메뉴 건너뛰기




Volumn 100, Issue 7, 1997, Pages 1863-1869

Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling

Author keywords

Adipocytes; Antidiabetic drugs; Insulin resistance; Insulin signaling; NIDDM

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CELL NUCLEUS RECEPTOR; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PIOGLITAZONE; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR; TROGLITAZONE;

EID: 0030885575     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119715     Document Type: Article
Times cited : (310)

References (48)
  • 1
    • 0025941863 scopus 로고
    • Affects of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patient with NIDDM
    • Iwamoti, Y., T. Kuzuya, A. Matsuda, T. Awata, S. Kumakura, G. Inooka, and I. Shiraishi. 1991. Affects of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patient with NIDDM. Diabetes Care. 14: 1083-1086.
    • (1991) Diabetes Care , vol.14 , pp. 1083-1086
    • Iwamoti, Y.1    Kuzuya, T.2    Matsuda, A.3    Awata, T.4    Kumakura, S.5    Inooka, G.6    Shiraishi, I.7
  • 2
    • 0026517631 scopus 로고
    • Metabolic effects of new oral hypoglicemic agent CS-045 in NIDDM subjects
    • Suter, S.L., J.J. Nolan, P. Wallace, B. Gumbiner, and J.M. Olefsky. 1992. Metabolic effects of new oral hypoglicemic agent CS-045 in NIDDM subjects. Diabetes Care. 15:193-203.
    • (1992) Diabetes Care , vol.15 , pp. 193-203
    • Suter, S.L.1    Nolan, J.J.2    Wallace, P.3    Gumbiner, B.4    Olefsky, J.M.5
  • 3
    • 0027983920 scopus 로고
    • Improvement of glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan, J.J., B. Ludvik, P. Beersden, M. Joyce, and J. Olefsky. 1994. Improvement of glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Eng. J. Med. 331:1188-1193.
    • (1994) N. Eng. J. Med. , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beersden, P.3    Joyce, M.4    Olefsky, J.5
  • 4
    • 0027304282 scopus 로고
    • Thiazolidinediones (AD-4533 and CS-045) improve hepatic insulin resistance in streptozotocin-induced diabetic rats
    • Tominaga, M., M. Igarashi, M. Daimon, H. Eguchi, M. Matsumoto, A. Sekiwaka, K. Yamamoti, and H. Sasaki. 1993. Thiazolidinediones (AD-4533 and CS-045) improve hepatic insulin resistance in streptozotocin-induced diabetic rats Endocr. J. 40:343-349.
    • (1993) Endocr. J. , vol.40 , pp. 343-349
    • Tominaga, M.1    Igarashi, M.2    Daimon, M.3    Eguchi, H.4    Matsumoto, M.5    Sekiwaka, A.6    Yamamoti, K.7    Sasaki, H.8
  • 5
    • 0026338157 scopus 로고
    • Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia
    • Stevenson, R.W., R.K. McPherson, B.E. Genereux, B. Danbury, and D.K. Kreutter. 1991. Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia. Metabolism. 40:1268-1274.
    • (1991) Metabolism , vol.40 , pp. 1268-1274
    • Stevenson, R.W.1    McPherson, R.K.2    Genereux, B.E.3    Danbury, B.4    Kreutter, D.K.5
  • 6
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saltiel, A.R., and J.M. Olefsky. 1996. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes. 45:1661-1669.
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 7
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxysome proliferalor-activated receptor γ
    • Lehman, J.M., L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Wilson, and S.A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxysome proliferalor-activated receptor γ. J. Biol. Chem. 270: 12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehman, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Wilson, T.M.5    Kliewer, S.A.6
  • 8
    • 0028972025 scopus 로고
    • 15-deoxy-d12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
    • Forman, B.M., P. Tontonoz, J. Chen, R.P. Brun, B.M. Spiegelman, and R.M. Evans. 1995. 15-deoxy-d12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell. 83:803-812.
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3    Brun, R.P.4    Spiegelman, B.M.5    Evans, R.M.6
  • 9
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz, P., E. Hu, and B.M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell. 79: 1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 10
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B.M., and J.S. Flier. 1996. Adipogenesis and obesity: rounding out the big picture. Cell. 87:377-389.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 12
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil, G.S., N.S. Shargill, and B.M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science (Wash. DC). 259:87-91.
    • (1993) Science (Wash. DC) , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 13
    • 0027972524 scopus 로고
    • Altered gene expression for tumor necrosis faetor-α and its receptors during drug and dietary modulation of insulin resistance
    • Hofmann, C., K. Lorenz, S.S. Braithwaite, J.R. Colca, B.J. Palazuk, G.S. Hotamisligil, and B.M. Spiegelman. 1994. Altered gene expression for tumor necrosis faetor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134:264-270.
    • (1994) Endocrinology , vol.134 , pp. 264-270
    • Hofmann, C.1    Lorenz, K.2    Braithwaite, S.S.3    Colca, J.R.4    Palazuk, B.J.5    Hotamisligil, G.S.6    Spiegelman, B.M.7
  • 14
  • 15
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
    • Hotamisligil, G.S., P. Arner, J.F. Caro, R.L. Atkinson, and B.M. Spiegelman. 1995. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J. Clin. Invest. 95:2409-2415.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 16
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern, P., M. Saghizadeh, J. Ong, R. Bosch, R. Deem, and R. Simsolo. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95:2111-2119.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2111-2119
    • Kern, P.1    Saghizadeh, M.2    Ong, J.3    Bosch, R.4    Deem, R.5    Simsolo, R.6
  • 17
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-α antibody (CPD571) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei, F., S. Hurel, J. Newkirk, M. Sopwith, and R. Taylor. 1996. Effects of an engineered human anti-TNF-α antibody (CPD571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes. 45:881-885.
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 18
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes
    • Hotamisligil, G.S., A. Budavari, D. Murray, and B.M. Spiegelman. 1994. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. J. Clin. Invest. 94:1543-1549.
    • (1994) J. Clin. Invest. , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 20
    • 0027332738 scopus 로고
    • Tumor necrosis factor-α supresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
    • Feinstein, R., H. Kanety, M.Z. Papa, B. Lunenfeld, and A. Karasik. 1993. Tumor necrosis factor-α supresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates J. Biol. Chem. 268:26055-26058.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26055-26058
    • Feinstein, R.1    Kanety, H.2    Papa, M.Z.3    Lunenfeld, B.4    Karasik, A.5
  • 22
    • 0029933665 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-α inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase
    • Peraldi, P., G.S. Hotamisligil, W.A. Buurman, M.F. White, and B.M. Spiegelman. 1996. Tumor necrosis factor (TNF)-α inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J. Biol. Chem. 271:13018-13022.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13018-13022
    • Peraldi, P.1    Hotamisligil, G.S.2    Buurman, W.A.3    White, M.F.4    Spiegelman, B.M.5
  • 23
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
    • Hotamisligil, G.S., P. Peraldi, A. Budavari, R. Ellis, M.F. White, and B.M. Spiegelman. 1996. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science (Wash. DC). 271:665-668.
    • (1996) Science (Wash. DC) , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 24
    • 0026623508 scopus 로고
    • Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis
    • Stephens, J., and P. Pekala. 1991. Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J. Biol. Chem. 267:13580-13584.
    • (1991) J. Biol. Chem. , vol.267 , pp. 13580-13584
    • Stephens, J.1    Pekala, P.2
  • 25
    • 0024367936 scopus 로고
    • The acquisition of increased insulin-responsive hexose transport in 3T3-L1 adipocytes correlates with expression of a novel transporter gene
    • Garcia de Herreros, A., and M. Birnbaum. 1989. The acquisition of increased insulin-responsive hexose transport in 3T3-L1 adipocytes correlates with expression of a novel transporter gene. J. Biol. Chem 264:19994-19999.
    • (1989) J. Biol. Chem , vol.264 , pp. 19994-19999
    • Garcia De Herreros, A.1    Birnbaum, M.2
  • 27
    • 0028124189 scopus 로고
    • Essential role of phosphatidylinositol-3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
    • Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and M. Ui. 1994. Essential role of phosphatidylinositol-3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J. Biol. Chem. 269:3568-3573.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3568-3573
    • Okada, T.1    Kawano, Y.2    Sakakibara, T.3    Hazeki, O.4    Ui, M.5
  • 28
    • 0029973135 scopus 로고    scopus 로고
    • Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
    • Martin, S., T. Haruta, A. Morris, A. Klippel, L. Williams, and J. Olefsky. 1996. Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J. Biol. Chem. 271: 17605-17608.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17605-17608
    • Martin, S.1    Haruta, T.2    Morris, A.3    Klippel, A.4    Williams, L.5    Olefsky, J.6
  • 29
    • 0029795178 scopus 로고    scopus 로고
    • Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocalion in adipocytes
    • Tanti, J., T. Gremeaux, S. Grillo, V. Calleja, A. Klippel, L. Williams, E. Van Obberghen, and Y. Le Marchand-Brustel. 1996. Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocalion in adipocytes. J. Biol. Chem. 271:25227-25232.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25227-25232
    • Tanti, J.1    Gremeaux, T.2    Grillo, S.3    Calleja, V.4    Klippel, A.5    Williams, L.6    Van Obberghen, E.7    Le Marchand-Brustel, Y.8
  • 30
    • 0028972026 scopus 로고
    • A prostaglandin J2 metabolite binds PPAR-γ and promotes adipocyte differentiation
    • Kliewer, S.A., J.M. Lenhard, T.M. Willson, I. Patel, D.C. Morris, and J.M. Lehman. 1995. A prostaglandin J2 metabolite binds PPAR-γ and promotes adipocyte differentiation. Cell. 83:813-819.
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Willson, T.M.3    Patel, I.4    Morris, D.C.5    Lehman, J.M.6
  • 32
    • 0026766036 scopus 로고
    • Pioglitazone increases insulin sensitivity by activating insulin receptor kinase
    • Kobayashi, M., M. Iwananishi, K. Egawa, and Y. Shigeta. 1992. Pioglitazone increases insulin sensitivity by activating insulin receptor kinase. Diabetes. 41:476-483.
    • (1992) Diabetes , vol.41 , pp. 476-483
    • Kobayashi, M.1    Iwananishi, M.2    Egawa, K.3    Shigeta, Y.4
  • 33
    • 0027228304 scopus 로고
    • Effect of pioglitazone on insulin receptors of skeletal muscles from high fat fed rats
    • Iwanashi, M., and M. Kobayashi. 1993. Effect of pioglitazone on insulin receptors of skeletal muscles from high fat fed rats. Metabolism. 42:1017-1021.
    • (1993) Metabolism , vol.42 , pp. 1017-1021
    • Iwanashi, M.1    Kobayashi, M.2
  • 34
  • 35
    • 0028032417 scopus 로고
    • Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in CHO cells expressing human insulin receptors and L6 myotubes
    • Zhang, B., D. Szalkowski, E. Diaz, N. Hayes, R. Smith, and J. Berger. 1994. Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in CHO cells expressing human insulin receptors and L6 myotubes. J. Biol. Chem. 269:25735-25741.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25735-25741
    • Zhang, B.1    Szalkowski, D.2    Diaz, E.3    Hayes, N.4    Smith, R.5    Berger, J.6
  • 36
    • 0025166078 scopus 로고
    • Insulin-like activity of new antidiabetic agent CPD68722 in 3T3-L1 adipocytes
    • Kreutter, D.K., K.M. Andrews, E.M. Gibbs, N.J. Hutson, and R.W. Stevenson. 1990. Insulin-like activity of new antidiabetic agent CPD68722 in 3T3-L1 adipocytes. Diabetes. 39:1414-1419.
    • (1990) Diabetes , vol.39 , pp. 1414-1419
    • Kreutter, D.K.1    Andrews, K.M.2    Gibbs, E.M.3    Hutson, N.J.4    Stevenson, R.W.5
  • 37
    • 0027292038 scopus 로고
    • The antidiabetic agent pioglitazone increases expression of glucose transporter in 3T3-F442A cells by increasing messenger ribonucleic acid transcript stability
    • Sandouk, T., D. Reda, and C. Hofman. 1993. The antidiabetic agent pioglitazone increases expression of glucose transporter in 3T3-F442A cells by increasing messenger ribonucleic acid transcript stability. Endocrinology. 133: 352-359.
    • (1993) Endocrinology , vol.133 , pp. 352-359
    • Sandouk, T.1    Reda, D.2    Hofman, C.3
  • 38
    • 0028111923 scopus 로고
    • Regulation of glucose transport by pioglitazone in cultured muscle cells
    • El-Kebbi, I.M., S. Roser, and R.J. Pollet. 1994. Regulation of glucose transport by pioglitazone in cultured muscle cells. Metabolism. 43:953-958.
    • (1994) Metabolism , vol.43 , pp. 953-958
    • El-Kebbi, I.M.1    Roser, S.2    Pollet, R.J.3
  • 39
    • 0028914922 scopus 로고
    • Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities
    • Maegawa, H., R. Ide, M. Hasegawa, S. Ugi, K. Egawa, M. Iwanishi, R. Kikkawa, Y. Shigeta, and A. Kashiwagi. 1995. Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities. J. Biol. Chem. 270:7724-7730.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7724-7730
    • Maegawa, H.1    Ide, R.2    Hasegawa, M.3    Ugi, S.4    Egawa, K.5    Iwanishi, M.6    Kikkawa, R.7    Shigeta, Y.8    Kashiwagi, A.9
  • 40
    • 0028916523 scopus 로고
    • Antidiabetic thiazolidinediones block the inhibitory effect of TNF-α on differentiation, insulin stimulated glucose uptake, and gene expression in 3T3-L1 cells
    • Szalkowski, D., S. White-Carrington, J. Berger, and B. Zhang. 1995. Antidiabetic thiazolidinediones block the inhibitory effect of TNF-α on differentiation, insulin stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology. 136:1474-1481.
    • (1995) Endocrinology , vol.136 , pp. 1474-1481
    • Szalkowski, D.1    White-Carrington, S.2    Berger, J.3    Zhang, B.4
  • 41
    • 0028043899 scopus 로고
    • Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocytes differentiation in 3T3-L1 cells
    • Ohsumi, J., S. Sakakibara, J. Yamaguchi, K. Miyadai, S. Yoshioka, T. Fujiwara, H. Horikoshi, and N. Serizawa. 1994. Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocytes differentiation in 3T3-L1 cells. Endocrinology. 135:2279-2282.
    • (1994) Endocrinology , vol.135 , pp. 2279-2282
    • Ohsumi, J.1    Sakakibara, S.2    Yamaguchi, J.3    Miyadai, K.4    Yoshioka, S.5    Fujiwara, T.6    Horikoshi, H.7    Serizawa, N.8
  • 42
    • 0030661983 scopus 로고    scopus 로고
    • The mechanism of TNF-α-induced insulin resistance in vivo and its prevention by troglitazone
    • In press
    • Miles, P., O. Romeo, K. Higo, K. Rafaat, and J. Olefsky. 1997. The mechanism of TNF-α-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes. In press.
    • (1997) Diabetes
    • Miles, P.1    Romeo, O.2    Higo, K.3    Rafaat, K.4    Olefsky, J.5
  • 48
    • 0029795431 scopus 로고    scopus 로고
    • Effect of troglitazone on leptin production. Studies in vitro and in human subjects
    • Nolan, J., J. Olefsky, M. Nyce, R. Considine, and J. Caro. 1996. Effect of troglitazone on leptin production. Studies in vitro and in human subjects. Diabetes. 45:1276-1278.
    • (1996) Diabetes , vol.45 , pp. 1276-1278
    • Nolan, J.1    Olefsky, J.2    Nyce, M.3    Considine, R.4    Caro, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.