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Volumn 22, Issue 6, 2011, Pages 761-774

The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; PROTEIN CHS4; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 79955852358     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2010.233     Document Type: Article
Times cited : (80)

References (108)
  • 1
    • 31944446094 scopus 로고    scopus 로고
    • Leukemia virus long terminal repeat activates NFκB pathway by a TLR3-dependent mechanism
    • DOI 10.1016/j.virol.2005.10.003, PII S0042682205006458
    • Abujamra, A.L., Spanjaard, R.A., Akinsheye, I., et al. (2006). Leukemia virus long terminal repeat activates NFkappaB pathway by a TLR3-dependent mechanism. Virology 345, 390-403. (Pubitemid 43189898)
    • (2006) Virology , vol.345 , Issue.2 , pp. 390-403
    • Abujamra, A.L.1    Spanjaard, R.A.2    Akinsheye, I.3    Zhao, X.4    Faller, D.V.5    Ghosh, S.K.6
  • 2
    • 0345863840 scopus 로고    scopus 로고
    • RTCGD: Ret-roviral tagged cancer gene database
    • Akagi, K., Suzuki, T., Stephens, R.M., et al. (2004). RTCGD: ret-roviral tagged cancer gene database. Nucleic Acids Res. 32, D523-527.
    • (2004) Nucleic Acids Res. , vol.32
    • Akagi, K.1    Suzuki, T.2    Stephens, R.M.3
  • 3
    • 78549280576 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier activity function of a vertebrate chromatin insulator
    • Aker, M., Bomsztyk, K., and Emery, D.W. (2010). Poly (ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier activity function of a vertebrate chromatin insulator. J. Biol. Chem. 285, 37589-37597.
    • (2010) J. Biol. Chem. , vol.285 , pp. 37589-37597
    • Aker, M.1    Bomsztyk, K.2    Emery, D.W.3
  • 5
    • 33745414660 scopus 로고    scopus 로고
    • Integration Bias of Gammaretrovirus Vectors following Transduction and Growth of Primary Mouse Hematopoietic Progenitor Cells with and without Selection
    • DOI 10.1016/j.ymthe.2006.02.016, PII S1525001606000943
    • Aker, M., Tubb, J., Miller, D.G., et al. (2006). Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection. Mol. Ther. 14, 226-235. (Pubitemid 43942346)
    • (2006) Molecular Therapy , vol.14 , Issue.2 , pp. 226-235
    • Aker, M.1    Tubb, J.2    Miller, D.G.3    Stamatoyannopoulos, G.4    Emery, D.W.5
  • 6
    • 0025908566 scopus 로고
    • The pro-karyotic neomycin-resistance-encoding gene acts as a tran-scriptional silencer in eukaryotic cells
    • Artelt, P., Grannemann, R., Stocking, C., et al. (1991). The pro-karyotic neomycin-resistance-encoding gene acts as a tran-scriptional silencer in eukaryotic cells. Gene 99, 249-254.
    • (1991) Gene , vol.99 , pp. 249-254
    • Artelt, P.1    Grannemann, R.2    Stocking, C.3
  • 7
    • 70449127224 scopus 로고    scopus 로고
    • Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region
    • Arumugam, P.I., Higashimoto, T., Urbinati, F., et al. (2009b). Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region. Mol. Ther. 17, 1929-1937.
    • (2009) Mol. Ther. , vol.17 , pp. 1929-1937
    • Arumugam, P.I.1    Higashimoto, T.2    Urbinati, F.3
  • 8
    • 34548791721 scopus 로고    scopus 로고
    • Improved Human β-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element
    • DOI 10.1038/sj.mt.6300259, PII 6300259
    • Arumugam, P.I., Scholes, J., Perelman, N., et al. (2007). Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element. Mol. Ther. 15, 1863-1871. (Pubitemid 47434195)
    • (2007) Molecular Therapy , vol.15 , Issue.10 , pp. 1863-1871
    • Arumugam, P.I.1    Scholes, J.2    Perelman, N.3    Xia, P.4    Yee, J.-K.5    Malik, P.6
  • 9
    • 70349185586 scopus 로고    scopus 로고
    • 0 region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity
    • 0 region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity. PLoS ONE 4, e6995.
    • (2009) PLoS ONE , vol.4
    • Arumugam, P.I.1    Urbinati, F.2    Velu, C.S.3
  • 10
    • 29744458522 scopus 로고    scopus 로고
    • A phase I/II clinical trial of β-globin gene therapy for β-thalassemia
    • DOI 10.1196/annals.1345.007
    • Bank, A., Dorazio, R., and Leboulch, P. (2005). A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia. Ann. N. Y. Acad. Sci. 1054, 308-316. (Pubitemid 43031038)
    • (2005) Annals of the New York Academy of Sciences , vol.1054 , pp. 308-316
    • Bank, A.1    Dorazio, R.2    Leboulch, P.3
  • 11
    • 33645451483 scopus 로고    scopus 로고
    • Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
    • Baum, C., Kustikova, O., Modlich, U., et al. (2006a). Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum. Gene Ther. 17, 252-263.
    • (2006) Hum. Gene Ther. , vol.17 , pp. 252-263
    • Baum, C.1    Kustikova, O.2    Modlich, U.3
  • 12
    • 33646875083 scopus 로고    scopus 로고
    • Retrovirus vectors: Toward the plentivirus?
    • DOI 10.1016/j.ymthe.2006.03.007, PII S1525001606000906
    • Baum, C., Schambach, A., Bohne, J., and Galla, M. (2006b). Retrovirus vectors: toward the plentivirus? Mol. Ther. 13, 1050-1063. (Pubitemid 43779189)
    • (2006) Molecular Therapy , vol.13 , Issue.6 , pp. 1050-1063
    • Baum, C.1    Schambach, A.2    Bohne, J.3    Galla, M.4
  • 13
    • 0033529654 scopus 로고    scopus 로고
    • The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
    • DOI 10.1016/S0092-8674(00)81967-4
    • Bell, A.C., West, A.G., and Felsenfeld, G. (1999). The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98, 387-396. (Pubitemid 29380573)
    • (1999) Cell , vol.98 , Issue.3 , pp. 387-396
    • Bell, A.C.1    West, A.G.2    Felsenfeld, G.3
  • 14
    • 33751418954 scopus 로고    scopus 로고
    • Selection of target sites for mobile DNA elements in the human genome
    • Berry, C., Hannenhalli, S., Leipzig, J., and Bushman, F.D. (2006). Selection of target sites for mobile DNA elements in the human genome. PLoS Comput. Biol. 2, e157.
    • (2006) PLoS Comput. Biol. , vol.2
    • Berry, C.1    Hannenhalli, S.2    Leipzig, J.3    Bushman, F.D.4
  • 15
    • 77957337971 scopus 로고    scopus 로고
    • Large double copy vectors are functional but show size-dependent decline in transduction efficiency
    • Bos, T.J., de Bruyne, E., van Lint, S., et al. (2010). Large double copy vectors are functional but show size-dependent decline in transduction efficiency. J. Biotechnol. 150, 37-40.
    • (2010) J. Biotechnol. , vol.150 , pp. 37-40
    • Bos, T.J.1    De Bruyne, E.2    Van Lint, S.3
  • 16
    • 77956928344 scopus 로고    scopus 로고
    • Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia
    • Cavazzana-Calvo, M., Payen, E., Negre, O., et al. (2010). Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia. Nature 467, 318-322.
    • (2010) Nature , vol.467 , pp. 318-322
    • Cavazzana-Calvo, M.1    Payen, E.2    Negre, O.3
  • 17
    • 0028815676 scopus 로고
    • Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells
    • Challita, P.M., Skelton, D., El-Khoueiry, A., et al. (1995). Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J. Virol. 69, 748-755.
    • (1995) J. Virol. , vol.69 , pp. 748-755
    • Challita, P.M.1    Skelton, D.2    El-Khoueiry, A.3
  • 18
    • 33847205752 scopus 로고    scopus 로고
    • The genetic engineering of hematopoietic stem cells: The rise of lentiviral vectors, the conundrum of the LTR, and the promise of lineage-restricted vectors
    • Chang, A.H., and Sadelain, M. (2007). The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the LTR, and the promise of lineage-restricted vectors. Mol. Ther. 15, 445-456.
    • (2007) Mol. Ther. , vol.15 , pp. 445-456
    • Chang, A.H.1    Sadelain, M.2
  • 19
    • 22744451729 scopus 로고    scopus 로고
    • Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1
    • DOI 10.1038/sj.gt.3302509
    • Chang, L.J., Liu, X., and He, J. (2005). Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1. Gene Ther. 12, 1133-1144. (Pubitemid 41030619)
    • (2005) Gene Therapy , vol.12 , Issue.14 , pp. 1133-1144
    • Chang, L.-J.1    Liu, X.2    He, J.3
  • 20
  • 21
    • 0027254748 scopus 로고
    • A 5' element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in drosophila
    • 0 element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effects in Drosophila. Cell 74, 505-514. (Pubitemid 23244616)
    • (1993) Cell , vol.74 , Issue.3 , pp. 505-514
    • Chung, J.H.1    Whiteley, M.2    Felsenfeld, G.3
  • 22
    • 68249125615 scopus 로고    scopus 로고
    • The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure
    • D'Apolito, D., Baiamonte, E., Bagliesi, M., et al. (2009). The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure. Mol. Ther. 17, 1434-1441.
    • (2009) Mol. Ther. , vol.17 , pp. 1434-1441
    • D'Apolito, D.1    Baiamonte, E.2    Bagliesi, M.3
  • 23
    • 67650132753 scopus 로고    scopus 로고
    • Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator
    • Desprat, R., and Bouhassira, E.E. (2009). Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator. PLoS 4, e5956.
    • (2009) PLoS , vol.4
    • Desprat, R.1    Bouhassira, E.E.2
  • 24
    • 76749155779 scopus 로고    scopus 로고
    • VEZF1 elements mediate protection from DNA methylation
    • Dickson, J., Gowher, H., Strogantsev, R., et al. (2010). VEZF1 elements mediate protection from DNA methylation. PLoS Genet. 6, e1000804.
    • (2010) PLoS Genet. , vol.6
    • Dickson, J.1    Gowher, H.2    Strogantsev, R.3
  • 26
    • 27744489220 scopus 로고    scopus 로고
    • Silencing and variegation of gammaretrovirus and lentivirus vectors
    • DOI 10.1089/hum.2005.16.1241
    • Ellis, J. (2005). Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum. Gene Ther. 16, 1241-1246. (Pubitemid 41611651)
    • (2005) Human Gene Therapy , vol.16 , Issue.11 , pp. 1241-1246
    • Ellis, J.1
  • 27
    • 36148977135 scopus 로고    scopus 로고
    • Chromatin insulators and position effects
    • DOI 10.1016/S0167-7306(03)38023-8, PII S0167730603380238, Gene Transfer and Expression in Mammalian Cells
    • Emery, D.W., Aker, M., and Stamatoyannopoulos, G. (2003). Chromatin insulators and position effects. In Gene Transfer and Expression in Mammalian Cells. Makrides, S.C., ed. (EIC Laboratories, Inc., Norwood, MA.) pp. 381-395. (Pubitemid 137641006)
    • (2003) New Comprehensive Biochemistry , vol.38 , pp. 381-395
    • Emery, D.W.1    Aker, M.2    Stamatoyannopoulos, G.3
  • 28
    • 0032170660 scopus 로고    scopus 로고
    • Development of a condensed locus control region cassette and testing in retrovirus vectors for (A)γ-globin
    • DOI 10.1006/bcmd.1998.0200
    • Emery, D.W., Chen, H., Li, Q., and Stamatoyannopoulos, G. (1998). Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin. Blood Cells Mol. Dis. 24, 322-339. (Pubitemid 28524833)
    • (1998) Blood Cells, Molecules, and Diseases , vol.24 , Issue.3 , pp. 322-339
    • Emery, D.W.1    Chen, H.2    Li, Q.3    Stamatoyannopoulos, G.4
  • 30
    • 79958211020 scopus 로고    scopus 로고
    • Core elements from Drosophila gypsy and chicken beta-globin HS4 do not insulate retrovirus vectors from position effects
    • Emery, D.W., Yannaki, E., Bell, A., et al. (1999). Core elements from Drosophila gypsy and chicken beta-globin HS4 do not insulate retrovirus vectors from position effects. Blood 94 (suppl. 1), 177a.
    • (1999) Blood , vol.94 , Issue.SUPPL. 1
    • Emery, D.W.1    Yannaki, E.2    Bell, A.3
  • 32
    • 0037105522 scopus 로고    scopus 로고
    • Development of virus vectors for gene therapy of b chain hemoglobinopathies: Flanking with a chromatin insulator reduces g-globin gene silencing in vivo
    • Emery, D.W., Yannaki, E., Tubb, J., et al. (2002). Development of virus vectors for gene therapy of b chain hemoglobinopathies: flanking with a chromatin insulator reduces g-globin gene silencing in vivo. Blood 100, 2012-2021.
    • (2002) Blood , vol.100 , pp. 2012-2021
    • Emery, D.W.1    Yannaki, E.2    Tubb, J.3
  • 33
    • 33947272049 scopus 로고    scopus 로고
    • Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector
    • DOI 10.1038/sj.mt.6300103, PII 6300103
    • Evans-Galea, M.V., Wielgosz, M.M., Hanawa, H., et al. (2007). Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector. Mol. Ther. 15, 801-809. (Pubitemid 46432001)
    • (2007) Molecular Therapy , vol.15 , Issue.4 , pp. 801-809
    • Evans-Galea, M.V.1    Wielgosz, M.M.2    Hanawa, H.3    Srivastava, D.K.4    Nienhuis, A.W.5
  • 34
    • 76749171311 scopus 로고    scopus 로고
    • Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation
    • Farrar, D., Rai, S., Chernukhin, I., et al. (2010). Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation. Mol. Cell. Biol. 30, 1199-1216.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1199-1216
    • Farrar, D.1    Rai, S.2    Chernukhin, I.3
  • 35
    • 78649819161 scopus 로고    scopus 로고
    • Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis
    • Gallagher, P.G., Steiner, L.A., Liem, R.I., et al. (2010). Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis. J. Clin. Invest. 120, 4453-3365.
    • (2010) J. Clin. Invest. , vol.120 , pp. 4453-3365
    • Gallagher, P.G.1    Steiner, L.A.2    Liem, R.I.3
  • 36
    • 33845987390 scopus 로고    scopus 로고
    • Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system
    • DOI 10.1016/j.brainres.2006.10.018, PII S0006899306029416
    • Gao, Q., Sun, M., Wang, X, and Geller, A.I. (2007). Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a Neurofilament promoter, in a helper virus-free HSV-1 vector system. Brain Res. 1130, 1-16. (Pubitemid 46053873)
    • (2007) Brain Research , vol.1130 , Issue.1 , pp. 1-16
    • Gao, Q.1    Sun, M.2    Wang, X.3    Geller, A.I.4
  • 37
    • 33747453473 scopus 로고    scopus 로고
    • Insulators: Exploiting transcriptional and epigenetic mechanisms
    • DOI 10.1038/nrg1925, PII NRG1925
    • Gaszner, M., and Felsenfeld, G. (2006). Insulators: exploiting transcriptional and epigenetic mechanisms. Nat. Rev. Genet. 7, 703-713. (Pubitemid 44260006)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.9 , pp. 703-713
    • Gaszner, M.1    Felsenfeld, G.2
  • 38
    • 78649447663 scopus 로고    scopus 로고
    • A functional screen for regulatory elements that improve retroviral vector gene expression
    • Groth, A.C., and Emery, D.W. (2010). A functional screen for regulatory elements that improve retroviral vector gene expression. Blood Cells Mol. Dis. 45, 343-350.
    • (2010) Blood Cells Mol. Dis. , vol.45 , pp. 343-350
    • Groth, A.C.1    Emery, D.W.2
  • 42
    • 63949087408 scopus 로고    scopus 로고
    • Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element
    • Hanawa, H., Yamamoto, M., Zhao, H., et al. (2009). Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element. Mol. Ther. 17, 667-674.
    • (2009) Mol. Ther. , vol.17 , pp. 667-674
    • Hanawa, H.1    Yamamoto, M.2    Zhao, H.3
  • 43
    • 0024672667 scopus 로고
    • Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector
    • Hantzopoulos, P.A., Sullenger, B.A., Ungers, G., and Gilboa, E. (1989). Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector. Proc. Natl. Acad. Sci. U.S.A. 86, 3519-3523.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 3519-3523
    • Hantzopoulos, P.A.1    Sullenger, B.A.2    Ungers, G.3    Gilboa, E.4
  • 44
  • 45
    • 34548125356 scopus 로고    scopus 로고
    • The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors
    • DOI 10.1038/sj.gt.3302979, PII 3302979
    • Higashimoto, T., Urbinati, F., Perumbeti, A., et al. (2007). The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors. Gene Ther. 14, 1298-1304. (Pubitemid 47299954)
    • (2007) Gene Therapy , vol.14 , Issue.17 , pp. 1298-1304
    • Higashimoto, T.1    Urbinati, F.2    Perumbeti, A.3    Jiang, G.4    Zarzuela, A.5    Chang, L.-J.6    Kohn, D.B.7    Malik, P.8
  • 46
    • 2642553379 scopus 로고    scopus 로고
    • Sea urchin insulator protects lentiviral vector from silencing by maintaining active chromatin structure
    • DOI 10.1038/sj.gt.3302227
    • Hino, S., Fan, J., Taguwa, S., et al. (2004). Sea urchin insulator protects lentiviral vector from silencing by maintaining active chromatin structure. Gene Ther. 11, 819-828. (Pubitemid 38714585)
    • (2004) Gene Therapy , vol.11 , Issue.10 , pp. 819-828
    • Hino, S.1    Fan, J.2    Taguwa, S.3    Akasaka, K.4    Matsuoka, M.5
  • 47
    • 77649261872 scopus 로고    scopus 로고
    • Cell type specificity of chromatin organization mediated by CTCF and cohesin
    • Hou, C., Dale, R. and Dean, A. (2010). Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proc. Natl. Acad. Sci. U. S. A. 107, 3651-3656.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 3651-3656
    • Hou, C.1    Dale, R.2    Dean, A.3
  • 48
    • 3242682377 scopus 로고    scopus 로고
    • Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator
    • DOI 10.1016/j.yexcr.2004.04.037, PII S0014482704002642
    • Jakobsson, J., Rosenqvist, N., Thompson, L., et al. (2004). Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator. Exp. Cell Res. 298, 611-623. (Pubitemid 38950876)
    • (2004) Experimental Cell Research , vol.298 , Issue.2 , pp. 611-623
    • Jakobsson, J.1    Rosenqvist, N.2    Thompson, L.3    Barraud, P.4    Lundberg, C.5
  • 49
    • 68149150830 scopus 로고    scopus 로고
    • H3.3/H2A.Z double variant-containing nucleosides are 'nucleosome-free regions' of active promoters and other regulatory regions
    • Jin, C., Zhang, C., Wei, G., et al. (2009). H3.3/H2A.Z double variant-containing nucleosides are 'nucleosome-free regions' of active promoters and other regulatory regions. Nat. Genet. 41, 941-945.
    • (2009) Nat. Genet. , vol.41 , pp. 941-945
    • Jin, C.1    Zhang, C.2    Wei, G.3
  • 51
    • 44649130038 scopus 로고    scopus 로고
    • Transcriptional control by PARP-1: Chro-matin modulation, enhancer-binding, coregulation, and insulation
    • Kraus, W.L. (2008). Transcriptional control by PARP-1: chro-matin modulation, enhancer-binding, coregulation, and insulation. Curr. Opin. Cell Biol. 20, 294-302.
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 294-302
    • Kraus, W.L.1
  • 52
    • 37249055565 scopus 로고    scopus 로고
    • The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus
    • DOI 10.1038/sj.gt.3303009, PII 3303009
    • Li, C.L., and Emery, D.W. (2008). The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus. Gene Ther. 15, 49-53. (Pubitemid 350269432)
    • (2008) Gene Therapy , vol.15 , Issue.1 , pp. 49-53
    • Li, C.L.1    Emery, D.W.2
  • 53
    • 63949083133 scopus 로고    scopus 로고
    • Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
    • Li, C.L., Xiong, D., Stamatoyannopoulos, G., and Emery, D.W. (2009). Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol. Ther. 17, 716-724.
    • (2009) Mol. Ther. , vol.17 , pp. 716-724
    • Li, C.L.1    Xiong, D.2    Stamatoyannopoulos, G.3    Emery, D.W.4
  • 54
    • 33645814398 scopus 로고    scopus 로고
    • CTCF mediates inter-chromosomal colocalization between Igf2/H19 and Wsb1/ Nf1
    • Ling, J.Q., Li, T., Hu, J.F., et al. (2006). CTCF mediates inter-chromosomal colocalization between Igf2/H19 and Wsb1/ Nf1. Science 312, 269-272.
    • (2006) Science , vol.312 , pp. 269-272
    • Ling, J.Q.1    Li, T.2    Hu, J.F.3
  • 55
    • 0035964869 scopus 로고    scopus 로고
    • Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus
    • DOI 10.1126/science.1064413
    • Litt, M.D., Simpson, M., Gaszner, M., et al. (2001). Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 293, 2453-2455. (Pubitemid 32917326)
    • (2001) Science , vol.293 , Issue.5539 , pp. 2453-2455
    • Litt, M.D.1    Simpson, M.2    Gaszner, M.3    Allis, C.D.4    Felsenfeld, G.5
  • 56
    • 0037240651 scopus 로고    scopus 로고
    • High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors
    • Ma, Y., Ramezani, A., Lewis, R., et al. (2003). High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells 21, 111-117. (Pubitemid 36120372)
    • (2003) Stem Cells , vol.21 , Issue.1 , pp. 111-117
    • Ma, Y.1    Ramezani, A.2    Lewis, R.3    Hawley, R.G.4    Thomson, J.A.5
  • 58
    • 1842717937 scopus 로고    scopus 로고
    • Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes
    • DOI 10.1089/hum.2004.15.995
    • Martin-Duque, P., Jezzard, S., Kaftansis, L., and Vassaux, G. (2004). Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes. Hum. Gene Ther. 15, 995-1002. (Pubitemid 39372576)
    • (2004) Human Gene Therapy , vol.15 , Issue.10 , pp. 995-1002
    • Martin-Duque, P.1    Jezzard, S.2    Kaftansis, L.3    Vassaux, G.4
  • 59
    • 0343628721 scopus 로고    scopus 로고
    • Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
    • DOI 10.1038/35017565
    • May, C., Rivella, S., Callegari, J., et al. (2000). Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing len-tivirus-encoded human beta-globin. Nature 406, 82-86. (Pubitemid 30460215)
    • (2000) Nature , vol.406 , Issue.6791 , pp. 82-86
    • Chad, M.1    Rivella, S.2    Callegari, J.3    Heller, G.4    Gaensler, K.M.L.5    Luzzatto, L.6    Sadelain, M.7
  • 60
    • 34548320032 scopus 로고    scopus 로고
    • Multiple tandem insulators may reduce retroviral insertional activation of oncogenes and lymphomagenesis
    • Mitra, K., Su, M., and Lenz, J. (2007). Multiple tandem insulators may reduce retroviral insertional activation of oncogenes and lymphomagenesis. Mol. Ther. 15 (suppl. 1), S28.
    • (2007) Mol. Ther. , vol.15 , Issue.SUPPL. 1
    • Mitra, K.1    Su, M.2    Lenz, J.3
  • 61
    • 0034467884 scopus 로고    scopus 로고
    • Lack of shielding of primer binding site silencer-mediated repression of an internal promoter in a retrovirus vector by the putative insulators scs, BEAD-1, and HS4
    • DOI 10.1128/JVI.74.24.11697-11707.2000
    • Modin, C., Pedersen, F.S., and Duch, M. (2000). Lack of shielding of primer binding site silencer-mediated repression of an internal promoter in a retrovirus vector by the putative insulators scs, BEAD-1, and HS4. J. Virol. 74, 11697-11707. (Pubitemid 32222319)
    • (2000) Journal of Virology , vol.74 , Issue.24 , pp. 11697-11707
    • Modin, C.1    Pedersen, F.S.2    Duch, M.3
  • 62
    • 33750624015 scopus 로고    scopus 로고
    • Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
    • Modlich, U., Bohne, J., Schmidt, M., et al. (2006). Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 108, 2545-2553.
    • (2006) Blood , vol.108 , pp. 2545-2553
    • Modlich, U.1    Bohne, J.2    Schmidt, M.3
  • 63
    • 34247146896 scopus 로고    scopus 로고
    • Stable gene expression occurs from a minority of integrated HIV-1-based vectors: Transcriptional silencing is present in the majority
    • DOI 10.1038/sj.gt.3302923, PII 3302923
    • Mok, H.P., Javed, S., and Lever, A. (2007). Stable gene expression occurs from a minority of integrated HIV-1-based vectors: transcriptional silencing is present in the majority. Gene Ther. 14, 741-751. (Pubitemid 46585655)
    • (2007) Gene Therapy , vol.14 , Issue.9 , pp. 741-751
    • Mok, H.P.1    Javed, S.2    Lever, A.3
  • 65
    • 65249101260 scopus 로고    scopus 로고
    • The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
    • Montini, E., Cesana, D., Schmidt, M., et al. (2009). The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J. Clin. Invest. 119, 964-975.
    • (2009) J. Clin. Invest. , vol.119 , pp. 964-975
    • Montini, E.1    Cesana, D.2    Schmidt, M.3
  • 66
    • 0037098039 scopus 로고    scopus 로고
    • The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation
    • DOI 10.1101/gad.988502
    • Mutskov, V.J., Farrell, C.M., Wade, P.A., et al. (2002). The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev. 16, 1540-1554. (Pubitemid 34686335)
    • (2002) Genes and Development , vol.16 , Issue.12 , pp. 1540-1554
    • Mutskov, V.J.1    Farrell, C.M.2    Wade, P.A.3    Wolffe, A.P.4    Felsenfeld, G.5
  • 67
    • 33646887376 scopus 로고    scopus 로고
    • Genotoxicity of retroviral integration in hematopoietic cells
    • DOI 10.1016/j.ymthe.2006.03.001, PII S1525001606000785
    • Nienhuis, A.W., Dunbar, C.E., and Sorrentino, B.P. (2006). Genotoxicity of retroviral integration in hematopoietic cells. Mol. Ther. 13, 1031-1049. (Pubitemid 43779188)
    • (2006) Molecular Therapy , vol.13 , Issue.6 , pp. 1031-1049
    • Nienhuis, A.W.1    Dunbar, C.E.2    Sorrentino, B.P.3
  • 68
    • 33745957856 scopus 로고    scopus 로고
    • Partial correction of murine β-thalassemia with a gammaretrovirus vector for human γ-globin
    • DOI 10.1016/j.bcmd.2006.05.001, PII S1079979606001252
    • Nishino, T., Tubb, J., and Emery, D.W. (2006). Partial correction of murine beta-thalassemia with a gammaretrovirus vector for human g-globin. Blood Cells Mol. Dis. 37, 1-7. (Pubitemid 44062363)
    • (2006) Blood Cells, Molecules, and Diseases , vol.37 , Issue.1 , pp. 1-7
    • Nishino, T.1    Tubb, J.2    Emery, D.W.3
  • 69
    • 33745914626 scopus 로고    scopus 로고
    • Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes
    • DOI 10.1016/j.jviromet.2006.04.003, PII S0166093406001285
    • Osti, D., Marras, E., Ceriani, I., et al. (2006). Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes. J. Virol. Methods 136, 93-101. (Pubitemid 44051581)
    • (2006) Journal of Virological Methods , vol.136 , Issue.1-2 , pp. 93-101
    • Osti, D.1    Marras, E.2    Ceriani, I.3    Grassini, G.4    Rubino, T.5    Vigano, D.6    Parolaro, D.7    Perletti, G.8
  • 70
    • 33645734405 scopus 로고    scopus 로고
    • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott, M.G., Schmidt, M., Schwarzwaelder, K., et al. (2006). Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat. Med. 12, 401-409.
    • (2006) Nat. Med. , vol.12 , pp. 401-409
    • Ott, M.G.1    Schmidt, M.2    Schwarzwaelder, K.3
  • 71
    • 0024992893 scopus 로고
    • Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: Deletions and deletions with insertions
    • Pathak, V.K., and Temin, H.M. (1990). Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions. Proc. Natl. Acad. Sci. U. S. A. 87, 6024-6028.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 6024-6028
    • Pathak, V.K.1    Temin, H.M.2
  • 72
    • 0037443467 scopus 로고    scopus 로고
    • The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number
    • DOI 10.1182/blood-2002-07-2211
    • Persons, D.A., Hargrove, P.W., Allay, E.R., et al. (2003). The degree of phenotypic correction of murine beta-thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number. Blood 101, 2175-2183. (Pubitemid 36302055)
    • (2003) Blood , vol.101 , Issue.6 , pp. 2175-2183
    • Persons, D.A.1    Hargrove, P.W.2    Allay, E.R.3    Hanawa, H.4    Nienhuis, A.W.5
  • 73
    • 67549119096 scopus 로고    scopus 로고
    • CTCF: Master weaver of the genome
    • Phillips, J.E., and Corces, V.G. (2009). CTCF: Master weaver of the genome. Cell 137, 1194-1211.
    • (2009) Cell , vol.137 , pp. 1194-1211
    • Phillips, J.E.1    Corces, V.G.2
  • 74
    • 21044449615 scopus 로고    scopus 로고
    • Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters
    • Pluta, K., Luce, M.J., Bao, L., et al. (2005). Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters. J. Gene Med. 7, 803-807.
    • (2005) J. Gene Med. , vol.7 , pp. 803-807
    • Pluta, K.1    Luce, M.J.2    Bao, L.3
  • 76
    • 77952563619 scopus 로고    scopus 로고
    • Insulators and promoters: Closer than we think
    • Raab, J.R., and Kamakaka, R.T. (2010). Insulators and promoters: closer than we think. Nat. Rev. Genet. 11, 439-446.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 439-446
    • Raab, J.R.1    Kamakaka, R.T.2
  • 77
    • 0038792207 scopus 로고    scopus 로고
    • Performance- and safety-enhanced lentiviral vectors containing the human interferon-β scaffold attachment region and the chicken β-globin insulator
    • Ramezani, A., Hawley, T.S., and Hawley, R.G. (2003). Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator. Blood 101, 4717-4724. (Pubitemid 36857727)
    • (2003) Blood , vol.101 , Issue.12 , pp. 4717-4724
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 78
    • 33745408076 scopus 로고    scopus 로고
    • Stable gammaretroviral vector expression during embryonic stem cell-derived in vitro hematopoietic development
    • DOI 10.1016/j.ymthe.2006.04.005, PII S1525001606001468
    • Ramezani, A., Hawley, T.S., and Hawley, R.G. (2006). Stable gammaretroviral vector expression during embryonic stem cell-derived in vitro hematopoietic development. Mol. Ther. 14, 245-254. (Pubitemid 43942353)
    • (2006) Molecular Therapy , vol.14 , Issue.2 , pp. 245-254
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 79
    • 58049220057 scopus 로고    scopus 로고
    • Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/ delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential
    • Ramezani, A., Hawley, T.S., and Hawley, R.G. (2008). Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/ delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential. Stem Cells 26, 3257-3266.
    • (2008) Stem Cells , vol.26 , pp. 3257-3266
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 80
    • 33947261036 scopus 로고    scopus 로고
    • Real-time fluorescence tracking of dynamic transgene variegation in stem cells
    • DOI 10.1038/sj.mt.6300073, PII 6300073
    • Ramunas, J., Montgomery, H.J., Kelly, L., et al. (2007). Real-time fluorescence tracking of dynamic transgene variegation in stem cells. Mol. Ther. 15, 810-817. (Pubitemid 46432002)
    • (2007) Molecular Therapy , vol.15 , Issue.4 , pp. 810-817
    • Ramunas, J.1    Montgomery, H.J.2    Kelly, L.3    Sukonnik, T.4    Ellis, J.5    Jervis, E.J.6
  • 82
    • 0023135557 scopus 로고
    • Instability of large direct repeats in retrovirus vectors
    • Rhode, B.W., Emerman, M., and Temin, H.M. (1987). Instability of large direct repeats in retrovirus vectors. J. Virol. 61, 925-927. (Pubitemid 17040225)
    • (1987) Journal of Virology , vol.61 , Issue.3 , pp. 925-927
    • Rhode, B.W.1    Emerman, M.2    Temin, H.M.3
  • 83
    • 0034000919 scopus 로고    scopus 로고
    • The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites
    • DOI 10.1128/JVI.74.10.4679-4687.2000
    • Rivella, S., Callegari, J.A., May, C., et al. (2000). The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites. J. Virol. 74, 4679-4687. (Pubitemid 30237894)
    • (2000) Journal of Virology , vol.74 , Issue.10 , pp. 4679-4687
    • Rivella, S.1    Callegari, J.A.2    May, C.3    Tan, C.W.4    Sadelain, M.5
  • 84
    • 33845996970 scopus 로고    scopus 로고
    • Murine retroviral but not human cellular promoters induce in vivo erythroid-specific deregulation that can be partially prevented by insulators
    • DOI 10.1038/sj.mt.6300030, PII 6300030
    • Robert-Richard, E., Richard, E., Malik, P., et al. (2007). Murine retroviral but not human cellular promoters induce in vivo erythroid-specific deregulation that can be partially prevented by insulators. Mol. Ther. 15, 173-182. (Pubitemid 46043663)
    • (2007) Molecular Therapy , vol.15 , Issue.1 , pp. 173-182
    • Robert-Richard, E.1    Richard, E.2    Malik, P.3    Ged, C.4    De Verneuil, H.5    Moreau-Gaudry, F.6
  • 86
    • 39549110741 scopus 로고    scopus 로고
    • An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation
    • DOI 10.1182/blood-2007-04-085506
    • Ryu, B.Y., Evans-Galea, M.V., Gray, J.T., et al. (2008). An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation. Blood 111, 1866-1875. (Pubitemid 351451495)
    • (2008) Blood , vol.111 , Issue.4 , pp. 1866-1875
    • Ryu, B.Y.1    Evans-Galea, M.V.2    Gray, J.T.3    Bodine, D.M.4    Persons, D.A.5    Nienhuis, A.W.6
  • 87
    • 34748902850 scopus 로고    scopus 로고
    • A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells
    • DOI 10.1016/j.bcmd.2007.05.003, PII S1079979607001064
    • Ryu, B.Y., Persons, D.A., Evans-Galea, M.V., et al. (2007). A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells. Blood Cells Mol. Dis. 39, 221-228. (Pubitemid 47484460)
    • (2007) Blood Cells, Molecules, and Diseases , vol.39 , Issue.3 , pp. 221-228
    • Ryu, B.Y.1    Persons, D.A.2    Evans-Galea, M.V.3    Gray, J.T.4    Nienhuis, A.W.5
  • 89
    • 34249298695 scopus 로고    scopus 로고
    • Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors
    • DOI 10.1038/sj.mt.6300152, PII 6300152
    • Schambach, A., Galla, M., Maetzig, T., et al. (2007). Improving transcriptional termination of self-inactivating gamma-retro-viral and lentiviral vectors. Mol. Ther. 15, 1167-1173. (Pubitemid 46813620)
    • (2007) Molecular Therapy , vol.15 , Issue.6 , pp. 1167-1173
    • Schambach, A.1    Galla, M.2    Maetzig, T.3    Loew, R.4    Baum, C.5
  • 91
    • 0034068781 scopus 로고    scopus 로고
    • Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo
    • Steinwaerder, D.S., and Lieber, A. (2000). Insulation from viral transcriptional regulatory elements improves inducible trans-gene expression from adenovirus vectors in vitro and in vivo. Gene Ther. 7, 556-567. (Pubitemid 30175558)
    • (2000) Gene Therapy , vol.7 , Issue.7 , pp. 556-567
    • Steinwaerder, D.S.1    Lieber, A.2
  • 94
    • 33645964652 scopus 로고    scopus 로고
    • The CD20/alphaCD20 "suicide" system: Novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells
    • Van Meerten, T., Classen, M.J., Hagenbeek, A., and Ebeling, S.B. (2006). The CD20/alphaCD20 "suicide" system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells. Gene Ther. 13, 789-797.
    • (2006) Gene Ther. , vol.13 , pp. 789-797
    • Van Meerten, T.1    Classen, M.J.2    Hagenbeek, A.3    Ebeling, S.B.4
  • 95
    • 35348911307 scopus 로고    scopus 로고
    • Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator
    • DOI 10.1634/stemcells.2007-0248
    • Vieyra, D.S., and Goodell, M.A. (2007). Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator. Stem Cells 25, 2559-2566. (Pubitemid 47582748)
    • (2007) Stem Cells , vol.25 , Issue.10 , pp. 2559-2566
    • Vieyra, D.S.1    Goodell, M.A.2
  • 96
    • 38649084453 scopus 로고    scopus 로고
    • Transcriptional activities of the sleeping beauty transposon and shielding its genetic cargo with insulators
    • DOI 10.1038/sj.mt.6300366, PII 6300366
    • Walisko, O., Schorn, S., Rolfs, F., et al. (2008). Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators. Mol. Ther. 16, 359-369. (Pubitemid 351168045)
    • (2008) Molecular Therapy , vol.16 , Issue.2 , pp. 359-369
    • Walisko, O.1    Schorn, A.2    Rolfs, F.3    Devaraj, A.4    Miskey, C.5    Izsvak, Z.6    Ivics, Z.7
  • 97
    • 0036467996 scopus 로고    scopus 로고
    • Insulators: Many functions, many mechanisms
    • DOI 10.1101/gad.954702
    • West, A.G., Gaszner, M., and Felsenfeld, G. (2002). Insulators: many functions, many mechanisms. Genes Dev. 16, 271-288. (Pubitemid 34111407)
    • (2002) Genes and Development , vol.16 , Issue.3 , pp. 271-288
    • West, A.G.1    Gaszner, M.2    Felsenfeld, G.3
  • 98
    • 8644240108 scopus 로고    scopus 로고
    • Recruitment of histone modifications by USF proteins at a vertebrate barrier element
    • DOI 10.1016/j.molcel.2004.10.005, PII S1097276504006124
    • West, A.G., Huang, S., Gaszner, M., et al. (2004). Recruitment of histone modifications by USF proteins at a vertebrate barrier element. Mol. Cell 16, 453-463. (Pubitemid 39504798)
    • (2004) Molecular Cell , vol.16 , Issue.3 , pp. 453-463
    • West, A.G.1    Huang, S.2    Gaszner, M.3    Litt, M.D.4    Felsenfeld, G.5
  • 99
    • 0036099418 scopus 로고    scopus 로고
    • Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors
    • DOI 10.1006/mthe.2002.0582
    • Yannaki, E., Tubb, J., Aker, M., et al. (2002). Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors. Mol. Ther. 5, 589-598. (Pubitemid 34546089)
    • (2002) Molecular Therapy , vol.5 , Issue.5 , pp. 589-598
    • Yannaki, E.1    Tubb, J.2    Aker, M.3    Stamatoyannopoulos, G.4    Emery, D.W.5
  • 101
    • 3042732990 scopus 로고    scopus 로고
    • Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications
    • DOI 10.1016/j.ymthe.2004.04.007, PII S1525001604001376
    • Yao, S., Sukonnik, T., Kean, T., et al. (2004). Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications. Mol. Ther. 10, 27-36. (Pubitemid 38878146)
    • (2004) Molecular Therapy , vol.10 , Issue.1 , pp. 27-36
    • Yao, S.1    Sukonnik, T.2    Kean, T.3    Bharadwaj, R.R.4    Pasceri, P.5    Ellis, J.6
  • 102
    • 0037768685 scopus 로고    scopus 로고
    • Insulation from viral transcriptional regulatory elements enables improvement to hepatoma-specific gene expression from adenovirus vectors
    • DOI 10.1016/S0006-291X(03)01251-8
    • Ye, X., Liang, M., Meng, X., et al. (2003). Insulation from viral transcriptional regulatory elements enables improvement to hepatoma-specific gene expression from adenovirus vectors. Biochem. Biophys. Res. Commun. 307, 759-764. (Pubitemid 36871636)
    • (2003) Biochemical and Biophysical Research Communications , vol.307 , Issue.4 , pp. 759-764
    • Ye, X.1    Liang, M.2    Meng, X.3    Ren, X.4    Chen, H.5    Li, Z.-Y.6    Ni, S.7    Lieber, A.8    Hu, F.9
  • 104
    • 0036632178 scopus 로고    scopus 로고
    • 0 readthrough of oncoretrovirus and lentivirus: Implications for vector safety and efficacy
    • 0 readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy. J. Virol. 76, 7209-7219.
    • (2002) J. Virol. , vol.76 , pp. 7209-7219
    • Zaiss, A.K.1    Son, S.2    Chang, L.J.3
  • 105
    • 34548843603 scopus 로고    scopus 로고
    • Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
    • DOI 10.1182/blood-2006-12-060814
    • Zhang, F., Thornhill, S.I., Howe, S.J., et al. (2007). Lentiviral vectors containing an enhancer-less ubiquitously-acting chro-matin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood 110, 1448-1457. (Pubitemid 47443959)
    • (2007) Blood , vol.110 , Issue.5 , pp. 1448-1457
    • Zhang, F.1    Thornhill, S.I.2    Howe, S.J.3    Ulaganathan, M.4    Schambach, A.5    Sinclair, J.6    Kinnon, C.7    Gaspar, H.B.8    Antoniou, M.9    Thrasher, A.J.10
  • 106
    • 4544330542 scopus 로고    scopus 로고
    • An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene
    • Zhao, H., and Dean, A. (2006). An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene. Nucleic Acids Res. 32, 4903-4919.
    • (2006) Nucleic Acids Res. , vol.32 , pp. 4903-4919
    • Zhao, H.1    Dean, A.2
  • 107
    • 77956502744 scopus 로고    scopus 로고
    • A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
    • Zhou, S., Mody, D., Deravin, S.S., et al. (2010). A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood 116, 900-908.
    • (2010) Blood , vol.116 , pp. 900-908
    • Zhou, S.1    Mody, D.2    Deravin, S.S.3


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