-
1
-
-
84974606818
-
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
-
Abudayyeh, O.O., Gootenberg, J.S., Konermann, S., Joung, J., Slaymaker, I.M., Cox, D.B., Shmakov, S., Makarova, K.S., Semenova, E., Minakhin, L., Severinov, K., Regev, A., Lander, E.S., Koonin, E.V., Zhang, F., C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science, 2016, 10.1126/science.aaf5573.
-
(2016)
Science
-
-
Abudayyeh, O.O.1
Gootenberg, J.S.2
Konermann, S.3
Joung, J.4
Slaymaker, I.M.5
Cox, D.B.6
Shmakov, S.7
Makarova, K.S.8
Semenova, E.9
Minakhin, L.10
Severinov, K.11
Regev, A.12
Lander, E.S.13
Koonin, E.V.14
Zhang, F.15
-
2
-
-
84987875388
-
Editing of the Bacillus subtilis genome by the CRISPR-Cas9 system
-
Altenbuchner, J., Editing of the Bacillus subtilis genome by the CRISPR-Cas9 system. Appl. Environ. Microbiol. 82 (2016), 5421–5427.
-
(2016)
Appl. Environ. Microbiol.
, vol.82
, pp. 5421-5427
-
-
Altenbuchner, J.1
-
3
-
-
84954537942
-
CRISPR-Cas adaptation: insights into the mechanism of action
-
Amitai, G., Sorek, R., CRISPR-Cas adaptation: insights into the mechanism of action. Nat. Rev. Microbiol. 14 (2016), 67–76.
-
(2016)
Nat. Rev. Microbiol.
, vol.14
, pp. 67-76
-
-
Amitai, G.1
Sorek, R.2
-
4
-
-
84908508061
-
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
-
Anders, C., Niewoehner, O., Duerst, A., Jinek, M., Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease. Nature 513 (2014), 569–573.
-
(2014)
Nature
, vol.513
, pp. 569-573
-
-
Anders, C.1
Niewoehner, O.2
Duerst, A.3
Jinek, M.4
-
5
-
-
79960468271
-
Using CRISPRs as a metagenomic tool to identify microbial hosts of a diffuse flow hydrothermal vent viral assemblage
-
Anderson, R.E., Brazelton, W.J., Baross, J.A., Using CRISPRs as a metagenomic tool to identify microbial hosts of a diffuse flow hydrothermal vent viral assemblage. FEMS Microbiol. Ecol. 77 (2011), 120–133.
-
(2011)
FEMS Microbiol. Ecol.
, vol.77
, pp. 120-133
-
-
Anderson, R.E.1
Brazelton, W.J.2
Baross, J.A.3
-
6
-
-
84920389030
-
Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system
-
Anton, T., Bultmann, S., Leonhardt, H., Markaki, Y., Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus 5 (2014), 163–172.
-
(2014)
Nucleus
, vol.5
, pp. 163-172
-
-
Anton, T.1
Bultmann, S.2
Leonhardt, H.3
Markaki, Y.4
-
7
-
-
0034889360
-
Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system
-
Aravind, L., Koonin, E.V., Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. Genome Res. 11 (2001), 1365–1374.
-
(2001)
Genome Res.
, vol.11
, pp. 1365-1374
-
-
Aravind, L.1
Koonin, E.V.2
-
8
-
-
71849086611
-
Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde
-
Atsumi, S., Higashide, W., Liao, J.C., Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde. Nat. Biotechnol. 27 (2009), 1177–1180.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 1177-1180
-
-
Atsumi, S.1
Higashide, W.2
Liao, J.C.3
-
9
-
-
78651083184
-
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair
-
Babu, M., Beloglazova, N., Flick, R., Graham, C., Skarina, T., Nocek, B., Gagarinova, A., Pogoutse, O., Brown, G., Binkowski, A., Phanse, S., Joachimiak, A., Koonin, E.V., Savchenko, A., Emili, A., Greenblatt, J., Edwards, A.M., Yakunin, A.F., A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol. Microbiol. 79 (2011), 484–502.
-
(2011)
Mol. Microbiol.
, vol.79
, pp. 484-502
-
-
Babu, M.1
Beloglazova, N.2
Flick, R.3
Graham, C.4
Skarina, T.5
Nocek, B.6
Gagarinova, A.7
Pogoutse, O.8
Brown, G.9
Binkowski, A.10
Phanse, S.11
Joachimiak, A.12
Koonin, E.V.13
Savchenko, A.14
Emili, A.15
Greenblatt, J.16
Edwards, A.M.17
Yakunin, A.F.18
-
10
-
-
84947240643
-
Bacterial chromosome organization and segregation
-
Badrinarayanan, A., Le, T.B., Laub, M.T., Bacterial chromosome organization and segregation. Annu. Rev. Cell Dev. Biol. 31 (2015), 171–199.
-
(2015)
Annu. Rev. Cell Dev. Biol.
, vol.31
, pp. 171-199
-
-
Badrinarayanan, A.1
Le, T.B.2
Laub, M.T.3
-
11
-
-
0025895183
-
Toward a science of metabolic engineering
-
Bailey, J.E., Toward a science of metabolic engineering. Science 252 (1991), 1668–1675.
-
(1991)
Science
, vol.252
, pp. 1668-1675
-
-
Bailey, J.E.1
-
12
-
-
84946558100
-
Diversity of CRISPR-Cas immune systems and molecular machines
-
Barrangou, R., Diversity of CRISPR-Cas immune systems and molecular machines. Genome Biol., 16, 2015, 247.
-
(2015)
Genome Biol.
, vol.16
, pp. 247
-
-
Barrangou, R.1
-
13
-
-
84920871112
-
The roles of CRISPR-Cas systems in adaptive immunity and beyond
-
Barrangou, R., The roles of CRISPR-Cas systems in adaptive immunity and beyond. Curr. Opin. Immunol. 32 (2015), 36–41.
-
(2015)
Curr. Opin. Immunol.
, vol.32
, pp. 36-41
-
-
Barrangou, R.1
-
14
-
-
84959889614
-
CRISPR-based typing and next-generation tracking technologies
-
Barrangou, R., Dudley, E.G., CRISPR-based typing and next-generation tracking technologies. Annu. Rev. Food Sci. Technol. 7 (2016), 395–411.
-
(2016)
Annu. Rev. Food Sci. Technol.
, vol.7
, pp. 395-411
-
-
Barrangou, R.1
Dudley, E.G.2
-
15
-
-
34047118522
-
CRISPR provides acquired resistance against viruses in prokaryotes
-
Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D.A., Horvath, P., CRISPR provides acquired resistance against viruses in prokaryotes. Science 315 (2007), 1709–1712.
-
(2007)
Science
, vol.315
, pp. 1709-1712
-
-
Barrangou, R.1
Fremaux, C.2
Deveau, H.3
Richards, M.4
Boyaval, P.5
Moineau, S.6
Romero, D.A.7
Horvath, P.8
-
16
-
-
84978492675
-
Rapid and efficient one-step metabolic pathway integration in E. coli
-
Bassalo, M.C., Garst, A.D., Halweg-Edwards, A.L., Grau, W.C., Domaille, D.W., Mutalik, V.K., Arkin, A.P., Gill, R.T., Rapid and efficient one-step metabolic pathway integration in E. coli. ACS Synth. Biol., 2016, 10.1021/acssynbio.5b00187.
-
(2016)
ACS Synth. Biol.
-
-
Bassalo, M.C.1
Garst, A.D.2
Halweg-Edwards, A.L.3
Grau, W.C.4
Domaille, D.W.5
Mutalik, V.K.6
Arkin, A.P.7
Gill, R.T.8
-
17
-
-
84955473435
-
Precision medicine: genetic repair of Retinitis pigmentosa in patient-derived stem cells
-
Bassuk, A.G., Zheng, A., Li, Y., Tsang, S.H., Mahajan, V.B., Precision medicine: genetic repair of Retinitis pigmentosa in patient-derived stem cells. Sci. Rep., 6, 2016, 19969.
-
(2016)
Sci. Rep.
, vol.6
, pp. 19969
-
-
Bassuk, A.G.1
Zheng, A.2
Li, Y.3
Tsang, S.H.4
Mahajan, V.B.5
-
18
-
-
84923868543
-
Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products
-
Becker, J., Wittmann, C., Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products. Angew. Chem. Int. Ed. Engl. 54 (2015), 3328–3350.
-
(2015)
Angew. Chem. Int. Ed. Engl.
, vol.54
, pp. 3328-3350
-
-
Becker, J.1
Wittmann, C.2
-
19
-
-
84865144676
-
CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection
-
Bikard, D., Hatoum-Aslan, A., Mucida, D., Marraffini, L.A., CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection. Cell Host Microbe 12 (2012), 177–186.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 177-186
-
-
Bikard, D.1
Hatoum-Aslan, A.2
Mucida, D.3
Marraffini, L.A.4
-
20
-
-
84882986957
-
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
-
Bikard, D., Jiang, W.Y., Samai, P., Hochschild, A., Zhang, F., Marraffini, L.A., Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res. 41 (2013), 7429–7437.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 7429-7437
-
-
Bikard, D.1
Jiang, W.Y.2
Samai, P.3
Hochschild, A.4
Zhang, F.5
Marraffini, L.A.6
-
21
-
-
84983142945
-
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
-
Bikard, D., Euler, C.W., Jiang, W., Nussenzweig, P.M., Goldberg, G.W., Duportet, X., Fischetti, V.A., Marraffini, L.A., Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat. Biotechnol. 32 (2014), 1146–1150.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1146-1150
-
-
Bikard, D.1
Euler, C.W.2
Jiang, W.3
Nussenzweig, P.M.4
Goldberg, G.W.5
Duportet, X.6
Fischetti, V.A.7
Marraffini, L.A.8
-
22
-
-
23844505202
-
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
-
Bolotin, A., Quinquis, B., Sorokin, A., Ehrlich, S.D., Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin. Microbiology 151 (2005), 2551–2561.
-
(2005)
Microbiology
, vol.151
, pp. 2551-2561
-
-
Bolotin, A.1
Quinquis, B.2
Sorokin, A.3
Ehrlich, S.D.4
-
23
-
-
33645781346
-
Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining
-
e8
-
Bowater, R., Doherty, A.J., Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genet., 2, 2006, e8.
-
(2006)
PLoS Genet.
, vol.2
-
-
Bowater, R.1
Doherty, A.J.2
-
24
-
-
84867018919
-
Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation
-
Broadbent, J.R., Neeno-Eckwall, E.C., Stahl, B., Tandee, K., Cai, H., Morovic, W., Horvath, P., Heidenreich, J., Perna, N.T., Barrangou, R., Steele, J.L., Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation. BMC Genomics, 13, 2012, 533.
-
(2012)
BMC Genomics
, vol.13
, pp. 533
-
-
Broadbent, J.R.1
Neeno-Eckwall, E.C.2
Stahl, B.3
Tandee, K.4
Cai, H.5
Morovic, W.6
Horvath, P.7
Heidenreich, J.8
Perna, N.T.9
Barrangou, R.10
Steele, J.L.11
-
25
-
-
49649114086
-
Small CRISPR RNAs guide antiviral defense in prokaryotes
-
Brouns, S.J., Jore, M.M., Lundgren, M., Westra, E.R., Slijkhuis, R.J., Snijders, A.P., Dickman, M.J., Makarova, K.S., Koonin, E.V., van der Oost, J., Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321 (2008), 960–964.
-
(2008)
Science
, vol.321
, pp. 960-964
-
-
Brouns, S.J.1
Jore, M.M.2
Lundgren, M.3
Westra, E.R.4
Slijkhuis, R.J.5
Snijders, A.P.6
Dickman, M.J.7
Makarova, K.S.8
Koonin, E.V.9
van der Oost, J.10
-
26
-
-
84991281155
-
Extending CRISPR-Cas9 technology from genome editing to transcriptional engineering in Clostridium
-
Bruder, M.R., Pyne, M.E., Moo-Young, M., Chung, D.A., Chou, C.P., Extending CRISPR-Cas9 technology from genome editing to transcriptional engineering in Clostridium. Appl. Environ. Microbiol., 2016.
-
(2016)
Appl. Environ. Microbiol.
-
-
Bruder, M.R.1
Pyne, M.E.2
Moo-Young, M.3
Chung, D.A.4
Chou, C.P.5
-
27
-
-
84941074753
-
Chromosome position effects on gene expression in Escherichia coli K-12
-
Bryant, J.A., Sellars, L.E., Busby, S.J., Lee, D.J., Chromosome position effects on gene expression in Escherichia coli K-12. Nucleic Acids Res. 42 (2014), 11383–11392.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 11383-11392
-
-
Bryant, J.A.1
Sellars, L.E.2
Busby, S.J.3
Lee, D.J.4
-
28
-
-
79951505084
-
Prevalence, conservation and functional analysis of Yersinia and Escherichia CRISPR regions in clinical Pseudomonas aeruginosa isolates
-
Cady, K.C., White, A.S., Hammond, J.H., Abendroth, M.D., Karthikeyan, R.S., Lalitha, P., Zegans, M.E., O'Toole, G.A., Prevalence, conservation and functional analysis of Yersinia and Escherichia CRISPR regions in clinical Pseudomonas aeruginosa isolates. Microbiology 157 (2011), 430–437.
-
(2011)
Microbiology
, vol.157
, pp. 430-437
-
-
Cady, K.C.1
White, A.S.2
Hammond, J.H.3
Abendroth, M.D.4
Karthikeyan, R.S.5
Lalitha, P.6
Zegans, M.E.7
O'Toole, G.A.8
-
29
-
-
84902185906
-
Genome engineering with targetable nucleases
-
Carroll, D., Genome engineering with targetable nucleases. Annu. Rev. Biochem. 83 (2014), 409–439.
-
(2014)
Annu. Rev. Biochem.
, vol.83
, pp. 409-439
-
-
Carroll, D.1
-
30
-
-
84904468142
-
Harnessing CRISPR-Cas9 immunity for genetic engineering
-
Charpentier, E., Marraffini, L.A., Harnessing CRISPR-Cas9 immunity for genetic engineering. Curr. Opin. Microbiol. 19 (2014), 114–119.
-
(2014)
Curr. Opin. Microbiol.
, vol.19
, pp. 114-119
-
-
Charpentier, E.1
Marraffini, L.A.2
-
31
-
-
85052347768
-
-
inventors unspecified. 2016. Zusammensetzungen für die durch RNA gesteuerte modifikation einer ziel-DNA und für die durch RNA gesteuerte modulation der transkription. DE patent 202013012240.
-
Charpentier, E., inventors unspecified. 2016. Zusammensetzungen für die durch RNA gesteuerte modifikation einer ziel-DNA und für die durch RNA gesteuerte modulation der transkription. DE patent 202013012240.
-
-
-
Charpentier, E.1
-
32
-
-
84926521955
-
Highly efficient Cas9-mediated transcriptional programming
-
Chavez, A., Scheiman, J., Vora, S., Pruitt, B.W., Tuttle, M., Iyer E.P.R., Lin, S., Kiani, S., Guzman, C.D., Wiegand, D.J., Ter-Ovanesyan, D., Braff, J.L., Davidsohn, N., Housden, B.E., Perrimon N., Weiss, R., Aach, J., Collins, J.J., Church, G.M., Highly efficient Cas9-mediated transcriptional programming. Nat. Methods 12 (2015), 326–328.
-
(2015)
Nat. Methods
, vol.12
, pp. 326-328
-
-
Chavez, A.1
Scheiman, J.2
Vora, S.3
Pruitt, B.W.4
Tuttle, M.5
Iyer E.P.R.6
Lin, S.7
Kiani, S.8
Guzman, C.D.9
Wiegand, D.J.10
Ter-Ovanesyan, D.11
Braff, J.L.12
Davidsohn, N.13
Housden, B.E.14
Perrimon N.15
Weiss, R.16
Aach, J.17
Collins, J.J.18
Church, G.M.19
-
33
-
-
84894063115
-
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
-
Chen, B., Gilbert, L.A., Cimini, B.A., Schnitzbauer, J., Zhang, W., Li, G.W., Park, J., Blackburn, E.H., Weissman, J.S., Qi, L.S., Huang, B., Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell 155 (2013), 1479–1491.
-
(2013)
Cell
, vol.155
, pp. 1479-1491
-
-
Chen, B.1
Gilbert, L.A.2
Cimini, B.A.3
Schnitzbauer, J.4
Zhang, W.5
Li, G.W.6
Park, J.7
Blackburn, E.H.8
Weissman, J.S.9
Qi, L.S.10
Huang, B.11
-
34
-
-
84885180675
-
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
-
Cheng, A.W., Wang, H., Yang, H., Shi, L., Katz, Y., Theunissen, T.W., Rangarajan, S., Shivalila, C.S., Dadon, D.B., Jaenisch, R., Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res. 23 (2013), 1163–1171.
-
(2013)
Cell Res.
, vol.23
, pp. 1163-1171
-
-
Cheng, A.W.1
Wang, H.2
Yang, H.3
Shi, L.4
Katz, Y.5
Theunissen, T.W.6
Rangarajan, S.7
Shivalila, C.S.8
Dadon, D.B.9
Jaenisch, R.10
-
35
-
-
84957435262
-
Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling
-
Cheng, A.W., Jillette, N., Lee, P., Plaskon, D., Fujiwara, Y., Wang, W., Taghbalout, A., Wang, H., Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling. Cell Res. 26 (2016), 254–257.
-
(2016)
Cell Res.
, vol.26
, pp. 254-257
-
-
Cheng, A.W.1
Jillette, N.2
Lee, P.3
Plaskon, D.4
Fujiwara, Y.5
Wang, W.6
Taghbalout, A.7
Wang, H.8
-
36
-
-
84874624936
-
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
-
Cho, S.W., Kim, S., Kim, J.M., Kim, J.S., Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31 (2013), 230–232.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 230-232
-
-
Cho, S.W.1
Kim, S.2
Kim, J.M.3
Kim, J.S.4
-
37
-
-
84996587591
-
Systems metabolic engineering of Escherichia coli
-
Choi, K.R., Shin, J.H., Cho, J.S., Yang, D., Lee, S.Y., Systems metabolic engineering of Escherichia coli. EcoSal Plus, 2016, 10.1128/ecosalplus.ESP-0010-2015.
-
(2016)
EcoSal Plus
-
-
Choi, K.R.1
Shin, J.H.2
Cho, J.S.3
Yang, D.4
Lee, S.Y.5
-
38
-
-
84923869859
-
Gene silencing by CRISPR interference in mycobacteria
-
Choudhary, E., Thakur, P., Pareek, M., Agarwal, N., Gene silencing by CRISPR interference in mycobacteria. Nat. Commun., 6, 2015, 6267.
-
(2015)
Nat. Commun.
, vol.6
, pp. 6267
-
-
Choudhary, E.1
Thakur, P.2
Pareek, M.3
Agarwal, N.4
-
39
-
-
84998644376
-
Enhanced integration of large DNA into E. coli chromosome by CRISPR/Cas9
-
Chung, M.E., Yeh, I.H., Sung, L.Y., Wu, M.Y., Chao, Y.P., Ng, I.S., Hu, Y.C., Enhanced integration of large DNA into E. coli chromosome by CRISPR/Cas9. Biotechnol. Bioeng., 2016.
-
(2016)
Biotechnol. Bioeng.
-
-
Chung, M.E.1
Yeh, I.H.2
Sung, L.Y.3
Wu, M.Y.4
Chao, Y.P.5
Ng, I.S.6
Hu, Y.C.7
-
40
-
-
84983208863
-
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
-
Citorik, R.J., Mimee, M., Lu, T.K., Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat. Biotechnol. 32 (2014), 1141–1145.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1141-1145
-
-
Citorik, R.J.1
Mimee, M.2
Lu, T.K.3
-
41
-
-
84973136613
-
Corynebacterium glutamicum metabolic engineering with CRISPR interference (CRISPRi)
-
Cleto, S., Jensen, J.V., Wendisch, V.F., Lu, T.K., Corynebacterium glutamicum metabolic engineering with CRISPR interference (CRISPRi). ACS Synth. Biol. 5 (2016), 375–385.
-
(2016)
ACS Synth. Biol.
, vol.5
, pp. 375-385
-
-
Cleto, S.1
Jensen, J.V.2
Wendisch, V.F.3
Lu, T.K.4
-
42
-
-
84934947770
-
High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system
-
Cobb, R.E., Wang, Y., Zhao, H., High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system. ACS Synth. Biol. 4 (2015), 723–728.
-
(2015)
ACS Synth. Biol.
, vol.4
, pp. 723-728
-
-
Cobb, R.E.1
Wang, Y.2
Zhao, H.3
-
43
-
-
0029080712
-
Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer
-
Colon, G.E., Nguyen, T.T., Jetten, M.S., Sinskey, A.J., Stephanopoulos, G., Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Appl. Microbiol. Biotechnol. 43 (1995), 482–488.
-
(1995)
Appl. Microbiol. Biotechnol.
, vol.43
, pp. 482-488
-
-
Colon, G.E.1
Nguyen, T.T.2
Jetten, M.S.3
Sinskey, A.J.4
Stephanopoulos, G.5
-
44
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L., Ran, F.A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P.D., Wu, X., Jiang, W., Marraffini, L.A., Zhang, F., Multiplex genome engineering using CRISPR/Cas systems. Science 339 (2013), 819–823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
Hsu, P.D.7
Wu, X.8
Jiang, W.9
Marraffini, L.A.10
Zhang, F.11
-
45
-
-
84927970389
-
Super-resolution imaging in live cells
-
Cox, S., Super-resolution imaging in live cells. Dev. Biol. 401 (2015), 175–181.
-
(2015)
Dev. Biol.
, vol.401
, pp. 175-181
-
-
Cox, S.1
-
46
-
-
84930971149
-
CRISPathBrick: modular combinatorial assembly of type II-A CRISPR arrays for dCas9-mediated multiplex transcriptional repression in E. coli
-
Cress, B.F., Toparlak, O.D., Guleria, S., Lebovich, M., Stieglitz, J.T., Englaender, J.A., Jones, J.A., Linhardt, R.J., Koffas, M.A., CRISPathBrick: modular combinatorial assembly of type II-A CRISPR arrays for dCas9-mediated multiplex transcriptional repression in E. coli. ACS Synth. Biol. 4 (2015), 987–1000.
-
(2015)
ACS Synth. Biol.
, vol.4
, pp. 987-1000
-
-
Cress, B.F.1
Toparlak, O.D.2
Guleria, S.3
Lebovich, M.4
Stieglitz, J.T.5
Englaender, J.A.6
Jones, J.A.7
Linhardt, R.J.8
Koffas, M.A.9
-
47
-
-
84945944020
-
Sensitive cells: enabling tools for static and dynamic control of microbial metabolic pathways
-
Cress, B.F., Trantas, E.A., Ververidis, F., Linhardt, R.J., Koffas, M.A., Sensitive cells: enabling tools for static and dynamic control of microbial metabolic pathways. Curr. Opin. Biotechnol. 36 (2015), 205–214.
-
(2015)
Curr. Opin. Biotechnol.
, vol.36
, pp. 205-214
-
-
Cress, B.F.1
Trantas, E.A.2
Ververidis, F.3
Linhardt, R.J.4
Koffas, M.A.5
-
48
-
-
84970002343
-
Rapid generation of CRISPR/dCas9-regulated, orthogonally repressible hybrid T7-lac promoters for modular, tuneable control of metabolic pathway fluxes in Escherichia coli
-
Cress, B.F., Jones, J.A., Kim, D.C., Leitz, Q.D., Englaender, J.A., Collins, S.M., Linhardt, R.J., Koffas, M.A., Rapid generation of CRISPR/dCas9-regulated, orthogonally repressible hybrid T7-lac promoters for modular, tuneable control of metabolic pathway fluxes in Escherichia coli. Nucleic Acids Res. 44 (2016), 4472–4485.
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 4472-4485
-
-
Cress, B.F.1
Jones, J.A.2
Kim, D.C.3
Leitz, Q.D.4
Englaender, J.A.5
Collins, S.M.6
Linhardt, R.J.7
Koffas, M.A.8
-
49
-
-
84970046200
-
Consequences of Cas9 cleavage in the chromosome of Escherichia coli
-
Cui, L., Bikard, D., Consequences of Cas9 cleavage in the chromosome of Escherichia coli. Nucleic Acids Res. 44 (2016), 4243–4251.
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 4243-4251
-
-
Cui, L.1
Bikard, D.2
-
50
-
-
50349083723
-
Insight into microevolution of Yersinia pestis by clustered regularly interspaced short palindromic repeats
-
e2652
-
Cui, Y., Li, Y., Gorge, O., Platonov, M.E., Yan, Y., Guo, Z., Pourcel, C., Dentovskaya, S.V., Balakhonov, S.V., Wang, X., Song, Y., Anisimov, A.P., Vergnaud, G., Yang, R., Insight into microevolution of Yersinia pestis by clustered regularly interspaced short palindromic repeats. PLoS One, 3, 2008, e2652.
-
(2008)
PLoS One
, vol.3
-
-
Cui, Y.1
Li, Y.2
Gorge, O.3
Platonov, M.E.4
Yan, Y.5
Guo, Z.6
Pourcel, C.7
Dentovskaya, S.V.8
Balakhonov, S.V.9
Wang, X.10
Song, Y.11
Anisimov, A.P.12
Vergnaud, G.13
Yang, R.14
-
51
-
-
84947225411
-
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
-
Dahlman, J.E., Abudayyeh, O.O., Joung, J., Gootenberg, J.S., Zhang, F., Konermann, S., Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease. Nat. Biotechnol. 33 (2015), 1159–1161.
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 1159-1161
-
-
Dahlman, J.E.1
Abudayyeh, O.O.2
Joung, J.3
Gootenberg, J.S.4
Zhang, F.5
Konermann, S.6
-
52
-
-
0034612342
-
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
-
Datsenko, K.A., Wanner, B.L., One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U. S. A. 97 (2000), 6640–6645.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6640-6645
-
-
Datsenko, K.A.1
Wanner, B.L.2
-
53
-
-
84864864464
-
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system
-
Datsenko, K.A., Pougach, K., Tikhonov, A., Wanner, B.L., Severinov, K., Semenova, E., Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system. Nat. Commun., 3, 2012, 945.
-
(2012)
Nat. Commun.
, vol.3
, pp. 945
-
-
Datsenko, K.A.1
Pougach, K.2
Tikhonov, A.3
Wanner, B.L.4
Severinov, K.5
Semenova, E.6
-
54
-
-
33747333128
-
A set of recombineering plasmids for Gram-negative bacteria
-
Datta, S., Costantino, N., Court, D.L., A set of recombineering plasmids for Gram-negative bacteria. Gene 379 (2006), 109–115.
-
(2006)
Gene
, vol.379
, pp. 109-115
-
-
Datta, S.1
Costantino, N.2
Court, D.L.3
-
55
-
-
77952260431
-
Legionella pneumophila pangenome reveals strain-specific virulence factors
-
D'Auria, G., Jimenez-Hernandez, N., Peris-Bondia, F., Moya, A., Latorre, A., Legionella pneumophila pangenome reveals strain-specific virulence factors. BMC Genomics, 11, 2010, 181.
-
(2010)
BMC Genomics
, vol.11
, pp. 181
-
-
D'Auria, G.1
Jimenez-Hernandez, N.2
Peris-Bondia, F.3
Moya, A.4
Latorre, A.5
-
56
-
-
79953250082
-
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
-
Deltcheva, E., Chylinski, K., Sharma, C.M., Gonzales, K., Chao, Y., Pirzada, Z.A., Eckert, M.R., Vogel, J., Charpentier, E., CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature 471 (2011), 602–607.
-
(2011)
Nature
, vol.471
, pp. 602-607
-
-
Deltcheva, E.1
Chylinski, K.2
Sharma, C.M.3
Gonzales, K.4
Chao, Y.5
Pirzada, Z.A.6
Eckert, M.R.7
Vogel, J.8
Charpentier, E.9
-
57
-
-
84874195392
-
A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus
-
Deng, L., Garrett, R.A., Shah, S.A., Peng, X., She, Q., A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus. Mol. Microbiol. 87 (2013), 1088–1099.
-
(2013)
Mol. Microbiol.
, vol.87
, pp. 1088-1099
-
-
Deng, L.1
Garrett, R.A.2
Shah, S.A.3
Peng, X.4
She, Q.5
-
58
-
-
84942845731
-
CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells
-
Deng, W., Shi, X., Tjian, R., Lionnet, T., Singer, R.H., CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 11870–11875.
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 11870-11875
-
-
Deng, W.1
Shi, X.2
Tjian, R.3
Lionnet, T.4
Singer, R.H.5
-
59
-
-
84884904381
-
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
-
Dickinson, D.J., Ward, J.D., Reiner, D.J., Goldstein, B., Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat. Methods 10 (2013), 1028–1034.
-
(2013)
Nat. Methods
, vol.10
, pp. 1028-1034
-
-
Dickinson, D.J.1
Ward, J.D.2
Reiner, D.J.3
Goldstein, B.4
-
60
-
-
84954421331
-
Orthogonal modular gene repression in Escherichia coli using engineered CRISPR/Cas9
-
Didovyk, A., Borek, B., Hasty, J., Tsimring, L., Orthogonal modular gene repression in Escherichia coli using engineered CRISPR/Cas9. ACS Synth. Biol. 5 (2016), 81–88.
-
(2016)
ACS Synth. Biol.
, vol.5
, pp. 81-88
-
-
Didovyk, A.1
Borek, B.2
Hasty, J.3
Tsimring, L.4
-
61
-
-
84921540377
-
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
-
Doench, J.G., Hartenian, E., Graham, D.B., Tothova, Z., Hegde, M., Smith, I., Sullender, M., Ebert, B.L., Xavier, R.J., Root, D.E., Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat. Biotechnol. 32 (2014), 1262–1267.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1262-1267
-
-
Doench, J.G.1
Hartenian, E.2
Graham, D.B.3
Tothova, Z.4
Hegde, M.5
Smith, I.6
Sullender, M.7
Ebert, B.L.8
Xavier, R.J.9
Root, D.E.10
-
62
-
-
84952639685
-
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation
-
Dominguez, A.A., Lim, W.A., Qi, L.S., Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat. Rev. Mol. Cell Biol. 17 (2016), 5–15.
-
(2016)
Nat. Rev. Mol. Cell Biol.
, vol.17
, pp. 5-15
-
-
Dominguez, A.A.1
Lim, W.A.2
Qi, L.S.3
-
63
-
-
84964831029
-
The crystal structure of Cpf1 in complex with CRISPR RNA
-
Dong, D., Ren, K., Qiu, X., Zheng, J., Guo, M., Guan, X., Liu, H., Li, N., Zhang, B., Yang, D., Ma, C., Wang, S., Wu, D., Ma, Y., Fan, S., Wang, J., Gao, N., Huang, Z., The crystal structure of Cpf1 in complex with CRISPR RNA. Nature 532 (2016), 522–526.
-
(2016)
Nature
, vol.532
, pp. 522-526
-
-
Dong, D.1
Ren, K.2
Qiu, X.3
Zheng, J.4
Guo, M.5
Guan, X.6
Liu, H.7
Li, N.8
Zhang, B.9
Yang, D.10
Ma, C.11
Wang, S.12
Wu, D.13
Ma, Y.14
Fan, S.15
Wang, J.16
Gao, N.17
Huang, Z.18
-
64
-
-
84991602680
-
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
-
US patent 20140068797.
-
Doudna, J.A., Jinek, M., Charpentier, E., Chylinski, K., Cate, J.H.D., Lim, W., Qi, L. 2013. Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription. US patent 20140068797.
-
(2013)
-
-
Doudna, J.A.1
Jinek, M.2
Charpentier, E.3
Chylinski, K.4
Cate, J.H.D.5
Lim, W.6
Qi, L.7
-
65
-
-
84880125937
-
CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance
-
Dupuis, M.E., Villion, M., Magadan, A.H., Moineau, S., CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance. Nat. Commun., 4, 2013, 2087.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2087
-
-
Dupuis, M.E.1
Villion, M.2
Magadan, A.H.3
Moineau, S.4
-
66
-
-
84886488970
-
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas
-
Farzadfard, F., Perli, S.D., Lu, T.K., Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. ACS Synth. Biol. 2 (2013), 604–613.
-
(2013)
ACS Synth. Biol.
, vol.2
, pp. 604-613
-
-
Farzadfard, F.1
Perli, S.D.2
Lu, T.K.3
-
67
-
-
84964862130
-
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
-
Fonfara, I., Richter, H., Bratovic, M., Le Rhun, A., Charpentier, E., The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA. Nature 532 (2016), 517–521.
-
(2016)
Nature
, vol.532
, pp. 517-521
-
-
Fonfara, I.1
Richter, H.2
Bratovic, M.3
Le Rhun, A.4
Charpentier, E.5
-
68
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu, Y., Foden, J.A., Khayter, C., Maeder, M.L., Reyon, D., Joung, J.K., Sander, J.D., High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31 (2013), 822–826.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 822-826
-
-
Fu, Y.1
Foden, J.A.2
Khayter, C.3
Maeder, M.L.4
Reyon, D.5
Joung, J.K.6
Sander, J.D.7
-
69
-
-
84978438340
-
DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
-
Gao, F., Shen, X.Z., Jiang, F., Wu, Y., Han, C., DNA-guided genome editing using the Natronobacterium gregoryi Argonaute. Nat. Biotechnol., 2016, 10.1038/nbt.3547.
-
(2016)
Nat. Biotechnol.
-
-
Gao, F.1
Shen, X.Z.2
Jiang, F.3
Wu, Y.4
Han, C.5
-
70
-
-
78149261827
-
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
-
Garneau, J.E., Dupuis, M.E., Villion, M., Romero, D.A., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadan, A.H., Moineau, S., The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468 (2010), 67–71.
-
(2010)
Nature
, vol.468
, pp. 67-71
-
-
Garneau, J.E.1
Dupuis, M.E.2
Villion, M.3
Romero, D.A.4
Barrangou, R.5
Boyaval, P.6
Fremaux, C.7
Horvath, P.8
Magadan, A.H.9
Moineau, S.10
-
71
-
-
84866859751
-
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
-
Gasiunas, G., Barrangou, R., Horvath, P., Siksnys, V., Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), E2579–E2586.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. E2579-E2586
-
-
Gasiunas, G.1
Barrangou, R.2
Horvath, P.3
Siksnys, V.4
-
72
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert, L.A., Larson, M.H., Morsut, L., Liu, Z., Brar, G.A., Torres, S.E., Stern-Ginossar, N., Brandman, O., Whitehead, E.H., Doudna, J.A., Lim, W.A., Weissman, J.S., Qi, L.S., CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154 (2013), 442–451.
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
Larson, M.H.2
Morsut, L.3
Liu, Z.4
Brar, G.A.5
Torres, S.E.6
Stern-Ginossar, N.7
Brandman, O.8
Whitehead, E.H.9
Doudna, J.A.10
Lim, W.A.11
Weissman, J.S.12
Qi, L.S.13
-
73
-
-
84908456823
-
Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting
-
Goldberg, G.W., Jiang, W., Bikard, D., Marraffini, L.A., Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting. Nature 514 (2014), 633–637.
-
(2014)
Nature
, vol.514
, pp. 633-637
-
-
Goldberg, G.W.1
Jiang, W.2
Bikard, D.3
Marraffini, L.A.4
-
74
-
-
84903362877
-
Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems
-
e00928-00913
-
Gomaa, A.A., Klumpe, H.E., Luo, M.L., Selle, K., Barrangou, R., Beisel, C.L., Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems. MBio, 5, 2014 e00928-00913.
-
(2014)
MBio
, vol.5
-
-
Gomaa, A.A.1
Klumpe, H.E.2
Luo, M.L.3
Selle, K.4
Barrangou, R.5
Beisel, C.L.6
-
75
-
-
34250662138
-
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
-
Grissa, I., Vergnaud, G., Pourcel, C., The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats. BMC Bioinforma., 8, 2007, 172.
-
(2007)
BMC Bioinforma.
, vol.8
, pp. 172
-
-
Grissa, I.1
Vergnaud, G.2
Pourcel, C.3
-
76
-
-
0027724480
-
Nature of DNA polymorphism in the direct repeat cluster of Mycobacterium tuberculosis; application for strain differentiation by a novel typing method
-
Groenen, P.M., Bunschoten, A.E., van Soolingen, D., van Embden, J.D., Nature of DNA polymorphism in the direct repeat cluster of Mycobacterium tuberculosis; application for strain differentiation by a novel typing method. Mol. Microbiol. 10 (1993), 1057–1065.
-
(1993)
Mol. Microbiol.
, vol.10
, pp. 1057-1065
-
-
Groenen, P.M.1
Bunschoten, A.E.2
van Soolingen, D.3
van Embden, J.D.4
-
77
-
-
84902210542
-
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
-
Guilinger, J.P., Thompson, D.B., Liu, D.R., Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat. Biotechnol. 32 (2014), 577–582.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 577-582
-
-
Guilinger, J.P.1
Thompson, D.B.2
Liu, D.R.3
-
78
-
-
84880074536
-
The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae
-
e00074-00013
-
Gunderson, F.F., Cianciotto, N.P., The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae. MBio, 4, 2013 e00074-00013.
-
(2013)
MBio
, vol.4
-
-
Gunderson, F.F.1
Cianciotto, N.P.2
-
79
-
-
34248400310
-
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
-
e60
-
Haft, D.H., Selengut, J., Mongodin, E.F., Nelson, K.E., A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput. Biol., 1, 2005, e60.
-
(2005)
PLoS Comput. Biol.
, vol.1
-
-
Haft, D.H.1
Selengut, J.2
Mongodin, E.F.3
Nelson, K.E.4
-
80
-
-
70449753811
-
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex
-
Hale, C.R., Zhao, P., Olson, S., Duff, M.O., Graveley, B.R., Wells, L., Terns, R.M., Terns, M.P., RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell 139 (2009), 945–956.
-
(2009)
Cell
, vol.139
, pp. 945-956
-
-
Hale, C.R.1
Zhao, P.2
Olson, S.3
Duff, M.O.4
Graveley, B.R.5
Wells, L.6
Terns, R.M.7
Terns, M.P.8
-
81
-
-
84856792673
-
Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs
-
Hale, C.R., Majumdar, S., Elmore, J., Pfister, N., Compton, M., Olson, S., Resch, A.M., Glover, C.V. 3rd, Graveley, B.R., Terns, R.M., Terns, M.P., Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs. Mol. Cell 45 (2012), 292–302.
-
(2012)
Mol. Cell
, vol.45
, pp. 292-302
-
-
Hale, C.R.1
Majumdar, S.2
Elmore, J.3
Pfister, N.4
Compton, M.5
Olson, S.6
Resch, A.M.7
Glover, C.V.8
Graveley, B.R.9
Terns, R.M.10
Terns, M.P.11
-
82
-
-
26444581314
-
Structure and function of Argonaute proteins
-
Hall, T.M., Structure and function of Argonaute proteins. Structure 13 (2005), 1403–1408.
-
(2005)
Structure
, vol.13
, pp. 1403-1408
-
-
Hall, T.M.1
-
83
-
-
84908432854
-
Abundant and diverse clustered regularly interspaced short palindromic repeat spacers in Clostridium difficile strains and prophages target multiple phage types within this pathogen
-
e01045-01013
-
Hargreaves, K.R., Flores, C.O., Lawley, T.D., Clokie, M.R., Abundant and diverse clustered regularly interspaced short palindromic repeat spacers in Clostridium difficile strains and prophages target multiple phage types within this pathogen. MBio, 5, 2014 e01045-01013.
-
(2014)
MBio
, vol.5
-
-
Hargreaves, K.R.1
Flores, C.O.2
Lawley, T.D.3
Clokie, M.R.4
-
84
-
-
84855475577
-
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site
-
Hatoum-Aslan, A., Maniv, I., Marraffini, L.A., Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 21218–21222.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 21218-21222
-
-
Hatoum-Aslan, A.1
Maniv, I.2
Marraffini, L.A.3
-
85
-
-
58349087246
-
Germ warfare in a microbial mat community: CRISPRs provide insights into the co-evolution of host and viral genomes
-
e4169
-
Heidelberg, J.F., Nelson, W.C., Schoenfeld, T., Bhaya, D., Germ warfare in a microbial mat community: CRISPRs provide insights into the co-evolution of host and viral genomes. PLoS One, 4, 2009, e4169.
-
(2009)
PLoS One
, vol.4
-
-
Heidelberg, J.F.1
Nelson, W.C.2
Schoenfeld, T.3
Bhaya, D.4
-
86
-
-
84924705939
-
Cas9 specifies functional viral targets during CRISPR-Cas adaptation
-
Heler, R., Samai, P., Modell, J.W., Weiner, C., Goldberg, G.W., Bikard, D., Marraffini, L.A., Cas9 specifies functional viral targets during CRISPR-Cas adaptation. Nature 519 (2015), 199–202.
-
(2015)
Nature
, vol.519
, pp. 199-202
-
-
Heler, R.1
Samai, P.2
Modell, J.W.3
Weiner, C.4
Goldberg, G.W.5
Bikard, D.6
Marraffini, L.A.7
-
87
-
-
38949214103
-
Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus
-
Horvath, P., Romero, D.A., Coute-Monvoisin, A.C., Richards, M., Deveau, H., Moineau, S., Boyaval, P., Fremaux, C., Barrangou, R., Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus. J. Bacteriol. 190 (2008), 1401–1412.
-
(2008)
J. Bacteriol.
, vol.190
, pp. 1401-1412
-
-
Horvath, P.1
Romero, D.A.2
Coute-Monvoisin, A.C.3
Richards, M.4
Deveau, H.5
Moineau, S.6
Boyaval, P.7
Fremaux, C.8
Barrangou, R.9
-
88
-
-
84888866065
-
Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish
-
Hruscha, A., Krawitz, P., Rechenberg, A., Heinrich, V., Hecht, J., Haass, C., Schmid, B., Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development 140 (2013), 4982–4987.
-
(2013)
Development
, vol.140
, pp. 4982-4987
-
-
Hruscha, A.1
Krawitz, P.2
Rechenberg, A.3
Heinrich, V.4
Hecht, J.5
Haass, C.6
Schmid, B.7
-
89
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
Hsu, P.D., Scott, D.A., Weinstein, J.A., Ran, F.A., Konermann, S., Agarwala, V., Li, Y., Fine, E.J., Wu, X., Shalem, O., Cradick, T.J., Marraffini, L.A., Bao, G., Zhang, F., DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 31 (2013), 827–832.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 827-832
-
-
Hsu, P.D.1
Scott, D.A.2
Weinstein, J.A.3
Ran, F.A.4
Konermann, S.5
Agarwala, V.6
Li, Y.7
Fine, E.J.8
Wu, X.9
Shalem, O.10
Cradick, T.J.11
Marraffini, L.A.12
Bao, G.13
Zhang, F.14
-
90
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
Hsu, P.D., Lander, E.S., Zhang, F., Development and applications of CRISPR-Cas9 for genome engineering. Cell 157 (2014), 1262–1278.
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
91
-
-
84926466507
-
One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
-
Huang, H., Zheng, G., Jiang, W., Hu, H., Lu, Y., One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces. Acta Biochim. Biophys. Sin. (Shanghai) 47 (2015), 231–243.
-
(2015)
Acta Biochim. Biophys. Sin. (Shanghai)
, vol.47
, pp. 231-243
-
-
Huang, H.1
Zheng, G.2
Jiang, W.3
Hu, H.4
Lu, Y.5
-
92
-
-
84981342035
-
Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins
-
Hur, J.K., Kim, K., Been, K.W., Baek, G., Ye, S., Hur, J.W., Ryu, S.-M., Lee, Y.S., Kim, J.-S., Targeted mutagenesis in mice by electroporation of Cpf1 ribonucleoproteins. Nat. Biotechnol., 2016, 10.1038/nbt.3596.
-
(2016)
Nat. Biotechnol.
-
-
Hur, J.K.1
Kim, K.2
Been, K.W.3
Baek, G.4
Ye, S.5
Hur, J.W.6
Ryu, S.-M.7
Lee, Y.S.8
Kim, J.-S.9
-
93
-
-
37549014207
-
Argonaute proteins: key players in RNA silencing
-
Hutvagner, G., Simard, M.J., Argonaute proteins: key players in RNA silencing. Nat. Rev. Mol. Cell Biol. 9 (2008), 22–32.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 22-32
-
-
Hutvagner, G.1
Simard, M.J.2
-
94
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPR-Cas system
-
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Tsai, S.Q., Sander, J.D., Peterson, R.T., Yeh, J.R., Joung, J.K., Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 31 (2013), 227–229.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 227-229
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.3
Maeder, M.L.4
Tsai, S.Q.5
Sander, J.D.6
Peterson, R.T.7
Yeh, J.R.8
Joung, J.K.9
-
95
-
-
79960502359
-
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
-
Isaacs, F.J., Carr, P.A., Wang, H.H., Lajoie, M.J., Sterling, B., Kraal, L., Tolonen, A.C., Gianoulis, T.A., Goodman, D.B., Reppas, N.B., Emig, C.J., Bang, D., Hwang, S.J., Jewett, M.C., Jacobson, J.M., Church, G.M., Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science 333 (2011), 348–353.
-
(2011)
Science
, vol.333
, pp. 348-353
-
-
Isaacs, F.J.1
Carr, P.A.2
Wang, H.H.3
Lajoie, M.J.4
Sterling, B.5
Kraal, L.6
Tolonen, A.C.7
Gianoulis, T.A.8
Goodman, D.B.9
Reppas, N.B.10
Emig, C.J.11
Bang, D.12
Hwang, S.J.13
Jewett, M.C.14
Jacobson, J.M.15
Church, G.M.16
-
96
-
-
0023600057
-
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product
-
Ishino, Y., Shinagawa, H., Makino, K., Amemura, M., Nakata, A., Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J. Bacteriol. 169 (1987), 5429–5433.
-
(1987)
J. Bacteriol.
, vol.169
, pp. 5429-5433
-
-
Ishino, Y.1
Shinagawa, H.2
Makino, K.3
Amemura, M.4
Nakata, A.5
-
97
-
-
84907208955
-
Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli
-
Jackson, R.N., Golden, S.M., van Erp, P.B., Carter, J., Westra, E.R., Brouns, S.J., van der Oost, J., Terwilliger, T.C., Read, R.J., Wiedenheft, B., Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science 345 (2014), 1473–1479.
-
(2014)
Science
, vol.345
, pp. 1473-1479
-
-
Jackson, R.N.1
Golden, S.M.2
van Erp, P.B.3
Carter, J.4
Westra, E.R.5
Brouns, S.J.6
van der Oost, J.7
Terwilliger, T.C.8
Read, R.J.9
Wiedenheft, B.10
-
98
-
-
84973165204
-
Design of a CRISPR-Cas system to increase resistance of Bacillus subtilis to bacteriophage SPP1
-
Jakutyte-Giraitiene, L., Gasiunas, G., Design of a CRISPR-Cas system to increase resistance of Bacillus subtilis to bacteriophage SPP1. J. Ind. Microbiol. Biotechnol., 2016, 10.1007/s10295-016-1784-0.
-
(2016)
J. Ind. Microbiol. Biotechnol.
-
-
Jakutyte-Giraitiene, L.1
Gasiunas, G.2
-
99
-
-
0036267740
-
Identification of genes that are associated with DNA repeats in prokaryotes
-
Jansen, R., Embden, J.D., Gaastra, W., Schouls, L.M., Identification of genes that are associated with DNA repeats in prokaryotes. Mol. Microbiol. 43 (2002), 1565–1575.
-
(2002)
Mol. Microbiol.
, vol.43
, pp. 1565-1575
-
-
Jansen, R.1
Embden, J.D.2
Gaastra, W.3
Schouls, L.M.4
-
100
-
-
84919634760
-
Specific gene repression by CRISPRi system transferred through bacterial conjugation
-
Ji, W., Lee, D., Wong, E., Dadlani, P., Dinh, D., Huang, V., Kearns, K., Teng, S., Chen, S., Haliburton, J., Heimberg, G., Heineike, B., Ramasubramanian, A., Stevens, T., Helmke, K.J., Zepeda, V., Qi, L.S., Lim, W.A., Specific gene repression by CRISPRi system transferred through bacterial conjugation. ACS Synth. Biol. 3 (2014), 929–931.
-
(2014)
ACS Synth. Biol.
, vol.3
, pp. 929-931
-
-
Ji, W.1
Lee, D.2
Wong, E.3
Dadlani, P.4
Dinh, D.5
Huang, V.6
Kearns, K.7
Teng, S.8
Chen, S.9
Haliburton, J.10
Heimberg, G.11
Heineike, B.12
Ramasubramanian, A.13
Stevens, T.14
Helmke, K.J.15
Zepeda, V.16
Qi, L.S.17
Lim, W.A.18
-
101
-
-
84874608929
-
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
-
Jiang, W., Bikard, D., Cox, D., Zhang, F., Marraffini, L.A., RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat. Biotechnol. 31 (2013), 233–239.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 233-239
-
-
Jiang, W.1
Bikard, D.2
Cox, D.3
Zhang, F.4
Marraffini, L.A.5
-
102
-
-
84925355124
-
Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system
-
Jiang, Y., Chen, B., Duan, C., Sun, B., Yang, J., Yang, S., Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system. Appl. Environ. Microbiol. 81 (2015), 2506–2514.
-
(2015)
Appl. Environ. Microbiol.
, vol.81
, pp. 2506-2514
-
-
Jiang, Y.1
Chen, B.2
Duan, C.3
Sun, B.4
Yang, J.5
Yang, S.6
-
103
-
-
84933574487
-
A Cas9-guide RNA complex preorganized for target DNA recognition
-
Jiang, F., Zhou, K., Ma, L., Gressel, S., Doudna, J.A., A Cas9-guide RNA complex preorganized for target DNA recognition. Science 348 (2015), 1477–1481.
-
(2015)
Science
, vol.348
, pp. 1477-1481
-
-
Jiang, F.1
Zhou, K.2
Ma, L.3
Gressel, S.4
Doudna, J.A.5
-
104
-
-
84958953000
-
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
-
Jiang, F., Taylor, D.W., Chen, J.S., Kornfeld, J.E., Zhou, K., Thompson, A.J., Nogales, E., Doudna, J.A., Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science 351 (2016), 867–871.
-
(2016)
Science
, vol.351
, pp. 867-871
-
-
Jiang, F.1
Taylor, D.W.2
Chen, J.S.3
Kornfeld, J.E.4
Zhou, K.5
Thompson, A.J.6
Nogales, E.7
Doudna, J.A.8
-
105
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., Charpentier, E., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337 (2012), 816–821.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
Charpentier, E.6
-
106
-
-
84876567971
-
RNA-programmed genome editing in human cells
-
e00471
-
Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., Doudna, J., RNA-programmed genome editing in human cells. Elife, 2, 2013, e00471.
-
(2013)
Elife
, vol.2
-
-
Jinek, M.1
East, A.2
Cheng, A.3
Lin, S.4
Ma, E.5
Doudna, J.6
-
107
-
-
84995341896
-
Methods and compositions for RNA-directed target DNA modification
-
UK patent 2518764.
-
Jinek, M., Cate, J.H.D., Lim, W., Qi, L., Chylinski, K., Charpentier, E., Doudna, J. 2016. Methods and compositions for RNA-directed target DNA modification. UK patent 2518764.
-
(2016)
-
-
Jinek, M.1
Cate, J.H.D.2
Lim, W.3
Qi, L.4
Chylinski, K.5
Charpentier, E.6
Doudna, J.7
-
108
-
-
79955574254
-
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
-
Jore, M.M., Lundgren, M., van Duijn, E., Bultema, J.B., Westra, E.R., Waghmare, S.P., Wiedenheft, B., Pul, U., Wurm, R., Wagner, R., Beijer, M.R., Barendregt, A., Zhou, K., Snijders, A.P., Dickman, M.J., Doudna, J.A., Boekema, E.J., Heck, A.J., van der Oost, J., Brouns, S.J., Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nat. Struct. Mol. Biol. 18 (2011), 529–536.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 529-536
-
-
Jore, M.M.1
Lundgren, M.2
van Duijn, E.3
Bultema, J.B.4
Westra, E.R.5
Waghmare, S.P.6
Wiedenheft, B.7
Pul, U.8
Wurm, R.9
Wagner, R.10
Beijer, M.R.11
Barendregt, A.12
Zhou, K.13
Snijders, A.P.14
Dickman, M.J.15
Doudna, J.A.16
Boekema, E.J.17
Heck, A.J.18
van der Oost, J.19
Brouns, S.J.20
more..
-
109
-
-
84995352150
-
First proposed human test of CRISPR passes initial safety review
-
Kaiser, J., First proposed human test of CRISPR passes initial safety review. Science, 2016, 10.1126/science.aaf5796.
-
(2016)
Science
-
-
Kaiser, J.1
-
110
-
-
84940453002
-
Non-GMO genetically edited crop plants
-
Kanchiswamy, C.N., Malnoy, M., Velasco, R., Kim, J.S., Viola, R., Non-GMO genetically edited crop plants. Trends Biotechnol. 33 (2015), 489–491.
-
(2015)
Trends Biotechnol.
, vol.33
, pp. 489-491
-
-
Kanchiswamy, C.N.1
Malnoy, M.2
Velasco, R.3
Kim, J.S.4
Viola, R.5
-
111
-
-
84946471431
-
Cas9 gRNA engineering for genome editing, activation and repression
-
Kiani, S., Chavez, A., Tuttle, M., Hall, R.N., Chari, R., Ter-Ovanesyan, D., Qian, J., Pruitt, B.W., Beal, J., Vora, S., Buchthal, J., Kowal, E.J., Ebrahimkhani, M.R., Collins, J.J., Weiss, R., Church, G., Cas9 gRNA engineering for genome editing, activation and repression. Nat. Methods 12 (2015), 1051–1054.
-
(2015)
Nat. Methods
, vol.12
, pp. 1051-1054
-
-
Kiani, S.1
Chavez, A.2
Tuttle, M.3
Hall, R.N.4
Chari, R.5
Ter-Ovanesyan, D.6
Qian, J.7
Pruitt, B.W.8
Beal, J.9
Vora, S.10
Buchthal, J.11
Kowal, E.J.12
Ebrahimkhani, M.R.13
Collins, J.J.14
Weiss, R.15
Church, G.16
-
112
-
-
84901834420
-
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
-
Kim, S., Kim, D., Cho, S.W., Kim, J., Kim, J.S., Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res. 24 (2014), 1012–1019.
-
(2014)
Genome Res.
, vol.24
, pp. 1012-1019
-
-
Kim, S.1
Kim, D.2
Cho, S.W.3
Kim, J.4
Kim, J.S.5
-
113
-
-
84923846574
-
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
-
Kim, D., Bae, S., Park, J., Kim, E., Kim, S., Yu, H.R., Hwang, J., Kim, J.I., Kim, J.S., Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells. Nat. Methods 12 (2015), 237–243.
-
(2015)
Nat. Methods
, vol.12
, pp. 237-243
-
-
Kim, D.1
Bae, S.2
Park, J.3
Kim, E.4
Kim, S.5
Yu, H.R.6
Hwang, J.7
Kim, J.I.8
Kim, J.S.9
-
114
-
-
84872021607
-
Emergence of sequence type 779 methicillin-resistant Staphylococcus aureus harboring a novel pseudo staphylococcal cassette chromosome mec (SCCmec)-SCC-SCCCRISPR composite element in Irish hospitals
-
Kinnevey, P.M., Shore, A.C., Brennan, G.I., Sullivan, D.J., Ehricht, R., Monecke, S., Slickers, P., Coleman, D.C., Emergence of sequence type 779 methicillin-resistant Staphylococcus aureus harboring a novel pseudo staphylococcal cassette chromosome mec (SCCmec)-SCC-SCCCRISPR composite element in Irish hospitals. Antimicrob. Agents Chemother. 57 (2013), 524–531.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 524-531
-
-
Kinnevey, P.M.1
Shore, A.C.2
Brennan, G.I.3
Sullivan, D.J.4
Ehricht, R.5
Monecke, S.6
Slickers, P.7
Coleman, D.C.8
-
115
-
-
84971006562
-
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
-
Komor, A.C., Kim, Y.B., Packer, M.S., Zuris, J.A., Liu, D.R., Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533 (2016), 420–424.
-
(2016)
Nature
, vol.533
, pp. 420-424
-
-
Komor, A.C.1
Kim, Y.B.2
Packer, M.S.3
Zuris, J.A.4
Liu, D.R.5
-
116
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S., Brigham, M.D., Trevino, A.E., Joung, J., Abudayyeh, O.O., Barcena, C., Hsu, P.D., Habib, N., Gootenberg, J.S., Nishimasu, H., Nureki, O., Zhang, F., Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517 (2015), 583–588.
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
Brigham, M.D.2
Trevino, A.E.3
Joung, J.4
Abudayyeh, O.O.5
Barcena, C.6
Hsu, P.D.7
Habib, N.8
Gootenberg, J.S.9
Nishimasu, H.10
Nureki, O.11
Zhang, F.12
-
117
-
-
84924333079
-
Who owns CRISPR-Cas9 in Europe?
-
Kupecz, A., Who owns CRISPR-Cas9 in Europe?. Nat. Biotechnol. 32 (2014), 1194–1196.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1194-1196
-
-
Kupecz, A.1
-
118
-
-
84903545084
-
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
-
Kuscu, C., Arslan, S., Singh, R., Thorpe, J., Adli, M., Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nat. Biotechnol. 32 (2014), 677–683.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 677-683
-
-
Kuscu, C.1
Arslan, S.2
Singh, R.3
Thorpe, J.4
Adli, M.5
-
119
-
-
84943200169
-
Advanced microscopy methods for visualizing chromatin structure
-
Lakadamyali, M., Cosma, M.P., Advanced microscopy methods for visualizing chromatin structure. FEBS Lett. 589 (2015), 3023–3030.
-
(2015)
FEBS Lett.
, vol.589
, pp. 3023-3030
-
-
Lakadamyali, M.1
Cosma, M.P.2
-
120
-
-
84955507318
-
Bitter fight over CRISPR patent heats up
-
Ledford, H., Bitter fight over CRISPR patent heats up. Nature, 529, 2016, 265.
-
(2016)
Nature
, vol.529
, pp. 265
-
-
Ledford, H.1
-
121
-
-
33645029734
-
Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production
-
Lee, S.J., Song, H., Lee, S.Y., Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production. Appl. Environ. Microbiol. 72 (2006), 1939–1948.
-
(2006)
Appl. Environ. Microbiol.
, vol.72
, pp. 1939-1948
-
-
Lee, S.J.1
Song, H.2
Lee, S.Y.3
-
122
-
-
84904572233
-
-
Lee, J.S., Kwak, S.J., Kim, J., Kim, A.K., Noh, H.M., Kim, J.S., Yu, K., RNA-guided genome editing in Drosophila with the purified Cas9 protein. G3 (Bethesda), 4, 2014, 1291–1295.
-
(2014)
RNA-guided genome editing in Drosophila with the purified Cas9 protein. G3 (Bethesda)
, vol.4
, pp. 1291-1295
-
-
Lee, J.S.1
Kwak, S.J.2
Kim, J.3
Kim, A.K.4
Noh, H.M.5
Kim, J.S.6
Yu, K.7
-
123
-
-
33646082272
-
Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus
-
Li, R., Townsend, C.A., Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab. Eng. 8 (2006), 240–252.
-
(2006)
Metab. Eng.
, vol.8
, pp. 240-252
-
-
Li, R.1
Townsend, C.A.2
-
124
-
-
84883779087
-
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
-
Li, W., Teng, F., Li, T., Zhou, Q., Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat. Biotechnol. 31 (2013), 684–686.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 684-686
-
-
Li, W.1
Teng, F.2
Li, T.3
Zhou, Q.4
-
125
-
-
84895823059
-
Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process
-
Li, M., Wang, R., Zhao, D., Xiang, H., Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process. Nucleic Acids Res. 42 (2014), 2483–2492.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 2483-2492
-
-
Li, M.1
Wang, R.2
Zhao, D.3
Xiang, H.4
-
126
-
-
84937538704
-
Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing
-
Li, Y., Lin, Z., Huang, C., Zhang, Y., Wang, Z., Tang, Y.J., Chen, T., Zhao, X., Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing. Metab. Eng. 31 (2015), 13–21.
-
(2015)
Metab. Eng.
, vol.31
, pp. 13-21
-
-
Li, Y.1
Lin, Z.2
Huang, C.3
Zhang, Y.4
Wang, Z.5
Tang, Y.J.6
Chen, T.7
Zhao, X.8
-
127
-
-
84977527317
-
CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii
-
Li, Q., Chen, J., Minton, N.P., Zhang, Y., Wen, Z., Liu, J., Yang, H., Zeng, Z., Ren, X., Yang, J., Gu, Y., Jiang, W., Jiang, Y., Yang, S., CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Biotechnol. J., 2016, 10.1002/biot.201600053.
-
(2016)
Biotechnol. J.
-
-
Li, Q.1
Chen, J.2
Minton, N.P.3
Zhang, Y.4
Wen, Z.5
Liu, J.6
Yang, H.7
Zeng, Z.8
Ren, X.9
Yang, J.10
Gu, Y.11
Jiang, W.12
Jiang, Y.13
Yang, S.14
-
128
-
-
33748096466
-
A putative viral defence mechanism in archaeal cells
-
Lillestol, R.K., Redder, P., Garrett, R.A., Brugger, K., A putative viral defence mechanism in archaeal cells. Archaea 2 (2006), 59–72.
-
(2006)
Archaea
, vol.2
, pp. 59-72
-
-
Lillestol, R.K.1
Redder, P.2
Garrett, R.A.3
Brugger, K.4
-
129
-
-
83155175251
-
Comparison of genotypic and phenotypic cluster analyses of virulence determinants and possible role of CRISPR elements towards their incidence in Enterococcus faecalis and Enterococcus faecium
-
Lindenstrauss, A.G., Pavlovic, M., Bringmann, A., Behr, J., Ehrmann, M.A., Vogel, R.F., Comparison of genotypic and phenotypic cluster analyses of virulence determinants and possible role of CRISPR elements towards their incidence in Enterococcus faecalis and Enterococcus faecium. Syst. Appl. Microbiol. 34 (2011), 553–560.
-
(2011)
Syst. Appl. Microbiol.
, vol.34
, pp. 553-560
-
-
Lindenstrauss, A.G.1
Pavlovic, M.2
Bringmann, A.3
Behr, J.4
Ehrmann, M.A.5
Vogel, R.F.6
-
130
-
-
84872618158
-
A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barre syndrome
-
Louwen, R., Horst-Kreft, D., de Boer, A.G., van der Graaf, L., de Knegt, G., Hamersma, M., Heikema, A.P., Timms, A.R., Jacobs, B.C., Wagenaar, J.A., Endtz, H.P., van der Oost, J., Wells, J.M., Nieuwenhuis, E.E., van Vliet, A.H., Willemsen, P.T., van Baarlen, P., van Belkum, A., A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barre syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 32 (2013), 207–226.
-
(2013)
Eur. J. Clin. Microbiol. Infect. Dis.
, vol.32
, pp. 207-226
-
-
Louwen, R.1
Horst-Kreft, D.2
de Boer, A.G.3
van der Graaf, L.4
de Knegt, G.5
Hamersma, M.6
Heikema, A.P.7
Timms, A.R.8
Jacobs, B.C.9
Wagenaar, J.A.10
Endtz, H.P.11
van der Oost, J.12
Wells, J.M.13
Nieuwenhuis, E.E.14
van Vliet, A.H.15
Willemsen, P.T.16
van Baarlen, P.17
van Belkum, A.18
-
131
-
-
84941084492
-
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
-
Luo, M.L., Mullis, A.S., Leenay, R.T., Beisel, C.L., Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression. Nucleic Acids Res. 43 (2015), 674–681.
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 674-681
-
-
Luo, M.L.1
Mullis, A.S.2
Leenay, R.T.3
Beisel, C.L.4
-
132
-
-
84949641392
-
Current and future prospects for CRISPR-based tools in bacteria
-
Luo, M.L., Leenay, R.T., Beisel, C.L., Current and future prospects for CRISPR-based tools in bacteria. Biotechnol. Bioeng. 113 (2016), 930–943.
-
(2016)
Biotechnol. Bioeng.
, vol.113
, pp. 930-943
-
-
Luo, M.L.1
Leenay, R.T.2
Beisel, C.L.3
-
133
-
-
84926645319
-
Application of CRISPRi for prokaryotic metabolic engineering involving multiple genes, a case study: controllable P(3HB-co-4HB) biosynthesis
-
Lv, L., Ren, Y.L., Chen, J.C., Wu, Q., Chen, G.Q., Application of CRISPRi for prokaryotic metabolic engineering involving multiple genes, a case study: controllable P(3HB-co-4HB) biosynthesis. Metab. Eng. 29 (2015), 160–168.
-
(2015)
Metab. Eng.
, vol.29
, pp. 160-168
-
-
Lv, L.1
Ren, Y.L.2
Chen, J.C.3
Wu, Q.4
Chen, G.Q.5
-
134
-
-
84924347318
-
Multicolor CRISPR labeling of chromosomal loci in human cells
-
Ma, H., Naseri, A., Reyes-Gutierrez, P., Wolfe, S.A., Zhang, S., Pederson, T., Multicolor CRISPR labeling of chromosomal loci in human cells. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 3002–3007.
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 3002-3007
-
-
Ma, H.1
Naseri, A.2
Reyes-Gutierrez, P.3
Wolfe, S.A.4
Zhang, S.5
Pederson, T.6
-
135
-
-
84884907424
-
CRISPR RNA-guided activation of endogenous human genes
-
Maeder, M.L., Linder, S.J., Cascio, V.M., Fu, Y., Ho, Q.H., Joung, J.K., CRISPR RNA-guided activation of endogenous human genes. Nat. Methods 10 (2013), 977–979.
-
(2013)
Nat. Methods
, vol.10
, pp. 977-979
-
-
Maeder, M.L.1
Linder, S.J.2
Cascio, V.M.3
Fu, Y.4
Ho, Q.H.5
Joung, J.K.6
-
136
-
-
79960554003
-
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
-
Makarova, K.S., Aravind, L., Wolf, Y.I., Koonin, E.V., Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol. Direct, 6, 2011, 38.
-
(2011)
Biol. Direct
, vol.6
, pp. 38
-
-
Makarova, K.S.1
Aravind, L.2
Wolf, Y.I.3
Koonin, E.V.4
-
137
-
-
79956157571
-
Evolution and classification of the CRISPR–Cas systems
-
Makarova, K.S., Haft, D.H., Barrangou, R., Brouns, S.J.J., Charpentier, E., Horvath, P., Moineau, S., Mojica, F.J.M., Wolf, Y.I., Yakunin, A.F., van der Oost, J., Koonin, E.V., Evolution and classification of the CRISPR–Cas systems. Nat. Rev. Microbiol. 9 (2011), 467–477.
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 467-477
-
-
Makarova, K.S.1
Haft, D.H.2
Barrangou, R.3
Brouns, S.J.J.4
Charpentier, E.5
Horvath, P.6
Moineau, S.7
Mojica, F.J.M.8
Wolf, Y.I.9
Yakunin, A.F.10
van der Oost, J.11
Koonin, E.V.12
-
138
-
-
84868685897
-
Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes
-
Makarova, K.S., Anantharaman, V., Aravind, L., Koonin, E.V., Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes. Biol. Direct, 7, 2012, 40.
-
(2012)
Biol. Direct
, vol.7
, pp. 40
-
-
Makarova, K.S.1
Anantharaman, V.2
Aravind, L.3
Koonin, E.V.4
-
139
-
-
84944449180
-
An updated evolutionary classification of CRISPR-Cas systems
-
Makarova, K.S., Wolf, Y.I., Alkhnbashi, O.S., Costa, F., Shah, S.A., Saunders, S.J., Barrangou, R., Brouns, S.J., Charpentier, E., Haft, D.H., Horvath, P., Moineau, S., Mojica, F.J., Terns, R.M., Terns, M.P., White, M.F., Yakunin, A.F., Garrett, R.A., van der Oost, J., Backofen, R., Koonin, E.V., An updated evolutionary classification of CRISPR-Cas systems. Nat. Rev. Microbiol. 13 (2015), 722–736.
-
(2015)
Nat. Rev. Microbiol.
, vol.13
, pp. 722-736
-
-
Makarova, K.S.1
Wolf, Y.I.2
Alkhnbashi, O.S.3
Costa, F.4
Shah, S.A.5
Saunders, S.J.6
Barrangou, R.7
Brouns, S.J.8
Charpentier, E.9
Haft, D.H.10
Horvath, P.11
Moineau, S.12
Mojica, F.J.13
Terns, R.M.14
Terns, M.P.15
White, M.F.16
Yakunin, A.F.17
Garrett, R.A.18
van der Oost, J.19
Backofen, R.20
Koonin, E.V.21
more..
-
140
-
-
84884160273
-
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali, P., Aach, J., Stranges, P.B., Esvelt, K.M., Moosburner, M., Kosuri, S., Yang, L., Church, G.M., CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 31 (2013), 833–838.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 833-838
-
-
Mali, P.1
Aach, J.2
Stranges, P.B.3
Esvelt, K.M.4
Moosburner, M.5
Kosuri, S.6
Yang, L.7
Church, G.M.8
-
141
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P., Yang, L., Esvelt, K.M., Aach, J., Guell, M., DiCarlo, J.E., Norville, J.E., Church, G.M., RNA-guided human genome engineering via Cas9. Science 339 (2013), 823–826.
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
Aach, J.4
Guell, M.5
DiCarlo, J.E.6
Norville, J.E.7
Church, G.M.8
-
142
-
-
84943160849
-
CRISPR-Cas immunity in prokaryotes
-
Marraffini, L.A., CRISPR-Cas immunity in prokaryotes. Nature 526 (2015), 55–61.
-
(2015)
Nature
, vol.526
, pp. 55-61
-
-
Marraffini, L.A.1
-
143
-
-
57849137502
-
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA
-
Marraffini, L.A., Sontheimer, E.J., CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science 322 (2008), 1843–1845.
-
(2008)
Science
, vol.322
, pp. 1843-1845
-
-
Marraffini, L.A.1
Sontheimer, E.J.2
-
144
-
-
75749118174
-
Self versus non-self discrimination during CRISPR RNA-directed immunity
-
Marraffini, L.A., Sontheimer, E.J., Self versus non-self discrimination during CRISPR RNA-directed immunity. Nature 463 (2010), 568–571.
-
(2010)
Nature
, vol.463
, pp. 568-571
-
-
Marraffini, L.A.1
Sontheimer, E.J.2
-
145
-
-
33748537078
-
The evolving story of the omega subunit of bacterial RNA polymerase
-
Mathew, R., Chatterji, D., The evolving story of the omega subunit of bacterial RNA polymerase. Trends Microbiol. 14 (2006), 450–455.
-
(2006)
Trends Microbiol.
, vol.14
, pp. 450-455
-
-
Mathew, R.1
Chatterji, D.2
-
146
-
-
84907007759
-
Bacterial nonhomologous end joining requires teamwork
-
Matthews, L.A., Simmons, L.A., Bacterial nonhomologous end joining requires teamwork. J. Bacteriol. 196 (2014), 3363–3365.
-
(2014)
J. Bacteriol.
, vol.196
, pp. 3363-3365
-
-
Matthews, L.A.1
Simmons, L.A.2
-
147
-
-
84879414849
-
Argonaute proteins: functional insights and emerging roles
-
Meister, G., Argonaute proteins: functional insights and emerging roles. Nat. Rev. Genet. 14 (2013), 447–459.
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 447-459
-
-
Meister, G.1
-
148
-
-
0027910069
-
Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic acetone operon
-
Mermelstein, L.D., Papoutsakis, E.T., Petersen, D.J., Bennett, G.N., Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic acetone operon. Biotechnol. Bioeng. 42 (1993), 1053–1060.
-
(1993)
Biotechnol. Bioeng.
, vol.42
, pp. 1053-1060
-
-
Mermelstein, L.D.1
Papoutsakis, E.T.2
Petersen, D.J.3
Bennett, G.N.4
-
149
-
-
80053528043
-
The human gut virome: inter-individual variation and dynamic response to diet
-
Minot, S., Sinha, R., Chen, J., Li, H., Keilbaugh, S.A., Wu, G.D., Lewis, J.D., Bushman, F.D., The human gut virome: inter-individual variation and dynamic response to diet. Genome Res. 21 (2011), 1616–1625.
-
(2011)
Genome Res.
, vol.21
, pp. 1616-1625
-
-
Minot, S.1
Sinha, R.2
Chen, J.3
Li, H.4
Keilbaugh, S.A.5
Wu, G.D.6
Lewis, J.D.7
Bushman, F.D.8
-
150
-
-
84880652104
-
Rapid evolution of the human gut virome
-
Minot, S., Bryson, A., Chehoud, C., Wu, G.D., Lewis, J.D., Bushman, F.D., Rapid evolution of the human gut virome. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 12450–12455.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 12450-12455
-
-
Minot, S.1
Bryson, A.2
Chehoud, C.3
Wu, G.D.4
Lewis, J.D.5
Bushman, F.D.6
-
151
-
-
0034034401
-
Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria
-
Mojica, F.J., Diez-Villasenor, C., Soria, E., Juez, G., Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria. Mol. Microbiol. 36 (2000), 244–246.
-
(2000)
Mol. Microbiol.
, vol.36
, pp. 244-246
-
-
Mojica, F.J.1
Diez-Villasenor, C.2
Soria, E.3
Juez, G.4
-
152
-
-
16444385662
-
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
-
Mojica, F.J., Diez-Villasenor, C., Garcia-Martinez, J., Soria, E., Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J. Mol. Evol. 60 (2005), 174–182.
-
(2005)
J. Mol. Evol.
, vol.60
, pp. 174-182
-
-
Mojica, F.J.1
Diez-Villasenor, C.2
Garcia-Martinez, J.3
Soria, E.4
-
153
-
-
64049118040
-
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
-
Mojica, F.J., Diez-Villasenor, C., Garcia-Martinez, J., Almendros, C., Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology 155 (2009), 733–740.
-
(2009)
Microbiology
, vol.155
, pp. 733-740
-
-
Mojica, F.J.1
Diez-Villasenor, C.2
Garcia-Martinez, J.3
Almendros, C.4
-
154
-
-
34547405296
-
Corynebacterium diphtheriae spoligotyping based on combined use of two CRISPR loci
-
Mokrousov, I., Limeschenko, E., Vyazovaya, A., Narvskaya, O., Corynebacterium diphtheriae spoligotyping based on combined use of two CRISPR loci. Biotechnol. J. 2 (2007), 901–906.
-
(2007)
Biotechnol. J.
, vol.2
, pp. 901-906
-
-
Mokrousov, I.1
Limeschenko, E.2
Vyazovaya, A.3
Narvskaya, O.4
-
155
-
-
84959123021
-
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
-
Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J., CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nat. Methods 12 (2015), 982–988.
-
(2015)
Nat. Methods
, vol.12
, pp. 982-988
-
-
Moreno-Mateos, M.A.1
Vejnar, C.E.2
Beaudoin, J.D.3
Fernandez, J.P.4
Mis, E.K.5
Khokha, M.K.6
Giraldez, A.J.7
-
156
-
-
84863329741
-
Crystal structure of the largest subunit of a bacterial RNA-guided immune complex and its role in DNA target binding
-
Mulepati, S., Orr, A., Bailey, S., Crystal structure of the largest subunit of a bacterial RNA-guided immune complex and its role in DNA target binding. J. Biol. Chem. 287 (2012), 22445–22449.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 22445-22449
-
-
Mulepati, S.1
Orr, A.2
Bailey, S.3
-
157
-
-
84907204893
-
Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target
-
Mulepati, S., Heroux, A., Bailey, S., Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Science 345 (2014), 1479–1484.
-
(2014)
Science
, vol.345
, pp. 1479-1484
-
-
Mulepati, S.1
Heroux, A.2
Bailey, S.3
-
158
-
-
84890787845
-
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis
-
Nakayama, T., Fish, M.B., Fisher, M., Oomen-Hajagos, J., Thomsen, G.H., Grainger, R.M., Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. Genesis 51 (2013), 835–843.
-
(2013)
Genesis
, vol.51
, pp. 835-843
-
-
Nakayama, T.1
Fish, M.B.2
Fisher, M.3
Oomen-Hajagos, J.4
Thomsen, G.H.5
Grainger, R.M.6
-
159
-
-
84865704094
-
Cas5d protein processes pre-crRNA and assembles into a Cascade-like interference complex in subtype I-C/Dvulg CRISPR-Cas system
-
Nam, K.H., Haitjema, C., Liu, X., Ding, F., Wang, H., DeLisa, M.P., Ke, A., Cas5d protein processes pre-crRNA and assembles into a Cascade-like interference complex in subtype I-C/Dvulg CRISPR-Cas system. Structure 20 (2012), 1574–1584.
-
(2012)
Structure
, vol.20
, pp. 1574-1584
-
-
Nam, K.H.1
Haitjema, C.2
Liu, X.3
Ding, F.4
Wang, H.5
DeLisa, M.P.6
Ke, A.7
-
160
-
-
84963940775
-
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
-
Nelson, C.E., Hakim, C.H., Ousterout, D.G., Thakore, P.I., Moreb, E.A., Castellanos Rivera, R.M., Madhavan, S., Pan, X., Ran, F.A., Yan, W.X., Asokan, A., Zhang, F., Duan, D., Gersbach, C.A., In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science 351 (2016), 403–407.
-
(2016)
Science
, vol.351
, pp. 403-407
-
-
Nelson, C.E.1
Hakim, C.H.2
Ousterout, D.G.3
Thakore, P.I.4
Moreb, E.A.5
Castellanos Rivera, R.M.6
Madhavan, S.7
Pan, X.8
Ran, F.A.9
Yan, W.X.10
Asokan, A.11
Zhang, F.12
Duan, D.13
Gersbach, C.A.14
-
161
-
-
85013159608
-
First-in-human CRISPR trial
-
News, First-in-human CRISPR trial. Nat. Biotechnol., 34, 2016, 796.
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 796
-
-
News1
-
162
-
-
84934936070
-
Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks
-
Nielsen, A.A., Voigt, C.A., Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks. Mol. Syst. Biol., 10, 2014, 763.
-
(2014)
Mol. Syst. Biol.
, vol.10
, pp. 763
-
-
Nielsen, A.A.1
Voigt, C.A.2
-
163
-
-
84896733529
-
Crystal structure of Cas9 in complex with guide RNA and target DNA
-
Nishimasu, H., Ran, F.A., Hsu, P.D., Konermann, S., Shehata, S.I., Dohmae, N., Ishitani, R., Zhang, F., Nureki, O., Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell 156 (2014), 935–949.
-
(2014)
Cell
, vol.156
, pp. 935-949
-
-
Nishimasu, H.1
Ran, F.A.2
Hsu, P.D.3
Konermann, S.4
Shehata, S.I.5
Dohmae, N.6
Ishitani, R.7
Zhang, F.8
Nureki, O.9
-
164
-
-
84924664059
-
Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity
-
Nunez, J.K., Lee, A.S., Engelman, A., Doudna, J.A., Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature 519 (2015), 193–198.
-
(2015)
Nature
, vol.519
, pp. 193-198
-
-
Nunez, J.K.1
Lee, A.S.2
Engelman, A.3
Doudna, J.A.4
-
165
-
-
84964315717
-
CRISPR-Cas9-assisted recombineering in Lactobacillus reuteri
-
e131
-
Oh, J.H., van Pijkeren, J.P., CRISPR-Cas9-assisted recombineering in Lactobacillus reuteri. Nucleic Acids Res., 42, 2014, e131.
-
(2014)
Nucleic Acids Res.
, vol.42
-
-
Oh, J.H.1
van Pijkeren, J.P.2
-
166
-
-
0025825737
-
Genetic improvement of Escherichia coli for ethanol production: chromosomal integration of Zymomonas mobilis genes encoding pyruvate decarboxylase and alcohol dehydrogenase II
-
Ohta, K., Beall, D.S., Mejia, J.P., Shanmugam, K.T., Ingram, L.O., Genetic improvement of Escherichia coli for ethanol production: chromosomal integration of Zymomonas mobilis genes encoding pyruvate decarboxylase and alcohol dehydrogenase II. Appl. Environ. Microbiol. 57 (1991), 893–900.
-
(1991)
Appl. Environ. Microbiol.
, vol.57
, pp. 893-900
-
-
Ohta, K.1
Beall, D.S.2
Mejia, J.P.3
Shanmugam, K.T.4
Ingram, L.O.5
-
167
-
-
84941143049
-
An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference
-
Peng, W., Feng, M., Feng, X., Liang, Y.X., She, Q., An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference. Nucleic Acids Res. 43 (2015), 406–417.
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 406-417
-
-
Peng, W.1
Feng, M.2
Feng, X.3
Liang, Y.X.4
She, Q.5
-
168
-
-
84884906690
-
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
-
Perez-Pinera, P., Kocak, D.D., Vockley, C.M., Adler, A.F., Kabadi, A.M., Polstein, L.R., Thakore, P.I., Glass, K.A., Ousterout, D.G., Leong, K.W., Guilak, F., Crawford, G.E., Reddy, T.E., Gersbach, C.A., RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods 10 (2013), 973–976.
-
(2013)
Nat. Methods
, vol.10
, pp. 973-976
-
-
Perez-Pinera, P.1
Kocak, D.D.2
Vockley, C.M.3
Adler, A.F.4
Kabadi, A.M.5
Polstein, L.R.6
Thakore, P.I.7
Glass, K.A.8
Ousterout, D.G.9
Leong, K.W.10
Guilak, F.11
Crawford, G.E.12
Reddy, T.E.13
Gersbach, C.A.14
-
169
-
-
84929593887
-
Codon compression algorithms for saturation mutagenesis
-
Pines, G., Pines, A., Garst, A.D., Zeitoun, R.I., Lynch, S.A., Gill, R.T., Codon compression algorithms for saturation mutagenesis. ACS Synth. Biol. 4 (2015), 604–614.
-
(2015)
ACS Synth. Biol.
, vol.4
, pp. 604-614
-
-
Pines, G.1
Pines, A.2
Garst, A.D.3
Zeitoun, R.I.4
Lynch, S.A.5
Gill, R.T.6
-
170
-
-
15844390228
-
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
-
Pourcel, C., Salvignol, G., Vergnaud, G., CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology 151 (2005), 653–663.
-
(2005)
Microbiology
, vol.151
, pp. 653-663
-
-
Pourcel, C.1
Salvignol, G.2
Vergnaud, G.3
-
171
-
-
84929206935
-
Cas9-mediated targeting of viral RNA in eukaryotic cells
-
Price, A.A., Sampson, T.R., Ratner, H.K., Grakoui, A., Weiss, D.S., Cas9-mediated targeting of viral RNA in eukaryotic cells. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 6164–6169.
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 6164-6169
-
-
Price, A.A.1
Sampson, T.R.2
Ratner, H.K.3
Grakoui, A.4
Weiss, D.S.5
-
172
-
-
84936967101
-
Coupling the CRISPR/Cas9 system with Lambda Red recombineering enables simplified chromosomal gene replacement in Escherichia coli
-
Pyne, M.E., Moo-Young, M., Chung, D.A., Chou, C.P., Coupling the CRISPR/Cas9 system with Lambda Red recombineering enables simplified chromosomal gene replacement in Escherichia coli. Appl. Environ. Microbiol. 81 (2015), 5103–5114.
-
(2015)
Appl. Environ. Microbiol.
, vol.81
, pp. 5103-5114
-
-
Pyne, M.E.1
Moo-Young, M.2
Chung, D.A.3
Chou, C.P.4
-
173
-
-
84971265340
-
Harnessing heterologous and endogenous CRISPR-Cas machineries for efficient markerless genome editing in Clostridium
-
Pyne, M.E., Bruder, M.R., Moo-Young, M., Chung, D.A., Chou, C.P., Harnessing heterologous and endogenous CRISPR-Cas machineries for efficient markerless genome editing in Clostridium. Sci. Rep., 6, 2016, 25666.
-
(2016)
Sci. Rep.
, vol.6
, pp. 25666
-
-
Pyne, M.E.1
Bruder, M.R.2
Moo-Young, M.3
Chung, D.A.4
Chou, C.P.5
-
174
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
-
Qi, L.S., Larson, M.H., Gilbert, L.A., Doudna, J.A., Weissman, J.S., Arkin, A.P., Lim, W.A., Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152 (2013), 1173–1183.
-
(2013)
Cell
, vol.152
, pp. 1173-1183
-
-
Qi, L.S.1
Larson, M.H.2
Gilbert, L.A.3
Doudna, J.A.4
Weissman, J.S.5
Arkin, A.P.6
Lim, W.A.7
-
175
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran, F.A., Hsu, P.D., Lin, C.Y., Gootenberg, J.S., Konermann, S., Trevino, A.E., Scott, D.A., Inoue, A., Matoba, S., Zhang, Y., Zhang, F., Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154 (2013), 1380–1389.
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
Hsu, P.D.2
Lin, C.Y.3
Gootenberg, J.S.4
Konermann, S.5
Trevino, A.E.6
Scott, D.A.7
Inoue, A.8
Matoba, S.9
Zhang, Y.10
Zhang, F.11
-
176
-
-
84941084368
-
Efficient programmable gene silencing by Cascade
-
Rath, D., Amlinger, L., Hoekzema, M., Devulapally, P.R., Lundgren, M., Efficient programmable gene silencing by Cascade. Nucleic Acids Res. 43 (2015), 237–246.
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 237-246
-
-
Rath, D.1
Amlinger, L.2
Hoekzema, M.3
Devulapally, P.R.4
Lundgren, M.5
-
177
-
-
84942079449
-
The CRISPR-Cas immune system: biology, mechanisms and applications
-
Rath, D., Amlinger, L., Rath, A., Lundgren, M., The CRISPR-Cas immune system: biology, mechanisms and applications. Biochimie 117 (2015), 119–128.
-
(2015)
Biochimie
, vol.117
, pp. 119-128
-
-
Rath, D.1
Amlinger, L.2
Rath, A.3
Lundgren, M.4
-
178
-
-
84944320385
-
The no-SCAR (Scarless Cas9 Assisted Recombineering) system for genome editing in Escherichia coli
-
Reisch, C.R., Prather, K.L., The no-SCAR (Scarless Cas9 Assisted Recombineering) system for genome editing in Escherichia coli. Sci. Rep., 5, 2015, 15096.
-
(2015)
Sci. Rep.
, vol.5
, pp. 15096
-
-
Reisch, C.R.1
Prather, K.L.2
-
179
-
-
84888108873
-
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
-
Ren, X., Sun, J., Housden, B.E., Hu, Y., Roesel, C., Lin, S., Liu, L.P., Yang, Z., Mao, D., Sun, L., Wu, Q., Ji, J.Y., Xi, J., Mohr, S.E., Xu, J., Perrimon, N., Ni, J.Q., Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 19012–19017.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 19012-19017
-
-
Ren, X.1
Sun, J.2
Housden, B.E.3
Hu, Y.4
Roesel, C.5
Lin, S.6
Liu, L.P.7
Yang, Z.8
Mao, D.9
Sun, L.10
Wu, Q.11
Ji, J.Y.12
Xi, J.13
Mohr, S.E.14
Xu, J.15
Perrimon, N.16
Ni, J.Q.17
-
180
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro, D.K., Paradise, E.M., Ouellet, M., Fisher, K.J., Newman, K.L., Ndungu, J.M., Ho, K.A., Eachus, R.A., Ham, T.S., Kirby, J., Chang, M.C., Withers, S.T., Shiba, Y., Sarpong, R., Keasling, J.D., Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440 (2006), 940–943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndungu, J.M.6
Ho, K.A.7
Eachus, R.A.8
Ham, T.S.9
Kirby, J.10
Chang, M.C.11
Withers, S.T.12
Shiba, Y.13
Sarpong, R.14
Keasling, J.D.15
-
181
-
-
84885336337
-
Structure of the CRISPR interference complex CSM reveals key similarities with cascade
-
Rouillon, C., Zhou, M., Zhang, J., Politis, A., Beilsten-Edmands, V., Cannone, G., Graham, S., Robinson, C.V., Spagnolo, L., White, M.F., Structure of the CRISPR interference complex CSM reveals key similarities with cascade. Mol. Cell 52 (2013), 124–134.
-
(2013)
Mol. Cell
, vol.52
, pp. 124-134
-
-
Rouillon, C.1
Zhou, M.2
Zhang, J.3
Politis, A.4
Beilsten-Edmands, V.5
Cannone, G.6
Graham, S.7
Robinson, C.V.8
Spagnolo, L.9
White, M.F.10
-
182
-
-
0016771381
-
Localization of transcribing genes in the bacterial cell by means of high resolution autoradiography
-
Ryter, A., Chang, A., Localization of transcribing genes in the bacterial cell by means of high resolution autoradiography. J. Mol. Biol. 98 (1975), 797–810.
-
(1975)
J. Mol. Biol.
, vol.98
, pp. 797-810
-
-
Ryter, A.1
Chang, A.2
-
183
-
-
84930085853
-
Co-transcriptional DNA and RNA cleavage during type III CRISPR-Cas immunity
-
Samai, P., Pyenson, N., Jiang, W., Goldberg, G.W., Hatoum-Aslan, A., Marraffini, L.A., Co-transcriptional DNA and RNA cleavage during type III CRISPR-Cas immunity. Cell 161 (2015), 1164–1174.
-
(2015)
Cell
, vol.161
, pp. 1164-1174
-
-
Samai, P.1
Pyenson, N.2
Jiang, W.3
Goldberg, G.W.4
Hatoum-Aslan, A.5
Marraffini, L.A.6
-
184
-
-
84877782955
-
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
-
Sampson, T.R., Saroj, S.D., Llewellyn, A.C., Tzeng, Y.L., Weiss, D.S., A CRISPR/Cas system mediates bacterial innate immune evasion and virulence. Nature 497 (2013), 254–257.
-
(2013)
Nature
, vol.497
, pp. 254-257
-
-
Sampson, T.R.1
Saroj, S.D.2
Llewellyn, A.C.3
Tzeng, Y.L.4
Weiss, D.S.5
-
185
-
-
84861990812
-
Mechanism of foreign DNA selection in a bacterial adaptive immune system
-
Sashital, D.G., Wiedenheft, B., Doudna, J.A., Mechanism of foreign DNA selection in a bacterial adaptive immune system. Mol. Cell 46 (2012), 606–615.
-
(2012)
Mol. Cell
, vol.46
, pp. 606-615
-
-
Sashital, D.G.1
Wiedenheft, B.2
Doudna, J.A.3
-
186
-
-
33745550745
-
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
-
Sebaihia, M., Wren, B.W., Mullany, P., Fairweather, N.F., Minton, N., Stabler, R., Thomson, N.R., Roberts, A.P., Cerdeno-Tarraga, A.M., Wang, H., Holden, M.T., Wright, A., Churcher, C., Quail, M.A., Baker, S., Bason, N., Brooks, K., Chillingworth, T., Cronin, A., Davis, P., Dowd, L., Fraser, A., Feltwell, T., Hance, Z., Holroyd, S., Jagels, K., Moule, S., Mungall, K., Price, C., Rabbinowitsch, E., Sharp, S., Simmonds, M., Stevens, K., Unwin, L., Whithead, S., Dupuy, B., Dougan, G., Barrell, B., Parkhill, J., The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat. Genet. 38 (2006), 779–786.
-
(2006)
Nat. Genet.
, vol.38
, pp. 779-786
-
-
Sebaihia, M.1
Wren, B.W.2
Mullany, P.3
Fairweather, N.F.4
Minton, N.5
Stabler, R.6
Thomson, N.R.7
Roberts, A.P.8
Cerdeno-Tarraga, A.M.9
Wang, H.10
Holden, M.T.11
Wright, A.12
Churcher, C.13
Quail, M.A.14
Baker, S.15
Bason, N.16
Brooks, K.17
Chillingworth, T.18
Cronin, A.19
Davis, P.20
Dowd, L.21
Fraser, A.22
Feltwell, T.23
Hance, Z.24
Holroyd, S.25
Jagels, K.26
Moule, S.27
Mungall, K.28
Price, C.29
Rabbinowitsch, E.30
Sharp, S.31
Simmonds, M.32
Stevens, K.33
Unwin, L.34
Whithead, S.35
Dupuy, B.36
Dougan, G.37
Barrell, B.38
Parkhill, J.39
more..
-
187
-
-
84874388110
-
A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity
-
Seed, K.D., Lazinski, D.W., Calderwood, S.B., Camilli, A., A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity. Nature 494 (2013), 489–491.
-
(2013)
Nature
, vol.494
, pp. 489-491
-
-
Seed, K.D.1
Lazinski, D.W.2
Calderwood, S.B.3
Camilli, A.4
-
188
-
-
84937886246
-
CRISPR-based screening of genomic island excision events in bacteria
-
Selle, K., Klaenhammer, T.R., Barrangou, R., CRISPR-based screening of genomic island excision events in bacteria. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 8076–8081.
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 8076-8081
-
-
Selle, K.1
Klaenhammer, T.R.2
Barrangou, R.3
-
189
-
-
85042815594
-
Targeted genome modification of crop plants using a CRISPR-Cas system
-
Shan, Q., Wang, Y., Li, J., Zhang, Y., Chen, K., Liang, Z., Zhang, K., Liu, J., Xi, J.J., Qiu, J.-L., Gao, C., Targeted genome modification of crop plants using a CRISPR-Cas system. Nat. Biotechnol. 31 (2013), 686–688.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 686-688
-
-
Shan, Q.1
Wang, Y.2
Li, J.3
Zhang, Y.4
Chen, K.5
Liang, Z.6
Zhang, K.7
Liu, J.8
Xi, J.J.9
Qiu, J.-L.10
Gao, C.11
-
190
-
-
84944176468
-
Characterization and evolution of Salmonella CRISPR-Cas systems
-
Shariat, N., Timme, R.E., Pettengill, J.B., Barrangou, R., Dudley, E.G., Characterization and evolution of Salmonella CRISPR-Cas systems. Microbiology 161 (2015), 374–386.
-
(2015)
Microbiology
, vol.161
, pp. 374-386
-
-
Shariat, N.1
Timme, R.E.2
Pettengill, J.B.3
Barrangou, R.4
Dudley, E.G.5
-
191
-
-
84897954175
-
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
-
Shen, B., Zhang, W., Zhang, J., Zhou, J., Wang, J., Chen, L., Wang, L., Hodgkins, A., Iyer, V., Huang, X., Skarnes, W.C., Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat. Methods 11 (2014), 399–402.
-
(2014)
Nat. Methods
, vol.11
, pp. 399-402
-
-
Shen, B.1
Zhang, W.2
Zhang, J.3
Zhou, J.4
Wang, J.5
Chen, L.6
Wang, L.7
Hodgkins, A.8
Iyer, V.9
Huang, X.10
Skarnes, W.C.11
-
192
-
-
84947736727
-
Discovery and functional characterization of diverse class 2 CRISPR-Cas systems
-
Shmakov, S., Abudayyeh, O.O., Makarova, K.S., Wolf, Y.I., Gootenberg, J.S., Semenova, E., Minakhin, L., Joung, J., Konermann, S., Severinov, K., Zhang, F., Koonin, E.V., Discovery and functional characterization of diverse class 2 CRISPR-Cas systems. Mol. Cell 60 (2015), 385–397.
-
(2015)
Mol. Cell
, vol.60
, pp. 385-397
-
-
Shmakov, S.1
Abudayyeh, O.O.2
Makarova, K.S.3
Wolf, Y.I.4
Gootenberg, J.S.5
Semenova, E.6
Minakhin, L.7
Joung, J.8
Konermann, S.9
Severinov, K.10
Zhang, F.11
Koonin, E.V.12
-
193
-
-
35348890199
-
Bacterial DNA repair by non-homologous end joining
-
Shuman, S., Glickman, M.S., Bacterial DNA repair by non-homologous end joining. Nat. Rev. Microbiol. 5 (2007), 852–861.
-
(2007)
Nat. Rev. Microbiol.
, vol.5
, pp. 852-861
-
-
Shuman, S.1
Glickman, M.S.2
-
194
-
-
84995362982
-
RNA-directed DNA cleavage by the Cas9-crRNA complex
-
WO patent 2013142578.
-
Siksnys, V., Gasiunas, G., Karvelis, T., Lubys, A., Zaliauskiene, L., Glemzaite, M., Smith, A. 2013. RNA-directed DNA cleavage by the Cas9-crRNA complex. WO patent 2013142578.
-
(2013)
-
-
Siksnys, V.1
Gasiunas, G.2
Karvelis, T.3
Lubys, A.4
Zaliauskiene, L.5
Glemzaite, M.6
Smith, A.7
-
195
-
-
84992170651
-
Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system
-
Singh, A.K., Carette, X., Potluri, L.P., Sharp, J.D., Xu, R., Prisic, S., Husson, R.N., Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system. Nucleic Acids Res., 2016.
-
(2016)
Nucleic Acids Res.
-
-
Singh, A.K.1
Carette, X.2
Potluri, L.P.3
Sharp, J.D.4
Xu, R.5
Prisic, S.6
Husson, R.N.7
-
196
-
-
84873571066
-
In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus
-
Sinkunas, T., Gasiunas, G., Waghmare, S.P., Dickman, M.J., Barrangou, R., Horvath, P., Siksnys, V., In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus. EMBO J. 32 (2013), 385–394.
-
(2013)
EMBO J.
, vol.32
, pp. 385-394
-
-
Sinkunas, T.1
Gasiunas, G.2
Waghmare, S.P.3
Dickman, M.J.4
Barrangou, R.5
Horvath, P.6
Siksnys, V.7
-
197
-
-
78149449833
-
Use of cellular CRISPR (clusters of regularly interspaced short palindromic repeats) spacer-based microarrays for detection of viruses in environmental samples
-
Snyder, J.C., Bateson, M.M., Lavin, M., Young, M.J., Use of cellular CRISPR (clusters of regularly interspaced short palindromic repeats) spacer-based microarrays for detection of viruses in environmental samples. Appl. Environ. Microbiol. 76 (2010), 7251–7258.
-
(2010)
Appl. Environ. Microbiol.
, vol.76
, pp. 7251-7258
-
-
Snyder, J.C.1
Bateson, M.M.2
Lavin, M.3
Young, M.J.4
-
198
-
-
84879744424
-
Rapid one-step inactivation of single or multiple genes in Escherichia coli
-
Song, C.W., Lee, S.Y., Rapid one-step inactivation of single or multiple genes in Escherichia coli. Biotechnol. J. 8 (2013), 776–784.
-
(2013)
Biotechnol. J.
, vol.8
, pp. 776-784
-
-
Song, C.W.1
Lee, S.Y.2
-
199
-
-
33747889217
-
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
-
Sonoda, E., Hochegger, H., Saberi, A., Taniguchi, Y., Takeda, S., Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst.) 5 (2006), 1021–1029.
-
(2006)
DNA Repair (Amst.)
, vol.5
, pp. 1021-1029
-
-
Sonoda, E.1
Hochegger, H.2
Saberi, A.3
Taniguchi, Y.4
Takeda, S.5
-
200
-
-
84885355637
-
Structure of an RNA silencing complex of the CRISPR-Cas immune system
-
Spilman, M., Cocozaki, A., Hale, C., Shao, Y., Ramia, N., Terns, R., Terns, M., Li, H., Stagg, S., Structure of an RNA silencing complex of the CRISPR-Cas immune system. Mol. Cell 52 (2013), 146–152.
-
(2013)
Mol. Cell
, vol.52
, pp. 146-152
-
-
Spilman, M.1
Cocozaki, A.2
Hale, C.3
Shao, Y.4
Ramia, N.5
Terns, R.6
Terns, M.7
Li, H.8
Stagg, S.9
-
201
-
-
84885334898
-
Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus
-
Staals, R.H., Agari, Y., Maki-Yonekura, S., Zhu, Y., Taylor, D.W., van Duijn, E., Barendregt, A., Vlot, M., Koehorst, J.J., Sakamoto, K., Masuda, A., Dohmae, N., Schaap, P.J., Doudna, J.A., Heck, A.J., Yonekura, K., van der Oost, J., Shinkai, A., Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus. Mol. Cell 52 (2013), 135–145.
-
(2013)
Mol. Cell
, vol.52
, pp. 135-145
-
-
Staals, R.H.1
Agari, Y.2
Maki-Yonekura, S.3
Zhu, Y.4
Taylor, D.W.5
van Duijn, E.6
Barendregt, A.7
Vlot, M.8
Koehorst, J.J.9
Sakamoto, K.10
Masuda, A.11
Dohmae, N.12
Schaap, P.J.13
Doudna, J.A.14
Heck, A.J.15
Yonekura, K.16
van der Oost, J.17
Shinkai, A.18
-
202
-
-
84947999145
-
Targeted large-scale deletion of bacterial genomes using CRISPR-nickases
-
Standage-Beier, K., Zhang, Q., Wang, X., Targeted large-scale deletion of bacterial genomes using CRISPR-nickases. ACS Synth. Biol. 4 (2015), 1217–1225.
-
(2015)
ACS Synth. Biol.
, vol.4
, pp. 1217-1225
-
-
Standage-Beier, K.1
Zhang, Q.2
Wang, X.3
-
203
-
-
77955085897
-
Self-targeting by CRISPR: gene regulation or autoimmunity?
-
Stern, A., Keren, L., Wurtzel, O., Amitai, G., Sorek, R., Self-targeting by CRISPR: gene regulation or autoimmunity?. Trends Genet. 26 (2010), 335–340.
-
(2010)
Trends Genet.
, vol.26
, pp. 335-340
-
-
Stern, A.1
Keren, L.2
Wurtzel, O.3
Amitai, G.4
Sorek, R.5
-
204
-
-
84865169354
-
CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome
-
Stern, A., Mick, E., Tirosh, I., Sagy, O., Sorek, R., CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome. Genome Res. 22 (2012), 1985–1994.
-
(2012)
Genome Res.
, vol.22
, pp. 1985-1994
-
-
Stern, A.1
Mick, E.2
Tirosh, I.3
Sagy, O.4
Sorek, R.5
-
205
-
-
84895871173
-
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
-
Sternberg, S.H., Redding, S., Jinek, M., Greene, E.C., Doudna, J.A., DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507 (2014), 62–67.
-
(2014)
Nature
, vol.507
, pp. 62-67
-
-
Sternberg, S.H.1
Redding, S.2
Jinek, M.3
Greene, E.C.4
Doudna, J.A.5
-
206
-
-
84894177844
-
Transformation of biomass into commodity chemicals using enzymes or cells
-
Straathof, A.J.J., Transformation of biomass into commodity chemicals using enzymes or cells. Chem. Rev. 114 (2014), 1871–1908.
-
(2014)
Chem. Rev.
, vol.114
, pp. 1871-1908
-
-
Straathof, A.J.J.1
-
207
-
-
33646837331
-
Engineered bacteriophage-defence systems in bioprocessing
-
Sturino, J.M., Klaenhammer, T.R., Engineered bacteriophage-defence systems in bioprocessing. Nat. Rev. Microbiol. 4 (2006), 395–404.
-
(2006)
Nat. Rev. Microbiol.
, vol.4
, pp. 395-404
-
-
Sturino, J.M.1
Klaenhammer, T.R.2
-
208
-
-
84921277835
-
Association of CRISPR/Cas evolution with Vibrio parahaemolyticus virulence factors and genotypes
-
Sun, H., Li, Y., Shi, X., Lin, Y., Qiu, Y., Zhang, J., Liu, Y., Jiang, M., Zhang, Z., Chen, Q., Sun, Q., Hu, Q., Association of CRISPR/Cas evolution with Vibrio parahaemolyticus virulence factors and genotypes. Foodborne Pathog. Dis. 12 (2015), 68–73.
-
(2015)
Foodborne Pathog. Dis.
, vol.12
, pp. 68-73
-
-
Sun, H.1
Li, Y.2
Shi, X.3
Lin, Y.4
Qiu, Y.5
Zhang, J.6
Liu, Y.7
Jiang, M.8
Zhang, Z.9
Chen, Q.10
Sun, Q.11
Hu, Q.12
-
209
-
-
84860433123
-
CRISPR interference directs strand specific spacer acquisition
-
e35888
-
Swarts, D.C., Mosterd, C., van Passel, M.W., Brouns, S.J., CRISPR interference directs strand specific spacer acquisition. PLoS One, 7, 2012, e35888.
-
(2012)
PLoS One
, vol.7
-
-
Swarts, D.C.1
Mosterd, C.2
van Passel, M.W.3
Brouns, S.J.4
-
210
-
-
84908604171
-
The evolutionary journey of Argonaute proteins
-
Swarts, D.C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R.F., Koonin, E.V., Patel, D.J., van der Oost, J., The evolutionary journey of Argonaute proteins. Nat. Struct. Mol. Biol. 21 (2014), 743–753.
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 743-753
-
-
Swarts, D.C.1
Makarova, K.2
Wang, Y.3
Nakanishi, K.4
Ketting, R.F.5
Koonin, E.V.6
Patel, D.J.7
van der Oost, J.8
-
211
-
-
84912096635
-
Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus
-
Tamulaitis, G., Kazlauskiene, M., Manakova, E., Venclovas, C., Nwokeoji, A.O., Dickman, M.J., Horvath, P., Siksnys, V., Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus. Mol. Cell 56 (2014), 506–517.
-
(2014)
Mol. Cell
, vol.56
, pp. 506-517
-
-
Tamulaitis, G.1
Kazlauskiene, M.2
Manakova, E.3
Venclovas, C.4
Nwokeoji, A.O.5
Dickman, M.J.6
Horvath, P.7
Siksnys, V.8
-
212
-
-
84908328232
-
A protein-tagging system for signal amplification in gene expression and fluorescence imaging
-
Tanenbaum, M.E., Gilbert, L.A., Qi, L.S., Weissman, J.S., Vale, R.D., A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell 159 (2014), 635–646.
-
(2014)
Cell
, vol.159
, pp. 635-646
-
-
Tanenbaum, M.E.1
Gilbert, L.A.2
Qi, L.S.3
Weissman, J.S.4
Vale, R.D.5
-
213
-
-
0037188531
-
Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus
-
Tang, T.H., Bachellerie, J.P., Rozhdestvensky, T., Bortolin, M.L., Huber, H., Drungowski, M., Elge, T., Brosius, J., Huttenhofer, A., Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 7536–7541.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 7536-7541
-
-
Tang, T.H.1
Bachellerie, J.P.2
Rozhdestvensky, T.3
Bortolin, M.L.4
Huber, H.5
Drungowski, M.6
Elge, T.7
Brosius, J.8
Huttenhofer, A.9
-
214
-
-
13144269598
-
Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus
-
Tang, T.H., Polacek, N., Zywicki, M., Huber, H., Brugger, K., Garrett, R., Bachellerie, J.P., Huttenhofer, A., Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus. Mol. Microbiol. 55 (2005), 469–481.
-
(2005)
Mol. Microbiol.
, vol.55
, pp. 469-481
-
-
Tang, T.H.1
Polacek, N.2
Zywicki, M.3
Huber, H.4
Brugger, K.5
Garrett, R.6
Bachellerie, J.P.7
Huttenhofer, A.8
-
215
-
-
84940106526
-
CRISPR-Cas9 based engineering of actinomycetal genomes
-
Tong, Y., Charusanti, P., Zhang, L., Weber, T., Lee, S.Y., CRISPR-Cas9 based engineering of actinomycetal genomes. ACS Synth. Biol. 4 (2015), 1020–1029.
-
(2015)
ACS Synth. Biol.
, vol.4
, pp. 1020-1029
-
-
Tong, Y.1
Charusanti, P.2
Zhang, L.3
Weber, T.4
Lee, S.Y.5
-
216
-
-
77957262402
-
Bacterial chromosome organization and segregation
-
Toro, E., Shapiro, L., Bacterial chromosome organization and segregation. Cold Spring Harb. Perspect. Biol., 2, 2010, a000349.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
, pp. a000349
-
-
Toro, E.1
Shapiro, L.2
-
217
-
-
84893415098
-
Association of clustered regularly interspaced short palindromic repeat (CRISPR) elements with specific serotypes and virulence potential of shiga toxin-producing Escherichia coli
-
Toro, M., Cao, G., Ju, W., Allard, M., Barrangou, R., Zhao, S., Brown, E., Meng, J., Association of clustered regularly interspaced short palindromic repeat (CRISPR) elements with specific serotypes and virulence potential of shiga toxin-producing Escherichia coli. Appl. Environ. Microbiol. 80 (2014), 1411–1420.
-
(2014)
Appl. Environ. Microbiol.
, vol.80
, pp. 1411-1420
-
-
Toro, M.1
Cao, G.2
Ju, W.3
Allard, M.4
Barrangou, R.5
Zhao, S.6
Brown, E.7
Meng, J.8
-
218
-
-
84902204289
-
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
-
Tsai, S.Q., Wyvekens, N., Khayter, C., Foden, J.A., Thapar, V., Reyon, D., Goodwin, M.J., Aryee, M.J., Joung, J.K., Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat. Biotechnol. 32 (2014), 569–576.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 569-576
-
-
Tsai, S.Q.1
Wyvekens, N.2
Khayter, C.3
Foden, J.A.4
Thapar, V.5
Reyon, D.6
Goodwin, M.J.7
Aryee, M.J.8
Joung, J.K.9
-
219
-
-
84902533278
-
Unravelling the structural and mechanistic basis of CRISPR-Cas systems
-
van der Oost, J., Westra, E.R., Jackson, R.N., Wiedenheft, B., Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nat. Rev. Microbiol. 12 (2014), 479–492.
-
(2014)
Nat. Rev. Microbiol.
, vol.12
, pp. 479-492
-
-
van der Oost, J.1
Westra, E.R.2
Jackson, R.N.3
Wiedenheft, B.4
-
220
-
-
84876845227
-
Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands
-
e1003454
-
Vercoe, R.B., Chang, J.T., Dy, R.L., Taylor, C., Gristwood, T., Clulow, J.S., Richter, C., Przybilski, R., Pitman, A.R., Fineran, P.C., Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands. PLoS Genet., 9, 2013, e1003454.
-
(2013)
PLoS Genet.
, vol.9
-
-
Vercoe, R.B.1
Chang, J.T.2
Dy, R.L.3
Taylor, C.4
Gristwood, T.5
Clulow, J.S.6
Richter, C.7
Przybilski, R.8
Pitman, A.R.9
Fineran, P.C.10
-
221
-
-
3042548402
-
Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication
-
Viollier, P.H., Thanbichler, M., McGrath, P.T., West, L., Meewan, M., McAdams, H.H., Shapiro, L., Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 9257–9262.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 9257-9262
-
-
Viollier, P.H.1
Thanbichler, M.2
McGrath, P.T.3
West, L.4
Meewan, M.5
McAdams, H.H.6
Shapiro, L.7
-
222
-
-
84964414181
-
Gene-edited CRISPR mushroom escapes US regulation
-
Waltz, E., Gene-edited CRISPR mushroom escapes US regulation. Nature, 532, 2016, 293.
-
(2016)
Nature
, vol.532
, pp. 293
-
-
Waltz, E.1
-
223
-
-
68949161807
-
Programming cells by multiplex genome engineering and accelerated evolution
-
Wang, H.H., Isaacs, F.J., Carr, P.A., Sun, Z.Z., Xu, G., Forest, C.R., Church, G.M., Programming cells by multiplex genome engineering and accelerated evolution. Nature 460 (2009), 894–898.
-
(2009)
Nature
, vol.460
, pp. 894-898
-
-
Wang, H.H.1
Isaacs, F.J.2
Carr, P.A.3
Sun, Z.Z.4
Xu, G.5
Forest, C.R.6
Church, G.M.7
-
224
-
-
84892749369
-
Genetic screens in human cells using the CRISPR-Cas9 system
-
Wang, T., Wei, J.J., Sabatini, D.M., Lander, E.S., Genetic screens in human cells using the CRISPR-Cas9 system. Science 343 (2014), 80–84.
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
Lander, E.S.4
-
225
-
-
84924425397
-
Markerless chromosomal gene deletion in Clostridium beijerinckii using CRISPR/Cas9 system
-
Wang, Y., Zhang, Z.T., Seo, S.O., Choi, K., Lu, T., Jin, Y.S., Blaschek, H.P., Markerless chromosomal gene deletion in Clostridium beijerinckii using CRISPR/Cas9 system. J. Biotechnol. 200 (2015), 1–5.
-
(2015)
J. Biotechnol.
, vol.200
, pp. 1-5
-
-
Wang, Y.1
Zhang, Z.T.2
Seo, S.O.3
Choi, K.4
Lu, T.5
Jin, Y.S.6
Blaschek, H.P.7
-
226
-
-
84950277538
-
Microbial production of value-added nutraceuticals
-
Wang, J., Guleria, S., Koffas, M.A., Yan, Y., Microbial production of value-added nutraceuticals. Curr. Opin. Biotechnol. 37 (2016), 97–104.
-
(2016)
Curr. Opin. Biotechnol.
, vol.37
, pp. 97-104
-
-
Wang, J.1
Guleria, S.2
Koffas, M.A.3
Yan, Y.4
-
227
-
-
84978699037
-
Bacterial genome editing with CRISPR-Cas9: deletion, integration, single nucleotide modification, and desirable “clean” mutant selection in Clostridium beijerinckii as an example
-
Wang, Y., Zhang, Z.T., Seo, S.O., Lynn, P., Lu, T., Jin, Y.S., Blaschek, H.P., Bacterial genome editing with CRISPR-Cas9: deletion, integration, single nucleotide modification, and desirable “clean” mutant selection in Clostridium beijerinckii as an example. ACS Synth. Biol., 2016, 10.1021/acssynbio.6b00060.
-
(2016)
ACS Synth. Biol.
-
-
Wang, Y.1
Zhang, Z.T.2
Seo, S.O.3
Lynn, P.4
Lu, T.5
Jin, Y.S.6
Blaschek, H.P.7
-
228
-
-
84975485770
-
Gene transcription repression in Clostridium beijerinckii using CRISPR-dCas9
-
Wang, Y., Zhang, Z.T., Seo, S.O., Lynn, P., Lu, T., Jin, Y.S., Blaschek, H.P., Gene transcription repression in Clostridium beijerinckii using CRISPR-dCas9. Biotechnol. Bioeng., 2016, 10.1002/bit.26020.
-
(2016)
Biotechnol. Bioeng.
-
-
Wang, Y.1
Zhang, Z.T.2
Seo, S.O.3
Lynn, P.4
Lu, T.5
Jin, Y.S.6
Blaschek, H.P.7
-
229
-
-
84922998282
-
Cas9 function and host genome sampling in type II-A CRISPR-Cas adaptation
-
Wei, Y., Terns, R.M., Terns, M.P., Cas9 function and host genome sampling in type II-A CRISPR-Cas adaptation. Genes Dev. 29 (2015), 356–361.
-
(2015)
Genes Dev.
, vol.29
, pp. 356-361
-
-
Wei, Y.1
Terns, R.M.2
Terns, M.P.3
-
230
-
-
84978153360
-
CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973
-
Wendt, K.E., Ungerer, J., Cobb, R.E., Zhao, H., Pakrasi, H.B., CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973. Microb. Cell Fact., 15, 2016, 115.
-
(2016)
Microb. Cell Fact.
, vol.15
, pp. 115
-
-
Wendt, K.E.1
Ungerer, J.2
Cobb, R.E.3
Zhao, H.4
Pakrasi, H.B.5
-
231
-
-
84903436527
-
Spatial organization of transcription in bacterial cells
-
Weng, X., Xiao, J., Spatial organization of transcription in bacterial cells. Trends Genet. 30 (2014), 287–297.
-
(2014)
Trends Genet.
, vol.30
, pp. 287-297
-
-
Weng, X.1
Xiao, J.2
-
232
-
-
84982107482
-
Development of a CRISPR-Cas9 toolkit for comprehensive engineering of Bacillus subtilis
-
Westbrook, A.W., Moo-Young, M., Chou, C.P., Development of a CRISPR-Cas9 toolkit for comprehensive engineering of Bacillus subtilis. Appl. Environ. Microbiol., 2016, 10.1128/AEM.01159-16.
-
(2016)
Appl. Environ. Microbiol.
-
-
Westbrook, A.W.1
Moo-Young, M.2
Chou, C.P.3
-
233
-
-
84868125172
-
Cascade-mediated binding and bending of negatively supercoiled DNA
-
Westra, E.R., Nilges, B., van Erp, P.B., van der Oost, J., Dame, R.T., Brouns, S.J., Cascade-mediated binding and bending of negatively supercoiled DNA. RNA Biol. 9 (2012), 1134–1138.
-
(2012)
RNA Biol.
, vol.9
, pp. 1134-1138
-
-
Westra, E.R.1
Nilges, B.2
van Erp, P.B.3
van der Oost, J.4
Dame, R.T.5
Brouns, S.J.6
-
234
-
-
84861996069
-
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
-
Westra, E.R., van Erp, P.B., Kunne, T., Wong, S.P., Staals, R.H., Seegers, C.L., Bollen, S., Jore, M.M., Semenova, E., Severinov, K., de Vos, W.M., Dame, R.T., de Vries, R., Brouns, S.J., van der Oost, J., CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3. Mol. Cell 46 (2012), 595–605.
-
(2012)
Mol. Cell
, vol.46
, pp. 595-605
-
-
Westra, E.R.1
van Erp, P.B.2
Kunne, T.3
Wong, S.P.4
Staals, R.H.5
Seegers, C.L.6
Bollen, S.7
Jore, M.M.8
Semenova, E.9
Severinov, K.10
de Vos, W.M.11
Dame, R.T.12
de Vries, R.13
Brouns, S.J.14
van der Oost, J.15
-
235
-
-
84899105533
-
CRISPR-Cas systems: beyond adaptive immunity
-
Westra, E.R., Buckling, A., Fineran, P.C., CRISPR-Cas systems: beyond adaptive immunity. Nat. Rev. Microbiol. 12 (2014), 317–326.
-
(2014)
Nat. Rev. Microbiol.
, vol.12
, pp. 317-326
-
-
Westra, E.R.1
Buckling, A.2
Fineran, P.C.3
-
236
-
-
80053169737
-
Structures of the RNA-guided surveillance complex from a bacterial immune system
-
Wiedenheft, B., Lander, G.C., Zhou, K., Jore, M.M., Brouns, S.J., van der Oost, J., Doudna, J.A., Nogales, E., Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature 477 (2011), 486–489.
-
(2011)
Nature
, vol.477
, pp. 486-489
-
-
Wiedenheft, B.1
Lander, G.C.2
Zhou, K.3
Jore, M.M.4
Brouns, S.J.5
van der Oost, J.6
Doudna, J.A.7
Nogales, E.8
-
237
-
-
84974784754
-
Targeted genome editing in the rare actinomycete Actinoplanes sp. SE50/110 by using the CRIPSR/Cas9 System
-
Wolf, T., Gren, T., Thieme, E., Wibberg, D., Zemke, T., Puhler, A., Kalinowski, J., Targeted genome editing in the rare actinomycete Actinoplanes sp. SE50/110 by using the CRIPSR/Cas9 System. J. Biotechnol., 2016, 10.1016/j.jbiotec.2016.05.039.
-
(2016)
J. Biotechnol.
-
-
Wolf, T.1
Gren, T.2
Thieme, E.3
Wibberg, D.4
Zemke, T.5
Puhler, A.6
Kalinowski, J.7
-
238
-
-
84986003578
-
Towards correlative super-resolution fluorescence and electron cryo-microscopy
-
Wolff, G., Hagen, C., Grunewald, K., Kaufmann, R., Towards correlative super-resolution fluorescence and electron cryo-microscopy. Biol. Cell., 2016, 10.1111/boc.201600008.
-
(2016)
Biol. Cell.
-
-
Wolff, G.1
Hagen, C.2
Grunewald, K.3
Kaufmann, R.4
-
239
-
-
84902095352
-
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
-
Wu, X., Scott, D.A., Kriz, A.J., Chiu, A.C., Hsu, P.D., Dadon, D.B., Cheng, A.W., Trevino, A.E., Konermann, S., Chen, S., Jaenisch, R., Zhang, F., Sharp, P.A., Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat. Biotechnol. 32 (2014), 670–676.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 670-676
-
-
Wu, X.1
Scott, D.A.2
Kriz, A.J.3
Chiu, A.C.4
Hsu, P.D.5
Dadon, D.B.6
Cheng, A.W.7
Trevino, A.E.8
Konermann, S.9
Chen, S.10
Jaenisch, R.11
Zhang, F.12
Sharp, P.A.13
-
240
-
-
84953635026
-
Expression of Shewanella frigidimarina fatty acid metabolic genes in E. coli by CRISPR/Cas9-coupled Lambda Red recombineering
-
Xia, J., Wang, L., Zhu, J.B., Sun, C.J., Zheng, M.G., Zheng, L., Lou, Y.H., Shi, L., Expression of Shewanella frigidimarina fatty acid metabolic genes in E. coli by CRISPR/Cas9-coupled Lambda Red recombineering. Biotechnol. Lett. 38 (2016), 117–122.
-
(2016)
Biotechnol. Lett.
, vol.38
, pp. 117-122
-
-
Xia, J.1
Wang, L.2
Zhu, J.B.3
Sun, C.J.4
Zheng, M.G.5
Zheng, L.6
Lou, Y.H.7
Shi, L.8
-
241
-
-
84930787559
-
Efficient genome editing in Clostridium cellulolyticum via CRISPR-Cas9 nickase
-
Xu, T., Li, Y., Shi, Z., Hemme, C.L., Li, Y., Zhu, Y., Van Nostrand, J.D., He, Z., Zhou, J., Efficient genome editing in Clostridium cellulolyticum via CRISPR-Cas9 nickase. Appl. Environ. Microbiol. 81 (2015), 4423–4431.
-
(2015)
Appl. Environ. Microbiol.
, vol.81
, pp. 4423-4431
-
-
Xu, T.1
Li, Y.2
Shi, Z.3
Hemme, C.L.4
Li, Y.5
Zhu, Y.6
Van Nostrand, J.D.7
He, Z.8
Zhou, J.9
-
242
-
-
84963973892
-
Crystal structure of Cpf1 in complex with guide RNA and target DNA
-
Yamano, T., Nishimasu, H., Zetsche, B., Hirano, H., Slaymaker, I.M., Li, Y., Fedorova, I., Nakane, T., Makarova, K.S., Koonin, E.V., Ishitani, R., Zhang, F., Nureki, O., Crystal structure of Cpf1 in complex with guide RNA and target DNA. Cell 165 (2016), 949–962.
-
(2016)
Cell
, vol.165
, pp. 949-962
-
-
Yamano, T.1
Nishimasu, H.2
Zetsche, B.3
Hirano, H.4
Slaymaker, I.M.5
Li, Y.6
Fedorova, I.7
Nakane, T.8
Makarova, K.S.9
Koonin, E.V.10
Ishitani, R.11
Zhang, F.12
Nureki, O.13
-
243
-
-
84884263150
-
The evolutionary divergence of Shiga toxin-producing Escherichia coli is reflected in clustered regularly interspaced short palindromic repeat (CRISPR) spacer composition
-
Yin, S., Jensen, M.A., Bai, J., Debroy, C., Barrangou, R., Dudley, E.G., The evolutionary divergence of Shiga toxin-producing Escherichia coli is reflected in clustered regularly interspaced short palindromic repeat (CRISPR) spacer composition. Appl. Environ. Microbiol. 79 (2013), 5710–5720.
-
(2013)
Appl. Environ. Microbiol.
, vol.79
, pp. 5710-5720
-
-
Yin, S.1
Jensen, M.A.2
Bai, J.3
Debroy, C.4
Barrangou, R.5
Dudley, E.G.6
-
244
-
-
84902095353
-
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
-
Yin, H., Xue, W., Chen, S., Bogorad, R.L., Benedetti, E., Grompe, M., Koteliansky, V., Sharp, P.A., Jacks, T., Anderson, D.G., Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat. Biotechnol. 32 (2014), 551–553.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 551-553
-
-
Yin, H.1
Xue, W.2
Chen, S.3
Bogorad, R.L.4
Benedetti, E.5
Grompe, M.6
Koteliansky, V.7
Sharp, P.A.8
Jacks, T.9
Anderson, D.G.10
-
245
-
-
84861639567
-
Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli
-
Yosef, I., Goren, M.G., Qimron, U., Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli. Nucleic Acids Res. 40 (2012), 5569–5576.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 5569-5576
-
-
Yosef, I.1
Goren, M.G.2
Qimron, U.3
-
246
-
-
23144438396
-
Crystal structure of A. aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage
-
Yuan, Y.R., Pei, Y., Ma, J.B., Kuryavyi, V., Zhadina, M., Meister, G., Chen, H.Y., Dauter, Z., Tuschl, T., Patel, D.J., Crystal structure of A. aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol. Cell 19 (2005), 405–419.
-
(2005)
Mol. Cell
, vol.19
, pp. 405-419
-
-
Yuan, Y.R.1
Pei, Y.2
Ma, J.B.3
Kuryavyi, V.4
Zhadina, M.5
Meister, G.6
Chen, H.Y.7
Dauter, Z.8
Tuschl, T.9
Patel, D.J.10
-
247
-
-
84899048370
-
CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus
-
Zebec, Z., Manica, A., Zhang, J., White, M.F., Schleper, C., CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus. Nucleic Acids Res. 42 (2014), 5280–5288.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 5280-5288
-
-
Zebec, Z.1
Manica, A.2
Zhang, J.3
White, M.F.4
Schleper, C.5
-
248
-
-
84948382257
-
Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system
-
Zeng, H., Wen, S., Xu, W., He, Z., Zhai, G., Liu, Y., Deng, Z., Sun, Y., Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system. Appl. Microbiol. Biotechnol. 99 (2015), 10575–10585.
-
(2015)
Appl. Microbiol. Biotechnol.
, vol.99
, pp. 10575-10585
-
-
Zeng, H.1
Wen, S.2
Xu, W.3
He, Z.4
Zhai, G.5
Liu, Y.6
Deng, Z.7
Sun, Y.8
-
249
-
-
84975678715
-
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system
-
Zetsche, B., Gootenberg, J.S., Abudayyeh, O.O., Slaymaker, I.M., Makarova, K.S., Essletzbichler, P., Volz, S.E., Joung, J., van der Oost, J., Regev, A., Koonin, E.V., Zhang, F., Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell 163 (2015), 759–771.
-
(2015)
Cell
, vol.163
, pp. 759-771
-
-
Zetsche, B.1
Gootenberg, J.S.2
Abudayyeh, O.O.3
Slaymaker, I.M.4
Makarova, K.S.5
Essletzbichler, P.6
Volz, S.E.7
Joung, J.8
van der Oost, J.9
Regev, A.10
Koonin, E.V.11
Zhang, F.12
-
250
-
-
84924322903
-
CRISPR-Cas systems and methods for altering expression of gene products
-
US patent 8697359.
-
Zhang, F. 2014. CRISPR-Cas systems and methods for altering expression of gene products. US patent 8697359.
-
(2014)
-
-
Zhang, F.1
-
251
-
-
84924322903
-
CRISPR-Cas systems and methods for altering expression of gene products
-
EP patent 2764103.
-
Zhang, F. 2015. CRISPR-Cas systems and methods for altering expression of gene products. EP patent 2764103.
-
(2015)
-
-
Zhang, F.1
-
252
-
-
84856778250
-
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity
-
Zhang, J., Rouillon, C., Kerou, M., Reeks, J., Brugger, K., Graham, S., Reimann, J., Cannone, G., Liu, H., Albers, S.V., Naismith, J.H., Spagnolo, L., White, M.F., Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity. Mol. Cell 45 (2012), 303–313.
-
(2012)
Mol. Cell
, vol.45
, pp. 303-313
-
-
Zhang, J.1
Rouillon, C.2
Kerou, M.3
Reeks, J.4
Brugger, K.5
Graham, S.6
Reimann, J.7
Cannone, G.8
Liu, H.9
Albers, S.V.10
Naismith, J.H.11
Spagnolo, L.12
White, M.F.13
-
253
-
-
84975061735
-
Multigene disruption in undomesticated Bacillus subtilis ATCC 6051a using the CRISPR/Cas9 system
-
Zhang, K., Duan, X., Wu, J., Multigene disruption in undomesticated Bacillus subtilis ATCC 6051a using the CRISPR/Cas9 system. Sci. Rep., 6, 2016, 27943.
-
(2016)
Sci. Rep.
, vol.6
, pp. 27943
-
-
Zhang, K.1
Duan, X.2
Wu, J.3
-
254
-
-
84961288301
-
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
-
Zuris, J.A., Thompson, D.B., Shu, Y., Guilinger, J.P., Bessen, J.L., Hu, J.H., Maeder, M.L., Joung, J.K., Chen, Z.Y., Liu, D.R., Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nat. Biotechnol. 33 (2015), 73–80.
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 73-80
-
-
Zuris, J.A.1
Thompson, D.B.2
Shu, Y.3
Guilinger, J.P.4
Bessen, J.L.5
Hu, J.H.6
Maeder, M.L.7
Joung, J.K.8
Chen, Z.Y.9
Liu, D.R.10
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