PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway

Free Radical Biology and Medicine

Volumn 52, Issue 9, 2012, Pages 1734-1743

  Schnegg, Caroline I ^a   Kooshki, Mitra ^a   Hsu, Fang Chi ^a   Sui, Guangchao ^a   Robbins, Mike E ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Free radicals; Inflammation; Ionizing radiation; Microglia; NF B; PKC MEK1 2 ERK1 2 AP 1 pathway; PPAR ; Radiation induced brain injury

Indexed keywords

4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROTEIN KINASE C ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; CONTROLLED STUDY; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION; REVIEW; SIGNAL TRANSDUCTION;

MURINAE;

EID: 84858972381     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.02.032     Document Type: Article

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