Digenome-seq: Genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

Nature Methods

Volumn 12, Issue 3, 2015, Pages 237-243

  Kim, Daesik ^a,b   Bae, Sangsu ^a,b,e   Park, Jeongbin ^b   Kim, Eunji ^c   Kim, Seokjoong ^c   Yu, Hye Ryeong ^c   Hwang, Jinha ^b   Kim, Jong Il ^b,d   Kim, Jin Soo ^a,b  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Seoul National University   (South Korea)

^c ToolGen Inc   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CRISPR ASSOCIATED PROTEIN; GENOMIC DNA; GUIDE RNA; ENDONUCLEASE;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DIGENOME SEQ; DNA CLEAVAGE; DNA SEQUENCE; GENE INACTIVATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENOME; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; HUMAN GENOME; IN VITRO STUDY; INDEL MUTATION; INDUCED MUTATION; LIMIT OF DETECTION; MUTATION RATE; POINT MUTATION; POSITION WEIGHT MATRIX; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SPONTANEOUS MUTATION; WILD TYPE; CELL LINE; GENETICS; HAPLOIDY; METABOLISM; MUTATION; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; ENDONUCLEASES; GENOME, HUMAN; HAPLOIDY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; LIMIT OF DETECTION; MUTATION; REPRODUCIBILITY OF RESULTS; RNA, GUIDE; SENSITIVITY AND SPECIFICITY;

EID: 84923846574     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.3284     Document Type: Article

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