Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Pan, Jie ^a   Jin, Jia li ^a,b,c   Ge, Hui ming ^b   Yin, Kai lin ^a   Chen, Xiang ^a   Han, Li juan ^a   Chen, Yan ^a   Qian, Lai ^a,b,c   Li, Xiao xi ^a   Xu, Yun ^a,b,c,d  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b NANJING UNIVERSITY   (China)

^c MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^d Jiangsu Province Stroke Center for Diagnosis and Therapy   (China)

Author keywords

Experimental stroke; Inflammation; M1 M2; Malibatol A; Microglia; PPAR

Indexed keywords

2 CHLORO 5 NITRO N (4 PYRIDYL)BENZAMIDE; BIOLOGICAL MARKER; CD16 ANTIGEN; CD206 ANTIGEN; CD32 ANTIGEN; CD86 ANTIGEN; MALIBATOL A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; YM 1 PROTEIN; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; BENZAMIDE DERIVATIVE; CALCIUM BINDING PROTEIN; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NEUROPROTECTIVE AGENT; PYRIDINE DERIVATIVE; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; HOPEA HAINANENSIS; MALE; MEDICINAL PLANT; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; TRANSIENT ISCHEMIC ATTACK; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN INFARCTION; CELL CULTURE; CELL POLARITY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; TIME FACTOR;

ANIMALS; BENZAMIDES; BRAIN INFARCTION; CALCIUM-BINDING PROTEINS; CELL POLARITY; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INFARCTION, MIDDLE CEREBRAL ARTERY; LIPOPOLYSACCHARIDES; MICE; MICROFILAMENT PROTEINS; MICROGLIA; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; PPAR GAMMA; PYRIDINES; STILBENES; TIME FACTORS;

EID: 84925685036     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0270-3     Document Type: Article

References (36)

1. Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87:779-89.
2. Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz). 2012;60:251-66.
3. Colton CA. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol: the official J Soc on Neuro Immune Pharmacol. 2009;4:399-418.
4. Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, et al. Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci: the official J Soc for Neurosci. 2008;28:11650-61.
5. Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, et al. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia. 2010;58:932-42.
6. Wang G, Zhang J, Hu X, Zhang L, Mao L, Jiang X, et al. Microglia/macrophage polarization dynamics in white matter after traumatic brain injury. J Cereb Blood Flow Metab. 2013;33:1864-74.
7. Yenari MA, Kauppinen TM, Swanson RA. Microglial activation in stroke: therapeutic targets. Neurotherapeutics. 2010;7:378-91.
8. Giaginis C, Tsourouflis G, Theocharis S. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury. CurrMol Med. 2008;8:562-79.
9. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-56.
10. Ge HM, Yang WH, Zhang J, Tan RX. Antioxidant oligostilbenoids from the stem wood of Hopea hainanensis. J Agric Food Chem. 2009;57:5756-61.
11. Inoue H, Jiang XF, Katayama T, Osada S, Umesono K, Namura S. Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice. NeurosciLett. 2003;352:203-6.
12. Nakata R, Takahashi S, Inoue H. Recent advances in the study on resveratrol. Biol Pharm Bull. 2012;35:273-9.
13. Orsu P, Murthy BV, Akula A. Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats. J Neural Transm. 2013;120:1217-23.
14. Chen ZB, Huang DQ, Niu FN, Zhang X, Li EG, Xu Y. Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor-kappaB. J Cereb Blood Flow Metab. 2010;30:1356-65.
15. Han L, Yin K, Zhang S, Wu Z, Wang C, Zhang Q, et al. Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-kappaB and p38/JNK activation in microglial cells. Neurochem Int. 2013;62:913-21.
16. Wang L, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol. 2009;609:40-4.
17. Zhang MJ, Sun JJ, Qian L, Liu Z, Zhang Z, Cao W, et al. Human umbilical mesenchymal stem cells enhance the expression of neurotrophic factors and protect ataxic mice. Brain Res. 2011;1402:122-31.
18. Hedrich CM, Bream JH. Cell type-specific regulation of IL-10 expression in inflammation and disease. Immunol Res. 2010;47:185-206.
19. Sun L, Ke Y, Zhu CY, Tang N, Tian DK, Gao YH, et al. Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats. Chin Med J (Engl). 2008;121:2305-11.
20. Yang W, Chen X, Pan J, Ge H, Yin K, Wu Z, et al. Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental stroke. Neurochem Int. 2014;80C:33-40.
21. Hu X, Li P, Guo Y, Wang H, Leak RK, Chen S, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012;43:3063-70.
22. Perego C, Fumagalli S, De Simoni MG. Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice. J Neuroinflammation. 2011;8:174.
23. Schilling M, Besselmann M, Muller M, Strecker JK, Ringelstein EB, Kiefer R. Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol. 2005;196:290-7.
24. Schilling M, Strecker JK, Schabitz WR, Ringelstein EB, Kiefer R. Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice. Neuroscience. 2009;161:806-12.
25. Byrav DSP, Medhi B, Prakash A, Chakrabarti A, Vaiphei K, Khanduja KL. Comparative evaluation of different doses of PPAR-gamma agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. PharmacolReports PR. 2013;65:951-9.
26. Ranganathan PV, Jayakumar C, Ramesh G. Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization. Am J Physiol Renal Physiol. 2013;304:F948-57.
27. Mrak RE, Landreth GE. PPARgamma, neuroinflammation, and disease. J Neuroinflammation. 2004;1:5.
28. Wang KC, Tsai CP, Lee CL, Chen SY, Lin GJ, Yen MH, et al. Alpha-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-gamma to ameliorate experimental autoimmune encephalomyelitis in mice. ClinSci (Lond). 2013;125:329-40.
29. Mandrekar-Colucci S, Karlo JC, Landreth GE. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci. 2012;32:10117-28.
30. Liu ZJ, Liu W, Liu L, Xiao C, Wang Y, Jiao JS. Curcumin protects neuron against cerebral ischemia-induced inflammation through improving PPAR-gamma function. Evid Based Complement Alternat Med eCAM. 2013;2013:470975.
31. Hasegawa-Moriyama M, Ohnou T, Godai K, Kurimoto T, Nakama M, Kanmura Y. Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates postincisional pain by regulating macrophage polarization. Biochem Biophys Res Commun. 2012;426:76-82.
32. Weinstein JR, Koerner IP, Moller T. Microglia in ischemic brain injury. Future Neurol. 2010;5:227-46.
33. Ekdahl CT, Kokaia Z, Lindvall O. Brain inflammation and adult neurogenesis: the dual role of microglia. Neurosci. 2009;158:1021-9.
34. Thored P, Heldmann U, Gomes-Leal W, Gisler R, Darsalia V, Taneera J, et al. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. 2009;57:835-49.
35. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007;447:1116-20.
36. Bouhlel MA, Derudas B, Rigamonti E, Dievart R, Brozek J, Haulon S, et al. PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 2007;6:137-43.