Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage

Molecular Cell

Volumn 19, Issue 3, 2005, Pages 405-419

  Yuan, Yu Ren ^a   Pei, Yi ^b   Ma, Jin Biao ^a   Kuryavyi, Vitaly ^a   Zhadina, Maria ^b   Meister, Gunter ^b   Chen, Hong Ying ^a   Dauter, Zbigniew ^c   Tuschl, Thomas ^b   Patel, Dinshaw J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEIN; DEOXYRIBONUCLEASE; DOUBLE STRANDED DNA; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

AQUIFEX AEOLICUS; ARTICLE; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA STRAND; ENZYME ACTIVE SITE; GENE SILENCING; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; RNA CLEAVAGE;

AMINO ACID SEQUENCE; BACTERIA; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; DNA, SINGLE-STRANDED; ELECTROSTATICS; ENDORIBONUCLEASES; EUKARYOTIC INITIATION FACTORS; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; PEPTIDE INITIATION FACTORS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RNA, DOUBLE-STRANDED; RNA, MESSENGER; RNA-INDUCED SILENCING COMPLEX; SEQUENCE HOMOLOGY, AMINO ACID;

AQUIFEX AEOLICUS;

EID: 23144438396     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.07.011     Document Type: Article

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