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Volumn 119, Issue 6, 2011, Pages 1194-1204

The phosphorylation status of extracellular-regulated kinase 1/2 in astrocytes and neurons from rat hippocampus determines the thrombin-induced calcium release and ROS generation

Author keywords

astrocyte; cytosolic calcium; ERK phosphorylation; neuron; neuroprotection; reactive oxygen species

Indexed keywords

APOCYNIN; CALCIUM ION; HYDROETHIDINE; MITOGEN ACTIVATED PROTEIN KINASE 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THROMBIN;

EID: 82955235593     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07527.x     Document Type: Article
Times cited : (12)

References (51)
  • 2
    • 33846818524 scopus 로고    scopus 로고
    • Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
    • DOI 10.1523/JNEUROSCI.4468-06.2007
    • Abramov A. Y., Scorziello A., and, Duchen M. R., (2007) Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J. Neurosci. 27, 1129-1138. (Pubitemid 46203321)
    • (2007) Journal of Neuroscience , vol.27 , Issue.5 , pp. 1129-1138
    • Abramov, A.Y.1    Scorziello, A.2    Duchen, M.R.3
  • 4
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • DOI 10.1152/physrev.00044.2005
    • Bedard K., and, Krause K. H., (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87, 245-313. (Pubitemid 46209993)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 245-313
    • Bedard, K.1    Krause, K.-H.2
  • 5
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • DOI 10.1038/nrn2038, PII NRN2038
    • Block M. L., Zecca L., and, Hong J. S., (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69. (Pubitemid 46011999)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 6
    • 70349653079 scopus 로고    scopus 로고
    • Calcium pumps in health and disease
    • Brini M., and, Carafoli E., (2009) Calcium pumps in health and disease. Physiol. Rev. 89, 1341-1378.
    • (2009) Physiol. Rev. , vol.89 , pp. 1341-1378
    • Brini, M.1    Carafoli, E.2
  • 7
    • 70349341899 scopus 로고    scopus 로고
    • Downstream targets and intracellular compartmentalization in Nox signaling
    • Chen K., Craige S. E., and, Keaney J. F., Jr, (2009) Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid. Redox Signal. 11, 2467-2480.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2467-2480
    • Chen, K.1    Craige, S.E.2    Keaney, Jr.J.F.3
  • 8
    • 70350747591 scopus 로고    scopus 로고
    • Targeting protein kinases in central nervous system disorders
    • Chico L. K., Van Eldik L. J., and, Watterson D. M., (2009) Targeting protein kinases in central nervous system disorders. Nat. Rev. Drug Discov. 8, 892-909.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 892-909
    • Chico, L.K.1    Van Eldik, L.J.2    Watterson, D.M.3
  • 9
    • 33644953299 scopus 로고    scopus 로고
    • Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme
    • Chinopoulos C., and, Adam-Vizi V., (2006) Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J. 273, 433-450.
    • (2006) FEBS J. , vol.273 , pp. 433-450
    • Chinopoulos, C.1    Adam-Vizi, V.2
  • 10
    • 0038383698 scopus 로고    scopus 로고
    • Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo
    • Choi S. H., Joe E. H., Kim S. U., and, Jin B. K., (2003) Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. J. Neurosci. 23, 5877-5886. (Pubitemid 36807867)
    • (2003) Journal of Neuroscience , vol.23 , Issue.13 , pp. 5877-5886
    • Choi, S.-H.1    Joe, E.H.2    Kim, S.U.3    Jin, B.K.4
  • 11
    • 17644366783 scopus 로고    scopus 로고
    • Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: Role of microglial NADPH oxidase
    • Choi S. H., Lee D. Y., Kim S. U., and, Jin B. K., (2005) Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase. J. Neurosci. 25, 4082-4090.
    • (2005) J. Neurosci. , vol.25 , pp. 4082-4090
    • Choi, S.H.1    Lee, D.Y.2    Kim, S.U.3    Jin, B.K.4
  • 13
    • 0030044360 scopus 로고    scopus 로고
    • Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
    • DOI 10.1038/379557a0
    • Daub H., Weiss F. U., Wallasch C., and, Ullrich A., (1996) Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379, 557-560. (Pubitemid 26049585)
    • (1996) Nature , vol.379 , Issue.6565 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 14
    • 0032557654 scopus 로고    scopus 로고
    • Signaling pathways involved in thrombin-induced cell protection
    • DOI 10.1074/jbc.273.21.12746
    • Donovan F. M., and, Cunningham D. D., (1998) Signaling pathways involved in thrombin-induced cell protection. J. Biol. Chem. 273, 12746-12752. (Pubitemid 28246827)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.21 , pp. 12746-12752
    • Donovan, F.M.1    Cunningham, D.D.2
  • 15
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dröge W., (2002) Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95. (Pubitemid 34654215)
    • (2002) Physiological Reviews , vol.82 , Issue.1 , pp. 47-95
    • Droge, W.1
  • 16
    • 33845220750 scopus 로고    scopus 로고
    • Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo
    • DOI 10.1016/j.neuroscience.2006.09.049, PII S030645220601311X
    • Fujimoto S., Katsuki H., Ohnishi M., Takagi M., Kume T., and, Akaike A., (2007) Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo. Neuroscience 144, 694-701. (Pubitemid 44855311)
    • (2007) Neuroscience , vol.144 , Issue.2 , pp. 694-701
    • Fujimoto, S.1    Katsuki, H.2    Ohnishi, M.3    Takagi, M.4    Kume, T.5    Akaike, A.6
  • 17
    • 44649130056 scopus 로고    scopus 로고
    • IP4/centaurin α-1
    • DOI 10.1111/j.1471-4159.2008.05308.x
    • Haase A., Nordmann C., Sedehizade F., Borrmann C., and, Reiser G., (2008) RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin alpha-1. J. Neurochem. 105, 2237-2248. (Pubitemid 351782253)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.6 , pp. 2237-2248
    • Haase, A.1    Nordmann, C.2    Sedehizade, F.3    Borrmann, C.4    Reiser, G.5
  • 18
    • 31844433443 scopus 로고    scopus 로고
    • Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats
    • DOI 10.1002/jnr.20746
    • Henrich-Noack P., Striggow F., Reiser G., and, Reymann K. G., (2006) Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats. J. Neurosci. Res. 83, 469-475. (Pubitemid 43184410)
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.3 , pp. 469-475
    • Henrich-Noack, P.1    Striggow, F.2    Reiser, G.3    Reymann, K.G.4
  • 19
    • 2942605831 scopus 로고    scopus 로고
    • Role of extracellular signal regulated kinases 1 and 2 in neuronal survival
    • DOI 10.1111/j.1432-1033.2004.04133.x
    • Hetman M., and, Gozdz A., (2004) Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur. J. Biochem. 271, 2050-2055. (Pubitemid 38747973)
    • (2004) European Journal of Biochemistry , vol.271 , Issue.11 , pp. 2050-2055
    • Hetman, M.1    Gosdz, A.2
  • 20
    • 33644898880 scopus 로고    scopus 로고
    • Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: Astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase
    • Ishida Y., Nagai A., Kobayashi S., and, Kim S. U., (2006) Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase. J. Neuropathol. Exp. Neurol. 65, 66-77.
    • (2006) J. Neuropathol. Exp. Neurol. , vol.65 , pp. 66-77
    • Ishida, Y.1    Nagai, A.2    Kobayashi, S.3    Kim, S.U.4
  • 21
    • 12244298207 scopus 로고    scopus 로고
    • 2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes
    • DOI 10.1002/jnr.20322, Brain Energy Metabolism: Transporters, Mitochondria and Neurodegeneration
    • 2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes. J. Neurosci. Res. 79, 262-271. (Pubitemid 40116444)
    • (2005) Journal of Neuroscience Research , vol.79 , Issue.1-2 , pp. 262-271
    • Kahlert, S.1    Zundorf, G.2    Reiser, G.3
  • 22
    • 33646583488 scopus 로고    scopus 로고
    • Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture
    • DOI 10.1111/j.1471-4159.2006.03752.x
    • Katsuki H., Okawara M., Shibata H., Kume T., and, Akaike A., (2006) Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. J. Neurochem. 97, 1232-1242. (Pubitemid 43725564)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.5 , pp. 1232-1242
    • Katsuki, H.1    Okawara, M.2    Shibata, H.3    Kume, T.4    Akaike, A.5
  • 23
    • 33846241298 scopus 로고    scopus 로고
    • Sources and targets of reactive oxygen species in synaptic plasticity and memory
    • DOI 10.1089/ars.2007.9.233
    • Kishida K. T., and, Klann E., (2007) Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid. Redox Signal. 9, 233-244. (Pubitemid 46105422)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.2 , pp. 233-244
    • Kishida, K.T.1    Klann, E.2
  • 24
    • 68949198337 scopus 로고    scopus 로고
    • αa-crystallin and αb-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death
    • Li R., Rohatgi T., Hanck T., and, Reiser G., (2009) αA-crystallin and αB-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. J. Neurochem. 110, 1433-1444.
    • (2009) J. Neurochem. , vol.110 , pp. 1433-1444
    • Li, R.1    Rohatgi, T.2    Hanck, T.3    Reiser, G.4
  • 25
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • DOI 10.1038/nature05292, PII NATURE05292
    • Lin M. T., and, Beal M. F., (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795. (Pubitemid 44622683)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 26
    • 42649110959 scopus 로고    scopus 로고
    • Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons
    • Liu D. Z., Cheng X. Y., Ander B. P., Xu H., Davis R. R., Gregg J. P., and, Sharp F. R., (2008) Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons. Neurobiol. Dis. 30, 201-211.
    • (2008) Neurobiol. Dis. , vol.30 , pp. 201-211
    • Liu, D.Z.1    Cheng, X.Y.2    Ander, B.P.3    Xu, H.4    Davis, R.R.5    Gregg, J.P.6    Sharp, F.R.7
  • 27
    • 36549089651 scopus 로고    scopus 로고
    • Protease-activated receptors in the brain: Receptor expression, activation, and functions in neurodegeneration and neuroprotection
    • DOI 10.1016/j.brainresrev.2007.08.002, PII S0165017307001841
    • Luo W., Wang Y., and, Reiser G., (2007) Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection. Brain Res. Brain Res. Rev. 56, 331-345. (Pubitemid 350176599)
    • (2007) Brain Research Reviews , vol.56 , Issue.2 , pp. 331-345
    • Luo, W.1    Wang, Y.2    Reiser, G.3
  • 28
    • 0027418205 scopus 로고
    • Measurement of co-localization of objects in dual-colour confocal images
    • Manders E. M. M., Verbeek F. J., and, Aten J. A., (1993) Measurement of colocalization of objects in dual colour confocal images. J. Microsc. 169, 375-382. (Pubitemid 23119681)
    • (1993) Journal of Microscopy , vol.169 , Issue.3 , pp. 375-382
    • Manders, E.M.M.1    Verbeek, F.J.2    Aten, J.A.3
  • 29
    • 1642279517 scopus 로고    scopus 로고
    • Protease-Activated Receptors: Contribution to Physiology and Disease
    • DOI 10.1152/physrev.00028.2003
    • Ossovskaya V. S., and, Bunnett N. W., (2004) Protease-activated receptors: contribution to physiology and disease. Physiol. Rev. 84, 579-621. (Pubitemid 38365493)
    • (2004) Physiological Reviews , vol.84 , Issue.2 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 30
    • 41149110642 scopus 로고    scopus 로고
    • Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: Role of neuronal NADPH oxidase
    • DOI 10.1002/jnr.21571
    • Park K. W., and, Jin B. K., (2008) Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase. J. Neurosci. Res. 86, 1053-1063. (Pubitemid 351441303)
    • (2008) Journal of Neuroscience Research , vol.86 , Issue.5 , pp. 1053-1063
    • Park, K.W.1    Jin, B.K.2
  • 31
    • 34249789273 scopus 로고    scopus 로고
    • Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase
    • DOI 10.1080/10715760701297354, PII 778898680
    • Peshavariya H. M., Dusting G. J., and, Selemidis S., (2007) Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase. Free Radic. Res. 41, 699-712. (Pubitemid 46845591)
    • (2007) Free Radical Research , vol.41 , Issue.6 , pp. 699-712
    • Peshavariya, H.M.1    Dusting, G.J.2    Selemidis, S.3
  • 32
    • 51249090123 scopus 로고    scopus 로고
    • The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells
    • Ramos J. W., (2008) The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int. J. Biochem. Cell Biol. 40, 2707-2719.
    • (2008) Int. J. Biochem. Cell Biol. , vol.40 , pp. 2707-2719
    • Ramos, J.W.1
  • 33
    • 24644446948 scopus 로고    scopus 로고
    • Protease-activated receptors: Regulation of neuronal function
    • Saito T., and, Bunnett N. W., (2005) Protease-activated receptors: regulation of neuronal function. Neuromol. Med. 7, 79-99.
    • (2005) Neuromol. Med. , vol.7 , pp. 79-99
    • Saito, T.1    Bunnett, N.W.2
  • 34
    • 58549105755 scopus 로고    scopus 로고
    • MAP'ing CNS development and cognition: An ERKsome process
    • Samuels I. S., Saitta S. C., and, Landreth G. E., (2009) MAP'ing CNS development and cognition: an ERKsome process. Neuron 61, 160-167.
    • (2009) Neuron , vol.61 , pp. 160-167
    • Samuels, I.S.1    Saitta, S.C.2    Landreth, G.E.3
  • 35
    • 28844433709 scopus 로고    scopus 로고
    • 4-binding protein: Membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor
    • DOI 10.1007/s11064-005-8804-1
    • 4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor. Neurochem. Res. 30, 1319-1330. (Pubitemid 41772279)
    • (2005) Neurochemical Research , vol.30 , Issue.10 , pp. 1319-1330
    • Sedehizade, F.1    Von Klot, C.2    Hanck, T.3    Reiser, G.4
  • 37
    • 34547204160 scopus 로고    scopus 로고
    • The MEK/ERK cascade: From signaling specificity to diverse functions
    • DOI 10.1016/j.bbamcr.2006.10.005, PII S0167488906003193
    • Shaul Y. D., and, Seger R., (2007) The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim. Biophys. Acta 1773, 1213-1226. (Pubitemid 47125968)
    • (2007) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1773 , Issue.8 , pp. 1213-1226
    • Shaul, Y.D.1    Seger, R.2
  • 38
    • 50549086078 scopus 로고    scopus 로고
    • Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin e receptor EP2 through cAMP elevation and protein kinase A
    • Sokolova E., Hartig R., and, Reiser G., (2008) Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A. FEBS J. 275, 3669-3679.
    • (2008) FEBS J. , vol.275 , pp. 3669-3679
    • Sokolova, E.1    Hartig, R.2    Reiser, G.3
  • 39
    • 67651184281 scopus 로고    scopus 로고
    • NOX enzymes in the central nervous system: From signaling to disease
    • Sorce S., and, Krause K. H., (2009) NOX enzymes in the central nervous system: from signaling to disease. Antioxid. Redox Signal. 11, 2481-2504.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2481-2504
    • Sorce, S.1    Krause, K.H.2
  • 41
    • 0031539290 scopus 로고    scopus 로고
    • Characteristics of thrombin-induced calcium signals in rat astrocytes
    • DOI 10.1002/(SICI)1098-1136(199712)21: 4<361::AID-GLIA3>3.0.CO;2-6
    • Ubl J. J., and, Reiser G., (1997) Characteristics of thrombin-induced calcium signals in rat astrocytes. Glia 21, 361-369. (Pubitemid 27526673)
    • (1997) GLIA , vol.21 , Issue.4 , pp. 361-369
    • Ubl, J.J.1    Reiser, G.2
  • 43
    • 0036006726 scopus 로고    scopus 로고
    • Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling
    • DOI 10.1002/glia.10012
    • Wang H., Ubl J. J., and, Reiser G., (2002a) Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling. Glia 37, 53-63. (Pubitemid 34103094)
    • (2002) GLIA , vol.37 , Issue.1 , pp. 53-63
    • Wang, H.1    Ubl, J.J.2    Reiser, G.3
  • 44
    • 0036838021 scopus 로고    scopus 로고
    • Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
    • Wang H., Ubl J. J., Stricker R., and, Reiser G., (2002b) Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am. J. Physiol. Cell Physiol. 283, C1351-C1364. (Pubitemid 35178427)
    • (2002) American Journal of Physiology - Cell Physiology , vol.283 , Issue.5
    • Wang, H.1    Ubl, J.J.2    Stricker, R.3    Reiser, G.4
  • 45
    • 33846316422 scopus 로고    scopus 로고
    • Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain
    • DOI 10.1042/BJ20060732
    • Wang Y., Luo W., and, Reiser G., (2007) Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain. Biochem. J. 401, 65-78. (Pubitemid 46114600)
    • (2007) Biochemical Journal , vol.401 , Issue.1 , pp. 65-78
    • Wang, Y.1    Luo, W.2    Reiser, G.3
  • 46
    • 11144295730 scopus 로고    scopus 로고
    • 'Ins and outs' of seven-transmembrane receptor signalling to ERK
    • DOI 10.1016/j.tem.2004.11.008, PII S1043276004002796
    • Werry T. D., Sexton P. M., and, Christopoulos A., (2005) "Ins and outs" of seven-transmembrane receptor signalling to ERK. Trends Endocrinol. Metab. 16, 26-33. (Pubitemid 40037724)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.1 , pp. 26-33
    • Werry, T.D.1    Sexton, P.M.2    Christopoulos, A.3
  • 47
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
    • DOI 10.1159/000094762, PII N130170763401
    • Yoon S., and, Seger R., (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24, 21-44. (Pubitemid 43108774)
    • (2006) Growth Factors , vol.24 , Issue.1 , pp. 21-44
    • Yoon, S.1    Seger, R.2
  • 49
    • 79952409731 scopus 로고    scopus 로고
    • Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection
    • Zündorf G., and, Reiser G., (2011) Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection. Antioxid. Redox Signal. 14, 1275-1288.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 1275-1288
    • Zündorf, G.1    Reiser, G.2
  • 50
    • 34347249935 scopus 로고    scopus 로고
    • Gap-junction blocker carbenoxolone differentially enhances NMDA-induced cell death in hippocampal neurons and astrocytes in co-culture
    • DOI 10.1111/j.1471-4159.2007.04509.x
    • Zündorf G., Kahlert S., and, Reiser G., (2007) Gap-junction blocker carbenoxolone differentially enhances NMDA-induced cell death in hippocampal neurons and astrocytes in co-culture. J. Neurochem. 102, 508-521. (Pubitemid 47000594)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.2 , pp. 508-521
    • Zundorf, G.1    Kahlert, S.2    Reiser, G.3
  • 51
    • 58149469744 scopus 로고    scopus 로고
    • Alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ
    • Zündorf G., Kahlert S., Bunik V. I., and, Reiser G., (2009) alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience 158, 610-616.
    • (2009) Neuroscience , vol.158 , pp. 610-616
    • Zündorf, G.1    Kahlert, S.2    Bunik, V.I.3    Reiser, G.4


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