-
1
-
-
84867746098
-
Gene therapy for primary immunodeficiencies: Part 2
-
Aiuti, A., Bacchetta, R., Seger, R., et al. (2012). Gene therapy for primary immunodeficiencies: part 2. Curr. Opin. Immunol. 24, 585-591.
-
(2012)
Curr. Opin. Immunol.
, vol.24
, pp. 585-591
-
-
Aiuti, A.1
Bacchetta, R.2
Seger, R.3
-
2
-
-
0032004354
-
Efficient 3¢-end formation of human b-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction
-
Antoniou, M., Geraghty, F., Hurst, J., et al. (1998). Efficient 3¢-end formation of human b-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction. Nucleic Acids Res., 26, 721-729.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 721-729
-
-
Antoniou, M.1
Geraghty, F.2
Hurst, J.3
-
3
-
-
12444283327
-
Transgenes encompassing dual promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing
-
Antoniou, M., Harland, L., Mustoe, T., et al. (2003). Transgenes encompassing dual promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing. Genomics 82, 269-279.
-
(2003)
Genomics
, vol.82
, pp. 269-279
-
-
Antoniou, M.1
Harland, L.2
Mustoe, T.3
-
5
-
-
34548791721
-
Improved human b-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element
-
Arumugam, P.I., Scholes, J., Perelman, N., et al. (2007). Improved human b-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element. Mol. Ther. 15, 1863-1871.
-
(2007)
Mol. Ther.
, vol.15
, pp. 1863-1871
-
-
Arumugam, P.I.1
Scholes, J.2
Perelman, N.3
-
6
-
-
70449127224
-
Genotoxic potential of lineage-specific lentivirus vectors carrying the b-globin locus control region
-
Arumugam, P.I., Higashimoto, T., Urbinati, F., et al. (2009a). Genotoxic potential of lineage-specific lentivirus vectors carrying the b-globin locus control region. Mol. Ther. 17, 1929-1937.
-
(2009)
Mol. Ther.
, vol.17
, pp. 1929-1937
-
-
Arumugam, P.I.1
Higashimoto, T.2
Urbinati, F.3
-
7
-
-
70349185586
-
The 3¢ region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity
-
Arumugam, P.I., Urbinati, F., Velu, C.S., et al. (2009b). The 3¢ region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity. PLoS One 4, e6995
-
(2009)
PLoS One
, vol.4
-
-
Arumugam, P.I.1
Urbinati, F.2
Velu, C.S.3
-
8
-
-
82255185569
-
Daedalus: A robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors
-
Bandaranayake, A.D., Correnti, C., Ryu, B.Y., et al. (2011). Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. Nucleic Acids Res. 39, e143.
-
(2011)
Nucleic Acids Res.
, vol.39
-
-
Bandaranayake, A.D.1
Correnti, C.2
Ryu, B.Y.3
-
9
-
-
84857321616
-
Chromatin insulator elements: Establishing barriers to set heterochromatin boundaries
-
Barkess, G., and West, A.G. (2012). Chromatin insulator elements: establishing barriers to set heterochromatin boundaries. Epigenomics 4, 67-80.
-
(2012)
Epigenomics
, vol.4
, pp. 67-80
-
-
Barkess, G.1
West, A.G.2
-
10
-
-
0036422427
-
The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein
-
Benton, T., Chen, T., McEntee, M., et al. (2002). The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein. Cytotechnology 38, 43-46.
-
(2002)
Cytotechnology
, vol.38
, pp. 43-46
-
-
Benton, T.1
Chen, T.2
McEntee, M.3
-
11
-
-
0033999084
-
Gene silencing as a threat to the success of gene therapy
-
Bestor, T.H. (2000). Gene silencing as a threat to the success of gene therapy. J. Clin. Invest. 105, 409-411.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 409-411
-
-
Bestor, T.H.1
-
12
-
-
79956007043
-
Gene therapy for leukodystrophies
-
Biffi, A., Aubourg, P., and Cartier, N. (2011). Gene therapy for leukodystrophies. Hum. Mol. Genet. 20, R42-53.
-
(2011)
Hum. Mol. Genet.
, vol.20
-
-
Biffi, A.1
Aubourg, P.2
Cartier, N.3
-
13
-
-
0024536789
-
The b-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner
-
Blom van Assendelft, G., Hanscombe, O., Grosveld, F., et al. (1989). The b-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner. Cell 56, 969-977.
-
(1989)
Cell
, vol.56
, pp. 969-977
-
-
Blom Van Assendelft, G.1
Hanscombe, O.2
Grosveld, F.3
-
14
-
-
0041878327
-
From DNA structure to gene expression: Mediators of nuclear compartmentaliza-tion and dynamics
-
Bode, J., Goetze, S., Heng, H., et al. (2003). From DNA structure to gene expression: mediators of nuclear compartmentaliza-tion and dynamics. Chromosome Res. 11, 435-445.
-
(2003)
Chromosome Res.
, vol.11
, pp. 435-445
-
-
Bode, J.1
Goetze, S.2
Heng, H.3
-
15
-
-
84860356388
-
Simple scale-up of recombinant antibody production using an UCOE containing vector
-
Boscolo, S., Mion, F., Licciulli, M., et al. (2012). Simple scale-up of recombinant antibody production using an UCOE containing vector. N. Biotechnol. 29, 477-484.
-
(2012)
N. Biotechnol.
, vol.29
, pp. 477-484
-
-
Boscolo, S.1
Mion, F.2
Licciulli, M.3
-
16
-
-
84858978712
-
Therapeutic hemoglobin levels after gene transfer in b-thalassemia mice and in hematopoietic cells of b-thalassemia and sickle cells disease patients
-
Breda, L., Casu, C., Gardenghi, S., et al. (2012). Therapeutic hemoglobin levels after gene transfer in b-thalassemia mice and in hematopoietic cells of b-thalassemia and sickle cells disease patients. PLoS One 7, e32345.
-
(2012)
PLoS One
, vol.7
-
-
Breda, L.1
Casu, C.2
Gardenghi, S.3
-
17
-
-
84867402831
-
Physiological regulation of transgene expression by a lenti-viral vector containing the A2UCOE linked to a myeloid promoter
-
Brendel, C., Mü ller-Kuller, U., Schultze-Strasser, S., et al. (2012). Physiological regulation of transgene expression by a lenti-viral vector containing the A2UCOE linked to a myeloid promoter. Gene Ther. 19, 1018-1029.
-
(2012)
Gene Ther.
, vol.19
, pp. 1018-1029
-
-
Brendel, C.1
Müller-Kuller, U.2
Schultze-Strasser, S.3
-
18
-
-
84874307076
-
Mechanisms of retroviral integration and mutagenesis
-
Cavazza, A., Moiani, A., and Mavilio, F. (2013). Mechanisms of retroviral integration and mutagenesis. Gene Ther. 24: 119-131.
-
(2013)
Gene Ther.
, Issue.24
, pp. 119-131
-
-
Cavazza, A.1
Moiani, A.2
Mavilio, F.3
-
19
-
-
77956928344
-
Transfusion independence and HMGA2 activation after gene therapy of human b-thalassaemia
-
Cavazzana-Calvo, M., Payen, E., Negre, O., et al. (2010). Transfusion independence and HMGA2 activation after gene therapy of human b-thalassaemia. Nature 467, 318-322.
-
(2010)
Nature
, vol.467
, pp. 318-322
-
-
Cavazzana-Calvo, M.1
Payen, E.2
Negre, O.3
-
20
-
-
84867742516
-
Gene therapy for primary immunodeficiencies: Part 1
-
Cavazzana-Calvo, M., Fischer, A., Hacein-Bey-Abina, S., et al. (2012). Gene therapy for primary immunodeficiencies: Part 1. Curr. Opin. Immunol. 24, 580-584.
-
(2012)
Curr. Opin. Immunol.
, vol.24
, pp. 580-584
-
-
Cavazzana-Calvo, M.1
Fischer, A.2
Hacein-Bey-Abina, S.3
-
21
-
-
33747076039
-
Stem cell-derived erythroid cells mediate long-term systemic protein delivery
-
Chang, A.H., Stephan, M.T., and Sadelain, M. (2006). Stem cell-derived erythroid cells mediate long-term systemic protein delivery. Nat. Biotechnol. 24, 1017-1021.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1017-1021
-
-
Chang, A.H.1
Stephan, M.T.2
Sadelain, M.3
-
22
-
-
0033795914
-
Ret-roviral expression in embryonic stem cells and hematopoietic stem cells
-
Cherry, S.R., Biniszkiewicz, D., van Parijs, L., et al. (2000). Ret-roviral expression in embryonic stem cells and hematopoietic stem cells. Mol. Cell. Biol. 20, 7419-7426.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 7419-7426
-
-
Cherry, S.R.1
Biniszkiewicz, D.2
Van Parijs, L.3
-
23
-
-
0025101148
-
Definition of the minimal requirements within the human b-globin gene and the dominant control region for high level expression
-
Collis, P., Antoniou, M., and Grosveld, F. (1990). Definition of the minimal requirements within the human b-globin gene and the dominant control region for high level expression. EMBO J. 9, 233-240.
-
(1990)
EMBO J.
, vol.9
, pp. 233-240
-
-
Collis, P.1
Antoniou, M.2
Grosveld, F.3
-
24
-
-
29444448047
-
On a chromosome far, far away: LCRs and gene expression
-
Dean, A. (2006). On a chromosome far, far away: LCRs and gene expression. Trends Genet. 22, 38-45.
-
(2006)
Trends Genet.
, vol.22
, pp. 38-45
-
-
Dean, A.1
-
25
-
-
79954510417
-
In the loop: Long range chromatin interactions and gene regulation
-
Dean, A. (2011). In the loop: long range chromatin interactions and gene regulation. Brief Funct. Genomics 10, 3-10.
-
(2011)
Brief Funct. Genomics
, vol.10
, pp. 3-10
-
-
Dean, A.1
-
26
-
-
0042880630
-
Spatial organization of gene expression: The active chromatin hub
-
de Laat, W., and Grosveld, F. (2003). Spatial organization of gene expression: the active chromatin hub. Chromosome Res. 11, 447-459.
-
(2003)
Chromosome Res.
, vol.11
, pp. 447-459
-
-
De Laat, W.1
Grosveld, F.2
-
27
-
-
0028446580
-
A locus control region in the T cell receptor alpha/delta locus
-
Diaz, P., Cado, D., and Winoto, A. (1994). A locus control region in the T cell receptor alpha/delta locus. Immunity 1: 207-217.
-
(1994)
Immunity
, vol.1
, pp. 207-217
-
-
Diaz, P.1
Cado, D.2
Winoto, A.3
-
28
-
-
84875155964
-
Gene therapy for hemoglobinopathies: Progress and challenges
-
pii: S1931-5244(12)00447-1. doi: 10.1016/j.trsl.2012.12.011. [Epub ahead of print]
-
Dong, A., Rivella, S., and Breda, L. (2013). Gene therapy for hemoglobinopathies: progress and challenges. Transl. Res. pii: S1931-5244(12)00447-1. doi: 10.1016/j.trsl.2012.12.011. [Epub ahead of print]
-
(2013)
Transl. Res.
-
-
Dong, A.1
Rivella, S.2
Breda, L.3
-
29
-
-
0023864651
-
Lineage-specific expression of a human b-globin gene in mu-rine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells
-
Dzierzak, E.A., Papayannopoulou, T., and Mulligan, R.C. (1988). Lineage-specific expression of a human b-globin gene in mu-rine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells. Nature 331, 35-41.
-
(1988)
Nature
, vol.331
, pp. 35-41
-
-
Dzierzak, E.A.1
Papayannopoulou, T.2
Mulligan, R.C.3
-
30
-
-
27744489220
-
Silencing and variegation of gammaretrovirus and lentivirus vectors
-
Ellis, J. (2005). Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum. Gene Ther. 16, 1241-1246.
-
(2005)
Hum. Gene Ther.
, vol.16
, pp. 1241-1246
-
-
Ellis, J.1
-
31
-
-
79955852358
-
The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
-
Emery, D.W. (2011). The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum. Gene Ther. 22, 761-774.
-
(2011)
Hum. Gene Ther.
, vol.22
, pp. 761-774
-
-
Emery, D.W.1
-
32
-
-
0029912235
-
Locus control region function and heterochromatin-induced position effect variegation
-
Festenstein, R., Tolaini, M., Corbella, P., et al. (1996). Locus control region function and heterochromatin-induced position effect variegation. Science 271, 1123-1125.
-
(1996)
Science
, vol.271
, pp. 1123-1125
-
-
Festenstein, R.1
Tolaini, M.2
Corbella, P.3
-
33
-
-
10344234192
-
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
-
Fields, P.E., Lee, G.R., Kim, S.T., et al. (2004) Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21, 865-876.
-
(2004)
Immunity
, vol.21
, pp. 865-876
-
-
Fields, P.E.1
Lee, G.R.2
Kim, S.T.3
-
34
-
-
84862785016
-
Chromatin domains, insulators, and the regulation of gene expression
-
Ghirlando, R., Giles, K., Gowher, H., et al. (2012). Chromatin domains, insulators, and the regulation of gene expression. Biochim. Biophys. Acta 1819, 644-651.
-
(1819)
Biochim. Biophys. Acta
, pp. 644-651
-
-
Ghirlando, R.1
Giles, K.2
Gowher, H.3
-
35
-
-
34548348766
-
Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells
-
Girod, P.A., Nguyen, D.Q., Calabrese, D., et al. (2007). Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells. Nat. Methods 4, 747-753.
-
(2007)
Nat. Methods
, vol.4
, pp. 747-753
-
-
Girod, P.A.1
Nguyen, D.Q.2
Calabrese, D.3
-
36
-
-
34548717752
-
CTCF-independent, but not CTCF-dependent, elements significantly contribute to TCR-alpha locus control region activity
-
Gomos-Klein, J., Harrow, F., Alarcón, J., et al. (2007). CTCF-independent, but not CTCF-dependent, elements significantly contribute to TCR-alpha locus control region activity. J. Immunol. 179, 1088-1095.
-
(2007)
J. Immunol.
, vol.179
, pp. 1088-1095
-
-
Gomos-Klein, J.1
Harrow, F.2
Alarcón, J.3
-
37
-
-
0024558096
-
Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice
-
Greaves, D.R., Wilson, F.D., Lang, G., et al. (1989). Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 56, 979-986.
-
(1989)
Cell
, vol.56
, pp. 979-986
-
-
Greaves, D.R.1
Wilson, F.D.2
Lang, G.3
-
38
-
-
0023663887
-
Position-independent, high-level expression of the human b-globin gene in transgenic mice
-
Grosveld, F., van Assendelft, G. B., Greaves, D. R., et al. (1987). Position-independent, high-level expression of the human b-globin gene in transgenic mice. Cell 51, 975-985.
-
(1987)
Cell
, vol.51
, pp. 975-985
-
-
Grosveld, F.1
Van Assendelft, G.B.2
Greaves, D.R.3
-
39
-
-
39849094315
-
Globin lentiviral vector insertions can perturb the expression of endogenous genes in b-thalassemic hematopoietic cells
-
Hargrove, P.W., Kepes, S., Hanawa, H., et al. (2008). Globin lentiviral vector insertions can perturb the expression of endogenous genes in b-thalassemic hematopoietic cells. Mol. Ther. 16, 525-533.
-
(2008)
Mol. Ther.
, vol.16
, pp. 525-533
-
-
Hargrove, P.W.1
Kepes, S.2
Hanawa, H.3
-
40
-
-
0036210471
-
Transcriptional regulation of the human TATA binding protein gene
-
Harland, L., Crombie, R., Anson, S., et al. (2002). Transcriptional regulation of the human TATA binding protein gene. Geno-mics 74, 479-482.
-
(2002)
Geno-mics
, vol.74
, pp. 479-482
-
-
Harland, L.1
Crombie, R.2
Anson, S.3
-
41
-
-
79957471146
-
Identification of a potent MAR element from the mouse genome and assessment of its activity in stable and transient transfections
-
Harraghy, N., Regamey, A., Girod, P.A., et al. (2011). Identification of a potent MAR element from the mouse genome and assessment of its activity in stable and transient transfections. J. Biotechnol. 154, 11-20.
-
(2011)
J. Biotechnol.
, vol.154
, pp. 11-20
-
-
Harraghy, N.1
Regamey, A.2
Girod, P.A.3
-
42
-
-
1842584772
-
Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
-
Heng, H.H., Goetze, S., Ye, C.J., et al. (2004). Chromatin loops are selectively anchored using scaffold/matrix-attachment regions. J. Cell Sci. 117, 999-1008.
-
(2004)
J. Cell Sci.
, vol.117
, pp. 999-1008
-
-
Heng, H.H.1
Goetze, S.2
Ye, C.J.3
-
43
-
-
84856404655
-
Thalassaemia
-
Higgs, D.R., Engel, J.D., and Stamatoyannopoulos, G. (2012). Thalassaemia. Lancet 379, 373-383.
-
(2012)
Lancet
, vol.379
, pp. 373-383
-
-
Higgs, D.R.1
Engel, J.D.2
Stamatoyannopoulos, G.3
-
44
-
-
0035895047
-
Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors
-
Indraccolo, S., Minuzzo, S., Roccaforte, F., et al. (2001). Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors. Blood 98, 3607-3617.
-
(2001)
Blood
, vol.98
, pp. 3607-3617
-
-
Indraccolo, S.1
Minuzzo, S.2
Roccaforte, F.3
-
45
-
-
0028806064
-
The human growth hormone gene is regulated by a multicomponent locus control region
-
Jones, B.K., Monks, B.R., Liebhaber, S.A., et al. (1995). The human growth hormone gene is regulated by a multicomponent locus control region. Mol. Cell. Biol. 15, 7010-7021.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 7010-7021
-
-
Jones, B.K.1
Monks, B.R.2
Liebhaber, S.A.3
-
46
-
-
0031907987
-
Expression pattern of CD2 locus control region containing retroviral vectors in hemopoietic cells in vitro and in vivo
-
Kaptein, L.C.M., Breuer, M., Valerio, D., et al. (1998). Expression pattern of CD2 locus control region containing retroviral vectors in hemopoietic cells in vitro and in vivo. Gene Ther. 5, 320-330.
-
(1998)
Gene Ther.
, vol.5
, pp. 320-330
-
-
Kaptein, L.C.M.1
Breuer, M.2
Valerio, D.3
-
47
-
-
36248995193
-
Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human HNRNPA2B1/CBX3 CpG island
-
Katsantoni, E.Z., Anghelescu, N.E., Robbert Rottier, R., et al. (2007). Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human HNRNPA2B1/CBX3 CpG island. BMC Dev. Biol. 7:108.
-
(2007)
BMC Dev. Biol.
, vol.7
, pp. 108
-
-
Katsantoni, E.Z.1
Anghelescu, N.E.2
Robbert Rottier, R.3
-
48
-
-
84861057518
-
Chromatin loop formation in the b-globin locus and its role in globin gene transcription
-
Kim, A., and Dean, A. (2012). Chromatin loop formation in the b-globin locus and its role in globin gene transcription. Mol. Cells 34, 1-5.
-
(2012)
Mol. Cells
, vol.34
, pp. 1-5
-
-
Kim, A.1
Dean, A.2
-
49
-
-
0034254827
-
Inactivation of a GFP retrovirus occurs at multiple levels in long-term re-populating stem cells and their differentiated progeny
-
Klug, C.A., Cheshier, S., and Weissman, I.L. (2000). Inactivation of a GFP retrovirus occurs at multiple levels in long-term re-populating stem cells and their differentiated progeny. Blood 96, 894-901.
-
(2000)
Blood
, vol.96
, pp. 894-901
-
-
Klug, C.A.1
Cheshier, S.2
Weissman, I.L.3
-
50
-
-
84866159865
-
Safer, silencing-resistant lentiviral vectors: Optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing
-
Knight, S., Zhang, F., Mueller-Kuller, U., et al. (2012). Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing. J. Virol. 86, 9088-9095.
-
(2012)
J. Virol.
, vol.86
, pp. 9088-9095
-
-
Knight, S.1
Zhang, F.2
Mueller-Kuller, U.3
-
51
-
-
0035037078
-
Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression
-
Kowolik, C.M., Hu, J., and Yee, J.K. (2001). Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression. J. Virol. 75, 4641-4648.
-
(2001)
J. Virol.
, vol.75
, pp. 4641-4648
-
-
Kowolik, C.M.1
Hu, J.2
Yee, J.K.3
-
52
-
-
84860379799
-
Enhancer and promoter interactions-long distance calls
-
Krivega, I., and Dean, A. (2012). Enhancer and promoter interactions-long distance calls. Curr. Opin. Genet. Dev. 22, 79-85.
-
(2012)
Curr. Opin. Genet. Dev.
, vol.22
, pp. 79-85
-
-
Krivega, I.1
Dean, A.2
-
53
-
-
0025992068
-
Deletion analysis of the human CD2 gene locus control region in transgenic mice
-
Lang, G., Mamalaki, C., Greenberg, D., et al. (1991). Deletion analysis of the human CD2 gene locus control region in transgenic mice. Nucleic Acids Res. 19, 5851-5856.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 5851-5856
-
-
Lang, G.1
Mamalaki, C.2
Greenberg, D.3
-
54
-
-
0028303758
-
Mutagenesis of retroviral vectors transducing human b-globin gene and b-globin locus control region derivatives results in stable transmission of an active transcriptional structure
-
Leboulch, P., Huang, G.M.S., Humphries, R.K., et al. (1994). Mutagenesis of retroviral vectors transducing human b-globin gene and b-globin locus control region derivatives results in stable transmission of an active transcriptional structure. EMBO J. 13, 3065-3076.
-
(1994)
EMBO J.
, vol.13
, pp. 3065-3076
-
-
Leboulch, P.1
Huang, G.M.S.2
Humphries, R.K.3
-
55
-
-
0037963472
-
Regulation of the Th2 cytokine locus by a locus control region
-
Lee, G.R., Fields, P.E., Griffin, T.J., et al. (2003). Regulation of the Th2 cytokine locus by a locus control region. Immunity 19, 145-153.
-
(2003)
Immunity
, vol.19
, pp. 145-153
-
-
Lee, G.R.1
Fields, P.E.2
Griffin, T.J.3
-
56
-
-
0036839549
-
Locus control regions
-
Li, Q., Peterson, K.R., Fang, X. et al. (2002). Locus control regions. Blood 100, 3077-3086.
-
(2002)
Blood
, vol.100
, pp. 3077-3086
-
-
Li, Q.1
Peterson, K.R.2
Fang, X.3
-
57
-
-
39749191443
-
Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE)
-
Lindahl Allen, M., and Antoniou, M. (2007). Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE). Epigenetics 2, 227-236.
-
(2007)
Epigenetics
, vol.2
, pp. 227-236
-
-
Lindahl Allen, M.1
Antoniou, M.2
-
58
-
-
39649110649
-
Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in b-thalassemic mice
-
Lisowski, L., and Sadelain, M. (2007). Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in b-thalassemic mice. Blood 110, 4175-4178.
-
(2007)
Blood
, vol.110
, pp. 4175-4178
-
-
Lisowski, L.1
Sadelain, M.2
-
59
-
-
0038468406
-
Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes
-
Lutzko, C., Senadheera, D., Skelton, D., et al. (2003). Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes. J. Virol. 77, 7341-7351.
-
(2003)
J. Virol.
, vol.77
, pp. 7341-7351
-
-
Lutzko, C.1
Senadheera, D.2
Skelton, D.3
-
60
-
-
0343628721
-
Therapeutic haemoglobin synthesis in b-thalassaemic mice expressing lenti-virus-encoded human b-globin
-
May, C., Rivella, S., Callegari, J., et al. (2000). Therapeutic haemoglobin synthesis in b-thalassaemic mice expressing lenti-virus-encoded human b-globin. Nature 406, 82-86.
-
(2000)
Nature
, vol.406
, pp. 82-86
-
-
May, C.1
Rivella, S.2
Callegari, J.3
-
61
-
-
45749135187
-
In vivo selection of genetically modified erythroblastic progenitors leads to longterm correction of b-thalassemia
-
Miccio, A., Cesari, R., Lotti, F., et al. (2008). In vivo selection of genetically modified erythroblastic progenitors leads to longterm correction of b-thalassemia. Proc. Natl. Acad. Sci. U.S.A. 105, 10547-10552.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 10547-10552
-
-
Miccio, A.1
Cesari, R.2
Lotti, F.3
-
62
-
-
82555187500
-
The GATA1-HS2 enhancer allows persistent and position-independent expression of a b-globin transgene
-
Miccio, A., Poletti, V., Tiboni, F., et al. (2011). The GATA1-HS2 enhancer allows persistent and position-independent expression of a b-globin transgene. PLoS One 6, e27955.
-
(2011)
PLoS One
, vol.6
-
-
Miccio, A.1
Poletti, V.2
Tiboni, F.3
-
63
-
-
47949121965
-
Instability of retroviral DNA methylation in embryonic stem cells
-
Minoguchi, S., and Iba, H. (2008). Instability of retroviral DNA methylation in embryonic stem cells. Stem Cells 26, 1166-1173.
-
(2008)
Stem Cells
, vol.26
, pp. 1166-1173
-
-
Minoguchi, S.1
Iba, H.2
-
64
-
-
84860594261
-
Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
-
Moiani, A., Paleari, Y., Sartori, D., et al. (2012). Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts. J. Clin. Invest. 122, 1653-1666.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1653-1666
-
-
Moiani, A.1
Paleari, Y.2
Sartori, D.3
-
65
-
-
34247146896
-
Stable gene expression occurs from a minority of integrated HIV-1-based vectors: Transcriptional silencing is present in the majority
-
Mok, H.P., Javed, S., and Lever, A. (2007). Stable gene expression occurs from a minority of integrated HIV-1-based vectors: transcriptional silencing is present in the majority. Gene Ther. 14, 741-751.
-
(2007)
Gene Ther.
, vol.14
, pp. 741-751
-
-
Mok, H.P.1
Javed, S.2
Lever, A.3
-
66
-
-
84863486353
-
The b-globin locus control region in combination with the EF1a short promoter allows enhanced lentiviral vector-mediated ery-throid gene expression with conserved multilineage activity
-
Montiel-Equihua, C.A., Zhang, L., Knight, S., et al. (2012). The b-globin locus control region in combination with the EF1a short promoter allows enhanced lentiviral vector-mediated ery-throid gene expression with conserved multilineage activity. Mol. Ther. 20, 1400-1409.
-
(2012)
Mol. Ther.
, vol.20
, pp. 1400-1409
-
-
Montiel-Equihua, C.A.1
Zhang, L.2
Knight, S.3
-
67
-
-
84855165141
-
CHD chromatin re-modelers and the transcription cycle
-
Murawska, M., and Brehm, A. (2011). CHD chromatin re-modelers and the transcription cycle. Transcription 2, 244-253.
-
(2011)
Transcription
, vol.2
, pp. 244-253
-
-
Murawska, M.1
Brehm, A.2
-
68
-
-
79958156431
-
Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIII
-
Nair, A.R., Jinger, X., and Hermiston, T.W. (2011). Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIII. BMC Res. Notes 4, 178.
-
(2011)
BMC Res. Notes
, vol.4
, pp. 178
-
-
Nair, A.R.1
Jinger, X.2
Hermiston, T.W.3
-
69
-
-
79954692758
-
Ex vivo gene transfer and correction for cell-based therapies
-
Naldini, L. (2011). Ex vivo gene transfer and correction for cell-based therapies. Nat. Rev. Genet. 12, 301-315.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 301-315
-
-
Naldini, L.1
-
70
-
-
41949142533
-
Transcription and chromatin organization of a housekeeping gene cluster containing an integrated b-globin locus control region
-
Noordermeer, D., Branco, M.R., Splinter, E., et al. (2008). Transcription and chromatin organization of a housekeeping gene cluster containing an integrated b-globin locus control region. PLoS Genet. 4, e1000016.
-
(2008)
PLoS Genet.
, vol.4
-
-
Noordermeer, D.1
Branco, M.R.2
Splinter, E.3
-
71
-
-
33645734405
-
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
-
Ott, M.G., Schmidt, M., Schwarzwaelder, K., et al. (2006). Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat. Med. 12, 401-409.
-
(2006)
Nat. Med.
, vol.12
, pp. 401-409
-
-
Ott, M.G.1
Schmidt, M.2
Schwarzwaelder, K.3
-
72
-
-
39049092286
-
B-globin regulation and long-range interactions
-
Palstra, R.J., de Laat, W., and Grosveld, F. (2008). b-globin regulation and long-range interactions. Adv. Genet. 61, 107-142.
-
(2008)
Adv. Genet.
, vol.61
, pp. 107-142
-
-
Palstra, R.J.1
De Laat, W.2
Grosveld, F.3
-
73
-
-
0034329445
-
Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code
-
Pannell, D., Osborne, C.S., Yao, S., et al. (2000). Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code. EMBO J. 19, 5884-5894.
-
(2000)
EMBO J.
, vol.19
, pp. 5884-5894
-
-
Pannell, D.1
Osborne, C.S.2
Yao, S.3
-
74
-
-
2142772598
-
Lack of evidence for protease evolution in HIV-1-infected patients after 2 years of successful highly active antiretroviral therapy
-
Parera, M., Ibañez, A., Clotet, B. et al. (2004). Lack of evidence for protease evolution in HIV-1-infected patients after 2 years of successful highly active antiretroviral therapy. J. Infect. Dis. 189, 1444-1451.
-
(2004)
J. Infect. Dis.
, vol.189
, pp. 1444-1451
-
-
Parera, M.1
Ibañez, A.2
Clotet, B.3
-
75
-
-
0034849315
-
Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo
-
Park, F., and Kay, M.A. (2001). Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo. Mol. Ther. 4, 164-173.
-
(2001)
Mol. Ther.
, vol.4
, pp. 164-173
-
-
Park, F.1
Kay, M.A.2
-
76
-
-
84865812140
-
Genomics. ENCODE project writes eulogy for junk DNA
-
Pennisi, E. (2012). Genomics. ENCODE project writes eulogy for junk DNA. Science 337, 1159.
-
(2012)
Science
, vol.337
, pp. 1159
-
-
Pennisi, E.1
-
77
-
-
77952826869
-
Genetic correction of sickle cell anemia and b-thalassemia: Progress and new perspective
-
Perumbeti, A., and Malik, P. (2010). Genetic correction of sickle cell anemia and b-thalassemia: progress and new perspective. ScientificWorldJournal 10, 644-654.
-
(2010)
ScientificWorldJournal
, vol.10
, pp. 644-654
-
-
Perumbeti, A.1
Malik, P.2
-
78
-
-
84874870904
-
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
-
Pfaff, N., Lachmann, N., Ackermann, M., et al. (2013). A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells 31, 488-499.
-
(2013)
Stem Cells
, vol.31
, pp. 488-499
-
-
Pfaff, N.1
Lachmann, N.2
Ackermann, M.3
-
79
-
-
9444281434
-
Successful correction of the human b-thalassemia major pheno-type using a lentiviral vector
-
Puthenveetil, G., Scholes, J., Carbonell, D., et al. (2004). Successful correction of the human b-thalassemia major pheno-type using a lentiviral vector. Blood 104, 3445-3453.
-
(2004)
Blood
, vol.104
, pp. 3445-3453
-
-
Puthenveetil, G.1
Scholes, J.2
Carbonell, D.3
-
80
-
-
0032169330
-
Muscle-specific locus control region activity associated with the human des-min gene
-
Raguz, S., Hobbs, C., Yagüe, E., et al. (1998). Muscle-specific locus control region activity associated with the human des-min gene. Dev. Biol. 201, 26-42.
-
(1998)
Dev. Biol.
, vol.201
, pp. 26-42
-
-
Raguz, S.1
Hobbs, C.2
Yagüe, E.3
-
81
-
-
77953922892
-
Strategies to insulate lentiviral vector-expressed transgenes
-
Ramezani, A., and Hawley, R.G. (2010). Strategies to insulate lentiviral vector-expressed transgenes. Methods Mol. Biol. 614, 77-100.
-
(2010)
Methods Mol. Biol.
, vol.614
, pp. 77-100
-
-
Ramezani, A.1
Hawley, R.G.2
-
82
-
-
0038792207
-
Performanceand safety-enhanced lentiviral vectors containing the human interferon-b scaffold attachment region and the chicken b-globin insulator
-
Ramezani, A., Hawley, T.S., and Hawley, R.G. (2003). Performanceand safety-enhanced lentiviral vectors containing the human interferon-b scaffold attachment region and the chicken b-globin insulator. Blood 101, 4717-4724.
-
(2003)
Blood
, vol.101
, pp. 4717-4724
-
-
Ramezani, A.1
Hawley, T.S.2
Hawley, R.G.3
-
83
-
-
0037606048
-
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human b-globin gene transfer
-
Rivella, S., May, C., Chadburn, A., et al. (2003). A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human b-globin gene transfer. Blood 101, 2932-2939.
-
(2003)
Blood
, vol.101
, pp. 2932-2939
-
-
Rivella, S.1
May, C.2
Chadburn, A.3
-
84
-
-
77956949262
-
Correction of b-thalassemia major by gene transfer in haematopoietic progenitors of pediatric patients
-
Roselli, E.A., Mezzadra, R., Frittoli, M.C., et al. (2010). Correction of b-thalassemia major by gene transfer in haematopoietic progenitors of pediatric patients. EMBO Mol. Med. 2, 315-328.
-
(2010)
EMBO Mol. Med.
, vol.2
, pp. 315-328
-
-
Roselli, E.A.1
Mezzadra, R.2
Frittoli, M.C.3
-
85
-
-
0036581925
-
Activation of silenced transgene expression in neural precursor cell lines by inhibitors of histone deacetylation
-
Rosenqvist, N., Hård Af Segerstad, C., Samuelsson, C., et al. (2002). Activation of silenced transgene expression in neural precursor cell lines by inhibitors of histone deacetylation. J. Gene Med. 4, 248-257.
-
(2002)
J. Gene Med.
, vol.4
, pp. 248-257
-
-
Rosenqvist, N.1
Hård, A.F.2
Segerstad, C.3
Samuelsson, C.4
-
86
-
-
0029084785
-
Generation of a high-titer retroviral vector capable of expressing high levels of the human b-globin gene
-
Sadelain, M., Wang, C.H., Antoniou, M., et al. (1995). Generation of a high-titer retroviral vector capable of expressing high levels of the human b-globin gene. Proc. Natl. Acad. Sci. U.S.A. 92, 6728-6732.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 6728-6732
-
-
Sadelain, M.1
Wang, C.H.2
Antoniou, M.3
-
87
-
-
73849116439
-
Supplying clotting factors from hematopoietic stem cell-derived erythroid and megakaryocytic lineage cells
-
Sadelain, M., Chang, A., and Lisowski, L. (2009). Supplying clotting factors from hematopoietic stem cell-derived erythroid and megakaryocytic lineage cells. Mol. Ther. 117, 1994-1999.
-
(2009)
Mol. Ther.
, vol.117
, pp. 1994-1999
-
-
Sadelain, M.1
Chang, A.2
Lisowski, L.3
-
88
-
-
30544436003
-
A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference
-
Samakoglu, S., Lisowski, L., Budak-Alpdogan, T., et al. (2006). A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference. Nat. Bio-technol. 24, 89-94.
-
(2006)
Nat. Bio-technol.
, vol.24
, pp. 89-94
-
-
Samakoglu, S.1
Lisowski, L.2
Budak-Alpdogan, T.3
-
89
-
-
84865800494
-
The long-range interaction landscape of gene promoters
-
Sanyal, A., Lajoie, B.R., Jain, G., et al. (2012). The long-range interaction landscape of gene promoters. Nature 489, 109-113.
-
(2012)
Nature
, vol.489
, pp. 109-113
-
-
Sanyal, A.1
Lajoie, B.R.2
Jain, G.3
-
90
-
-
84868128257
-
The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells
-
Sharma, N., Hollensen, A.K., Bak, R.O., et al. (2012). The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells. PLoS One 7, e48421.
-
(2012)
PLoS One
, vol.7
-
-
Sharma, N.1
Hollensen, A.K.2
Bak, R.O.3
-
91
-
-
84872008190
-
ReSETting chromatin during transcription elongation
-
Smolle, M., Workman, J.L., and Venkatesh, S. (2013). reSETting chromatin during transcription elongation. Epigenetics 8, 10-15.
-
(2013)
Epigenetics
, vol.8
, pp. 10-15
-
-
Smolle, M.1
Workman, J.L.2
Venkatesh, S.3
-
92
-
-
76249131912
-
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granuloma-tous disease
-
Stein, S., Ott, M.G., Schultze-Strasser, S., et al. (2010) Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granuloma-tous disease. Nat. Med. 16, 198-204.
-
(2010)
Nat. Med.
, vol.16
, pp. 198-204
-
-
Stein, S.1
Ott, M.G.2
Schultze-Strasser, S.3
-
93
-
-
45749089359
-
Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors
-
Taher, T.E., Tulone, C., Fatah, R., et al. (2008). Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors. Gene Ther. 15, 998-1006.
-
(2008)
Gene Ther.
, vol.15
, pp. 998-1006
-
-
Taher, T.E.1
Tulone, C.2
Fatah, R.3
-
94
-
-
77649271983
-
Desmin-regulated lentiviral vectors for skeletal muscle gene transfer
-
Talbot, G.E., Waddington, S.N., Bales, O., et al. (2010). Desmin-regulated lentiviral vectors for skeletal muscle gene transfer. Mol. Ther. 18, 601-608.
-
(2010)
Mol. Ther.
, vol.18
, pp. 601-608
-
-
Talbot, G.E.1
Waddington, S.N.2
Bales, O.3
-
95
-
-
33746523370
-
The human desmin locus: Gene organisation and LCR-mediated transcriptional control
-
Tam, J.L.Y., Triantaphyllopoulos, K., Todd, H., et al. (2006). The human desmin locus: gene organisation and LCR-mediated transcriptional control. Genomics 87, 733-746.
-
(2006)
Genomics
, vol.87
, pp. 733-746
-
-
Tam, J.L.Y.1
Triantaphyllopoulos, K.2
Todd, H.3
-
96
-
-
84861913473
-
Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome
-
Uchiyama, T., Adriani, M., Jagadeesh, G.J., et al. (2012). Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome. Mol. Ther. 20, 1270-1279.
-
(2012)
Mol. Ther.
, vol.20
, pp. 1270-1279
-
-
Uchiyama, T.1
Adriani, M.2
Jagadeesh, G.J.3
-
97
-
-
0029051646
-
Transcription complex stability and chromatin dynamics in vivo
-
Wijgerde, M., Grosveld, F., and Fraser, P. (1995). Transcription complex stability and chromatin dynamics in vivo. Nature 377, 209-213.
-
(1995)
Nature
, vol.377
, pp. 209-213
-
-
Wijgerde, M.1
Grosveld, F.2
Fraser, P.3
-
98
-
-
26944481086
-
CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
-
Williams, S., Mustoe, T., Mulcahy, T., et al. (2005). CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells. BMC Biotechnol. 5, 17.
-
(2005)
BMC Biotechnol.
, vol.5
, pp. 17
-
-
Williams, S.1
Mustoe, T.2
Mulcahy, T.3
-
99
-
-
84871616547
-
Relationship between DNA replication and the nuclear matrix
-
Wilson, R.H., and Coverley, D. (2013). Relationship between DNA replication and the nuclear matrix. Genes Cells 18, 17-31.
-
(2013)
Genes Cells
, vol.18
, pp. 17-31
-
-
Wilson, R.H.1
Coverley, D.2
-
100
-
-
79955844395
-
The histone chaperone FACT: Structural insights and mechanisms for nucleosome reorganization
-
Winkler, D.D., and Luger, K. (2011). The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. J. Biol. Chem. 286, 18369-18374.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 18369-18374
-
-
Winkler, D.D.1
Luger, K.2
-
101
-
-
33847636745
-
Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner
-
Xia, X., Zhang, Y., Zieth, C.R., et al. (2007). Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner. Stem Cells Dev. 16, 167-176.
-
(2007)
Stem Cells Dev.
, vol.16
, pp. 167-176
-
-
Xia, X.1
Zhang, Y.2
Zieth, C.R.3
-
102
-
-
84862777531
-
Insulators, long-range interactions, and genome function
-
Yang, J., and Corces, V.G. (2012). Insulators, long-range interactions, and genome function. Curr. Opin. Genet. Dev. 22, 86-92.
-
(2012)
Curr. Opin. Genet. Dev.
, vol.22
, pp. 86-92
-
-
Yang, J.1
Corces, V.G.2
-
103
-
-
34548843603
-
Lentiviral vectors containing an enhancer-less ubiquitously-acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in haematopoietic cells
-
Zhang, F., Thornhill, S.I., Howe, S.J., et al. (2007). Lentiviral vectors containing an enhancer-less ubiquitously-acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in haematopoietic cells. Blood 110, 1448-1457.
-
(2007)
Blood
, vol.110
, pp. 1448-1457
-
-
Zhang, F.1
Thornhill, S.I.2
Howe, S.J.3
-
104
-
-
77956265818
-
A Ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation mediated silencing of lentiviral vectors
-
Zhang, F., Frost, A.F., Blundell, M., et al. (2010). A Ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation mediated silencing of lentiviral vectors. Mol. Ther. 18, 1640-1649.
-
(2010)
Mol. Ther.
, vol.18
, pp. 1640-1649
-
-
Zhang, F.1
Frost, A.F.2
Blundell, M.3
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