Assay development of inducible human renal phosphate transporter Npt2A (SLC34A1) in Flp-In-Trex-HEK293 cells

European Journal of Pharmacology

Volumn 721, Issue 1-3, 2013, Pages 332-340

  Wu, Hongzhong ^a,b   Mao, Chonghong ^b   Duenstl, Georg ^c   Su, Wan ^d   Qian, Su ^b  

^a Sundia MedTech Co Ltd   (China)

^b Metabolic Disease Franchise   (China)

^c LEO PHARMA A S   (Denmark)

^d LONGHUA HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Assay development; Hyperphosphatemia; Npt2A; Phosphate uptake; SLC34A1; Specific inhibitor

Indexed keywords

DOXYCYCLINE; SODIUM; SODIUM PHOSPHATE COTRANSPORTER 2A;

ARTICLE; CARDIOVASCULAR MORTALITY; CELL STRAIN HEK293; CELL VIABILITY; CELL VIABILITY ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLP IN TREX HEK293CELL; HUMAN; HUMAN CELL; HYPERPHOSPHATEMIA; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; MOLECULAR LIBRARY; NUCLEOTIDE SEQUENCE; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN EXPRESSION; VALIDATION PROCESS;

ASSAY DEVELOPMENT; HYPERPHOSPHATEMIA; NPT2A; PHOSPHATE UPTAKE; SLC34A1; SPECIFIC INHIBITOR;

BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; DRUG EVALUATION, PRECLINICAL; HEK293 CELLS; HUMANS; PHOSPHATES; SESQUITERPENES; SODIUM; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA; TIME FACTORS; TRANSFECTION;

EID: 84890126665     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.09.005     Document Type: Article

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