Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

Nature Biotechnology

Volumn 32, Issue 11, 2014, Pages 1141-1145

  Citorik, Robert J ^a,b   Mimee, Mark ^a,b   Lu, Timothy K ^a,b,c,d,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c USA   (United States)

^d HARVARD UNIVERSITY   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; DNA; DNA SEQUENCES; DRUG THERAPY; ESCHERICHIA COLI; GENES; RNA;

ANTIBIOTIC RESISTANCE; BACTERIAL POPULATION; ENTEROBACTERIACEAE; ENTEROHEMORRHAGIC ESCHERICHIA COLI; GALLERIA MELLONELLA; INFECTION MODELS; MICROBIAL POPULATIONS; SELECTIVE PRESSURE;

NUCLEIC ACIDS;

ANTIBIOTIC AGENT; BETA LACTAMASE; CARBAPENEM; CARBENICILLIN; CHLORAMPHENICOL; DNA; INTIMIN; NUCLEASE; PROBIOTIC AGENT; RNA GUIDED NUCLEASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; GUIDE RNA; RIBONUCLEASE;

ANTIBIOTIC RESISTANCE; ARTICLE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA SEQUENCE; ENTEROHEMORRHAGIC ESCHERICHIA COLI; GALLERIA MELLONELLA; GALLERIA MELLONELLA INFECTION; MICROBIAL COMMUNITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; BACTERIOPHAGE; CRISPR CAS SYSTEM; GENE TARGETING; GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PLASMID;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BACTERIOPHAGES; BASE SEQUENCE; CARBAPENEMS; CRISPR-CAS SYSTEMS; DRUG RESISTANCE, MICROBIAL; ENTEROHEMORRHAGIC ESCHERICHIA COLI; GENE TARGETING; PLASMIDS; RIBONUCLEASES; RNA, GUIDE;

EID: 84983208863     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3011     Document Type: Article

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