Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Nature

Volumn 440, Issue 7086, 2006, Pages 940-943

  Ro, Dae Kyun ^a   Paradise, Eric M ^b   Quellet, Mario ^a   Fisher, Karl J ^f   Newman, Karyn L ^a   Ndungu, John M ^c   Ho, Kimberly A ^a   Eachus, Rachel A ^a   Ham, Timothy S ^d   Kirby, James ^b   Chang, Michelle C Y ^a   Withers, Sydnor T ^b   Shiba, Yoichiro ^b   Sarpong, Richmond ^c   Keasling, Jay D ^a,b,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d University of California at Berkeley   (United States)

^e Berkeley   (United States)

^f Amyris Biotechnologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; DISEASE CONTROL; DRUG PRODUCTS; ENZYMES; HEALTH CARE; MALARIA CONTROL; VACCINES;

ANTIMALARIAL DRUGS; ARTEMISINIC ACID; ARTEMISININ COMBINATION THERAPIES; CLINICAL TESTING;

YEAST;

ALKADIENE; AMORPHA 4,11 DIENE; AMORPHADIENE SYNTHASE; ARTEMISINIC ACID; CYTOCHROME P450; CYTOCHROME P450 71AV1; MEVALONIC ACID; SYNTHETASE; UNCLASSIFIED DRUG;

CYTOCHROME; DISEASE BY PATHOGEN; DISEASE CONTROL; DRUG; DRUG RESISTANCE; MALARIA; PARASITE; YEAST;

ARTEMISIA ANNUA; ARTICLE; BIOENGINEERING; BIOSYNTHESIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FERMENTATION; GENE EXPRESSION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PURIFICATION; SACCHAROMYCES CEREVISIAE;

AMORPHA; ARTEMISIA ANNUA; ASTERACEAE; SACCHAROMYCES CEREVISIAE;

EID: 33645870422     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04640     Document Type: Article

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