Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells

Molecular and Cellular Biology

Volumn 18, Issue 7, 1998, Pages 4070-4078

  Donoho, Greg ^a,c   Jasin, Maria ^b   Berg, Paul ^a  

^a STANFORD UNIVERSITY   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CLONING VECTOR; CONTROLLED STUDY; DNA STRAND BREAKAGE; ELECTROPORATION; EMBRYO CELL; GENE FREQUENCY; GENE INSERTION; GENE TARGETING; GENETIC RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; RODENTIA;

EID: 0031863007     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.7.4070     Document Type: Article

References (43)

1. Adra, C. N., P. H. Boer, and M. W. McBurney. 1987. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. Gene 60:65-74.
2. Belmaaza, A., and P. Chartrand. 1994. One-sided invasion events in homologous recombination at double-strand breaks. Mutat. Res. 314:199-208.
3. Bollag, R. J., D. R. Elwood, E. D. Tobin, A. R. Godwin, and R. M. Liskay. 1992. Formation of heteroduplex DNA during mammalian intrachromosomal gene conversion. Mol. Cell. Biol. 12:1546-1552.
4. Brenneman, M., F. S. Gimble, and J. H. Wilson. 1996. Stimulation of intrachromosomal homologous recombination in human cells by electroporation with site-specific endonucleases. Proc. Natl. Acad. Sci. USA 93:3608-3612.
5. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
6. Choulika, A., A. Perrin, B. Dujon, and J. F. Nicolas. 1995. Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol. Cell. Biol. 15:1968-1973.
7. Colleaux, L., L. D'Auriol, F. Galibert, and B. Dujon. 1988. Recognition and cleavage site of the intron-encoded omega transposase. Proc. Natl. Acad. Sci. USA 85:6022-6026.
8. Doetschman, T., R. G. Gregg, N. Maeda, M. L. Hooper, D. W. Melton, S. Thompson, and O. Smithies. 1987. Targeted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330:576-578.
9. Donoho, G. P. 1996. Ph.D. thesis. Stanford University, Stanford, Calif.
10. Elliott, B., C. Richardson, J. Winderbaum, J. A. Nickoloff, and M. Jasin. 1998. Gene conversion tracts from double-strand break repair in mammalian cells. Mol. Cell. Biol. 18:93-101.
11. Esposito, M. S. 1971. Postmeiotic segregation in Saccharomyces. Mol. Gen. Genet. 111:297-299.
12. Gregg, R. G., and O. Smithies. 1986. Targeted modification of human chromosomal genes. Cold Spring Harbor Symp. Quant. Biol. 51:1093-1099.
13. Haber, J. E. 1995. In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases. Bioessays 17:609-620.
14. Hasty, P., R. Ramirez-Solis, R. Krumlauf, and A. Bradley. 1991. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350:243-246.
15. Hasty, P., J. Rivera-Perez, C. Chang, and A. Bradley. 1991. Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol. Cell. Biol. 11:4509-4517.
16. Holliday, R. 1964. A mechanism for gene conversion in fungi. Genet. Res. 5:282-304.
17. Jasin, M. 1996. Genetic manipulation of genomes with rare-cutting endonucleases. Trends Genet. 12:224-228.
18. Jasin, M., and P. Berg. 1988. Homologous integration in mammalian cells without target gene selection. Genes Dev. 2:1353-1363.
19. Kogoma, T. 1996. Recombination by replication. Cell 85:625-627.
20. Konecki, D. S., J. Brennand, J. C. Fuscoe, C. T. Caskey, and A. C. Chinault. 1982. Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants. Nucleic Acids Res. 10:6763-6775.
21. Liang, F., P. J. Romanienko, D. T. Weaver, P. A. Jeggo, and M. Jasin. 1996. Chromosomal double-strand break repair in Ku80-deficient cells. Proc. Natl. Acad. Sci. USA 93:8929-8933.
22. Lin, F. L., K. Sperle, and N. Sternberg. 1984. Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process. Mol. Cell. Biol. 4:1020-1034.
23. Lin, F. L., K. Sperle, and N. Sternberg. 1985. Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences. Proc. Natl. Acad. Sci. USA 82:1391-1395.
24. Mansour, S. L., K. R. Thomas, and M. R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348-352.
25. McDonald, J. P., and R. Rothstein. 1994. Unrepaired heteroduplex DNA in Saccharomyces cerevisiae is decreased in RAD1 RAD52-independent recombination. Genetics 137:393-405.
26. Meselson, M. S., and C. M. Radding. 1975. A general model for genetic recombination. Proc. Natl. Acad. Sci. USA 72:358-361.
27. Moynahan, M. E., and M. Jasin. 1997. Loss of heterozygosity induced by a chromosomal double-strand break. Proc. Natl. Acad. Sci. USA 94:8988-8993.
28. Nag, D. K., M. A. White, and T. D. Petes. 1989. Palindromic sequences in heteroduplex DNA inhibit mismatch repair in yeast. Nature 340:318-320.
29. Puchta, H., B. Dujon, and B. Hohn. 1996. Two different but related mechanisms are used in plants for the repair of genomic double-strand breaks by homologous recombination. Proc. Natl. Acad. Sci. USA 93:5055-5060.
30. Reid, L. H., E. G. Shesely, H. S. Kim, and O. Smithies. 1991. Cotransformation and gene targeting in mouse embryonic stem cells. Mol. Cell. Biol. 11:2769-2777.
31. Robertson, E., A. Bradley, M. Kuehn, and M. Evans. 1986. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323:445-448.
32. Ronne, H., and R. Rothstein. 1988. Mitotic sectored colonies: evidence of heteroduplex DNA formation during direct repeat recombination. Proc. Natl. Acad. Sci. USA 85:2696-2700.
33. Rouet, P., F. Smih, and M. Jasin. 1994. Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proc. Natl. Acad. Sci. USA 91:6064-6068.
34. Rouet, P., F. Smih, and M. Jasin. 1994. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell. Biol. 14:8096-8106.
35. Sargent, R. G., M. A. Brenneman, and J. H. Wilson. 1997. Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination. Mol. Cell. Biol. 17:267-277.
36. Smih, F., P. Rouet, P. J. Romanienko, and M. Jasin. 1995. Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells. Nucleic Acids Res. 23:5012-5019.
37. Smith, A. J., and P. Berg. 1984. Homologous recombination between defective neo genes in mouse 3T6 cells. Cold Spring Harbor Symp. Quant. Biol. 49:171-181.
38. Smithies, O., M. A. Koralewski, K. Y. Song, and R. S. Kucherlapati. 1984. Homologous recombination with DNA introduced into mammalian cells. Cold Spring Harbor Symp. Quant. Biol. 49:161-170.
39. Szostak, J. W., T. L. Orr-Weaver, R. J. Rothstein, and F. W. Stahl. 1983. The double-strand-break repair model for recombination. Cell 33:25-35.
40. Taghian, D. G., and J. A. Nickoloff. 1997. Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells. Mol. Cell. Biol. 17:6386-6393.
41. Thomas, K. R., and M. R. Capecchi. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512.
42. Thomas, K. R., K. R. Folger, and M. R. Capecchi. 1986. High frequency targeting of genes to specific sites in the mammalian genome. Cell 44:419-428.
43. Valancius, V., and O. Smithies. 1991. Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol. Cell. Biol. 11:1402-1408.