Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ

Science

Volumn 302, Issue 5644, 2003, Pages 453-457

  Lee, Chih Hao ^a   Chawla, Ajay ^a,c   Urbiztondo, Ned ^a   Liao, Debbie ^a   Boisvert, William A ^b   Evans, Ronald M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES;

INFLAMMATORY SUPPRESSORS;

LIPIDS;

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DISEASE COURSE; FOAM CELL; LIPID TRANSPORT; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; ARTERIOSCLEROSIS; BONE MARROW TRANSPLANTATION; CHEMOKINE CCL2; CHOLESTEROL; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FOAM CELLS; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-1; LIGANDS; LIPID METABOLISM; LIPIDS; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0142116239     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087344     Document Type: Article

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23. We thank J. L Witztum, C. K. Glass, P. Tontonoz, W. Alaynick, P. Olson, and R. Nofsinger for valuable comments; R. Yu, M. Downes, Y. Wang, and W. He for reagents; I. Mehl for Q-PCR analyses; L K. Curtiss and A. S. Black for assistance in macrophage differentiation; A. L. Dent for pGCN-BCL-6 plasmid; H.-Y. Kao for BCL-6 deletion plasmids; and E. Stevens and L Ong for administrative assistance. R.M.E. is an investigator of the Howard Hughes Medical Institute at the Salk Institute for Biological Studies and March of Dimes Chair in Molecular and Developmental Biology. Supported by the Howard Hughes Medical Institute (R.M.E.) and NIH grant HL69474 (W.A.B.).