Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

PLoS Genetics

Volumn 9, Issue 4, 2013, Pages

  Vercoe, Reuben B ^a   Chang, James T ^a   Dy, Ron L ^a   Taylor, Corinda ^a   Gristwood, Tamzin ^a   Clulow, James S ^a   Richter, Corinna ^a   Przybilski, Rita ^a   Pitman, Andrew R ^b,c   Fineran, Peter C ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^c LINCOLN UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CAS GENE; CHROMOSOME ANALYSIS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT GENE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA MODIFICATION; EVOLUTIONARY ADAPTATION; GENE DELETION; GENE EXPRESSION SYSTEM; GENE TARGETING; GROWTH INHIBITION; HOST PATHOGEN INTERACTION; MICROFILAMENT; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE MOTIF; OPERON; PATHOGENICITY ISLAND; PHENOTYPE; PROTOSPACER ADJACENT MOTIF; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; GENOMIC ISLAND; PLASMID;

BACTERIA (MICROORGANISMS); PECTOBACTERIUM ATROSEPTICUM; PROKARYOTA;

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; GENOME, BACTERIAL; GENOMIC ISLANDS; PLASMIDS;

EID: 84876845227     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003454     Document Type: Article

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