
    • Zandbergen, F. & Plutzky, J. (2007). PPPARalpha in atherosclerosis and inflammation. Biochimica et Biophysica Acta 1771, 972–982.
    • (2007) Biochimica et Biophysica Acta , vol.1771 , pp. 972-982
    • Zandbergen, F.1    Plutzky, J.2
  • 339
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptor as integrators of metabolic and inflammatory signaling
    • Zelcer, N. & Tontonoz, P. (2006). Liver X receptor as integrators of metabolic and inflammatory signaling. Journal of Clinical Investigation 116, 607–614.
    • (2006) Journal of Clinical Investigation , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 340
    • 0029775642 scopus 로고    scopus 로고
    • Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma
    • Zhang, B., Berger, J., Zhou, G., Elbrecht, A., Biswas, S., White-Carrington, S., Szalkowski, D. & Moller, D. E. (1996). Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. Journal of Biological Chemistry 271, 31771–31774.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 31771-31774
    • Zhang, B.1    Berger, J.2    Zhou, G.3    Elbrecht, A.4    Biswas, S.5    White-Carrington, S.6    Szalkowski, D.7    Moller, D.E.8
  • 341
    • 84908556265 scopus 로고    scopus 로고
    • Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease
    • Zhang, J., Hu, M., Teng, Z., Tang, Y. P. & Chen, C. (2014). Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. Journal of Neuroscience 34, 14919–14933.
    • (2014) Journal of Neuroscience , vol.34 , pp. 14919-14933
    • Zhang, J.1    Hu, M.2    Teng, Z.3    Tang, Y.P.4    Chen, C.5
  • 342
    • 42749100646 scopus 로고    scopus 로고
    • Selective modulators of PPAR-γ activity: molecular aspects related to obesity and side-effects
    • Zhang, F., Lavan, B. E. & Gregoire, F. M. (2007). Selective modulators of PPAR-γ activity: molecular aspects related to obesity and side-effects. PPAR Research 2007, 32696.
    • (2007) PPAR Research , vol.2007 , pp. 32696
    • Zhang, F.1    Lavan, B.E.2    Gregoire, F.M.3
  • 343
    • 84878428124 scopus 로고    scopus 로고
    • Angiotensin II receptor blocker Telmisartan prevents new-onset diabetes in pre-diabetes OLETF rats on a high-fat diet: evidence of anti-diabetes action
    • Zhao, Z. Q., Luo, R., Li, L. Y. & Tian, F. S. (2013). Angiotensin II receptor blocker Telmisartan prevents new-onset diabetes in pre-diabetes OLETF rats on a high-fat diet: evidence of anti-diabetes action. Canadian Journal of Diabetes 37, 156–168.
    • (2013) Canadian Journal of Diabetes , vol.37 , pp. 156-168
    • Zhao, Z.Q.1    Luo, R.2    Li, L.Y.3    Tian, F.S.4
  • 344
    • 0027749599 scopus 로고
    • Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver
    • Zhu, Y., Alvares, K., Huang, Q., Rao, M. S. & Reddy, J. K. (1993). Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. Journal of Biological Chemistry 268, 26817–26820.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 26817-26820
    • Zhu, Y.1    Alvares, K.2    Huang, Q.3    Rao, M.S.4    Reddy, J.K.5
  • 345
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic, B. V. (2011). Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nature Reviews Neuroscience 12, 723–738.
    • (2011) Nature Reviews Neuroscience , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 346
    • 84904694734 scopus 로고    scopus 로고
    • Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs
    • Zolezzi, J. M., Bastías-Candia, S., Santos, M. J. & Inestrosa, N. C. (2014). Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs. Frontiers in Aging Neuroscience 6, 176.
    • (2014) Frontiers in Aging Neuroscience , vol.6 , pp. 176
    • Zolezzi, J.M.1    Bastías-Candia, S.2    Santos, M.J.3    Inestrosa, N.C.4
  • 347
    • 84888009677 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier
    • Zolezzi, J. M. & Inestrosa, N. C. (2013). Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier. Molecular Neurobiology 48, 438–451.
    • (2013) Molecular Neurobiology , vol.48 , pp. 438-451
    • Zolezzi, J.M.1    Inestrosa, N.C.2
  • 348
    • 84877654967 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitocondrial fusión-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?
    • Zolezzi, J. M., Silva-Alvarez, C., Ordenes, D., Godoy, J. A., Carvajal, F. J., Santos, M. J. & Inestrosa, N. C. (2013). Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitocondrial fusión-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? PLoS One 8, e64019.
    • (2013) PLoS One , vol.8
    • Zolezzi, J.M.1    Silva-Alvarez, C.2    Ordenes, D.3    Godoy, J.A.4    Carvajal, F.J.5    Santos, M.J.6    Inestrosa, N.C.7
  • 349
    • 82955235593 scopus 로고    scopus 로고
    • The phosphorylation status of extracellular-regulated kinase 1/2 in astrocytes and neurons from rat hippocampus determines the thrombin-induced calcium release and ROS generation
    • Zündorf, G. & Reiser, G. (2011). The phosphorylation status of extracellular-regulated kinase 1/2 in astrocytes and neurons from rat hippocampus determines the thrombin-induced calcium release and ROS generation. Journal of Neurochemistry 119, 1194–1204.
    • (2011) Journal of Neurochemistry , vol.119 , pp. 1194-1204
    • Zündorf, G.1    Reiser, G.2


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