Signal transduction during amyloid-β-peptide neurotoxicity: Role in Alzheimer disease

Brain Research Reviews

Volumn 47, Issue 1-3, 2004, Pages 275-289

  Fuentealba, Rodrigo A ^a   Farias, Ginny ^a   Scheu, Jessica ^a   Bronfman, Miguel ^a   Marzolo, María Paz ^a   Inestrosa, Nibaldo C ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Amyloid toxicity; Acetylcholinesterase; Alzheimer's disease; bcl 2; Lithium; M1 mAChR; PPAR ; Wnt catenin signaling

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BETA CATENIN; COPPER; GLYCOGEN SYNTHASE KINASE 3BETA; MUSCARINIC RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ALZHEIMER DISEASE; CLINICAL FEATURE; CONFERENCE PAPER; DEGENERATIVE DISEASE; DISEASE COURSE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; METABOLIC DISORDER; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TARGETING; SENILE PLAQUE; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BETA CATENIN; CELL SURVIVAL; CYTOSKELETAL PROTEINS; HIPPOCAMPUS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; WNT PROTEINS;

EID: 9644275641     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2004.07.018     Document Type: Conference Paper

References (163)

1. H. Aberle, A. Bauer, J. Stappert, A. Kispert, and R. Kemler β-Catenin is a target for the ubiquitin-proteasome pathway EMBO J. 16 1997 3797 3804
2. A. Alvarez, C. Opazo, R. Alarcón, J. Garrido, and N.C. Inestrosa Acetylcholinesterase promotes the aggregation of amyloid-β-peptide fragments by forming a complex with the growing fibrils J. Mol. Biol. 272 1997 348 361
3. A. Alvarez, R. Alarcón, C. Opazo, E. Campos, F.J. Muñoz, F.H. Calderón, F. Dajas, M.K. Gentry, B.P. Doctor, F.G. De Mello, and N.C. Inestrosa Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils J. Neurosci. 18 1998 3213 3223
4. A. Alvarez, J.A. Godoy, and N.C. Inestrosa The association of acetylcholinesterase with amyloid-β-peptide aggregates increases its neurotoxicity N.C. Inestrosa E.O. Campos Cholinesterases in the Second Millenium: Biomolecular and Pathological Aspects 2004 P. Universidad Catolica de Chile-FONDAP Biomedicina Chile 147 152
5. A.R. Alvarez, J.A. Godoy, K. Mullendorff, G.H. Olivares, M. Bronfman, and N.C. Inestrosa Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons Exp. Cell Res. 297 2004 186 196
6. B.H. Anderton, J.P. Brion, A.M. Couck, D.R. Davis, J.M. Gallo, D.P. Hanger, K. Ladhani, D.A. Latimer, C. Lewis, S. Lovestone, B. Marquardt, C.C.J. Miller, S.F.C. Mulot, C.H. Reynolds, T. Rupniak, C.J. Smith, S. Stabel, and J. Woodgett Modulation of PHF-like tau phosphorylation in cultured neurons and transfected cells Neurobiol. Aging 16 1995 389 397
7. W. Annaert, and B. De Strooper A cell biological perspective on Alzheimer's disease Annu. Rev. Cell Dev. Biol. 18 2002 25 51
8. P. Aoun, J.W. Simpkins, and N. Agarwal Role of PPAR-γ ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells Investig. Ophthalmol. Vis. Sci. 44 2003 2999 3004
9. C.S. Atwood, R.D. Moir, X. Huang, R.C. Scarpa, N.M.E. Bacarra, D.M. Romano, M.A. Hartshorn, R.E. Tanzi, and A.I. Bush Dramatic aggregation of Alzheimer Aβ by Cu (II) is induced by conditions representing physiological acidosis J. Biol. Chem. 273 1998 12817 12826
10. C.S. Atwood, R.C. Scarpa, X. Huang, R.D. Moir, W.D. Jones, D.P. Fairlie, R.E. Tanzi, and A.I. Bush Characterization of copper interactions with Alzheimer amyloid-β-peptides: identification of an attomolar-affinity copper binding site on amyloid β1-42 J. Neurochem. 75 2000 1219 1233
11. C.S. Atwood, G. Perry, H. Zeng, Y. Kato, W.D. Jones, K.Q. Ling, X. Huang, R.D. Moir, D. Wang, L.M. Sayre, M.A. Smith, S.G. Chen, and A.I. Bush Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β Biochemistry 43 2004 560 568
12. S.X. Bamji, K. Shimazu, N. Kimes, J. Huelsken, W. Birchmeier, B. Lu, and L.F. Reichardt Role of β-catenin in synaptic vesicle localization and presynaptic assembly Neuron 40 2003 719 731
13. C.N. Bennett, S.E. Ross, K.A. Longo, L. Bajnok, N. Hemati, K.W. Johnson, S.D. Harrison, and O.A. MacDougald Regulation of Wnt signaling during adipogenesis J. Biol. Chem. 277 2002 30998 31004
14. J. Berger, and D.E. Moller The mechanisms of action of PPARs Annu. Rev. Med. 53 2002 409 435
15. H. Braak, and E. Braak Staging of Alzheimer's disease-related neurofibrillary changes Neurobiol. Aging 16 1995 271 284
16. E. Braak, and H. Braak Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn Acta Neuropathol. (Berl.) 93 1997 323 325
17. J. Busciglio, A. Lorenzo, J. Yeh, and B.A. Yankner β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding Neuron 14 1995 879 888
18. A.I. Bush, W.H. Pettingell, G. Multhaup, M.D. Paradis, J.-P. Vonsattel, J.F. Gusella, K. Beyreuther, C.L. Masters, and R.E. Tanzi Rapid induction of Alzheimer Aβ amyloid formation by zinc Science 265 1994 1464 1467
19. A. Caricasole, A. Copani, A. Caruso, F. Caraci, L. Iacovelli, M.A. Sortino, G.C. Terstappen, and F. Nicoletti The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease? Trends Pharmacol. Sci. 24 2003 233 238
20. K.A. Carson, C. Geula, and M.M. Mesulam Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue Brain Res. 540 1991 204 208
21. E. Chalecka-Franaszek, and D.M. Chuang Lithium activates the serine/threonine kinase akt-1 and suppresses glutamate-induced inhibition of akt-1 activity in neurons Proc. Natl. Acad. Sci. U. S. A. 96 1999 8745 8750
22. R.W. Chen, and D.M. Chuang Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity J. Biol. Chem. 274 1999 6039 6042
23. G. Chen, W.Z. Zeng, P.X. Yuan, L.D. Huang, Y.M. Jiang, Z.H. Zhao, and H.K. Manji The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS J. Neurochem. 72 1999 879 882
24. R.H. Chen, W.V. Ding, and F. McCormick Wnt signaling to β-catenin involves two interactive components. Glycogen synthase kinase-3β inhibition and activation of protein kinase C J. Biol. Chem. 275 2000 17894 17899
25. R.A. Cherny, C.S. Atwood, M.E. Xilinas, D.N. Gray, W.D. Jones, C.A. McLean, K.J. Barnham, I. Volitakis, F.W. Fraser, Y. Kim, X. Huang, L.E. Goldstein, R.D. Moir, J.T. Lim, K. Beyreuther, H. Zheng, R.E. Tanzi, C.L. Masters, and A.I. Bush Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice Neuron 30 2001 665 676
26. L. Ciani, O. Krylova, M.J. Smalley, T.C. Dale, and P.C. Salinas A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules J. Cell Biol. 164 2004 243 253
27. A.A. Culbert, M.J. Brown, S. Frame, T. Hagen, D.A. Cross, B. Bax, and A.D. Reith GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β-catenin stabilisation without elevation of glycogen synthase activity FEBS Lett. 507 2001 288 294
28. K.N. Dahlgren, A.M. Manelli, W.B. StineJr, L.K. Baker, G.A. Krafft, and M.J. LaDu Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability J. Biol. Chem. 277 2002 32046 32053
29. A. Damalas, A. Ben-Ze'ev, I. Simcha, M. Shtutman, J.F. Leal, J. Zhurinsky, B. Geiger, and M. Oren Excess β-catenin promotes accumulation of transcriptionally active p53 EMBO J. 18 1999 3054 3063
30. G.V. De Ferrari, and N.C. Inestrosa Wnt signaling function and Alzheimer's disease Brain Res. Rev. 33 2000 1 12
31. G.V. De Ferrari, M.A. Canales, I. Shin, L.M. Weiner, I. Silman, and N.C. Inestrosa A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation Biochemistry 40 2001 10447 10457
32. G.V. De Ferrari, M. Chacón, M.I. Barría, J.L. Garrido, J.A. Godoy, G. Olivares, A.E. Reyes, A.R. Alvarez, M. Bronfman, and N.C. Inestrosa Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils Mol. Psychiatry 8 2003 195 208
33. P. De Sarno, S.A. Shestopal, T.D. King, A. Zmijewska, L. Song, and R.S. Jope Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition J. Biol. Chem. 278 2003 11086 11093
34. G.G. Farias, J.A. Godoy, F. Hernández, J. Avila, A. Fisher, and N.C. Inestrosa M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway? Neurobiol. Dis. 2004 (in press)
35. J. García-Pérez, J. Avila, and J. Diaz-Nido Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells J. Neurosci. Res. 52 1998 445 452
36. J.L. Garrido, J.A. Godoy, A. Alvarez, M. Bronfman, and N.C. Inestrosa Protein kinase C inhibits amyloid β peptide neurotoxicity by acting on members of the Wnt pathway FASEB J. 16 2002 1982 1984
37. C. Geula Abnormalities of neural circuitry in Alzheimer's disease: hippocampus and cortical cholinergic innervation Neurology 51 1998 S18 S29
38. C. Geula, and M. Mesulam Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease Brain Res. 498 1989 185 189
39. C. Geula, and M. Mesulam Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease Brain Res. 498 1989 185 189
40. E. Giacobini From molecular structure to Alzheimer therapy Jpn. J. Pharmacol. 74 1997 225 241
41. E. Giacobini Invited review: cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications Neurochem. Int. 32 1998 413 419
42. E. Giacobini Long-term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer' disease J. Neural Transm., Suppl. 62 2002 181 187
43. S. Hakimelahi, H.R. Parker, A.J. Gilchrist, M. Barry, Z. Li, R.C. Bleackley, and M. Pasdar Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2 J. Biol. Chem. 275 2000 10905 10911
44. A.C. Hall, F.R. Lucas, and P.C. Salinas Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signalling Cell 100 2000 525 535
45. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
46. R. Haring, A. Fisher, D. Marciano, Z. Pittel, Y. Kloog, A. Zuckerman, N. Eshhar, and E. Heldman Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to β-amyloid precursor protein secretion J. Neurochem. 71 1998 2094 2103
47. J.D. Harper, and P.T. Lansbury Jr. Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins Annu. Rev. Biochem. 66 1997 385 407
48. T.C. He, T.A. Chan, B. Vogelstein, and K.W. Kinzler PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs Cell 99 1999 335 345
49. X. He, M. Semenov, K. Tamai, and X. Zeng LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way Development 131 2004 1663 1677
50. C.M. Hedgepeth, L.J. Conrad, J. Zhang, H.C. Huang, V.M. Lee, and P.S. Klein Activation of the Wnt signaling pathway: a molecular mechanism for lithium action Dev. Biol. 185 1997 82 91
51. F. Hernandez, J. Borrell, C. Guaza, J. Avila, and J.J. Lucas Spatial learning deficit in transgenic mice that conditionally over-express GSK-3β in the brain but do not form tau filaments J. Neurochem. 83 2002 1529 1533
52. Y. Hirabayashi, Y. Itoh, H. Tabata, K. Nakajima, T. Akiyama, N. Masuyama, and Y. Gotoh The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells Development 131 2004 2791 2801
53. B.A. Hocevar, F. Mou, J.L. Rennolds, S.M. Morris, J.A. Cooper, and P.H. Howe Regulation of the Wnt signaling pathway by disabled-2 (Dab2) EMBO J. 22 2003 3084 3094
54. M. Hong, D.C.R. Chen, P.S. Klein, and V.M.-Y. Lee Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3 J. Biol. Chem. 272 1997 25326 25332
55. M. Hoshi, M. Sato, S. Matsumoto, A. Noguchi, K. Yasutake, N. Yoshida, and K. Sato Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β Proc. Natl. Acad. Sci. U. S. A. 100 2003 6370 6375
56. A.Y. Hsia, E. Masliah, L. McConlogue, G.Q. Yu, G. Tatsuno, K. Hu, D. Kholodenko, R.C. Malenka, R.A. Nicoll, and L. Mucke Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models Proc. Natl. Acad. Sci. U. S. A. 96 1999 3228 3233
57. X. Huang, M.P. Cuajungco, C.S. Atwood, M.A. Hartshorn, J.D. Tyndall, G.R. Hanson, K.C. Stokes, M. Leopold, G. Multhaup, L.E. Goldstein, R.C. Scarpa, A.J. Saunders, J. Lim, R.D. Moir, C. Glabe, E.F. Bowden, C.L. Masters, D.P. Fairlie, R.E. Tanzi, and A.I. Bush Cu(II) potentiation of Alzheimer Aβ neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction J. Biol. Chem. 274 1999 37111 37116
58. N.C. Inestrosa, A. Alvarez, C.A. Pérez, R.D. Moreno, M. Vicente, C. Linker, O.I. Casanueva, C. Soto, and J. Garrido Acetylcholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme Neuron 16 1996 881 891
59. N.C. Inestrosa, A. Alvarez, J. Godoy, A. Reyes, and G.V. De Ferrari Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity Acta Neurol. Scand., Suppl. 176 2000 53 59
60. N.C. Inestrosa, M. Colambres, and G.V. De Ferrari, Neurodegenerative Processes in Alzheimer's Disease: Role of Aβ-AChE Complexes and Wnt Signaling, in: N.C. Inestrosa, E.O. Campos (Eds.), Cholinesterases in the Second Millenium: Biomolecular and Pathological Aspects, P. Universidad Catolica de Chile-FONDAP Biomedicina, Chile, pp. 147-152.
61. N.C. Inestrosa, J.A. Godoy, R.A. Quintanilla, C. Koenig, and M. Bronfman Peroxisome Proliferator-Activated Receptor γ (PPARγ) is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: role of Wnt signaling Exp. Cell Res. 2004 (in press)
62. G. Jiang, Q. Dallas-Yang, Z. Li, D. Szalkowski, F. Liu, X. Shen, M. Wu, G. Zhou, T. Doebber, J. Berger, D.E. Moller, and B.B. Zhang Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARγ agonists Diabetes 51 2002 2412 2419
63. R.S. Jope Anti-bipolar therapy: mechanism of action of lithium Mol. Psychiatry 4 1999 117 128
64. D.E. Kang, S. Soriano, M.P. Frosch, T. Collins, S. Naruse, S.S. Sisodia, G. Leibowitz, F. Levine, and E.H. Koo Presenilin 1 facilitates the constitutive turnover of β-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the β-catenin-signaling pathway J. Neurosci. 19 1999 4229 4237
65. M. Katoh Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review) Int. J. Mol. Med. 10 2002 683 687
66. G.M. Kelly, P. Greenstein, D.F. Erezyilmaz, and R.T. Moon Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways Development 121 1995 1787 1799
67. S. Kersten, B. Desvergne, and W. Wahli Roles of PPARs in health and disease Nature 405 2000 421 424
68. C.H. Kim, W.C. Xiong, and L. Mei Regulation of MuSK expression by a novel signaling pathway J. Biol. Chem. 278 2003 38522 38527
69. Y. Kitamura, S. Shimohama, H. Koike, J. Kakimura, Y. Matsuoka, Y. Nomura, P.J. Gebicke-Haerter, and T. Taniguchi Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-γ in Alzheimer's disease brains Biochem. Biophys. Res. Commun. 254 1999 582 586
70. P.S. Klein, and D.A. Melton A molecular mechanism for the effect of lithium on development Proc. Natl. Acad. Sci. U. S. A. 93 1996 8455 8459
71. N. Kozlovsky, R.H. Belmaker, and G. Agam GSK-3 and the neurodevelopmental hypothesis of schizophrenia Eur. Neuropsychopharmacol. 12 2002 13 25
72. J.E. Kratz, D. Stearns, D.L. Huso, H.H. Slunt, D.L. Price, D.R. Borchelt, and C.G. Eberhart Expression of stabilized β-catenin in differentiated neurons of transgenic mice does not result in tumor formation BMC Cancer 2 2002 33
73. O. Krylova, M.J. Messenger, and P.C. Salinas Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3β J. Cell Biol. 151 2000 83 94
74. M.P. Lambert, A.K. Barlow, B.A. Chromy, C. Edwards, R. Freed, M. Liosatos, T.E. Morgan, I. Rozovsky, B. Trommer, K.L. Viola, P. Wals, C. Zhang, C.E. Finch, G.A. Krafft, and W.L. Klein Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins Proc. Natl. Acad. Sci. U. S. A. 95 1998 6448 6453
75. S.J. Lee, U. Liyanage, P.E. Bickel, W. Xia, P.T. Lansbury Jr., and K.S. Kosik A detergent-insoluble membrane compartment contains Aβ in vivo Nat. Med. 4 1998 730 734
76. J.Y. Lee, I. Mook-Jung, and J.Y. Koh Histochemically reactive zinc in plaques of the Swedish mutant β-amyloid precursor protein transgenic mice J. Neurosci. 19 1999 1 5 (RC10)
77. A.M. Lefebvre, I. Chen, P. Desreumaux, J. Najib, J.C. Fruchart, K. Geboes, M. Briggs, R. Heyman, and J. Auwerx Activation of the peroxisome proliferator-activated receptor (promotes the development of colon tumors in C57BL/6J-APCMin/+ mice Nat. Med. 4 1998 1053 1057
78. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ) J. Biol. Chem. 270 1995 12953 12956
79. R.H. Lenox, and L. Wang Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks Mol. Psychiatry 8 2003 135 144
80. G. Levesque, G. Yu, M. Nishimura, D.M. Zhang, L. Levesque, H. Yu, D. Xu, Y. Liang, E. Rogaeva, M. Ikeda, M. Duthie, N. Murgolo, L. Wang, P. VanderVere, M.L. Bayne, C.D. Strader, J.M. Rommens, P.E. Fraser, and P. St George-Hyslop Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin J. Neurochem. 72 1999 999 1008
81. M.A. Lovell, J.D. Robertson, W.J. Teesdale, J.L. Campbell, and W.R. Markesbery Copper, iron and zinc in Alzheimer's disease senile plaques J. Neurol. Sci. 158 1998 47 52
82. J.J. Lucas, F. Hernandez, P. Gomez-Ramos, M.A. Moran, R. Hen, and J. Avila Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice EMBO J. 20 2001 27 39
83. W. Luo, and S.C. Lin Axin: a master scaffold for multiple signaling pathways NeuroSignals 13 2004 99 113
84. J. Lyu, F. Costantini, E.H. Jho, and C.K. Joo Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells J. Biol. Chem. 278 2003 13487 13495
85. O. Maeda, N. Usami, M. Kondo, M. Takahashi, H. Goto, K. Shimokata, K. Kusugami, and Y. Sekido Plakoglobin (γ-catenin) has TCF/LEF family-dependent transcriptional activity in β-catenin-deficient cell line Oncogene 23 2004 964 972
86. S. Mandard, M. Muller, and S. Kersten Peroxisome proliferator-activated receptor alpha target genes Cell. Mol. Life Sci. 61 2004 393 416
87. E.M. Mandelkow, and E. Mandelkow Tau in Alzheimer's disease Trends Cell Biol. 8 1998 425 427
88. M.F. McEntee, C.H. Chiu, and J. Whelan Relationship of β-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice Carcinogenesis 20 1999 635 640
89. T. Miyaoka, H. Seno, and H. Ishino Increased expression of Wnt-1 in schizophrenic brains Schizophr. Res. 38 1999 1 6
90. M.A. Moran, E.J. Mufson, and P. Gomez-Ramos Colocalization of cholinesterases with β amyloid protein in aged and Alzheimer's brains Acta Neuropathol. (Berl.) 85 1993 362 369
91. S. Moreno, S. Farioli-Vecchioli, and M.P. Ceru Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS Neuroscience 123 2004 131 145
92. L. Mucke, E. Masliah, G.Q. Yu, M. Mallory, E.M. Rockenstein, G. Tatsuno, K. Hu, D. Kholodenko, K. Johnson-Wood, and L. McConlogue High-level neuronal expression of Aβ 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation J. Neurosci. 20 2000 4050 4058
93. A. Mudher, and S. Lovestone Alzheimer's disease-do Tauists and Baptists finally shake hands? Trends Neurosci. 25 2002 22 26
94. A. Mudher, S. Chapman, J. Richardson, A. Asuni, G. Gibb, C. Pollard, R. Killick, T. Iqbal, L. Raymond, I. Varndell, P. Sheppard, A. Makoff, E. Gower, P.E. Soden, P. Lewis, M. Murphy, T.E. Golde, H.T. Rupniak, B.H. Anderton, and S. Lovestone Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase J. Neurosci. 21 2001 4987 4995
95. D.M. Muller, K. Mendla, S.A. Farber, and R.M. Nitsch Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain Life Sci. 60 1997 985 991
96. G. Multhaup, A. Schlicksupp, L. Hess, D. Beher, T. Ruppert, C.L. Masters, and K. Beyreuther The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I) Science 271 1996 1406 1409
97. J.R. Muñoz-Montano, F.J. Moreno, J. Avila, and J. Diaz-Nido Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons FEBS Lett. 411 1997 183 188
98. Y. Muroyama, H. Kondoh, and S. Takada Wnt proteins promote neuronal differentiation in neural stem cell culture Biochem. Biophys. Res. Commun. 313 2004 915 921
99. W.J. Nelson, and R. Nusse Convergence of Wnt, β-catenin, and cadherin pathways Science 303 2004 1483 1487
100. M. Nishimura, G. Yu, G. Levesque, D.M. Zhang, L. Ruel, F. Chen, P. Milman, E. Holmes, Y. Liang, T. Kawarai, E. Jo, A. Supala, E. Rogaeva, D.M. Xu, C. Janus, L. Levesque, Q. Bi, M. Duthie, R. Rozmahel, K. Mattila, L. Lannfelt, D. Westaway, H.T. Mount, J. Woodgett, and P. St George-Hyslop Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex Nat. Med. 5 1999 164 169
101. R.M. Nitsch, B.E. Slack, R.J. Wurtman, and J.H. Growdon Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors Science 258 1992 304 307
102. S. Nonaka, and D.M. Chuang Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats NeuroReport 9 1998 2081 2084
103. R. Nusse, and H.E. Varmus Wnt genes Cell 69 1992 1073 1087
104. C. Opazo, F.C. Ruiz, and N.C. Inestrosa Amyloid β-peptide reduces copper (II) to copper (I) independent of its aggregation state Biol. Res. 33 2000 1288 1292
105. 2 J. Biol. Chem. 277 2002 40302 40308
106. C. Opazo, M.I. Barria, F.H. Ruiz, and N.C. Inestrosa Copper reduction by copper binding proteins and its relation to neurodegenerative diseases BioMetals 16 2003 91 98
107. J.J. Palacino, M.P. Murphy, O. Murayama, K. Iwasaki, M. Fujiwara, A. Takashima, T.E. Golde, and B. Wolozin Presenilin 1 regulates β-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion J. Biol. Chem. 276 2001 38563 38569
108. E. Paradis, H. Douillard, M. Koutroumanis, C. Goodyer, and A. LeBlanc Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons J. Neurosci. 16 1996 7533 7539
109. B.A. Parr, and A.P. McMahon Wnt genes and vertebrate development Curr. Opin. Genet. Dev. 4 1994 523 528
110. B.A. Parr, M.J. Shea, G. Vassileva, and A.P. McMahon Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds Development 119 1993 247 261
111. A. Patapoutian, and L.F. Reichardt Roles of Wnt proteins in neural development and maintenance Curr. Opin. Neurobiol. 10 2000 392 399
112. J.J. Pei, T. Tanaka, Y.C. Tung, E. Braak, K. Iqbal, and I. Grundke-Iqbal Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain J. Neuropathol. Exp. Neurol. 56 1997 70 78
113. S.L. Pelech Networking with proline-directed protein kinases implicated in tau phosphorylation Neurobiol. Aging 16 1995 247 256
114. G. Perry, M.A. Taddeo, R.B. Petersen, R.J. Castellani, P.L. Harris, S.L. Siedlak, A.D. Cash, Q. Liu, A. Nunomura, C.S. Atwood, and M.A. Smith Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease BioMetals 16 2003 77 81
115. P. Polakis Wnt signaling and cancer Genes Dev. 14 2000 1837 1851
116. M. Racchi, M. Mazzucchelli, A. Pascale, M. Sironi, and S. Govoni Role of protein kinase Cα in the regulated secretion of the amyloid precursor protein Mol. Psychiatry 8 2003 209 216
117. T. Rees, P.I. Hammond, H. Soreq, S. Younkin, and S. Brimijoin Acetylcholinesterase promotes β-amyloid plaques in cerebral cortex Neurobiol. Aging 24 2003 777 787
118. A.E. Reyes, D. Perez, A. Alvarez, J. Garrido, M.K. Gentry, B.P. Doctor, and N.C. Inestrosa A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme Biochem. Biophys. Res. Commun. 232 1997 652 655
119. A.E. Reyes, M.A. Chacón, M.C. Dinamarca, W. Cerpa, C. Morgan, and N.C. Inestrosa Acetylcholinesterase-Aβ complexes are more toxic than Aβ fibrils in rat hippocampus: effect on rat β-amyloid aggregation, laminin expression, reactive astrocytosis and neuronal cell loss Am. J. Pathol. 164 2004 2163 2174
120. C.H. Reynolds, M.A. Utton, G.B. Gibb, A. Yates, and B.H. Anderton Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein J. Neurochem. 68 1997 1736 1744
121. E.D. Rosen, and B.M. Spiegelman PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth J. Biol. Chem. 276 2001 37731 37734
122. S.E. Ross, N. Hemati, K.A. Longo, C.N. Bennett, P.C. Lucas, R.L. Erickson, and O.A. MacDougald Inhibition of adipogenesis by Wnt signaling Science 289 2000 950 953
123. F.H. Ruiz, M. Gonzalez, M. Bodini, C. Opazo, and N.C. Inestrosa Cysteine 144 is a key residue in the copper reduction by the β-amyloid precursor protein J. Neurochem. 73 1999 1288 1292
124. E. Saez, J. Rosenfeld, A. Livolsi, P. Olson, E. Lombardo, M. Nelson, E. Banayo, R.D. Cardiff, J.C. Izpisua-Belmonte, and R.M. Evans PPARγ signaling exacerbates mammary gland tumor development Genes Dev. 18 2004 528 540
125. D. Salomon, P.A. Sacco, S.G. Roy, I. Simcha, K.R. Johnson, M.J. Wheelock, and A. Ben-Ze'ev Regulation of β-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system J. Cell Biol. 139 1997 1325 1335
126. T. Satou, B.J. Cummings, and C.W. Cotman Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity Brain Res. 697 1995 35 43
127. C.R. Schatz, C. Geula, and M. Mesulam Competitive substrate inhibition in the histochemistry of cholinesterase activity in Alzheimer's disease Neurosci. Lett. 117 1990 56 61
128. 1-40 arctic (E22G) neurotoxicity depends on amylospheroids formation XVII Annual Meeting of the Society of Cellular Biology of Chile. Pucón, Chile, October 2003 2003
129. J. Scheu, C. Morgan, M. Hitschfeld, and N.C. Inestrosa The neurotoxicity of arctic amyloid-β-peptide is associated with its ability to form amylospheroids Neurobiol. Aging 2004 (submitted for publication)
130. D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol. Rev. 81 2001 741 766
131. D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
132. D.J. Selkoe Alzheimer disease: mechanistic understanding predicts novel therapies Ann. Intern. Med. 140 2004 627 638
133. K. Shiozaki, E. Iseki, H. Hino, and K. Kosaka Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies-an immunohistochemical study J. Neurol. Sci. 193 2001 23 28
134. D.M. Skovronsky, R.W. Doms, and V.M.-Y. Lee Detection of a novel intraneuronal pool of insoluble amyloid (protein that accumulates with time in culture J. Cell Biol. 141 1998 1031 1039
135. D.H. Small, S.S. Mok, and J.C. Bornstein Alzheimer's disease and Aβ toxicity: from top to bottom Nat. Rev., Neurosci. 2 2001 595 598
136. M.D. Smith, E.A. Ensor, R.S. Coffin, L.M. Boxer, and D.S. Latchman Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor J. Biol. Chem. 273 1998 16715 16722
137. C. Soto, E. Castaño, B. Frangione, and N.C. Inestrosa The α-helical to β-strand transition in the amino-terminal fragment of the amyloid β-peptide modulates amyloid formation J. Biol. Chem. 270 1995 3063 3067
138. V. Stambolik, L. Ruel, and J.R. Woodgett Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signaling in intact cells Curr. Biol. 6 1996 1664 1668
139. R.H. Takahashi, C.G. Almeida, P.F. Kearney, F. Yu, M.T. Lin, T.A. Milner, and G.K. Gouras Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain J. Neurosci. 24 2004 3592 3599
140. A. Takashima, K. Noguchi, K. Sato, T. Hoshino, and K. Imahori Tau protein kinase I is essential for amyloid β-protein-induced neurotoxicity Proc. Natl. Acad. Sci. U. S. A. 90 1993 7789 7793
141. A. Takashima, K. Noguchi, G. Michel, M. Mercken, M. Hoshi, K. Ishiguro, and K. Imahori Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β Neurosci. Lett. 203 1996 33 36
142. A. Takashima, M. Murayama, O. Murayama, T. Kohno, T. Honda, K. Yasutake, N. Nihonmatsu, and M. Mercken Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau Proc. Natl. Acad. Sci. U. S. A. 95 1998 9637 9641
143. K. Tang, J. Yang, X. Gao, C. Wang, L. Liu, H. Kitani, T. Atsumi, and N. Jing Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells Biochem. Biophys. Res. Commun. 293 2002 167 173
144. A.V. TerryJr, and J.J. Buccafusco The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development J. Pharmacol. Exp. Ther. 306 2003 821 827
145. R.D. Terry, E. Masliah, D.P. Salmon, N. Butters, R. DeTeresa, R. Hill, L.A. Hansen, and R. Katzman Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment Ann. Neurol. 30 1991 572 580
146. G. Tesco, and R.E. Tanzi GSK3 β forms a tetrameric complex with endogenous PS1-CTF/NTF and β-catenin. Effects of the D257/D385A and FAD-linked mutations Ann. N.Y. Acad. Sci. 920 2000 227 232
147. S. Uryu, J. Harada, M. Hisamoto, and T. Oda Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons Brain Res. 924 2002 229 236
148. E.A. van der Zee, P.G. Luiten, K. Shiozaki, E. Iseki, H. Hino, and K. Kosaka Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory Prog. Neurobiol. 58 1999 409 471
149. I. Vincent, J.H. Zheng, D.W. Dickson, Y. Kress, and P. Davies Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease Neurobiol. Aging 19 1998 287 296
150. L.A. Volpicelli, and A.I. Levey Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus Prog. Brain Res. 145 2004 59 66
151. U. Wagner, J. Brownlees, N.G. Irving, F.R. Lucas, P.C. Salinas, and C.C. Miller Overexpression of the mouse dishevelled-1 protein inhibits GSK-3β-mediated phosphorylation of tau in transfected mammalian cells FEBS Lett. 411 1997 369 372
152. J. Wang, Z. Jing, L. Zhang, G. Zhou, J. Braun, Y. Yao, and Z.Z. Wang Regulation of acetylcholine receptor clustering by the tumor suppressor APC Nat. Neurosci. 6 2003 1017 1018
153. R.V. Ward, K.H. Jennings, R. Jepras, W. Neville, D.E. Owen, J. Hawkins, G. Christie, J.B. Davis, A. George, E.H. Karran, and D.R. Howlett Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of β-amyloid peptide Biochem. J. 348 2000 137 144
154. G.S. Watson, and S. Craft The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment CNS Drugs 17 2003 27 45
155. X. Xia, S. Qian, S. Soriano, Y. Wu, A.M. Fletcher, X.J. Wang, E.H. Koo, X. Wu, and H. Zheng Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis Proc. Natl. Acad. Sci. U. S. A. 98 2001 10863 10868
156. J. Xie, Q. Guo, H. Zhu, M.W. Wooten, and M.P. Mattson Protein kinase C iota protects neural cells against apoptosis induced by amyloid β-peptide Brain Res. Mol. Brain Res. 82 2000 107 113
157. X. Yu, and R.C. Malenka β-Catenin is critical for dendritic morphogenesis Nat. Neurosci. 6 2003 1169 1177
158. G. Yu, F. Chen, G. Levesque, M. Nishimura, D.M. Zhang, L. Levesque, E. Rogaeva, D. Xu, Y. Liang, M. Duthie, P.H. St George-Hyslop, and P.E. Fraser The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin J. Biol. Chem. 273 1998 16470 16475
159. C.V. Zerbinatti, D.F. Wozniak, J. Cirrito, J.A. Cam, H. Osaka, K.R. Bales, M. Zhuo, S.M. Paul, D.M. Holtzman, and G. Bu Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein Proc. Natl. Acad. Sci. U. S. A. 101 2004 1075 1080
160. Z. Zhang, H. Hartmann, V.M. Do, D. Abramowski, C. Sturchler-Pierrat, M. Staufenbiel, B. Sommer, M. van de Wetering, H. Clevers, P. Saftig, B. De Strooper, X. He, and B.A. Yankner Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis Nature 395 1998 698 702
161. Q. Zheng-Fischhofer, J. Biernat, E.M. Mandelkow, S. Illenberger, R. Godemann, and E. Mandelkow Sequential phosphorylation of Tau by glycogen synthase kinase-3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical- filament-like conformation Eur. J. Biochem. 252 1998 542 552
162. Y. Zhu, K. Alvares, Q. Huang, M.S. Rao, and J.K. Reddy Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver J. Biol. Chem. 268 1993 26817 26820
163. J. Zhurinsky, M. Shtutman, and A. Ben-Ze'ev Differential mechanisms of LEF/TCF family-dependent transcriptional activation by β-catenin and plakoglobin, wMol Cell Biol. 20 2000 4238 4252