HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

Cell Metabolism

Volumn 22, Issue 2, 2015, Pages 253-265

  Roy, Avik ^a   Jana, Malabendu ^a   Kundu, Madhuchhanda ^a   Corbett, Grant T ^a   Rangaswamy, Suresh B ^a   Mishra, Rama K ^b   Luan, Chi Hao ^b   Gonzalez, Frank J ^c   Pahan, Kalipada ^a,d  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ATORVASTATIN; BRAIN DERIVED NEUROTROPHIC FACTOR; COMPACTIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LEUCINE; NEUROTROPHIN; NEUROTROPHIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; TYROSINE; NERVE GROWTH FACTOR;

ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASTROCYTE; BINDING AFFINITY; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ELECTROSPRAY MASS SPECTROMETRY; FETUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLIA; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LIGAND BINDING; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; BRAIN; DRUG EFFECTS; GENETICS; METABOLISM; MUTANT MOUSE STRAIN; NERVE CELL; PATHOLOGY;

ANIMALIA; MUS;

ALZHEIMER DISEASE; ANIMALS; BRAIN; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEMORY; MICE; MICE, MUTANT STRAINS; NERVE GROWTH FACTORS; NEURONS; PPAR ALPHA; SIMVASTATIN; UP-REGULATION;

EID: 84938749022     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.05.022     Document Type: Article

References (39)

1. K. Abe Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury J. Cereb. Blood Flow Metab. 20 2000 1393 1408
2. M.L. Ancelin, I. Carrière, P. Barberger-Gateau, S. Auriacombe, O. Rouaud, S. Fourlanos, C. Berr, A.M. Dupuy, and K. Ritchie Lipid lowering agents, cognitive decline, and dementia: the three-city study J. Alzheimers Dis. 30 2012 629 637
3. J.S. Burgos, J. Benavides, P. Douillet, J. Velasco, and F. Valdivieso How statins could be evaluated successfully in clinical trials for Alzheimer's disease? Am. J. Alzheimers Dis. Other Demen. 27 2012 151 153
4. J. Chen, C. Zhang, H. Jiang, Y. Li, L. Zhang, A. Robin, M. Katakowski, M. Lu, and M. Chopp Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice J. Cereb. Blood Flow Metab. 25 2005 281 290
5. B. Cheng, and M.P. Mattson NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults Brain Res. 640 1994 56 67
6. A. Cordle, and G. Landreth 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses J. Neurosci. 25 2005 299 307
7. A. Cordle, J. Koenigsknecht-Talboo, B. Wilkinson, A. Limpert, and G. Landreth Mechanisms of statin-mediated inhibition of small G-protein function J. Biol. Chem. 280 2005 34202 34209
8. S. Dasgupta, M. Jana, X. Liu, and K. Pahan Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contact-induced expression of proinflammatory cytokines in microglial cells J. Biol. Chem. 278 2003 22424 22431
9. H. Dell, and M. Hadzopoulou-Cladaras CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression J. Biol. Chem. 274 1999 9013 9021
10. A. Endo, M. Kuroda, and Y. Tsujita ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium J. Antibiot. 29 1976 1346 1348
11. A. Ghosh, A. Roy, J. Matras, S. Brahmachari, H.E. Gendelman, and K. Pahan Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease J. Neurosci. 29 2009 13543 13556
12. D. Giulian, and T.J. Baker Characterization of ameboid microglia isolated from developing mammalian brain J. Neurosci. 6 1986 2163 2178
13. S. Herzig, S. Hedrick, I. Morantte, S.H. Koo, F. Galimi, and M. Montminy CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma Nature 426 2003 190 193
14. A. Jana, and K. Pahan Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease J. Biol. Chem. 279 2004 51451 51459
15. A. Jana, and K. Pahan Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase J. Neurosci. 24 2004 9531 9540
16. J. Jin, J. Albertz, Z. Guo, Q. Peng, G. Rudow, J.C. Troncoso, C.A. Ross, and W. Duan Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease J. Neurochem. 125 2013 410 419
17. J.M. Karasinska, and M.R. Hayden Cholesterol metabolism in Huntington disease Nat. Rev. Neurol. 7 2011 561 572
18. T. Kariharan, G. Nanayakkara, K. Parameshwaran, I. Bagasrawala, M. Ahuja, E. Abdel-Rahman, A.T. Amin, M. Dhanasekaran, V. Suppiramaniam, and R.H. Amin Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression Neurobiol. Aging 36 2015 1451 1461
19. A.P. Kells, D.M. Fong, M. Dragunow, M.J. During, D. Young, and B. Connor AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease Mol. Ther. 9 2004 682 688
20. M. Kerschensteiner, E. Gallmeier, L. Behrens, V.V. Leal, T. Misgeld, W.E. Klinkert, R. Kolbeck, E. Hoppe, R.L. Oropeza-Wekerle, I. Bartke, and et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J. Exp. Med. 189 1999 865 870
21. J.P. Liu, Y. Tang, S. Zhou, B.H. Toh, C. McLean, and H. Li Cholesterol involvement in the pathogenesis of neurodegenerative diseases Mol. Cell. Neurosci. 43 2010 33 42
22. P.C. Maisonpierre, L. Belluscio, S. Squinto, N.Y. Ip, M.E. Furth, R.M. Lindsay, and G.D. Yancopoulos Neurotrophin-3: a neurotrophic factor related to NGF and BDNF Science 247 1990 1446 1451
23. J.K. Morse, S.J. Wiegand, K. Anderson, Y. You, N. Cai, J. Carnahan, J. Miller, P.S. DiStefano, C.A. Altar, R.M. Lindsay, and et al. Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection J. Neurosci. 13 1993 4146 4156
24. A.H. Nagahara, D.A. Merrill, G. Coppola, S. Tsukada, B.E. Schroeder, G.M. Shaked, L. Wang, A. Blesch, A. Kim, J.M. Conner, and et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease Nat. Med. 15 2009 331 337
25. K. Pahan Lipid-lowering drugs Cell. Mol. Life Sci. 63 2006 1165 1178
26. K. Pahan, F.G. Sheikh, A.M. Namboodiri, and I. Singh Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages J. Clin. Invest. 100 1997 2671 2679
27. A. Roy, and K. Pahan Prospects of statins in Parkinson disease Neuroscientist 17 2011 244 255
28. A. Roy, Y.K. Fung, X. Liu, and K. Pahan Up-regulation of microglial CD11b expression by nitric oxide J. Biol. Chem. 281 2006 14971 14980
29. A. Roy, X. Liu, and K. Pahan Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin J. Biol. Chem. 282 2007 32222 32232
30. A. Roy, M. Jana, G.T. Corbett, S. Ramaswamy, J.H. Kordower, F.J. Gonzalez, and K. Pahan Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α Cell Rep. 4 2013 724 737
31. R.N. Saha, and K. Pahan Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia Free Radic. Biol. Med. 42 2007 1866 1878
32. M. Sano, K.L. Bell, D. Galasko, J.E. Galvin, R.G. Thomas, C.H. van Dyck, and P.S. Aisen A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease Neurology 77 2011 556 563
33. C. Stadelmann, M. Kerschensteiner, T. Misgeld, W. Brück, R. Hohlfeld, and H. Lassmann BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 125 2002 75 85
34. R. Suzuki, K. Lee, E. Jing, S.B. Biddinger, J.G. McDonald, T.J. Montine, S. Craft, and C.R. Kahn Diabetes and insulin in regulation of brain cholesterol metabolism Cell Metab. 12 2010 567 579
35. S.J. Tsai Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression Med. Hypotheses 68 2007 1296 1299
36. M. Valenza, V. Leoni, J.M. Karasinska, L. Petricca, J. Fan, J. Carroll, M.A. Pouladi, E. Fossale, H.P. Nguyen, O. Riess, and et al. Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes J. Neurosci. 30 2010 10844 10850
37. M.S. Weber, T. Prod'homme, L. Steinman, and S.S. Zamvil Drug Insight: using statins to treat neuroinflammatory disease Nat. Clin. Pract. Neurol. 1 2005 106 112
38. R. West, M.S. Beeri, J. Schmeidler, C.M. Hannigan, G. Angelo, H.T. Grossman, C. Rosendorff, and J.M. Silverman Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele Am. J. Geriatr. Psychiatry 16 2008 781 785
39. H. Wu, D. Lu, H. Jiang, Y. Xiong, C. Qu, B. Li, A. Mahmood, D. Zhou, and M. Chopp Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury J. Neurotrauma 25 2008 130 139