In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model

Journal of Neuroscience

Volumn 34, Issue 6, 2014, Pages 2191-2202

  Vargas, Jessica Y ^a   Fuenzalida, Marco ^b   Inestrosa, Nibaldo C ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSIDAD DE VALPARAÍSO   (Chile)

Author keywords

Alzheimer's disease; APP PS1 mice; Cognitive function; Memory; Synaptic plasticity; Wnt signaling

Indexed keywords

AMYLOID BETA PROTEIN; BETA ACTIN; BETA CATENIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; GLYCOGEN SYNTHASE KINASE 3BETA; HEXAPEPTIDE; MYC PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N, N DIISOPROPYL 5 METHOXYTRYPTAMINE; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN P46; PROTEIN P54; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPSIN I; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; WNT7A PROTEIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN DYSFUNCTION; BRAIN ELECTROPHYSIOLOGY; CANNULA; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; EPISODIC MEMORY; HIPPOCAMPUS; INFUSION SYSTEM; LONG TERM POTENTIATION; MALE; METABOLIC ACTIVATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

ALZHEIMER'S DISEASE; APP/PS1 MICE; COGNITIVE FUNCTION; MEMORY; SYNAPTIC PLASTICITY; WNT SIGNALING;

ALZHEIMER DISEASE; ANIMALS; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MICE; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; WNT SIGNALING PATHWAY;

EID: 84893494679     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0862-13.2014     Document Type: Article

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