Involvement of PPARs in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines

PPAR Research

Volumn , Issue , 2007, Pages

  Martinasso, G ^a   Oraldi, M ^a   Trombetta, A ^a   Maggiora, M ^a   Bertetto, O ^a   Canuto, R A ^a   Muzio, G ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CLOFIBRATE; DOCOSAHEXAENOIC ACID; MYC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; COLON CANCER; COLON MUCOSA; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; NICK END LABELING; PREVALENCE; PROTEIN DETERMINATION; WESTERN BLOTTING;

EID: 37649029200     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2007/93416     Document Type: Article

References (37)

1. H. Kawamata h-kawama@dokkyomed.ac.jp M. Tachibana T. Fujimori Y. Imai Differentiation-inducing therapy for solid tumors. Current Pharmaceutical Design 12 3 2006 379 385
2. G. Chinetti J.-C. Fruchart B. Staels Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflammation Research 49 10 2000 497 505
3. G. D. Girnun W. M. Smith S. Drori APC-dependent suppression of colon carcinogenesis by PPARγ Proceedings of the National Academy of Sciences of the United States of America 99 21 2002 13771 13776
4. R. A. Gupta R. N. DuBois Controversy: PPARγ as a target for treatment of colorectal cancer. American Journal of Physiology. Gastrointestinal and Liver Physiology 283 2 2002 G266 G269
5. A. Bernando L. Minghetti luisa.minghetti@iss.it PPAR-γ agonists as regulators of microglial activation and brain inflammation. Current Pharmaceutical Design 12 1 2006 93 109
6. R. Kostadinova W. Wahli L. Michalik liliane.michalik@unil.ch PPARs in diseases: control mechanisms of inflammation. Current Medicinal Chemistry 12 25 2005 2995 3009
7. T. Wang J. Xu X. Yu R. Yang Z. C. Han tihzchan@public.tpt.tj.cn Peroxisome proliferator-activated receptor γ in malignant diseases. Critical Reviews in Oncology/Hematology 58 1 2006 1 14
8. K. Yang K.-H. Fan S. A. Lamprecht Peroxisome proliferator-activated receptor γ agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. International Journal of Cancer 116 4 2005 495 499
9. M. Lehrke M. A. Lazar lazar@mail.med.upenn.edu The many faces of PPARγ Cell 123 6 2005 993 999
10. R. Grau C. Punzón M. Fresno M. A. Ĩiguez Mainiguez@cbm.uam.es Peroxisome-proliferator-activated receptor α agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. Biochemical Journal 395 1 2006 81 88
11. M. Grabacka P. M. Plonka K. Urbanska K. Reiss kreiss@temple.edu Peroxisome proliferator-activated receptor α activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clinical Cancer Research 12 10 2006 3028 3036
12. N. Strakova J. Ehrmann jiri.ehrmann@tiscali.cz J. Bartos J. Malikova J. Dolezel Z. Kolar Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors. Neoplasma 52 2 2005 126 136
13. B. P. Kota T. H.-W. Huang B. D. Roufogalis basilr@pharm.usyd.edu.au An overview on biological mechanisms of PPARs. Pharmacological Research 51 2 2005 85 94
14. R. Cunard rcunard@ucsd.edu The potential use of PPARα agonists as immunosuppressive agents. Current Opinion in Investigational Drugs 6 5 2005 467 472
15. G. Martinasso M. Maggiora A. Trombetta R. A. Canuto rosangela. canuto@unito.it G. Muzio Effects of di(2-ethylhexyl) phthalate, a widely used peroxisome proliferator and plasticizer, on cell growth in the human keratinocyte cell line NCTC 2544. Journal of Toxicology and Environmental Health, Part A 69 5 2006 353 365
16. A. D. Burdick D. J. Kim M. A. Peraza F. J. Gonzalez J. M. Peters jmp21@psu.edu The role of peroxisome proliferator-activated receptor-β/ δ in epithelial cell growth and differentiation. Cellular Signalling 18 1 2006 9 20
17. H. Sampath Sampath@nutrisci.wisc.edu J. M. Ntambi ntambi@biochem.wisc.edu Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annual Review of Nutrition 25 2005 317 340
18. M. Maggiora M. Bologna M. P. Cerù An overview of the effect of linoleic and conjugated-linoleic acids on the growth of several human tumor cell lines. International Journal of Cancer 112 6 2004 909 919
19. G. Muzio A. Trombetta M. Maggiora Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression. Free Radical Biology and Medicine 40 11 2006 1929 1938
20. G. Muzio G. Martinasso A. Trombetta D. Di Simone R. A. Canuto rosangela.canuto@unito.it M. Maggiora HMG-CoA reductase and PPARα are involved in clofibrate-induced apoptosis in human keratinocytes. Apoptosis 11 2 2006 265 275
21. V. G. Keshamouni R. C. Reddy D. A. Arenberg Peroxisome proliferator-activated receptor-γ activation inhibits tumor progression in non-small-cell lung cancer. Oncogene 23 1 2004 100 108
22. G. Muzio M. Maggiora A. Trombetta Mechanisms involved in growth inhibition induced by clofibrate in hepatoma cells. Toxicology 187 2-3 2003 149 159
23. R. A. Canuto rosangela.canuto@unito.it M. Maggiora A. Trombetta G. Martinasso G. Muzio Aldehyde dehydrogenase 3 expression is decreased by clofibrate via PPAR gamma induction in JM2 rat hepatoma cell line. Chemico-Biological Interactions 143-144 2003 29 35
24. R. A. Canuto M. Ferro R. A. Salvo Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells. Biochemical Journal 357 3 2001 811 818
25. J. A. Brockman R. A. Gupta R. N. DuBois Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology 115 5 1998 1049 1055
26. R. A. Gupta J. A. Brockman P. Sarraf T. M. Willson R. N. DuBois raymond.dubois@mcmail.vanderbilt.edu Target genes of peroxisome proliferator-activated receptor γ in colorectal cancer cells. Journal of Biological Chemistry 276 32 2001 29681 29687
27. S. Ulrich S. M. Loitsch O. Rau Peroxisome proliferator-activated receptor γ as a molecular target of resveratrol-induced modulation of polyamine metabolism. Cancer Research 66 14 2006 7348 7354
28. M. Mutoh N. Niho K. Wakabayashi Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. Biological Chemistry. 387 4 2006 381 385
29. M.-Y. Li T. W. Lee A. P. C. Yim G. G. Chen gchen@cuhk.edu.hk Function of PPARγ and its ligands in lung cancer. Critical Reviews in Clinical Laboratory Sciences 43 2 2006 183 202
30. T.-H. Chang E. Szabo szaboe@mail.nih.gov Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor γ in non-small cell lung cancer. Cancer Research 60 4 2000 1129 1138
31. M. W. Matthiessen G. Pedersen T. Albrektsen S. Adamsen J. Fleckner J. Brynskov brynskov@dadlnet.dk Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scandinavian Journal of Gastroenterology 40 2 2005 198 205
32. N. Strakova J. Ehrmann jiri.ehrmann@tiscali.cz J. Bartos J. Malikova J. Dolezel Z. Kolar Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors. Neoplasma 52 2 2005 126 136
33. M.-C. Clemencet G. Muzio A. Trombetta Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. Cancer Letters 222 2 2005 217 226
34. P. Zahradka peterz@sbrc.ca B. Wright M. Fuerst N. Yurkova K. Molnar C. G. Taylor Peroxisome proliferator-activated receptor α and γ ligands differentially affect smooth muscle cell proliferation and migration. Journal of Pharmacology and Experimental Therapeutics 317 2 2006 651 659
35. R. A. Roberts ruth.roberts@aventis.com S. Chevalier S. C. Hasmall N. H. James S. C. Cosulich N. Macdonald PPARα and the regulation of cell division and apoptosis. Toxicology 181-182 2002 167 170
36. J. E. Klaunig M. A. Babich K. P. Baetcke PPARα agonist-induced rodent tumors: modes of action and human relevance. Critical Reviews in Toxicology 33 6 2003 655 780
37. G. Icre W. Wahli L. Michalik liliane.michalik@unil.ch Functions of the peroxisome proliferator-activated receptor (PPAR) α and β in skin homeostasis, epithelial repair, and morphogenesis. Journal of Investigative Dermatology 126 2006 30 35