Peroxisome-proliferator-activated receptor α agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1

Biochemical Journal

Volumn 395, Issue 1, 2006, Pages 81-88

  Grau, Raquel ^a   Punzón, Carmen ^a   Fresno, Manuel ^a   Iñiguez, Miguel A ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Cyclo oxygenase 2 (COX 2); LY 171883; Peroxisome proliferator activated receptor (PPAR ); SW620 cell; Vascular endothelial growth factor (VEGF); WY 14,643

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DISEASE CONTROL; ENZYME INHIBITION; GENETIC ENGINEERING; MECHANISMS; MOLECULAR DYNAMICS;

CYCLO-OXYGENASE 2 (COX-2); LY-171883; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR Α (PPARΑ); SW620 CELL; VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF); WY-14,643;

ENZYMES;

CYCLOOXYGENASE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; PROTEIN C JUN; TOMELUKAST; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR GROWTH;

CACO-2 CELLS; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIGANDS; PPAR ALPHA; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33645562489     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050964     Document Type: Article

References (50)

1. Berger, J. and Moller, D. E. (2002) The mechanisms of action of PPARs. Annu. Rev. Med. 53, 409-435
2. Michalik, L. and Wahli, W. (1999) Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. Curr. Opin. Biotechnol. 10, 564-570
3. Auboeuf, D., Rieusset, J., Fajas, L., Vallier, P., Frering, V., Riou, J. P., Staels, B., Auwerx, J., Laville, M. and Vidal, H. (1997) Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46, 1319-1327
4. Inoue, I., Shino, K., Noji, S., Awata, T. and Katayama, S. (1998) Expression of peroxisome proliferator-activated receptor α (PPARα) in primary cultures of human vascular endothelial cells. Biochem. Biophys. Res. Commun. 246, 370-374
5. Corton, J. C., Anderson, S. P. and Stauber, A. (2000) Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu. Rev. Pharmacol. Toxicol. 40, 491-518
6. Daynes, R. A. and Jones, D. C. (2002) Emerging roles of PPARs in inflammation and immunity. Nat. Rev. Immunol. 2, 748-759
7. Fruchart, J. C., Duriez, P. and Staels, B. (1999) Peroxisome proliferator-activated receptor-α activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr. Opin. Lipidol. 10, 245-257
8. Jackson, L., Wahli, W., Michalik, L., Watson, S. A., Morris, T., Anderton, K., Bell, D. R., Smith, J. A., Hawkey, C. J. and Bennett, A. J. (2003) Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer. Gut 52, 1317-1322
9. Kohno, H., Suzuki, R., Sugie, S. and Tanaka, T. (2005) Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer 5, 46
10. Niho, N., Takahashi, M., Kitamura, T., Shoji, Y., Itoh, M., Noda, T., Sugimura, T. and Wakabayashi, K. (2003) Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res. 63, 6090-6095
11. Tanaka, T., Kohno, H., Yoshitani, S., Takashima, S., Okumura, A., Murakami, A. and Hosokawa, M. (2001) Ligands for peroxisome proliferator- activated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res. 61, 2424-2428
12. Michalik, L., Desvergne, B. and Wahli, W. (2004) Peroxisome-proliferator- activated receptors and cancers: complex stories. Nat. Rev. Cancer 4, 61-70
13. Gervois, P., Vu-Dac, N., Kleemann, R., Kockx, M., Dubois, G., Laine, B., Kosykh, V., Fruchart, J. C., Kooistra, T. and Staels, B. (2001) Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor α agonists via inhibition of CCAAT box/enhancer-binding protein β. J. Biol. Chem. 276, 33471-33477
14. Marx, N., Kehrle, B., Kohlhammer, K., Grub, M., Koenig, W., Hombach, V., Libby, P. and Plutzky, J. (2002) PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ. Res. 90, 703-710
15. Staels, B., Koenig, W., Habib, A., Merval, R., Lebret, M., Torra, I. P., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J. C. et al. (1998) Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature (London) 393, 790-793
16. Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J. C., Tedgui, A., Haegeman, G. and Staels, B. (1999) Peroxisome proliterator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J. Biol. Chem. 274, 32048-32054
17. Meissner, M., Stein, M., Urbich, C., Reisinger, K., Suske, G., Staels, B., Kaufmann, R. and Gille, J. (2004) PPARα activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circ. Res. 94, 324-332
18. Subbaramaiah, K. and Dannenberg, A. J. (2003) Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol. Sci. 24, 96-102
19. Iñiguez, M. A., Rodriguez, A., Volpert, O. V., Fresno, M. and Redondo, J. M. (2003) Cyclooxygenase-2: a therapeutic target in angiogenesis. Trends Mol. Med. 9, 73-78
20. Smith, W. L., DeWitt, D. L. and Garavito, R. M. (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem. 69, 145-182
21. Eberhart, C. E., Coffey, R. J., Radhika, A., Giardiello, F. M., Ferrenbach, S. and DuBois, R. N. (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107, 1183-1188
22. Marnett, L. J. and DuBois, R. N. (2002) COX-2: a target for colon cancer prevention. Annu. Rev. Pharmacol. Toxicol. 42, 55-80
23. Carmeliet, P. and Jain, R. K. (2000) Angiogenesis in cancer and other diseases. Nature (London) 407, 249-257
24. Griffioen, A. W. and Molema, G. (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 52, 237-268
25. Iniguez, M. A., Martinez-Martinez, S., Punzon, C., Redondo, J. M. and Fresno, M. (2000) An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J. Biol. Chem. 275, 23627-23635
26. Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D. and Semenza, G. L. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613
27. Deng, T. and Karin, M. (1993) JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev. 7, 479-490
28. 2-microglobulin enhancers. EMBO J. 6, 3317-3324
29. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812
30. Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T. and Karin, M. (1988) Oncogene jun encodes a seguence-specific trans-activator similar to AP-1. Nature (London) 332, 166-171
31. 2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. Cancer Res. 64, 5162-5171
32. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K. and Evans, R. M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. U.S.A. 91, 7355-7359
33. Subbaramaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J. M. and Dannenberg, A. J. (1998) Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem. 273, 21875-21882
34. Guo, Y. S., Hellmich, M. R., Wen, X. D. and Townsend, Jr, C. M. (2001) Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. J. Biol. Chem. 276, 22941-22947
35. Radler-Pohl, A., Sachsenmaier, C., Gebel, S., Auer, H. P., Bruder, J. T., Rapp, U., Angel, P., Rahmsdorf, H. J. and Herrlich, P. (1993) UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J. 12, 1005-1012
36. Gelman, L., Fruchart, J. C. and Auwerx, J. (1999) An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer. Cell. Mol. Life Sci. 55, 932-943
37. Blanquart, C., Barbier, O., Fruchart, J. C., Staels, B. and Glineur, C. (2003) Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J. Steroid Biochem. Mol. Biol. 85, 267-273
38. Panigrahy, D., Singer, S., Shen, L. Q., Butterfield, C. E., Freedman, D. A., Chen, E. J., Moses, M. A., Kilroy, S., Duensing, S., Fletcher, C. et al. (2002) PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J. Clin. Invest. 110, 923-932
39. Itzkowitz, S. H. and Yio, X. (2004) Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 287, G7-G17
40. Shift, S. J., Shivaprasad, P. and Santini, D. L. (2003) Cyclooxygenase inhibitors: drugs for cancer prevention. Curr. Opin. Pharmacol. 3, 352-361
41. Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M. and Kliewer, S. A. (1997) Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272, 3406-3410
42. Sarraf, P., Mueller, E., Jones, D., King, F. J., DeAngelo, D. J., Partridge, J. B., Holden, S. A., Chen, L. B., Singer, S., Fletcher, C. and Spiegelman, B. M. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med. 4, 1046-1052
43. Girnun, G. D., Smith, W. M., Drori, S., Sarraf, P., Mueller, E., Eng, C., Nambiar, P., Rosenberg, D. W., Bronson, R. T., Edelmann, W. et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARγ. Proc. Natl. Acad. Sci. U.S.A. 99, 13771-13776
44. Maier, J. A., Hla, T. and Maciag, T. (1990) Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J. Biol. Chem. 265, 10805-10808
45. Stier, H., Fahimi, H. D., Van Veldhoven, P. P., Mannaerts, G. P., Volkl, A. and Baumgart, E. (1998) Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor α (PPARα). Differentiation 64, 55-66
46. Colville-Nash, P. R., Qureshi, S. S., Willis, D. and Willoughby, D. A. (1998) Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. J. Immunol. 161, 978-984
47. Li, M., Pascual, G. and Glass, C. K. (2000) Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20, 4699-4707
48. Delerive, P., Martin-Nizard, F., Chinetti, G., Trottein, F., Fruchart, J. C., Najib, J., Duriez, P. and Staels, B. (1999) Peroxisome proliferator- activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ. Res. 85, 394-402
49. Irukayama-Tomobe, Y., Miyauchi, T., Sakai, S., Kasuya, Y., Ogata, T., Takanashi, M., Iemitsu, M., Sudo, T., Goto, K. and Yamaguchi, I. (2004) Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH2-terminal kinase pathway. Circulation 109, 904-910
50. Karin, M., Liu, Z. and Zandi, E. (1997) AP-1 function and regulation. Curr. Opin. Cell Biol. 9, 240-246