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Volumn , Issue , 2014, Pages 173-215

Rational approaches for transgene expression: Targeted integration and episomal maintenance

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING;

EID: 84979153673     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1515/9783110278965.173     Document Type: Chapter
Times cited : (3)

References (258)
  • 1
    • 2342446492 scopus 로고    scopus 로고
    • Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer
    • Blesch A. Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer. Methods 2004;33:164-72.
    • (2004) Methods , vol.33 , pp. 164-172
    • Blesch, A.1
  • 2
    • 4644318481 scopus 로고    scopus 로고
    • Lentiviral vectors: Optimization of packaging, transduction and gene expression
    • Delenda C. Lentiviral vectors: optimization of packaging, transduction and gene expression. J Gene Med 2004;6(1):S125-38.
    • (2004) J Gene Med , vol.6 , Issue.1
    • Delenda, C.1
  • 3
    • 77649273815 scopus 로고    scopus 로고
    • Recent advances in lentiviral vector development and applications
    • Matrai J, Chuah MK, VandenDriessche T. Recent advances in lentiviral vector development and applications. Mol Ther 2010;18:477-90.
    • (2010) Mol Ther , vol.18 , pp. 477-490
    • Matrai, J.1    Chuah, M.K.2    Vandendriessche, T.3
  • 4
    • 80052996913 scopus 로고    scopus 로고
    • Nonviral gene delivery with the sleeping beauty transposon system
    • Ivics Z, Izsvak Z. Nonviral gene delivery with the sleeping beauty transposon system. Hum Gene Ther 2011;22:1043-51.
    • (2011) Hum Gene Ther , vol.22 , pp. 1043-1051
    • Ivics, Z.1    Izsvak, Z.2
  • 5
    • 79959660693 scopus 로고    scopus 로고
    • Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size
    • Batenchuk C, St-Pierre S, Tepliakova L, et al. Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size. Biophys J 2011;100:L56-8.
    • (2011) Biophys J , vol.100
    • Batenchuk, C.1    St-Pierre, S.2    Tepliakova, L.3
  • 6
    • 84862745388 scopus 로고    scopus 로고
    • Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases
    • Daboussi F, Zaslavskiy M, Poirot L, et al. Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases. Nucleic Acids Res 2012;40:6367-79.
    • (2012) Nucleic Acids Res , vol.40 , pp. 6367-6379
    • Daboussi, F.1    Zaslavskiy, M.2    Poirot, L.3
  • 7
    • 68049110321 scopus 로고    scopus 로고
    • Boundary sequences stabilize transgene expression from subtle position effects in retroviral vectors
    • Moreno R, Martinez I, Petriz J, et al. Boundary sequences stabilize transgene expression from subtle position effects in retroviral vectors. Blood Cells Mol Dis 2009;43:214-20.
    • (2009) Blood Cells Mol Dis , vol.43 , pp. 214-220
    • Moreno, R.1    Martinez, I.2    Petriz, J.3
  • 8
    • 0141566659 scopus 로고    scopus 로고
    • Transposon mutagenesis of the mouse germline
    • Carlson CM, Dupuy AJ, Fritz S, et al. Transposon mutagenesis of the mouse germline. Genetics 2003;165:243-56.
    • (2003) Genetics , vol.165 , pp. 243-256
    • Carlson, C.M.1    Dupuy, A.J.2    Fritz, S.3
  • 9
    • 14844355218 scopus 로고    scopus 로고
    • High-resolution genome-wide mapping of transposon integration in mammals
    • Yant SR, Wu X, Huang Y et al. High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol 2005;25:2085-94.
    • (2005) Mol Cell Biol , vol.25 , pp. 2085-2094
    • Yant, S.R.1    Wu, X.2    Huang, Y.3
  • 10
    • 33645451483 scopus 로고    scopus 로고
    • Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
    • Baum C, Kustikova O, Modlich U, et al. Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum Gene Ther 2006;17:253-63.
    • (2006) Hum Gene Ther , vol.17 , pp. 253-263
    • Baum, C.1    Kustikova, O.2    Modlich, U.3
  • 11
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu X, Li Y Crise B, et al. Transcription start regions in the human genome are favored targets for MLV integration. Science 2003;300:1749-51.
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li Y Crise, B.2
  • 12
    • 19344375031 scopus 로고    scopus 로고
    • Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
    • Mitchell RS, Beitzel BF, Schroder AR, et al. Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS biology 2004;2:E234.
    • (2004) Plos Biology , vol.2
    • Mitchell, R.S.1    Beitzel, B.F.2    Schroder, A.R.3
  • 13
    • 0029584719 scopus 로고
    • Scaffold/matrix-attached regions: Structural properties creating transcriptionally active loci
    • Bode J, Schlake T, Rios-Ramirez M, et al. Scaffold/matrix-attached regions: structural properties creating transcriptionally active loci. Int Rev Cytol 1995;162(A):389-454.
    • (1995) Int Rev Cytol , vol.162 , Issue.A , pp. 389-454
    • Bode, J.1    Schlake, T.2    Rios-Ramirez, M.3
  • 14
    • 80055093830 scopus 로고    scopus 로고
    • High-level transgene expression by homologous recombination-mediated gene transfer
    • Grandjean M, Girod PA, Calabrese D, et al. High-level transgene expression by homologous recombination-mediated gene transfer. Nucleic Acids Res 2011;39:e104.
    • (2011) Nucleic Acids Res , vol.39
    • Grandjean, M.1    Girod, P.A.2    Calabrese, D.3
  • 15
    • 0029758174 scopus 로고    scopus 로고
    • Scaffold/matrix-attached regions act upon transcription in a context-dependent manner
    • Schubeler D, Mielke C, Maass K, et al. Scaffold/matrix-attached regions act upon transcription in a context-dependent manner. Biochemistry 1996;35:11160-9.
    • (1996) Biochemistry , vol.35 , pp. 11160-11169
    • Schubeler, D.1    Mielke, C.2    Maass, K.3
  • 16
    • 0026842288 scopus 로고
    • Scaffold-associated regions: Cis-acting determinants of chromatin structural loops and functional domains
    • Laemmli UK, Kas E, Poljak L, et al. Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. Curr Opin Genet Dev 1992;2:275-85.
    • (1992) Curr Opin Genet Dev , vol.2 , pp. 275-285
    • Laemmli, U.K.1    Kas, E.2    Poljak, L.3
  • 17
    • 0030025649 scopus 로고    scopus 로고
    • Anatomy of highly expressing chromosomal sites targeted by retroviral vectors
    • Mielke C, Maass K, Tummler M, et al. Anatomy of highly expressing chromosomal sites targeted by retroviral vectors. Biochemistry 1996;35:2239-52.
    • (1996) Biochemistry , vol.35 , pp. 2239-2252
    • Mielke, C.1    Maass, K.2    Tummler, M.3
  • 18
    • 0026035178 scopus 로고
    • Retroviral integrase domains: DNA binding and the recognition of LTR sequences
    • Khan E, Mack JP, Katz RA, et al. Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res 1991;19:851-60.
    • (1991) Nucleic Acids Res , vol.19 , pp. 851-860
    • Khan, E.1    Mack, J.P.2    Katz, R.A.3
  • 19
    • 0025308614 scopus 로고
    • Conserved DNA structures in origins of replication
    • Eckdahl TT, Anderson JN. Conserved DNA structures in origins of replication. Nucleic Acids Res 1990;18:1609-12.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1609-1612
    • Eckdahl, T.T.1    Erson, J.N.2
  • 20
    • 34147175089 scopus 로고    scopus 로고
    • A comparative study of S/MAR prediction tools
    • Evans K, Ott S, Hansen A, et al. A comparative study of S/MAR prediction tools. BMC Bioinformatics 2007;8:71.
    • (2007) BMC Bioinformatics , vol.8 , pp. 71
    • Evans, K.1    Ott, S.2    Hansen, A.3
  • 21
    • 0036087378 scopus 로고    scopus 로고
    • S/MARt DB: A database on scaffold/matrix attached regions
    • Liebich I, Bode J, Frisch M, et al. S/MARt DB: a database on scaffold/matrix attached regions. Nucleic Acids Res 2002;30:372-4.
    • (2002) Nucleic Acids Res , vol.30 , pp. 372-374
    • Liebich, I.1    Bode, J.2    Frisch, M.3
  • 22
    • 34548348766 scopus 로고    scopus 로고
    • Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells
    • Girod PA, Nguyen DQ, Calabrese D, et al. Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells. Nat Meth 2007;4:747-53.
    • (2007) Nat Meth , vol.4 , pp. 747-753
    • Girod, P.A.1    Nguyen, D.Q.2    Calabrese, D.3
  • 23
    • 0025869479 scopus 로고
    • Scaffold-attached regions from the human interferon beta domain can be used to enhance the stable expression of genes under the control of various promoters
    • Klehr D, Maass K, Bode J. Scaffold-attached regions from the human interferon beta domain can be used to enhance the stable expression of genes under the control of various promoters. Biochemistry 1991;30:1264-70.
    • (1991) Biochemistry , vol.30 , pp. 1264-1270
    • Klehr, D.1    Maass, K.2    Bode, J.3
  • 24
    • 59249084751 scopus 로고    scopus 로고
    • Sustained transgene expression using MAR elements
    • Harraghy N, Gaussin A, Mermod N. Sustained transgene expression using MAR elements. Curr Gene Ther 2008;8:353-66.
    • (2008) Curr Gene Ther , vol.8 , pp. 353-366
    • Harraghy, N.1    Gaussin, A.2    Mermod, N.3
  • 25
    • 78650970383 scopus 로고    scopus 로고
    • Use of human MAR elements to improve retroviral vector production
    • Buceta M, Galbete JL, Kostic C, et al. Use of human MAR elements to improve retroviral vector production. Gene Ther 2011;18:7-13.
    • (2011) Gene Ther , vol.18 , pp. 7-13
    • Buceta, M.1    Galbete, J.L.2    Kostic, C.3
  • 26
    • 0033118880 scopus 로고    scopus 로고
    • Stopped at the border: Boundaries and insulators
    • Bell AC, Felsenfeld G. Stopped at the border: boundaries and insulators. Curr Opin Genet Dev 1999;9:191-8.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 191-198
    • Bell, A.C.1    Felsenfeld, G.2
  • 27
    • 0028145804 scopus 로고
    • A plant scaffold attached region detected close to a T-DNA integration site is active in mammalian cells
    • Dietz A, Kay V, Schlake T, et al. A plant scaffold attached region detected close to a T-DNA integration site is active in mammalian cells. Nucleic Acids Res 1994;22:2744-51.
    • (1994) Nucleic Acids Res , vol.22 , pp. 2744-2751
    • Dietz, A.1    Kay, V.2    Schlake, T.3
  • 28
    • 80555144167 scopus 로고    scopus 로고
    • Using matrix attachment regions to improve recombinant protein production
    • Harraghy N, Buceta M, Regamey A, et al. Using matrix attachment regions to improve recombinant protein production. Methods Mol Biol 2012;801:93-110.
    • (2012) Methods Mol Biol , vol.801 , pp. 93-110
    • Harraghy, N.1    Buceta, M.2    Regamey, A.3
  • 29
    • 84873693244 scopus 로고    scopus 로고
    • Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells
    • Grabundzija I, Wang J, Sebe A, et al. Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res 2013;41:1829-47.
    • (2013) Nucleic Acids Res , vol.41 , pp. 1829-1847
    • Grabundzija, I.1    Wang, J.2    Sebe, A.3
  • 30
    • 21344449323 scopus 로고    scopus 로고
    • Use of the chicken lysozyme 5’ matrix attachment region to generate high producer CHO cell lines
    • Girod PA, Zahn-Zabal M, Mermod N. Use of the chicken lysozyme 5’ matrix attachment region to generate high producer CHO cell lines. Biotechnol Bioeng 2005;91:1-11.
    • (2005) Biotechnol Bioeng , vol.91 , pp. 1-11
    • Girod, P.A.1    Zahn-Zabal, M.2    Mermod, N.3
  • 31
    • 3543018516 scopus 로고    scopus 로고
    • Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
    • Murrell A, Heeson S, Reik W. Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet 2004;36:889-93.
    • (2004) Nat Genet , vol.36 , pp. 889-893
    • Murrell, A.1    Heeson, S.2    Reik, W.3
  • 32
    • 23044463888 scopus 로고    scopus 로고
    • Chromosome loops, insulators, and histone methylation: New insights into regulation of imprinting in clusters
    • Reik W, Murrell A, Lewis A, et al. Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters. Cold Spring Harb Symp Quant Biol 2004;69:29-37.
    • (2004) Cold Spring Harb Symp Quant Biol , vol.69 , pp. 29-37
    • Reik, W.1    Murrell, A.2    Lewis, A.3
  • 33
    • 0036467996 scopus 로고    scopus 로고
    • Insulators: Many functions, many mechanisms
    • West AG, Gaszner M, Felsenfeld G. Insulators: many functions, many mechanisms. Genes Dev 2002;16:271-88.
    • (2002) Genes Dev , vol.16 , pp. 271-288
    • West, A.G.1    Gaszner, M.2    Felsenfeld, G.3
  • 34
    • 84885310526 scopus 로고    scopus 로고
    • Is a functional component of a chromatin insulator complex
    • Matzat LH, Dale RK, Lei EP. Messenger RNA is a functional component of a chromatin insulator complex. EMBO Rep 2013;14(10):916-22.
    • (2013) EMBO Rep , vol.14 , Issue.10 , pp. 916-922
    • Matzat, L.H.1    Dale, R.K.2    Lei, E.P.3    Messenger, R.4
  • 35
    • 1842715884 scopus 로고    scopus 로고
    • CTCF protects the boundaries
    • Lewis A, Murrell A. Genomic imprinting: CTCF protects the boundaries. Curr Biol 2004;14:R284-6.
    • (2004) Curr Biol , vol.14
    • Lewis, A.1    Imprinting, M.A.G.2
  • 36
    • 84857251182 scopus 로고    scopus 로고
    • CTCF: Insights into insulator function during development
    • Herold M, Bartkuhn M, Renkawitz R. CTCF: insights into insulator function during development. Development;139:1045-57.
    • Development , vol.139 , pp. 1045-1057
    • Herold, M.1    Bartkuhn, M.2    Renkawitz, R.3
  • 37
    • 2542543539 scopus 로고    scopus 로고
    • CTCF-dependent enhancer blockers at the upstream region of the chicken alpha-globin gene domain
    • Valadez-Graham V, Razin SV, Recillas-Targa F. CTCF-dependent enhancer blockers at the upstream region of the chicken alpha-globin gene domain. Nucleic Acids Res 2004;32:1354-62.
    • (2004) Nucleic Acids Res , vol.32 , pp. 1354-1362
    • Valadez-Graham, V.1    Razin, S.V.2    Recillas-Targa, F.3
  • 38
    • 35348928725 scopus 로고    scopus 로고
    • Protection against telomeric position effects by the chicken cHS4 beta-globin insulator
    • Rincon-Arano H, Furlan-Magaril M, Recillas-Targa F. Protection against telomeric position effects by the chicken cHS4 beta-globin insulator. Proc Natl Acad Sci USA 2007;104:14044-9.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14044-14049
    • Rincon-Arano, H.1    Furlan-Magaril, M.2    Recillas-Targa, F.3
  • 39
    • 79952261267 scopus 로고    scopus 로고
    • Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch
    • Roman AC, Gonzalez-Rico FJ, Molto E, et al. Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res 2011;21:422-32.
    • (2011) Genome Res , vol.21 , pp. 422-432
    • Roman, A.C.1    Gonzalez-Rico, F.J.2    Molto, E.3
  • 40
    • 63949087408 scopus 로고    scopus 로고
    • Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element
    • Hanawa H, Yamamoto M, Zhao H, et al. Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element. Mol Ther 2009;17:667-74.
    • (2009) Mol Ther , vol.17 , pp. 667-674
    • Hanawa, H.1    Yamamoto, M.2    Zhao, H.3
  • 41
    • 84878746110 scopus 로고    scopus 로고
    • The chicken hypersensitivity site 4 core insulator blocks promoter interference in lentiviral vectors
    • Uchida N, Hanawa H, Yamamoto M, et al. The chicken hypersensitivity site 4 core insulator blocks promoter interference in lentiviral vectors. Hum Gene Ther Meth 2013;24:117-24.
    • (2013) Hum Gene Ther Meth , vol.24 , pp. 117-124
    • Uchida, N.1    Hanawa, H.2    Yamamoto, M.3
  • 42
    • 33947272049 scopus 로고    scopus 로고
    • Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector
    • Evans-Galea MV, Wielgosz MM, Hanawa H, et al. Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector. Mol Ther 2007;15:801-9.
    • (2007) Mol Ther , vol.15 , pp. 801-809
    • Evans-Galea, M.V.1    Wielgosz, M.M.2    Hanawa, H.3
  • 43
    • 34248140839 scopus 로고    scopus 로고
    • Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects
    • Aker M, Tubb J, Groth AC, et al. Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects. Hum Gene Ther 2007;18:333-43.
    • (2007) Hum Gene Ther , vol.18 , pp. 333-343
    • Aker, M.1    Tubb, J.2    Groth, A.C.3
  • 44
    • 3342878376 scopus 로고    scopus 로고
    • Prospects and implications of using chromatin insulators in gene therapy and transgenesis
    • Recillas-Targa F, Valadez-Graham V, Farrell CM. Prospects and implications of using chromatin insulators in gene therapy and transgenesis. Bioessays 2004;26:796-807.
    • (2004) Bioessays , vol.26 , pp. 796-807
    • Recillas-Targa, F.1    Valadez-Graham, V.2    Farrell, C.M.3
  • 45
    • 79955852358 scopus 로고    scopus 로고
    • The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
    • Emery DW. The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther 2011;22:761-74.
    • (2011) Hum Gene Ther , vol.22 , pp. 761-774
    • Emery, D.W.1
  • 46
    • 61949341072 scopus 로고    scopus 로고
    • Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants
    • Nielsen TT, Jakobsson J, Rosenqvist N, et al. Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants. BMC Biotechnology 2009;9:13.
    • (2009) BMC Biotechnology , vol.9 , pp. 13
    • Nielsen, T.T.1    Jakobsson, J.2    Rosenqvist, N.3
  • 48
    • 77956265818 scopus 로고    scopus 로고
    • Blundell MP, et al. A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors
    • Zhang F, Frost AR, Blundell MP, et al. A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors. Mol Ther 2010;18:1640-9.
    • (2010) Mol Ther , vol.18 , pp. 1640-1649
    • Zhang, F.1    Frost, A.R.2
  • 49
    • 84874870904 scopus 로고    scopus 로고
    • A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
    • Pfaff N, Lachmann N, Ackermann M, et al. A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells 2013;31:488-99.
    • (2013) Stem Cells , vol.31 , pp. 488-499
    • Pfaff, N.1    Lachmann, N.2    Ackermann, M.3
  • 50
    • 84866159865 scopus 로고    scopus 로고
    • Safer, silencing-resistant lentiviral vectors: Optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing
    • Knight S, Zhang F, Mueller-Kuller U, et al. Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing. J Virol 2012;86:9088-95.
    • (2012) J Virol , vol.86 , pp. 9088-9095
    • Knight, S.1    Zhang, F.2    Mueller-Kuller, U.3
  • 51
    • 84857234389 scopus 로고    scopus 로고
    • Chromatin structure of the LCR in the human beta-globin locus transcribing the adult delta- and beta-globin genes
    • Kim S, Kim YW, Shim SH, et al. Chromatin structure of the LCR in the human beta-globin locus transcribing the adult delta- and beta-globin genes. Int J Biochem Cell Biol 2012;44:505-13.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 505-513
    • Kim, S.1    Kim, Y.W.2    Shim, S.H.3
  • 52
    • 0025602457 scopus 로고
    • Autonomous developmental control of human embryonic globin gene switching in transgenic mice
    • Raich N, Enver T, Nakamoto B, et al. Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science 1990;250:1147-9.
    • (1990) Science , vol.250 , pp. 1147-1149
    • Raich, N.1    Enver, T.2    Nakamoto, B.3
  • 53
    • 84861057518 scopus 로고    scopus 로고
    • Chromatin loop formation in the beta-globin locus and its role in globin gene transcription
    • Kim A, Dean A. Chromatin loop formation in the beta-globin locus and its role in globin gene transcription. Mol Cells 2012;34:1-5.
    • (2012) Mol Cells , vol.34 , pp. 1-5
    • Kim, A.1    Dean, A.2
  • 54
    • 0035895047 scopus 로고    scopus 로고
    • Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors
    • Indraccolo S, Minuzzo S, Roccaforte F, et al. Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors. Blood 2001;98:3607-17.
    • (2001) Blood , vol.98 , pp. 3607-3617
    • Indraccolo, S.1    Minuzzo, S.2    Roccaforte, F.3
  • 55
    • 77953789765 scopus 로고    scopus 로고
    • Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma
    • Koh BH, Hwang SS, Kim JY, et al. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci USA 2010;107:10614-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10614-10619
    • Koh, B.H.1    Hwang, S.S.2    Kim, J.Y.3
  • 56
    • 0038106627 scopus 로고    scopus 로고
    • Adding a new piece to the regulatory puzzle
    • Smale ST. A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle. Immunity 2003;19:1-2.
    • (2003) Immunity , vol.19 , pp. 1-2
    • Smale, S.1    Th2 Cytokine, L.C.R.2
  • 57
    • 39049092286 scopus 로고    scopus 로고
    • Beta-globin regulation and long-range interactions
    • Palstra RJ, de Laat W, Grosveld F. Beta-globin regulation and long-range interactions. Adv Genet 2008;61:107-42.
    • (2008) Adv Genet , vol.61 , pp. 107-142
    • Palstra, R.J.1    De Laat, W.2    Grosveld, F.3
  • 58
    • 0031825239 scopus 로고    scopus 로고
    • Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders
    • Pawliuk R, Bachelot T, Raftopoulos H, et al. Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders. Ann N Y Acad Sci 1998;850:151-62.
    • (1998) Ann N Y Acad Sci , vol.850 , pp. 151-162
    • Pawliuk, R.1    Bachelot, T.2    Raftopoulos, H.3
  • 59
    • 0035164259 scopus 로고    scopus 로고
    • The beta-globin locus control region versus gene therapy vectors: A struggle for expression
    • Ellis J, Pannell D. The beta-globin locus control region versus gene therapy vectors: a struggle for expression. Clin Genet 2001;59:17-24.
    • (2001) Clin Genet , vol.59 , pp. 17-24
    • Ellis, J.1    Pannell, D.2
  • 60
    • 84858006799 scopus 로고    scopus 로고
    • Comparative analysis of FV vectors with human alpha-or beta-globin gene regulatory elements for the correction of beta-thalassemia
    • Morianos I, Siapati EK, Pongas G, et al. Comparative analysis of FV vectors with human alpha-or beta-globin gene regulatory elements for the correction of beta-thalassemia. Gene Ther 2012;19:303-11.
    • (2012) Gene Ther , vol.19 , pp. 303-311
    • Morianos, I.1    Siapati, E.K.2    Pongas, G.3
  • 61
    • 0035037078 scopus 로고    scopus 로고
    • Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression
    • Kowolik CM, Hu J, Yee JK. Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression. J Virol 2001;75:46 41-8.
    • J Virol 2001;75 , vol.46 , pp. 41-48
    • Kowolik, C.M.1    Hu, J.2    Yee, J.K.3
  • 62
    • 0034677895 scopus 로고    scopus 로고
    • The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse
    • Su Y, Liebhaber SA, Cooke NE. The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse. J Biol Chem 2000;275:7902-9.
    • (2000) J Biol Chem , vol.275 , pp. 7902-7909
    • Su, Y.1    Liebhaber, S.A.2    Cooke, N.E.3
  • 63
    • 0034331235 scopus 로고    scopus 로고
    • The tkNeo gene, but not the pgkPuro gene, can influence the ability of the beta-globin LCR to enhance and confer position-independent expression onto the beta-globin gene
    • Mei Q, Kothary R, Wall L. The tkNeo gene, but not the pgkPuro gene, can influence the ability of the beta-globin LCR to enhance and confer position-independent expression onto the beta-globin gene. Exp Cell Res 2000;260:304-12.
    • (2000) Exp Cell Res , vol.260 , pp. 304-312
    • Mei, Q.1    Kothary, R.2    Wall, L.3
  • 64
    • 84863486353 scopus 로고    scopus 로고
    • The beta-globin locus control region in combination with the EF1alpha short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity
    • Montiel-Equihua CA, Zhang L, Knight S, et al. The beta-globin locus control region in combination with the EF1alpha short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity. Mol Ther 2012;20:1400-9.
    • (2012) Mol Ther , vol.20 , pp. 1400-1409
    • Montiel-Equihua, C.A.1    Zhang, L.2    Knight, S.3
  • 65
    • 70449127224 scopus 로고    scopus 로고
    • Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region
    • Arumugam PI, Higashimoto T, Urbinati F, et al. Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region. Mol Ther 2009;17:1929-37.
    • (2009) Mol Ther , vol.17 , pp. 1929-1937
    • Arumugam, P.I.1    Higashimoto, T.2    Urbinati, F.3
  • 66
    • 84876575492 scopus 로고    scopus 로고
    • Optimizing retroviral gene expression for effective therapies
    • Antoniou MN, Skipper KA, Anakok O. Optimizing retroviral gene expression for effective therapies. Hum Gene Ther 2013;24:363-74.
    • (2013) Hum Gene Ther , vol.24 , pp. 363-374
    • Antoniou, M.N.1    Skipper, K.A.2    Anakok, O.3
  • 67
    • 82455219275 scopus 로고    scopus 로고
    • Site-specific recombinases as tools for heterologous gene integration
    • Hirano N, Muroi T, Takahashi H, et al. Site-specific recombinases as tools for heterologous gene integration. Appl Microbiol Biotechnol 2011;92:227-39.
    • (2011) Appl Microbiol Biotechnol , vol.92 , pp. 227-239
    • Hirano, N.1    Muroi, T.2    Takahashi, H.3
  • 68
    • 0029860719 scopus 로고    scopus 로고
    • Different thermostabilities of FLP and Cre recombinases: Implications for applied site-specific recombination
    • Buchholz F, Ringrose L, Angrand PO, et al. Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res 1996;24:4256-62.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4256-4262
    • Buchholz, F.1    Ringrose, L.2    Angrand, P.O.3
  • 69
    • 36148961543 scopus 로고    scopus 로고
    • Road to precision: Recombinase-based targeting technologies for genome engineering
    • Wirth D, Gama-Norton L, Riemer P, et al. Road to precision: recombinase-based targeting technologies for genome engineering. Curr Opin Biotechnol 2007;18:411-9.
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 411-419
    • Wirth, D.1    Gama-Norton, L.2    Riemer, P.3
  • 70
    • 84872271412 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE) - a rapidly-expanding toolbox for targeted genomic modifications
    • Turan S, Zehe C, Kuehle J, et al. Recombinase-mediated cassette exchange (RMCE) - a rapidly-expanding toolbox for targeted genomic modifications. Gene 2013;515:1-27.
    • (2013) Gene , vol.515 , pp. 1-27
    • Turan, S.1    Zehe, C.2    Kuehle, J.3
  • 71
    • 84883593530 scopus 로고    scopus 로고
    • Rapid Creation of Stable Mammalian Cell Lines for Regulated Expression of Proteins Using the Gateway(R) Recombination Cloning Technology and Flp-In T-REx(R) Lines
    • Spitzer J, Landthaler M, Tuschl T. Rapid Creation of Stable Mammalian Cell Lines for Regulated Expression of Proteins Using the Gateway(R) Recombination Cloning Technology and Flp-In T-REx(R) Lines. Methods Enzymol 2013;529:99-124.
    • (2013) Methods Enzymol , vol.529 , pp. 99-124
    • Spitzer, J.1    Landthaler, M.2    Tuschl, T.3
  • 72
    • 84890126665 scopus 로고    scopus 로고
    • Assay development of inducible human renal phosphate transporter Npt2A (SLC34A1) in Flp-In-Trex-HEK293 cells
    • Wu H, Mao C, Duenstl G, et al. Assay development of inducible human renal phosphate transporter Npt2A (SLC34A1) in Flp-In-Trex-HEK293 cells. Eur J Pharmacol 2013;721(1-3):332-40.
    • (2013) Eur J Pharmacol , vol.721 , Issue.1-3 , pp. 332-340
    • Wu, H.1    Mao, C.2    Duenstl, G.3
  • 73
    • 27644546742 scopus 로고    scopus 로고
    • Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange
    • Wong ET, Kolman JL, Li YC, et al. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res 2005;33:e147.
    • (2005) Nucleic Acids Res , vol.33
    • Wong, E.T.1    Kolman, J.L.2    Li, Y.C.3
  • 74
    • 0034925739 scopus 로고    scopus 로고
    • Evaluation of retroviral vector design in defined chromosomal loci by Flp-mediated cassette replacement
    • Verhoeyen E, Hauser H, Wirth D. Evaluation of retroviral vector design in defined chromosomal loci by Flp-mediated cassette replacement. Hum Gene Ther 2001;12:933-44.
    • (2001) Hum Gene Ther , vol.12 , pp. 933-944
    • Verhoeyen, E.1    Hauser, H.2    Wirth, D.3
  • 75
    • 33745668475 scopus 로고    scopus 로고
    • A new generation of retroviral producer cells: Predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors
    • Schucht R, Coroadinha AS, Zanta-Boussif MA, et al. A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors. Mol Ther 2006;14:285-92.
    • (2006) Mol Ther , vol.14 , pp. 285-292
    • Schucht, R.1    Coroadinha, A.S.2    Zanta-Boussif, M.A.3
  • 76
    • 78651322759 scopus 로고    scopus 로고
    • Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells
    • Sandhu U, Cebula M, Behme S, et al. Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells. Nucleic Acids Res 2011;39:e1.
    • (2011) Nucleic Acids Res , vol.39
    • Sandhu, U.1    Cebula, M.2    Behme, S.3
  • 77
    • 79952310557 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE): Traditional concepts and current challenges
    • Turan S, Galla M, Ernst E, et al. Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges. J Mol Biol 2011;407:193-221.
    • (2011) J Mol Biol , vol.407 , pp. 193-221
    • Turan, S.1    Galla, M.2    Ernst, E.3
  • 78
    • 80155187833 scopus 로고    scopus 로고
    • Lentivirus production is influenced by SV40 large T-antigen and chromosomal integration of the vector in HEK293 cells
    • Gama-Norton L, Botezatu L, Herrmann S, et al. Lentivirus production is influenced by SV40 large T-antigen and chromosomal integration of the vector in HEK293 cells. Hum Gene Ther 2011;22:1269-79.
    • (2011) Hum Gene Ther , vol.22 , pp. 1269-1279
    • Gama-Norton, L.1    Botezatu, L.2    Herrmann, S.3
  • 79
    • 35548970476 scopus 로고    scopus 로고
    • Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent
    • Strathdee D, Ibbotson H, Grant SG. Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent. PLoS One 2006;1:e4.
    • (2006) Plos One , vol.1
    • Strathdee, D.1    Ibbotson, H.2    Grant, S.G.3
  • 80
    • 84872272027 scopus 로고    scopus 로고
    • Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci
    • Nehlsen K, da Gama-Norton L, Schucht R, et al. Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci. BMC Proc 2011;5 Suppl 8:O6.
    • BMC Proc 2011;5 Suppl , vol.8
    • Nehlsen, K.1    Da Gama-Norton, L.2    Schucht, R.3
  • 81
    • 74749086258 scopus 로고    scopus 로고
    • Recombinant protein expression by targeting pre-selected chromosomal loci
    • Nehlsen K, Schucht R, da Gama-Norton L, et al. Recombinant protein expression by targeting pre-selected chromosomal loci. BMC Biotechnology 2009;9:100.
    • (2009) BMC Biotechnology , vol.9 , pp. 100
    • Nehlsen, K.1    Schucht, R.2    Da Gama-Norton, L.3
  • 82
    • 84855855098 scopus 로고    scopus 로고
    • A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters
    • Tchorz JS, Suply T, Ksiazek I, et al. A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLoS One 2012;7:e30011.
    • (2012) Plos One , vol.7
    • Tchorz, J.S.1    Suply, T.2    Ksiazek, I.3
  • 83
    • 80051613693 scopus 로고    scopus 로고
    • A comparison of exogenous promoter activity at the ROSA26 locus using a PhiiC31 integrase mediated cassette exchange approach in mouse ES cells
    • Chen CM, Krohn J, Bhattacharya S, et al. A comparison of exogenous promoter activity at the ROSA26 locus using a PhiiC31 integrase mediated cassette exchange approach in mouse ES cells. PLoS One 2011;6:e23376.
    • (2011) Plos One , vol.6
    • Chen, C.M.1    Krohn, J.2    Bhattacharya, S.3
  • 84
    • 79954616712 scopus 로고    scopus 로고
    • Rapid establishment of G-protein-coupled receptor-expressing cell lines by site-specific integration
    • Schucht R, Lydford S, Andzinski L, et al. Rapid establishment of G-protein-coupled receptor-expressing cell lines by site-specific integration. J Biomol Screen 2011;16:323-31.
    • (2011) J Biomol Screen , vol.16 , pp. 323-331
    • Schucht, R.1    Lydford, S.2    Zinski, L.3
  • 85
    • 79952650338 scopus 로고    scopus 로고
    • Integrated strategy for the production of therapeutic retroviral vectors
    • Carrondo M, Panet A, Wirth D, et al. Integrated strategy for the production of therapeutic retroviral vectors. Hum Gene Ther 2011;22:370-9.
    • (2011) Hum Gene Ther , vol.22 , pp. 370-379
    • Carrondo, M.1    Panet, A.2    Wirth, D.3
  • 86
    • 77952580874 scopus 로고    scopus 로고
    • Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system
    • Zhou H, Liu ZG, Sun ZW, et al. Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system. J Biotechnol 2010;147:122-9.
    • (2010) J Biotechnol , vol.147 , pp. 122-129
    • Zhou, H.1    Liu, Z.G.2    Sun, Z.W.3
  • 87
    • 55249126886 scopus 로고    scopus 로고
    • Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation
    • Kaufman WL, Kocman I, Agrawal V, et al. Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation. Nucleic Acids Res 2008;36:e111.
    • (2008) Nucleic Acids Res , vol.36
    • Kaufman, W.L.1    Kocman, I.2    Agrawal, V.3
  • 88
    • 84863717325 scopus 로고    scopus 로고
    • Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system
    • Kawabe Y, Makitsubo H, Kameyama Y et al. Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system. Cytotechnology 2012;64:267-79.
    • (2012) Cytotechnology , vol.64 , pp. 267-279
    • Kawabe, Y.1    Makitsubo, H.2    Kameyama, Y.3
  • 89
    • 84886746943 scopus 로고    scopus 로고
    • Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined phiC31 integrase and CRE-Lox technologies
    • Crawford Y Zhou M, Hu Z, et al. Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined phiC31 integrase and CRE-Lox technologies. Biotechnology Prog 2013;29(5):1307-15.
    • (2013) Biotechnology Prog , vol.29 , Issue.5 , pp. 1307-1315
    • Crawford Y Zhou, M.1    Hu, Z.2
  • 90
    • 0037212982 scopus 로고    scopus 로고
    • Construction of engineered CHO strains for high-level production of recombinant proteins
    • Kito M, Itami S, Fukano Y et al. Construction of engineered CHO strains for high-level production of recombinant proteins. Appl Microbiol Biotechnol 2002;60:442-8.
    • (2002) Appl Microbiol Biotechnol , vol.60 , pp. 442-448
    • Kito, M.1    Itami, S.2    Fukano, Y.3
  • 91
    • 34147179033 scopus 로고    scopus 로고
    • An efficient and targeted gene integration system for high-level antibody expression
    • Huang Y, Li Y Wang YG, et al. An efficient and targeted gene integration system for high-level antibody expression. J Immunol Methods 2007;322(1-2):28-39.
    • (2007) J Immunol Methods , vol.322 , Issue.1-2 , pp. 28-39
    • Huang, Y.1    Li Y Wang, Y.G.2
  • 92
    • 50249137032 scopus 로고    scopus 로고
    • Use of Flp-mediated cassette exchange in the development of a CHO cell line stably producing erythropoietin
    • Kim MS, Lee GM. Use of Flp-mediated cassette exchange in the development of a CHO cell line stably producing erythropoietin. J Microbiol Biotechnol 2008;18:1342-51.
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 1342-1351
    • Kim, M.S.1    Lee, G.M.2
  • 93
    • 83055168492 scopus 로고    scopus 로고
    • Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development
    • Wilke S, Groebe L, Maffenbeier V, et al. Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development. PLoS One 2011;6:e27829.
    • (2011) Plos One , vol.6
    • Wilke, S.1    Groebe, L.2    Maffenbeier, V.3
  • 94
    • 33744498904 scopus 로고    scopus 로고
    • Production of target-specific recombinant human polyclonal antibodies in mammalian cells
    • Wiberg FC, Rasmussen SK, Frandsen TP, et al. Production of target-specific recombinant human polyclonal antibodies in mammalian cells. Biotechnol Bioeng 2006;94:396-405.
    • (2006) Biotechnol Bioeng , vol.94 , pp. 396-405
    • Wiberg, F.C.1    Rasmussen, S.K.2    Frandsen, T.P.3
  • 95
    • 33745220778 scopus 로고    scopus 로고
    • The use of recombinase mediated cassette exchange in retroviral vector producer cell lines: Predictability and efficiency by transgene exchange
    • Coroadinha AS, Schucht R, Gama-Norton L, et al. The use of recombinase mediated cassette exchange in retroviral vector producer cell lines: predictability and efficiency by transgene exchange. J Biotechnol 2006;124:457-68.
    • (2006) J Biotechnol , vol.124 , pp. 457-468
    • Coroadinha, A.S.1    Schucht, R.2    Gama-Norton, L.3
  • 96
    • 77955506625 scopus 로고    scopus 로고
    • Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines
    • Gama-Norton L, Herrmann S, Schucht R, et al. Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines. Hum Gene Ther 2010;21:979-91.
    • (2010) Hum Gene Ther , vol.21 , pp. 979-991
    • Gama-Norton, L.1    Herrmann, S.2    Schucht, R.3
  • 97
    • 28544434189 scopus 로고    scopus 로고
    • An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo
    • Mao J, Barrow J, McMahon J, et al. An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res 2005;33:e155.
    • (2005) Nucleic Acids Res , vol.33
    • Mao, J.1    Barrow, J.2    Mc Mahon, J.3
  • 98
    • 0036797451 scopus 로고    scopus 로고
    • Stable nonviral genetic correction of inherited human skin disease
    • Ortiz-Urda S, Thyagarajan B, Keene DR, et al. Stable nonviral genetic correction of inherited human skin disease. Nat Med 2002;8:1166-70.
    • (2002) Nat Med , vol.8 , pp. 1166-1170
    • Ortiz-Urda, S.1    Thyagarajan, B.2    Keene, D.R.3
  • 99
    • 0036842502 scopus 로고    scopus 로고
    • Site-specific genomic integration produces therapeutic Factor IX levels in mice
    • Olivares EC, Hollis RP, Chalberg TW, et al. Site-specific genomic integration produces therapeutic Factor IX levels in mice. Nat Biotechnol 2002;20:1124-8.
    • (2002) Nat Biotechnol , vol.20 , pp. 1124-1128
    • Olivares, E.C.1    Hollis, R.P.2    Chalberg, T.W.3
  • 100
    • 14044257947 scopus 로고    scopus 로고
    • In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery
    • Held PK, Olivares EC, Aguilar CP, et al. In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery. Mol Ther 2005;11:399-408.
    • (2005) Mol Ther , vol.11 , pp. 399-408
    • Held, P.K.1    Olivares, E.C.2    Aguilar, C.P.3
  • 101
    • 32344453096 scopus 로고    scopus 로고
    • Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells
    • Beard C, Hochedlinger K, Plath K, et al. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 2006;44:23-8.
    • (2006) Genesis , vol.44 , pp. 23-28
    • Beard, C.1    Hochedlinger, K.2    Plath, K.3
  • 102
    • 84860380381 scopus 로고    scopus 로고
    • Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases
    • Perez-Pinera P, Ousterout DG, Brown MT, et al. Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases. Nucleic Acids Res 2012;40:3741-52.
    • (2012) Nucleic Acids Res , vol.40 , pp. 3741-3752
    • Perez-Pinera, P.1    Ousterout, D.G.2    Brown, M.T.3
  • 103
    • 23844527864 scopus 로고    scopus 로고
    • Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement
    • Shmerling D, Danzer CP, Mao X, et al. Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement. Genesis 2005;42:229-35.
    • (2005) Genesis , vol.42 , pp. 229-235
    • Shmerling, D.1    Danzer, C.P.2    Mao, X.3
  • 104
    • 79954508872 scopus 로고    scopus 로고
    • Rapid derivation of genetically related mutants from embryonic cells harboring a recombinase-specific Trp53 platform
    • Wei QX, Odell AF, van der Hoeven F, et al. Rapid derivation of genetically related mutants from embryonic cells harboring a recombinase-specific Trp53 platform. Cell Cycle 2011;10:1261-70.
    • (2011) Cell Cycle , vol.10 , pp. 1261-1270
    • Wei, Q.X.1    Odell, A.F.2    Van Der Hoeven, F.3
  • 105
    • 33846011896 scopus 로고    scopus 로고
    • Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence
    • Wallace HA, Marques-Kranc F, Richardson M, et al. Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell 2007;128:197-209.
    • (2007) Cell , vol.128 , pp. 197-209
    • Wallace, H.A.1    Marques-Kranc, F.2    Richardson, M.3
  • 106
    • 0029739282 scopus 로고    scopus 로고
    • A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs
    • Buchholz F, Angrand PO, Stewart AF. A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs. Nucleic Acids Res 1996;24:3118-9.
    • (1996) Nucleic Acids Res , vol.24 , pp. 3118-3119
    • Buchholz, F.1    Angrand, P.O.2    Stewart, A.F.3
  • 107
    • 0031874849 scopus 로고    scopus 로고
    • Improved properties of FLP recombinase evolved by cycling mutagenesis
    • Buchholz F, Angrand PO, Stewart AF. Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol 1998;16:657-62.
    • (1998) Nat Biotechnol , vol.16 , pp. 657-662
    • Buchholz, F.1    Angrand, P.O.2    Stewart, A.F.3
  • 108
    • 33947647023 scopus 로고    scopus 로고
    • High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells
    • Raymond CS, Soriano P. High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One 2007;2:e162.
    • (2007) Plos One , vol.2
    • Raymond, C.S.1    Soriano, P.2
  • 109
    • 84880698370 scopus 로고    scopus 로고
    • A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics
    • Hirsch MR, d'Autreaux F, Dymecki SM, et al. A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics. Genesis 2013;51:506-14.
    • (2013) Genesis , vol.51 , pp. 506-514
    • Hirsch, M.R.1    D'autreaux, F.2    Dymecki, S.M.3
  • 110
    • 77955344365 scopus 로고    scopus 로고
    • An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase
    • Kranz A, Fu J, Duerschke K, et al. An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase. Genesis 2010;48:512-20.
    • (2010) Genesis , vol.48 , pp. 512-520
    • Kranz, A.1    Fu, J.2    Duerschke, K.3
  • 111
    • 77951231140 scopus 로고    scopus 로고
    • High-efficient FLPo deleter mice in C57BL/6J background
    • Wu Y Wang C, Sun H, et al. High-efficient FLPo deleter mice in C57BL/6J background. PLoS One 2009;4:e8054.
    • (2009) Plos One , vol.4
    • Wu Y Wang, C.1    Sun, H.2
  • 112
    • 79952310557 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE): Traditional concepts and current challenges
    • Turan S, Galla M, Ernst E, et al. Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges. J Mol Biol 2011;407:193-221.
    • (2011) J Mol Biol , vol.407 , pp. 193-221
    • Turan, S.1    Galla, M.2    Ernst, E.3
  • 113
    • 0036158916 scopus 로고    scopus 로고
    • Codon-improved Cre recombinase (ICre) expression in the mouse
    • Shimshek DR, Kim J, Hubner MR, et al. Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis 2002;32:19-26.
    • (2002) Genesis , vol.32 , pp. 19-26
    • Shimshek, D.R.1    Kim, J.2    Hubner, M.R.3
  • 114
    • 11344273450 scopus 로고    scopus 로고
    • DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages
    • Sauer B, McDermott J. DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages. Nucleic Acids Res 2004;32:6086-95.
    • (2004) Nucleic Acids Res , vol.32 , pp. 6086-6095
    • Sauer, B.1    Mc Dermott, J.2
  • 115
    • 79955370157 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE) and BAC engineering via VCre/VloxP and SCre/SloxP systems
    • Minorikawa S, Nakayama M. Recombinase-mediated cassette exchange (RMCE) and BAC engineering via VCre/VloxP and SCre/SloxP systems. Biotechniques 2011;50:235-46.
    • (2011) Biotechniques , vol.50 , pp. 235-246
    • Minorikawa, S.1    Nakayama, M.2
  • 116
    • 79955401514 scopus 로고    scopus 로고
    • VCre/VloxP and SCre/SloxP: New site-specific recombination systems for genome engineering
    • Suzuki E, Nakayama M. VCre/VloxP and SCre/SloxP: new site-specific recombination systems for genome engineering. Nucleic Acids Res 2011;39:e49.
    • (2011) Nucleic Acids Res , vol.39
    • Suzuki, E.1    Nakayama, M.2
  • 117
    • 84875434512 scopus 로고    scopus 로고
    • Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system
    • Karimova M, Abi-Ghanem J, Berger N, et al. Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system. Nucleic Acids Res 2013;41:e37.
    • (2013) Nucleic Acids Res , vol.41
    • Karimova, M.1    Abi-Ghanem, J.2    Berger, N.3
  • 118
    • 77955484494 scopus 로고    scopus 로고
    • TK.007: A novel, codon-optimized HSVtk(A168H) mutant for suicide gene therapy
    • Preuss E, Treschow A, Newrzela S, et al. TK.007: A novel, codon-optimized HSVtk(A168H) mutant for suicide gene therapy. Hum Gene Ther 2010;21:929-41.
    • (2010) Hum Gene Ther , vol.21 , pp. 929-941
    • Preuss, E.1    Treschow, A.2    Newrzela, S.3
  • 119
    • 0035979247 scopus 로고    scopus 로고
    • Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
    • Loonstra A, Vooijs M, Beverloo HB, et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci USA 2001;98:9209-14.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9209-9214
    • Loonstra, A.1    Vooijs, M.2    Beverloo, H.B.3
  • 120
    • 21744436924 scopus 로고    scopus 로고
    • Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells
    • Baba Y Nakano M, Yamada Y et al. Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells. Microbiol Immunol 2005;49:559-70.
    • (2005) Microbiol Immunol , vol.49 , pp. 559-570
    • Baba Y Nakano, M.1    Yamada, Y.2
  • 121
    • 33750997895 scopus 로고    scopus 로고
    • Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration
    • Ehrhardt A, Engler JA, Xu H, et al. Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration. Hum Gene Ther 2006;17:1077-94.
    • (2006) Hum Gene Ther , vol.17 , pp. 1077-1094
    • Ehrhardt, A.1    Engler, J.A.2    Xu, H.3
  • 122
    • 0343415768 scopus 로고    scopus 로고
    • Mammalian genomes contain active recombinase recognition sites
    • Thyagarajan B, Guimaraes MJ, Groth AC, et al. Mammalian genomes contain active recombinase recognition sites. Gene 2000;244:47-54.
    • (2000) Gene , vol.244 , pp. 47-54
    • Thyagarajan, B.1    Guimaraes, M.J.2    Groth, A.C.3
  • 123
    • 34247130822 scopus 로고    scopus 로고
    • Cryptic loxP sites in mammalian genomes: Genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques
    • Semprini S, Troup TJ, Kotelevtseva N, et al. Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic Acids Res 2007;35:1402-10.
    • (2007) Nucleic Acids Res , vol.35 , pp. 1402-1410
    • Semprini, S.1    Troup, T.J.2    Kotelevtseva, N.3
  • 124
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas KR, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987;51:503-12.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 125
    • 0023630807 scopus 로고
    • Targetted correction of a mutant HPRT gene in mouse embryonic stem cells
    • Doetschman T, Gregg RG, Maeda N, et al. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 1987;330:576-8.
    • (1987) Nature , vol.330 , pp. 576-578
    • Doetschman, T.1    Gregg, R.G.2    Maeda, N.3
  • 126
    • 19544371373 scopus 로고    scopus 로고
    • Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
    • Capecchi MR. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 2005;6:507-12.
    • (2005) Nat Rev Genet , vol.6 , pp. 507-512
    • Capecchi, M.R.1
  • 127
    • 0035464996 scopus 로고    scopus 로고
    • Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: An amazingly versatile tool for the study of mammalian biology
    • Babinet C, Cohen-Tannoudji M. Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology. An Acad Bras de Cienc 2001;73:365-83.
    • (2001) An Acad Bras De Cienc , vol.73 , pp. 365-383
    • Babinet, C.1    Cohen-Tannoudji, M.2
  • 128
    • 0037133550 scopus 로고    scopus 로고
    • Embryonic stem cells and somatic cells differ in mutation frequency and type
    • Cervantes RB, Stringer JR, Shao C, et al. Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc Natl Acad Sci USA 2002;99:35 86-90.
    • Proc Natl Acad Sci USA 2002;99 , vol.35 , pp. 86-90
    • Cervantes, R.B.1    Stringer, J.R.2    Shao, C.3
  • 129
    • 0025943412 scopus 로고
    • The length of homology required for gene targeting in embryonic stem cells
    • Hasty P, Rivera-Perez J, Bradley A. The length of homology required for gene targeting in embryonic stem cells. Mol Cell Biol 1991;11:5586-91.
    • (1991) Mol Cell Biol , vol.11 , pp. 5586-5591
    • Hasty, P.1    Rivera-Perez, J.2    Bradley, A.3
  • 130
    • 0030794157 scopus 로고    scopus 로고
    • Efficient gene targeting in mouse embryonic stem cells
    • Templeton NS, Roberts DD, Safer B. Efficient gene targeting in mouse embryonic stem cells. Gene Ther 1997;4:700-9.
    • (1997) Gene Ther , vol.4 , pp. 700-709
    • Templeton, N.S.1    Roberts, D.D.2    Safer, B.3
  • 131
    • 0038658494 scopus 로고
    • Positive genetic selection for gene disruption in mammalian cells by homologous recombination
    • Sedivy JM, Sharp PA. Positive genetic selection for gene disruption in mammalian cells by homologous recombination. Proc Natl Acad Sci USA 1989;86:227-31.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 227-231
    • Sedivy, J.M.1    Sharp, P.A.2
  • 132
    • 0026771287 scopus 로고
    • Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
    • te Riele H, Maandag ER, Berns A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc Natl Acad Sci USA 1992;89:5128-32.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5128-5132
    • Te Riele, H.1    Maandag, E.R.2    Berns, A.3
  • 133
    • 0043240053 scopus 로고    scopus 로고
    • Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells
    • Lu ZH, Books JT, Kaufman RM, et al. Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells. Blood 2003;102:1531-3.
    • (2003) Blood , vol.102 , pp. 1531-1533
    • Lu, Z.H.1    Books, J.T.2    Kaufman, R.M.3
  • 134
    • 35649010954 scopus 로고    scopus 로고
    • Using homologous recombination to manipulate the genome of human somatic cells
    • Porteus M. Using homologous recombination to manipulate the genome of human somatic cells. Biotechnol Gent Eng Rev 2007;24:195-212.
    • (2007) Biotechnol Gent Eng Rev , vol.24 , pp. 195-212
    • Porteus, M.1
  • 135
    • 78049381196 scopus 로고    scopus 로고
    • Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks
    • Tichy ED, Pillai R, Deng L, et al. Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks. Stem Cells Dev 2010;19:1699-711.
    • (2010) Stem Cells Dev , vol.19 , pp. 1699-1711
    • Tichy, E.D.1    Pillai, R.2    Deng, L.3
  • 136
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • Smithies O, Gregg RG, Boggs SS, et al. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 1985;317:230-4.
    • (1985) Nature , vol.317 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3
  • 137
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
    • Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 1997;277:831-4.
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 138
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998;282:1497-501.
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3
  • 139
    • 0025936509 scopus 로고
    • Increased ratio of targeted to random integration after transfection of chicken B cell lines
    • Buerstedde JM, Takeda S. Increased ratio of targeted to random integration after transfection of chicken B cell lines. Cell 1991;67:179-88.
    • (1991) Cell , vol.67 , pp. 179-188
    • Buerstedde, J.M.1    Takeda, S.2
  • 140
    • 60049088906 scopus 로고    scopus 로고
    • Conditional knockout of nucleolin in DT40 cells reveals the functional redundancy of its RNA-binding domains
    • Storck S, Thiry M, Bouvet P. Conditional knockout of nucleolin in DT40 cells reveals the functional redundancy of its RNA-binding domains. Biol Cell 2009;101:153-67.
    • (2009) Biol Cell , vol.101 , pp. 153-167
    • Storck, S.1    Thiry, M.2    Bouvet, P.3
  • 141
    • 84883049739 scopus 로고    scopus 로고
    • Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: A comparison study employing chicken DT40 cells
    • Lee S, Liu X, Takeda S, et al. Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: a comparison study employing chicken DT40 cells. Chemosphere 2013;93:434-40.
    • (2013) Chemosphere , vol.93 , pp. 434-440
    • Lee, S.1    Liu, X.2    Takeda, S.3
  • 142
    • 79960962204 scopus 로고    scopus 로고
    • The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination
    • Qing Y Yamazoe M, Hirota K, et al. The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS genetics 2011;7:e1002148.
    • (2011) Plos Genetics , vol.7
    • Qing Y Yamazoe, M.1    Hirota, K.2
  • 143
    • 0024977417 scopus 로고
    • Elevated recombination rates in transcriptionally active DNA
    • Thomas BJ, Rothstein R. Elevated recombination rates in transcriptionally active DNA. Cell 1989;56:619-30.
    • (1989) Cell , vol.56 , pp. 619-630
    • Thomas, B.J.1    Rothstein, R.2
  • 144
    • 0031897270 scopus 로고    scopus 로고
    • Human gene targeting by viral vectors
    • Russell DW, Hirata RK. Human gene targeting by viral vectors. Nat Genet 1998;18:325-30.
    • (1998) Nat Genet , vol.18 , pp. 325-330
    • Russell, D.W.1    Hirata, R.K.2
  • 145
    • 37549069296 scopus 로고    scopus 로고
    • Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta
    • Chamberlain JR, Deyle DR, Schwarze U, et al. Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta. Mol Ther 2008;16:187-93.
    • (2008) Mol Ther , vol.16 , pp. 187-193
    • Chamberlain, J.R.1    Deyle, D.R.2    Schwarze, U.3
  • 146
    • 33747046320 scopus 로고    scopus 로고
    • Gene targeting in vivo by adeno-associated virus vectors
    • Miller DG, Wang PR, Petek LM, et al. Gene targeting in vivo by adeno-associated virus vectors. Nat Biotechnol 2006;24:1022-6.
    • (2006) Nat Biotechnol , vol.24 , pp. 1022-1026
    • Miller, D.G.1    Wang, P.R.2    Petek, L.M.3
  • 147
    • 10744222737 scopus 로고    scopus 로고
    • Gene targeting in stem cells from individuals with osteogenesis imperfecta
    • Chamberlain JR, Schwarze U, Wang PR, et al. Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science 2004;303:1198-201.
    • (2004) Science , vol.303 , pp. 1198-1201
    • Chamberlain, J.R.1    Schwarze, U.2    Wang, P.R.3
  • 148
    • 0028061666 scopus 로고
    • Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
    • Rouet P, Smih F, Jasin M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol Cell Biol 1994;14:8096-106.
    • (1994) Mol Cell Biol , vol.14 , pp. 8096-8106
    • Rouet, P.1    Smih, F.2    Jasin, M.3
  • 149
    • 0028919608 scopus 로고
    • Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae
    • Choulika A, Perrin A, Dujon B, et al. Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol Cell Biol 1995;15:1968-73.
    • (1995) Mol Cell Biol , vol.15 , pp. 1968-1973
    • Choulika, A.1    Perrin, A.2    Dujon, B.3
  • 150
    • 0031962185 scopus 로고    scopus 로고
    • Gene conversion tracts from double-strand break repair in mammalian cells
    • Elliott B, Richardson C, Winderbaum J, et al. Gene conversion tracts from double-strand break repair in mammalian cells. Mol Cell Biol 1998;18:93-101.
    • (1998) Mol Cell Biol , vol.18 , pp. 93-101
    • Elliott, B.1    Richardson, C.2    Winderbaum, J.3
  • 151
    • 0031911791 scopus 로고    scopus 로고
    • I-SceI-induced gene replacement at a natural locus in embryonic stem cells
    • Cohen-Tannoudji M, Robine S, Choulika A, et al. I-SceI-induced gene replacement at a natural locus in embryonic stem cells. Mol Cell Biol 1998;18:1444-8.
    • (1998) Mol Cell Biol , vol.18 , pp. 1444-1448
    • Cohen-Tannoudji, M.1    Robine, S.2    Choulika, A.3
  • 152
    • 0031863007 scopus 로고    scopus 로고
    • Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells
    • Donoho G, Jasin M, Berg P. Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells. Mol Cell Biol 1998;18:4070-8.
    • (1998) Mol Cell Biol , vol.18 , pp. 4070-4078
    • Donoho, G.1    Jasin, M.2    Berg, P.3
  • 153
    • 0038523969 scopus 로고    scopus 로고
    • Chimeric nucleases stimulate gene targeting in human cells
    • Porteus MH, Baltimore D. Chimeric nucleases stimulate gene targeting in human cells. Science 2003;300:763.
    • (2003) Science , vol.300 , pp. 763
    • Porteus, M.H.1    Baltimore, D.2
  • 154
    • 77955126358 scopus 로고    scopus 로고
    • Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology
    • Orlando SJ, Santiago Y DeKelver RC, et al. Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology. Nucleic Acids Res 2010;38:e152.
    • (2010) Nucleic Acids Res , vol.38
    • Orlando, S.J.1    Santiago Y Dekelver, R.C.2
  • 155
    • 8644255915 scopus 로고    scopus 로고
    • Homing endonuclease genes: The rise and fall and rise again of a selfish element
    • Burt A, Koufopanou V. Homing endonuclease genes: the rise and fall and rise again of a selfish element. Curr Opin Genet Dev 2004;14:609-15.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 609-615
    • Burt, A.1    Koufopanou, V.2
  • 156
    • 79952415961 scopus 로고    scopus 로고
    • Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein
    • Hartlerode A, Odate S, Shim I, et al. Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PLoS One 2011;6:e16501.
    • (2011) Plos One , vol.6
    • Hartlerode, A.1    Odate, S.2    Shim, I.3
  • 157
    • 0032778677 scopus 로고    scopus 로고
    • I-SceI endonuclease, a new tool for studying DNA doublestrand break repair mechanisms in Drosophila
    • Bellaiche Y Mogila V, Perrimon N. I-SceI endonuclease, a new tool for studying DNA doublestrand break repair mechanisms in Drosophila. Genetics 1999;152:1037-44.
    • (1999) Genetics , vol.152 , pp. 1037-1044
    • Bellaiche Y Mogila, V.1    Perrimon, N.2
  • 158
    • 34447323568 scopus 로고    scopus 로고
    • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
    • Szczepek M, Brondani V, Buchel J, et al. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 2007;25:786-93.
    • (2007) Nat Biotechnol , vol.25 , pp. 786-793
    • Szczepek, M.1    Brondani, V.2    Buchel, J.3
  • 159
    • 84862727936 scopus 로고    scopus 로고
    • I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells
    • Fenina M, Simon-Chazottes D, Vandormael-Pournin S, et al. I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells. PLoS One 2012;7:e39895.
    • (2012) Plos One , vol.7
    • Fenina, M.1    Simon-Chazottes, D.2    Vandormael-Pournin, S.3
  • 160
    • 84865727967 scopus 로고    scopus 로고
    • Leduc S, et al. 5’-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases
    • Valton J, Daboussi F, Leduc S, et al. 5’-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases. J Biol Chem 2012;287:30139-50.
    • (2012) J Biol Chem , vol.287 , pp. 30139-30150
    • Valton, J.1    Daboussi, F.2
  • 161
    • 33744781256 scopus 로고    scopus 로고
    • Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break
    • Gouble A, Smith J, Bruneau S, et al. Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break. J Gene Med 2006;8:616-22.
    • (2006) J Gene Med , vol.8 , pp. 616-622
    • Gouble, A.1    Smith, J.2    Bruneau, S.3
  • 162
    • 0036714153 scopus 로고    scopus 로고
    • Mutations altering the cleavage specificity of a homing endonuclease
    • Seligman LM, Chisholm KM, Chevalier BS, et al. Mutations altering the cleavage specificity of a homing endonuclease. Nucleic Acids Res 2002;30:3870-9.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3870-3879
    • Seligman, L.M.1    Chisholm, K.M.2    Chevalier, B.S.3
  • 163
    • 33750209424 scopus 로고    scopus 로고
    • Homing endonuclease I-CreI derivatives with novel DNA target specificities
    • Rosen LE, Morrison HA, Masri S, et al. Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res 2006;34:4791-800.
    • (2006) Nucleic Acids Res , vol.34 , pp. 4791-4800
    • Rosen, L.E.1    Morrison, H.A.2    Masri, S.3
  • 164
    • 84884325112 scopus 로고    scopus 로고
    • Genome engineering at the dawn of the golden age
    • Segal DJ, Meckler JF. Genome engineering at the dawn of the golden age. Annu Rev Genomics Hum Genet 2013;14:135-58.
    • (2013) Annu Rev Genomics Hum Genet , vol.14 , pp. 135-158
    • Segal, D.J.1    Meckler, J.F.2
  • 165
    • 0028046895 scopus 로고
    • Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions
    • Choo Y, Klug A. Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions. Proc Natl Acad Sci USA 1994;91:11168-72.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11168-11172
    • Choo, Y.1    Klug, A.2
  • 166
    • 0028328872 scopus 로고
    • Zinc finger phage: Affinity selection of fingers with new DNA-binding specificities
    • Rebar EJ, Pabo CO. Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. Science 1994;263:671-3.
    • (1994) Science , vol.263 , pp. 671-673
    • Rebar, E.J.1    Pabo, C.O.2
  • 167
    • 77954055872 scopus 로고    scopus 로고
    • Zinc finger nucleases as tools to understand and treat human diseases
    • Davis D, Stokoe D. Zinc finger nucleases as tools to understand and treat human diseases. BMC Medicine 2010;8:42.
    • (2010) BMC Medicine , vol.8 , pp. 42
    • Davis, D.1    Stokoe, D.2
  • 168
    • 84878861985 scopus 로고    scopus 로고
    • Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification
    • Wilson KA, McEwen AE, Pruett-Miller SM, et al. Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification. Mol Ther Nucleic Acids 2013;2:e88.
    • (2013) Mol Ther Nucleic Acids , vol.2
    • Wilson, K.A.1    Mc Ewen, A.E.2    Pruett-Miller, S.M.3
  • 169
    • 77955867185 scopus 로고    scopus 로고
    • Genome editing with engineered zinc finger nucleases
    • Urnov FD, Rebar EJ, Holmes MC, et al. Genome editing with engineered zinc finger nucleases. Nat Rev Genet 2010;11:636-46.
    • (2010) Nat Rev Genet , vol.11 , pp. 636-646
    • Urnov, F.D.1    Rebar, E.J.2    Holmes, M.C.3
  • 170
    • 77953633943 scopus 로고    scopus 로고
    • The discovery of zinc fingers and their applications in gene regulation and genome manipulation
    • Klug A. The discovery of zinc fingers and their applications in gene regulation and genome manipulation. Annu Rev Biochem 2010;79:213-31.
    • (2010) Annu Rev Biochem , vol.79 , pp. 213-231
    • Klug, A.1
  • 171
    • 84867743649 scopus 로고    scopus 로고
    • Development of nuclease-mediated site-specific genome modification
    • Wirt SE, Porteus MH. Development of nuclease-mediated site-specific genome modification. Curr Opin Immunol 2012;24:609-16.
    • (2012) Curr Opin Immunol , vol.24 , pp. 609-616
    • Wirt, S.E.1    Porteus, M.H.2
  • 172
    • 80052766645 scopus 로고    scopus 로고
    • An unbiased genome-wide analysis of zinc-finger nuclease specificity
    • Gabriel R, Lombardo A, Arens A, et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol 2011;29:816-23.
    • (2011) Nat Biotechnol , vol.29 , pp. 816-823
    • Gabriel, R.1    Lombardo, A.2    Arens, A.3
  • 173
    • 80052293623 scopus 로고    scopus 로고
    • Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
    • Pattanayak V, Ramirez CL, Joung JK, et al. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Meth 2011;8:765-70.
    • (2011) Nat Meth , vol.8 , pp. 765-770
    • Pattanayak, V.1    Ramirez, C.L.2    Joung, J.K.3
  • 174
    • 84861982214 scopus 로고    scopus 로고
    • An optimized two-finger archive for ZFN-mediated gene targeting
    • Gupta A, Christensen RG, Rayla AL, et al. An optimized two-finger archive for ZFN-mediated gene targeting. Nat Meth 2012;9:588-90.
    • (2012) Nat Meth , vol.9 , pp. 588-590
    • Gupta, A.1    Christensen, R.G.2    Rayla, A.L.3
  • 175
    • 77449139581 scopus 로고    scopus 로고
    • Genome editing with modularly assembled zinc-finger nucleases
    • Kim JS, Lee HJ, Carroll D. Genome editing with modularly assembled zinc-finger nucleases. Nat Meth 2010;7:91.
    • (2010) Nat Meth , vol.7 , pp. 91
    • Kim, J.S.1    Lee, H.J.2    Carroll, D.3
  • 176
    • 34447319080 scopus 로고    scopus 로고
    • An improved zinc-finger nuclease architecture for highly specific genome editing
    • Miller JC, Holmes MC, Wang J, et al. An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol 2007;25:778-85.
    • (2007) Nat Biotechnol , vol.25 , pp. 778-785
    • Miller, J.C.1    Holmes, M.C.2    Wang, J.3
  • 177
    • 78650912707 scopus 로고    scopus 로고
    • Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures
    • Doyon Y Vo TD, Mendel MC, et al. Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nat Meth 2011;8:74-9.
    • (2011) Nat Meth , vol.8 , pp. 74-79
    • Doyon Y Vo, T.D.1    Mendel, M.C.2
  • 178
    • 77953702888 scopus 로고    scopus 로고
    • 3rd. Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases
    • Guo J, Gaj T, Barbas CF, 3rd. Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol 2010;400:96-107.
    • (2010) J Mol Biol , vol.400 , pp. 96-107
    • Guo, J.1    Gaj, T.2    Barbas, C.F.3
  • 179
    • 84864439768 scopus 로고    scopus 로고
    • Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
    • Gaj T, Guo J, Kato Y et al. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Meth 2012;9:805-7.
    • (2012) Nat Meth , vol.9 , pp. 805-807
    • Gaj, T.1    Guo, J.2    Kato, Y.3
  • 180
    • 61449266636 scopus 로고    scopus 로고
    • Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels
    • Pruett-Miller SM, Reading DW, Porter SN, et al. Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet 2009;5:e1000376.
    • (2009) Plos Genet , vol.5
    • Pruett-Miller, S.M.1    Reading, D.W.2    Porter, S.N.3
  • 181
    • 65249139484 scopus 로고    scopus 로고
    • Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
    • McConnell Smith A, Takeuchi R, Pellenz S, et al. Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci USA 2009;106:5099-104.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 5099-5104
    • Mc Connell Smith, A.1    Takeuchi, R.2    Pellenz, S.3
  • 182
    • 84861990434 scopus 로고    scopus 로고
    • Precision genome engineering with programmable DNA-nicking enzymes
    • Kim E, Kim S, Kim DH, et al. Precision genome engineering with programmable DNA-nicking enzymes. Genome Res 2012;22:1327-33.
    • (2012) Genome Res , vol.22 , pp. 1327-1333
    • Kim, E.1    Kim, S.2    Kim, D.H.3
  • 183
    • 84861984839 scopus 로고    scopus 로고
    • Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme
    • Wang J, Friedman G, Doyon Y et al. Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme. Genome Res 2012;22:1316-26.
    • (2012) Genome Res , vol.22 , pp. 1316-1326
    • Wang, J.1    Friedman, G.2    Doyon, Y.3
  • 184
    • 84861960685 scopus 로고    scopus 로고
    • Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
    • Ramirez CL, Certo MT, Mussolino C, et al. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res 2012;40:5560-8.
    • (2012) Nucleic Acids Res , vol.40 , pp. 5560-5568
    • Ramirez, C.L.1    Certo, M.T.2    Mussolino, C.3
  • 185
    • 72149110399 scopus 로고    scopus 로고
    • Breaking the code of DNA binding specificity of TAL-type III effectors
    • Boch J, Scholze H, Schornack S, et al. Breaking the code of DNA binding specificity of TAL-type III effectors. Science 2009;326:1509-12.
    • (2009) Science , vol.326 , pp. 1509-1512
    • Boch, J.1    Scholze, H.2    Schornack, S.3
  • 186
    • 72149090954 scopus 로고    scopus 로고
    • A simple cipher governs DNA recognition by TAL effectors
    • Moscou MJ, Bogdanove AJ. A simple cipher governs DNA recognition by TAL effectors. Science 2009;326:1501.
    • (2009) Science , vol.326 , pp. 1501
    • Moscou, M.J.1    Bogdanove, A.J.2
  • 187
    • 84857032466 scopus 로고    scopus 로고
    • Structural basis for sequence-specific recognition of DNA by TAL effectors
    • Deng D, Yan C, Pan X, et al. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science 2012;335:720-3.
    • (2012) Science , vol.335 , pp. 720-723
    • Deng, D.1    Yan, C.2    Pan, X.3
  • 188
    • 84864475122 scopus 로고    scopus 로고
    • TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: Tools for TAL effector design and target prediction
    • Doyle EL, Booher NJ, Standage DS, et al. TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction. Nucleic Acids Res 2012;40:W117-22.
    • (2012) Nucleic Acids Res , vol.40
    • Doyle, E.L.1    Booher, N.J.2    Standage, D.S.3
  • 189
    • 79960064013 scopus 로고    scopus 로고
    • Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
    • Cermak T, Doyle EL, Christian M, et al. Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res 2011;39:e82.
    • (2011) Nucleic Acids Res , vol.39
    • Cermak, T.1    Doyle, E.L.2    Christian, M.3
  • 190
    • 84861361409 scopus 로고    scopus 로고
    • Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs)
    • Moore FE, Reyon D, Sander JD, et al. Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). PLoS One 2012;7:e37877.
    • (2012) Plos One
    • Moore, F.E.1    Reyon, D.2    Sander, J.D.3
  • 191
    • 84891385829 scopus 로고    scopus 로고
    • Transcription activator-like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing
    • Sun N, Zhao H. Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing. Biotechnol Bioeng 2013;110:1811-21.
    • (2013) Biotechnol Bioeng , vol.110 , pp. 1811-1821
    • Sun, N.1    Zhao, H.2
  • 192
    • 84872203111 scopus 로고    scopus 로고
    • Kaiser V, et al. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes
    • Schmid-Burgk JL, Schmidt T, Kaiser V, et al. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes. Nat Biotechnol 2013;31:76-81.
    • (2013) Nat Biotechnol , vol.31 , pp. 76-81
    • Schmid-Burgk, J.L.1    Schmidt, T.2
  • 193
    • 84880815042 scopus 로고    scopus 로고
    • Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly
    • Reyon D, Maeder ML, Khayter C, et al. Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly. Curr Protoc Mol Bio 2013;Chapter 12:Unit 12.16.
    • Curr Protoc Mol Bio 2013;Chapter 12:Unit , vol.12 , pp. 16
    • Reyon, D.1    Maeder, M.L.2    Khayter, C.3
  • 194
    • 84866879789 scopus 로고    scopus 로고
    • Iterative capped assembly: Rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
    • Briggs AW, Rios X, Chari R, et al. Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res 2012;40:e117.
    • (2012) Nucleic Acids Res , vol.40
    • Briggs, A.W.1    Rios, X.2    Chari, R.3
  • 195
    • 84861170955 scopus 로고    scopus 로고
    • A transcription activator-like effector toolbox for genome engineering
    • Sanjana NE, Cong L, Zhou Y et al. A transcription activator-like effector toolbox for genome engineering. Nat Protoc 2012;7:171-92.
    • (2012) Nat Protoc , vol.7 , pp. 171-192
    • Sanjana, N.E.1    Cong, L.2    Zhou, Y.3
  • 196
    • 79960066049 scopus 로고    scopus 로고
    • Assembly of custom TALE-type DNA binding domains by modular cloning
    • Morbitzer R, Elsaesser J, Hausner J, et al. Assembly of custom TALE-type DNA binding domains by modular cloning. Nucleic Acids Res 2011;39:5790-9.
    • (2011) Nucleic Acids Res , vol.39 , pp. 5790-5799
    • Morbitzer, R.1    Elsaesser, J.2    Hausner, J.3
  • 197
    • 70249114821 scopus 로고    scopus 로고
    • Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
    • Hockemeyer D, Soldner F, Beard C, et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol 2009;27:851-7.
    • (2009) Nat Biotechnol , vol.27 , pp. 851-857
    • Hockemeyer, D.1    Soldner, F.2    Beard, C.3
  • 198
    • 79952302385 scopus 로고    scopus 로고
    • De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks
    • Mahfouz MM, Li L, Shamimuzzaman M, et al. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci USA 2011;108:2623-8.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2623-2628
    • Mahfouz, M.M.1    Li, L.2    Shamimuzzaman, M.3
  • 199
    • 84870786425 scopus 로고    scopus 로고
    • Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression
    • Li Y Moore R, Guinn M, et al. Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression. Sci Rep 2012;2:897.
    • (2012) Sci Rep , vol.2 , pp. 897
    • Li Y Moore, R.1    Guinn, M.2
  • 200
    • 84876389220 scopus 로고    scopus 로고
    • Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells
    • Holkers M, Maggio I, Liu J, et al. Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res 2013;41:e63.
    • (2013) Nucleic Acids Res , vol.41
    • Holkers, M.1    Maggio, I.2    Liu, J.3
  • 201
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M, Chylinski K, Fonfara I, et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012;337:816-21.
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3
  • 202
    • 74249095519 scopus 로고    scopus 로고
    • CRISPR/Cas, the immune system of bacteria and archaea
    • Horvath P, Barrangou R. CRISPR/Cas, the immune system of bacteria and archaea. Science 2010;327:167-70.
    • (2010) Science , vol.327 , pp. 167-170
    • Horvath, P.1    Barrangou, R.2
  • 203
    • 84887010498 scopus 로고    scopus 로고
    • Genome engineering using the CRISPR-Cas9 system
    • Ran FA, Hsu PD, Wright J, et al. Genome engineering using the CRISPR-Cas9 system. Nat Protoc 2013;8:2281-308.
    • (2013) Nat Protoc , vol.8 , pp. 2281-2308
    • Ran, F.A.1    Hsu, P.D.2    Wright, J.3
  • 204
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L, Ran FA, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013;339:819-23.
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1    Ran, F.A.2    Cox, D.3
  • 205
    • 84884289608 scopus 로고    scopus 로고
    • One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
    • Yang H, Wang H, Shivalila CS, et al. One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering. Cell 2013;154:1370-9.
    • (2013) Cell , vol.154 , pp. 1370-1379
    • Yang, H.1    Wang, H.2    Shivalila, C.S.3
  • 206
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang H, Yang H, Shivalila CS, et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013;153:910-8.
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3
  • 207
    • 84874624936 scopus 로고    scopus 로고
    • Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    • Cho SW, Kim S, Kim JM, et al. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol 2013;31:230-2.
    • (2013) Nat Biotechnol , vol.31 , pp. 230-232
    • Cho, S.W.1    Kim, S.2    Kim, J.M.3
  • 208
    • 84873734105 scopus 로고    scopus 로고
    • RNA-guided human genome engineering via Cas9
    • Mali P, Yang L, Esvelt KM, et al. RNA-guided human genome engineering via Cas9. Science 2013;339:823-6.
    • (2013) Science , vol.339 , pp. 823-826
    • Mali, P.1    Yang, L.2    Esvelt, K.M.3
  • 209
    • 84874617789 scopus 로고    scopus 로고
    • Efficient genome editing in zebrafish using a CRISPR-Cas system
    • Hwang WY, Fu Y Reyon D, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol 2013;31:227-9.
    • (2013) Nat Biotechnol , vol.31 , pp. 227-229
    • Hwang, W.Y.1    Fu Y Reyon, D.2
  • 210
    • 84876575031 scopus 로고    scopus 로고
    • Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
    • DiCarlo JE, Norville JE, Mali P, et al. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res 2013;41:4336-43.
    • (2013) Nucleic Acids Res , vol.41 , pp. 4336-4343
    • Dicarlo, J.E.1    Norville, J.E.2    Mali, P.3
  • 211
    • 84874608929 scopus 로고    scopus 로고
    • RNA-guided editing of bacterial genomes using CRISPR-Cas systems
    • Jiang W, Bikard D, Cox D, et al. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol 2013;31:233-9.
    • (2013) Nat Biotechnol , vol.31 , pp. 233-239
    • Jiang, W.1    Bikard, D.2    Cox, D.3
  • 212
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
    • Fu Y, Foden JA, Khayter C, et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol 2013;31:822-6.
    • (2013) Nat Biotechnol , vol.31 , pp. 822-826
    • Fu, Y.1    Foden, J.A.2    Khayter, C.3
  • 213
    • 84884950106 scopus 로고    scopus 로고
    • CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity
    • Cradick TJ, Fine EJ, Antico CJ, et al. CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res 2013;41:9584-92.
    • (2013) Nucleic Acids Res , vol.41 , pp. 9584-9592
    • Cradick, T.J.1    Fine, E.J.2    Antico, C.J.3
  • 214
    • 84884288934 scopus 로고    scopus 로고
    • Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
    • Ran FA, Hsu PD, Lin CY et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 2013;154:1380-9.
    • (2013) Cell , vol.154 , pp. 1380-1389
    • Ran, F.A.1    Hsu, P.D.2    Lin, C.Y.3
  • 215
    • 79960833952 scopus 로고    scopus 로고
    • Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
    • Soldner F, Laganiere J, Cheng AW, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 2011;146:318-31.
    • (2011) Cell , vol.146 , pp. 318-331
    • Soldner, F.1    Laganiere, J.2    Cheng, A.W.3
  • 216
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
    • Yusa K, Rashid ST, Strick-Marchand H, et al. Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature 2011;478:391-4.
    • (2011) Nature , vol.478 , pp. 391-394
    • Yusa, K.1    Rashid, S.T.2    Strick-Marchand, H.3
  • 217
    • 80055069793 scopus 로고    scopus 로고
    • Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease
    • Zou J, Mali P, Huang X, et al. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood 2011;118:4599-608.
    • (2011) Blood , vol.118 , pp. 4599-4608
    • Zou, J.1    Mali, P.2    Huang, X.3
  • 218
    • 44449120801 scopus 로고    scopus 로고
    • Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
    • Santiago Y, Chan E, Liu PQ, et al. Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases. Proc Natl Acad Sci USA 2008;105:5809-14.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5809-5814
    • Santiago, Y.1    Chan, E.2    Liu, P.Q.3
  • 219
    • 77955390706 scopus 로고    scopus 로고
    • Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies
    • Malphettes L, Freyvert Y, Chang J, et al. Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies. Biotechnol Bioeng 2010;106:774-83.
    • (2010) Biotechnol Bioeng , vol.106 , pp. 774-783
    • Malphettes, L.1    Freyvert, Y.2    Chang, J.3
  • 220
    • 84880020391 scopus 로고    scopus 로고
    • Engineering Chinese hamster ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglu-cosaminyltransferase (Mgat1)
    • Sealover NR, Davis AM, Brooks JK, et al. Engineering Chinese hamster ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglu-cosaminyltransferase (Mgat1). J Biotechnol 2013;167:24-32.
    • (2013) J Biotechnol , vol.167 , pp. 24-32
    • Sealover, N.R.1    Davis, A.M.2    Brooks, J.K.3
  • 221
    • 77951599072 scopus 로고    scopus 로고
    • Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases
    • Liu PQ, Chan EM, Cost GJ, et al. Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases. Biotechnol Bioeng 2010;106:97-105.
    • (2010) Biotechnol Bioeng , vol.106 , pp. 97-105
    • Liu, P.Q.1    Chan, E.M.2    Cost, G.J.3
  • 222
    • 74849089122 scopus 로고    scopus 로고
    • BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells
    • Cost GJ, Freyvert Y Vafiadis A, et al. BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells. Biotechnol Bioeng 2010;105:330-40.
    • (2010) Biotechnol Bioeng , vol.105 , pp. 330-340
    • Cost, G.J.1    Freyvert Y Vafiadis, A.2
  • 223
    • 33847246298 scopus 로고    scopus 로고
    • Meganucleases and DNA double-strand break-induced recombination: Perspectives for gene therapy
    • Paques F, Duchateau P. Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy. Curr Gene Rher 2007;7:49-66.
    • (2007) Curr Gene Rher , vol.7 , pp. 49-66
    • Paques, F.1    Duchateau, P.2
  • 224
    • 78651337233 scopus 로고    scopus 로고
    • Genomic safe harbors permit high beta-globin transgene expression in thalassemia induced pluripotent stem cells
    • Papapetrou EP, Lee G, Malani N, et al. Genomic safe harbors permit high beta-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol 2011;29:73-8.
    • (2011) Nat Biotechnol , vol.29 , pp. 73-78
    • Papapetrou, E.P.1    Lee, G.2    Malani, N.3
  • 225
    • 84655170273 scopus 로고    scopus 로고
    • Safe harbours for the integration of new DNA in the human genome
    • Sadelain M, Papapetrou EP, Bushman FD. Safe harbours for the integration of new DNA in the human genome. Nat Rev Cancer 2012;12:51-8.
    • (2012) Nat Rev Cancer , vol.12 , pp. 51-58
    • Sadelain, M.1    Papapetrou, E.P.2    Bushman, F.D.3
  • 226
    • 71849119231 scopus 로고    scopus 로고
    • Nuclear organization in the 3D space of the nucleus - cause or consequence?
    • Nunez E, Fu XD, Rosenfeld MG. Nuclear organization in the 3D space of the nucleus - cause or consequence? Curr Opin Genet Dev 2009;19:424-36.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 424-436
    • Nunez, E.1    Fu, X.D.2    Rosenfeld, M.G.3
  • 227
    • 84872272027 scopus 로고    scopus 로고
    • Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci
    • Nehlsen K, da Gama-Norton L, Schucht R, et al. Towards rational engineering of cells: Recombinant gene expression in defined chromosomal loci. BMC Proc 2011;5 Suppl 8:O6.
    • (2011) BMC Proc , vol.5
    • Nehlsen, K.1    Da Gama-Norton, L.2    Schucht, R.3
  • 228
    • 39849093502 scopus 로고    scopus 로고
    • Recombineering: Genetic engineering in bacteria using homologous recombination
    • Chapter 1:Unit 1
    • Thomason L, Court DL, Bubunenko M, et al. Recombineering: genetic engineering in bacteria using homologous recombination. Curr Protoc Mol Biol 2007;Chapter 1:Unit 1 16.
    • (2007) Curr Protoc Mol Biol , pp. 16
    • Thomason, L.1    Court, D.L.2    Bubunenko, M.3
  • 229
    • 0035487293 scopus 로고    scopus 로고
    • Recombineering: A powerful new tool for mouse functional genomics
    • Copeland NG, Jenkins NA, Court DL. Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet 2001;2:769-79.
    • (2001) Nat Rev Genet , vol.2 , pp. 769-779
    • Copeland, N.G.1    Jenkins, N.A.2    Court, D.L.3
  • 230
    • 79251539547 scopus 로고    scopus 로고
    • Bacterial artificial chromosome mutagenesis using recombineering
    • Narayanan K, Chen Q. Bacterial artificial chromosome mutagenesis using recombineering. J Biomed Biotechnol 2011;2011:9712-96.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 9712-9796
    • Narayanan, K.1    Chen, Q.2
  • 231
    • 0034278464 scopus 로고    scopus 로고
    • Point mutation of bacterial artificial chromosomes by ET recombination
    • Muyrers JP, Zhang Y Benes V, et al. Point mutation of bacterial artificial chromosomes by ET recombination. EMBO Rep 2000;1:239-43.
    • (2000) EMBO Rep , vol.1 , pp. 239-243
    • Muyrers, J.P.1    Zhang Y Benes, V.2
  • 232
    • 26644453335 scopus 로고    scopus 로고
    • Simple and highly efficient BAC recombineering using galK selection
    • Warming S, Costantino N, Court DL, et al. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res 2005;33:e36.
    • (2005) Nucleic Acids Res , vol.33
    • Warming, S.1    Costantino, N.2    Court, D.L.3
  • 233
    • 2542503672 scopus 로고    scopus 로고
    • Phage annealing proteins promote oligonucleotide-directed mutagenesis in Escherichia coli and mouse ES cells
    • Zhang Y Muyrers JP, Rientjes J, et al. Phage annealing proteins promote oligonucleotide-directed mutagenesis in Escherichia coli and mouse ES cells. BMC Mol Biol 2003;4:1.
    • (2003) BMC Mol Biol , vol.4 , pp. 1
    • Zhang Y Muyrers, J.P.1    Rientjes, J.2
  • 234
    • 84856436841 scopus 로고    scopus 로고
    • High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes
    • Bird AW, Erler A, Fu J, et al. High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes. Nat Meth 2012;9:103-9.
    • (2012) Nat Meth , vol.9 , pp. 103-109
    • Bird, A.W.1    Erler, A.2    Fu, J.3
  • 235
    • 83755224329 scopus 로고    scopus 로고
    • Mobilization of giant piggyBac transposons in the mouse genome
    • Li MA, Turner DJ, Ning Z, et al. Mobilization of giant piggyBac transposons in the mouse genome. Nucleic Acids Res 2011;39:e148.
    • (2011) Nucleic Acids Res , vol.39
    • Li, M.A.1    Turner, D.J.2    Ning, Z.3
  • 236
    • 84868102032 scopus 로고    scopus 로고
    • Transposon-mediated BAC transgenesis in human ES cells
    • Rostovskaya M, Fu J, Obst M, et al. Transposon-mediated BAC transgenesis in human ES cells. Nucleic Acids Res 2012;40:e150.
    • (2012) Nucleic Acids Res , vol.40
    • Rostovskaya, M.1    Fu, J.2    Obst, M.3
  • 237
    • 77956643985 scopus 로고    scopus 로고
    • Temporal and spatial resolution of type I and III interferon responses in vivo
    • Pulverer JE, Rand U, Lienenklaus S, et al. Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol 2010;84:8626-38.
    • (2010) J Virol , vol.84 , pp. 8626-8638
    • Pulverer, J.E.1    Rand, U.2    Lienenklaus, S.3
  • 238
    • 42949095911 scopus 로고    scopus 로고
    • BAC TransgeneOmics: A high-throughput method for exploration of protein function in mammals
    • Poser I, Sarov M, Hutchins JR, et al. BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Meth 2008;5:409-15.
    • (2008) Nat Meth , vol.5 , pp. 409-415
    • Poser, I.1    Sarov, M.2    Hutchins, J.R.3
  • 239
    • 84855955718 scopus 로고    scopus 로고
    • The Use of Bacterial Artificial Chromosomes for Recombinant Protein Production in Mammalian Cell Lines Recombinant Gene Expression
    • Lorence A
    • Blaas L, Musteanu M, Grabner B, et al. The Use of Bacterial Artificial Chromosomes for Recombinant Protein Production in Mammalian Cell Lines Recombinant Gene Expression. In: Lorence A (ed): Springer New York; 2012:581-93.
    • (2012) Springer New York , pp. 581-593
    • Blaas, L.1    Musteanu, M.2    Grabner, B.3
  • 240
    • 62349130284 scopus 로고    scopus 로고
    • Bacterial artificial chromosomes improve recombinant protein production in mammalian cells
    • Blaas L, Musteanu M, Eferl R, et al. Bacterial artificial chromosomes improve recombinant protein production in mammalian cells. BMC Biotechnol 2009;9:3.
    • (2009) BMC Biotechnol , vol.9 , pp. 3
    • Blaas, L.1    Musteanu, M.2    Eferl, R.3
  • 241
    • 77954367689 scopus 로고    scopus 로고
    • BAC TG-EMBED: One-step method for high-level, copy-number-dependent, position-independent transgene expression
    • Bian Q, Belmont AS. BAC TG-EMBED: one-step method for high-level, copy-number-dependent, position-independent transgene expression. Nucleic Acids Res 2010;38:e127.
    • (2010) Nucleic Acids Res , vol.38
    • Bian, Q.1    Belmont, A.S.2
  • 242
    • 80052401275 scopus 로고    scopus 로고
    • Human artificial chromosomes for gene delivery and the development of animal models
    • Kazuki Y Oshimura M. Human artificial chromosomes for gene delivery and the development of animal models. Mol Ther 2011;19:1591-601.
    • (2011) Mol Ther , vol.19 , pp. 1591-1601
    • Kazuki Y Oshimura, M.1
  • 243
    • 79960924581 scopus 로고    scopus 로고
    • Engineered mammalian chromosomes in cellular protein production: Future prospects
    • Kennard ML. Engineered mammalian chromosomes in cellular protein production: future prospects. Meth Mol Biol 2011;738:217-38.
    • (2011) Meth Mol Biol , vol.738 , pp. 217-238
    • Kennard, M.L.1
  • 244
    • 84876675718 scopus 로고    scopus 로고
    • A new generation of human artificial chromosomes for functional genomics and gene therapy
    • Kouprina N, Earnshaw WC, Masumoto H, et al. A new generation of human artificial chromosomes for functional genomics and gene therapy. Cell Mol Life Sci 2013;70:1135-48.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 1135-1148
    • Kouprina, N.1    Earnshaw, W.C.2    Masumoto, H.3
  • 245
    • 50549090204 scopus 로고    scopus 로고
    • Advances in high-capacity extrachromosomal vector technology: Episomal maintenance, vector delivery, and transgene expression
    • Lufino MM, Edser PA, Wade-Martins R. Advances in high-capacity extrachromosomal vector technology: episomal maintenance, vector delivery, and transgene expression. Mol Ther 2008;16:1525-38.
    • (2008) Mol Ther , vol.16 , pp. 1525-1538
    • Lufino, M.M.1    Edser, P.A.2    Wade-Martins, R.3
  • 246
    • 0034724646 scopus 로고    scopus 로고
    • Long-term replication of Epstein-Barr virus-derived episomal vectors in the rodent cells
    • Mizuguchi H, Hosono T, Hayakawa T. Long-term replication of Epstein-Barr virus-derived episomal vectors in the rodent cells. FEBS Lett 2000;472:173-8.
    • (2000) FEBS Lett , vol.472 , pp. 173-178
    • Mizuguchi, H.1    Hosono, T.2    Hayakawa, T.3
  • 247
    • 0036789010 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen-1 is highly colocalized with interphase chromatin and its newly replicated regions in particular
    • Ito S, Gotoh E, Ozawa S, et al. Epstein-Barr virus nuclear antigen-1 is highly colocalized with interphase chromatin and its newly replicated regions in particular. J Gen Virol 2002;83:2377-83.
    • (2002) J Gen Virol , vol.83 , pp. 2377-2383
    • Ito, S.1    Gotoh, E.2    Ozawa, S.3
  • 248
    • 80051956027 scopus 로고    scopus 로고
    • Scaffold/matrix attached region-based nonviral episomal vectors
    • Hagedorn C, Wong SP, Harbottle R, Lipps HJ. Scaffold/matrix attached region-based nonviral episomal vectors. Hum Gene Ther 2011;22:915-23.
    • (2011) Hum Gene Ther , vol.22 , pp. 915-923
    • Hagedorn, C.1    Wong, S.P.2    Harbottle, R.3    Lipps, H.J.4
  • 249
    • 0033780721 scopus 로고    scopus 로고
    • Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix
    • Baiker A, Maercker C, Piechaczek C, et al. Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix. Nat Cell Biol 2000;2:182-4.
    • (2000) Nat Cell Biol , vol.2 , pp. 182-184
    • Baiker, A.1    Maercker, C.2    Piechaczek, C.3
  • 250
    • 34548382578 scopus 로고    scopus 로고
    • Establishment and mitotic stability of an extra-chromosomal mammalian replicon
    • Stehle IM, Postberg J, Rupprecht S, et al. Establishment and mitotic stability of an extra-chromosomal mammalian replicon. BMC Cell Biol 2007;8:33.
    • (2007) BMC Cell Biol , vol.8 , pp. 33
    • Stehle, I.M.1    Postberg, J.2    Rupprecht, S.3
  • 251
    • 0042379603 scopus 로고    scopus 로고
    • Exploiting a minimal system to study the epigenetic control of DNA replication: The interplay between transcription and replication
    • Stehle IM, Scinteie MF, Baiker A, et al. Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication. Chromosome Res 2003;11:413-21.
    • (2003) Chromosome Res , vol.11 , pp. 413-421
    • Stehle, I.M.1    Scinteie, M.F.2    Baiker, A.3
  • 252
    • 3843139313 scopus 로고    scopus 로고
    • Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome
    • Jenke AC, Stehle IM, Herrmann F, et al. Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome. Proc Natl Acad Sci USA 2004;101:11322-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11322-11327
    • Jenke, A.C.1    Stehle, I.M.2    Herrmann, F.3
  • 253
    • 0033555686 scopus 로고    scopus 로고
    • A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells
    • Piechaczek C, Fetzer C, Baiker A, et al. A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells. Nucleic Acids Res 1999;27:426-8.
    • (1999) Nucleic Acids Res , vol.27 , pp. 426-428
    • Piechaczek, C.1    Fetzer, C.2    Baiker, A.3
  • 254
    • 29244487057 scopus 로고    scopus 로고
    • Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element
    • Papapetrou EP, Ziros PG, Micheva ID, et al. Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element. Gene Ther 2006;13:40-51.
    • (2006) Gene Ther , vol.13 , pp. 40-51
    • Papapetrou, E.P.1    Ziros, P.G.2    Micheva, I.D.3
  • 255
    • 80054732670 scopus 로고    scopus 로고
    • Episomal transgene expression in pluripotent stem cells
    • Lufino MM, Poppleston AR, Cowley SA, et al. Episomal transgene expression in pluripotent stem cells. Methods Mol Biol 2011;767:369-87.
    • (2011) Methods Mol Biol , vol.767 , pp. 369-387
    • Lufino, M.M.1    Poppleston, A.R.2    Cowley, S.A.3
  • 256
    • 33845322322 scopus 로고    scopus 로고
    • Genetically modified pigs produced with a nonviral episomal vector
    • Manzini SA, Vargiolu IM, Stehle ML, et al. Genetically modified pigs produced with a nonviral episomal vector. Proc Natl Acad Sci USA 2006;103(47):17672-7.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.47 , pp. 17672-17677
    • Manzini, S.A.1    Vargiolu, I.M.2    Stehle, M.L.3
  • 257
    • 80051533518 scopus 로고    scopus 로고
    • Non-viral episomal modification of cells using S/MAR elements
    • Argyros O, Wong SP, Harbottle RP. Non-viral episomal modification of cells using S/MAR elements. Expert Opin Biol Ther 2011;11:1177-91.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1177-1191
    • Argyros, O.1    Wong, S.P.2    Harbottle, R.P.3
  • 258
    • 84884736571 scopus 로고    scopus 로고
    • Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells
    • Hacker DL, Kiseljak D, Rajendra Y et al. Polyethyleneimine-based transient gene expression processes for suspension-adapted HEK-293E and CHO-DG44 cells. Protein Expr Purif 2013;92:67-76.
    • (2013) Protein Expr Purif , vol.92 , pp. 67-76
    • Hacker, D.L.1    Kiseljak, D.2    Rajendra, Y.3


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