The Β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity

Molecular Therapy

Volumn 20, Issue 7, 2012, Pages 1400-1409

  Montiel Equihua, Claudia A ^a   Zhang, Lin ^a   Knight, Sean ^b   Saadeh, Heba ^c   Scholz, Simone ^d   Carmo, Marlene ^a   Alonso Ferrero, Maria E ^a   Blundell, Michael P ^a   Monkeviciute, Aiste ^a   Schulz, Reiner ^c   Collins, Mary ^b   Takeuchi, Yasuhiro ^a   Schmidt, Manfred ^d   Fairbanks, Lynette ^e   Antoniou, Michael ^c   Thrasher, Adrian J ^a   Bobby Gaspar, H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; BETA GLOBIN; DEOXYRIBONUCLEASE; ELONGATION FACTOR 1ALPHA; GREEN FLUORESCENT PROTEIN; GROWTH HORMONE RECEPTOR; LENTIVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; BONE MARROW CELL; CD34 SELECTION; CELL DIFFERENTIATION; CELL LINEAGE; CODON; CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROID CELL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE INSERTION; GENE THERAPY; GENETIC CONSERVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LONG TERMINAL REPEAT; LYSOSOME STORAGE DISEASE; MICROARRAY ANALYSIS; MOUSE; MUTAGENESIS; NONHUMAN; PROMOTER REGION; REGULATOR GENE; REPORTER GENE; STEM CELL; TRANSGENE; UPREGULATION;

EID: 84863486353     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.50     Document Type: Conference Paper

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