PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Nature Medicine

Volumn 22, Issue 1, 2016, Pages 37-45

  Dickey, Audrey S ^a   Pineda, Victor V ^b   Tsunemi, Taiji ^a   Liu, Patrick P ^a,c   Miranda, Helen C ^a   Gilmore Hall, Stephen K ^a   Lomas, Nicole ^a   Sampat, Kunal R ^a   Buttgereit, Anne ^a   Torres, Mark Joseph Manalang ^b   Flores, April L ^a   Arreola, Martin ^a   Arbez, Nicolas ^d   Akimov, Sergey S ^a   Gaasterland, Terry ^e   Lazarowski, Eduardo R ^d   Ross, Christopher A ^a,c   Yeo, Gene W ^a,c   Sopher, Bryce L ^b   Magnuson, Gavin K ^f   Pinkerton, Anthony B ^f   Masliah, Eliezer ^a,g   La Spada, Albert R ^a,c,g,h,i   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f BURNHAM INSTITUTE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

ⁱ RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2,6 DIMETHYL 4 (4 TRIFLUOROMETHOXYPHENYL)PIPERAZINE 1 SULFONYL]INDAN 2 CARBOXYLIC ACID TOSYLATE; BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINE ACETYLTRANSFERASE; FENOFIBRATE; HUNTINGTIN; NEUROPROTECTIVE AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; POLYGLUTAMINE; UNCLASSIFIED DRUG; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; 4-(2,6-DIMETHYL-4-(4-TRIFLUOROMETHOXYPHENYL)PIPERAZINE-1-SULFONYL)INDAN-2-CARBOXYLIC ACID; CELL RECEPTOR; HTT PROTEIN, HUMAN; NERVE PROTEIN; PIPERAZINE DERIVATIVE; PPARD PROTEIN, MOUSE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; MOUSE MODEL; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; TRANSACTIVATION; TRANSCRIPTION REGULATION; AGONISTS; ANIMAL; CELL DEATH; CHROMATIN IMMUNOPRECIPITATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; HEK293 CELL LINE; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MITOCHONDRION; MOVEMENT (PHYSIOLOGY); NEOSTRIATUM; NERVE CELL; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; CELL DEATH; CHROMATIN IMMUNOPRECIPITATION; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; HEK293 CELLS; HUMANS; HUNTINGTIN PROTEIN; HUNTINGTON DISEASE; IN VITRO TECHNIQUES; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MOVEMENT; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEURONS; PIPERAZINES; PPAR DELTA; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SULFONAMIDES;

EID: 84954389400     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4003     Document Type: Article

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