Cas9-mediated targeting of viral RNA in eukaryotic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 19, 2015, Pages 6164-6169

  Price, Aryn A ^a,b   Sampson, Timothy R ^a,b,c   Ratner, Hannah K ^a,b   Grakoui, Arash ^a,b   Weiss, David S ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c California Institute of Technology   (United States)

Author keywords

Cas9; CRISPR Cas; Francisella; Hepatitis C virus; RNA targeting

Indexed keywords

ALANINE; CAS9 PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; ENDONUCLEASE; GLYCOPROTEIN E2; GUIDE RNA; UNCLASSIFIED DRUG; VIRUS RNA; 3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; BACTERIAL PROTEIN; CAS9 PROTEIN, FRANCISELLA NOVICIDA; CRISPR ASSOCIATED PROTEIN; DNA; EPITOPE; VIRUS PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CELL LYSATE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA CLEAVAGE; EUKARYOTIC CELL; FRANCISELLA NOVICIDA; GENE TARGETING; HEPATITIS C; HEPATITIS C VIRUS GENOTYPE 2; HEPATITIS C VIRUS GENOTYPE 5; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE-STRANDED RNA VIRUS; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; CHEMISTRY; FRANCISELLA; GENETIC TRANSFECTION; HEPACIVIRUS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLASMID; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS); EUKARYOTA; FRANCISELLA; FRANCISELLA TULARENSIS SUBSP. NOVICIDA; HEPATITIS C VIRUS; PROKARYOTA;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; BACTERIAL PROTEINS; BASE SEQUENCE; CELL LINE, TUMOR; CRISPR-ASSOCIATED PROTEINS; DNA; ENDONUCLEASES; EPITOPES; FRANCISELLA; HEPACIVIRUS; HUMANS; MOLECULAR SEQUENCE DATA; PLASMIDS; RNA, VIRAL; TRANSFECTION; VIRAL PROTEINS;

EID: 84929206935     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1422340112     Document Type: Article

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