Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 23, 2010, Pages 10614-10619

  Koh, Byung Hee ^a   Hwang, Soo Seok ^a   Kim, Joo Young ^b   Lee, Wonyong ^a   Kang, Min Jong ^c   Lee, Chun Geun ^c   Park, Jung Won ^b   Flavell, Richard A ^c,d   Lee, Gap Ryol ^a,c  

^a Sogang University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Chromatin remodeling; Differentiation; Locus control region

Indexed keywords

CYTOKINE; HISTONE H3; IMMUNOGLOBULIN E; OVALBUMIN;

ACETYLATION; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EOSINOPHIL COUNT; GENE CONTROL; GENE LOCUS; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; TH2 CELL;

ANIMALS; ASTHMA; CELL LINEAGE; CYTOKINES; GENE EXPRESSION REGULATION; HYPERSENSITIVITY; IMMUNITY, INNATE; LOCUS CONTROL REGION; MICE; MICE, KNOCKOUT; TH2 CELLS;

MUS;

EID: 77953789765     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1005383107     Document Type: Article

References (43)

1. Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383:787-793.
2. Dong C, Flavell RA (2001) Th1 and Th2 cells. Curr Opin Hematol 8:47-51.
3. Glimcher LH, Murphy KM (2000) Lineage commitment in the immune system: The T helper lymphocyte grows up. Genes Dev 14:1693-1711.
4. Stockinger B, Veldhoen M (2007) Differentiation and function of Th17 T cells. Curr Opin Immunol 19:281-286.
5. Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821-852.
6. Ansel KM, Djuretic IM, Tanasa B, Rao A (2006) Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 24:607-656.
7. Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA (2006) T helper cell differentiation: Regulation by cis elements and epigenetics. Immunity 24:369-379.
8. Agarwal S, Rao A (1998) Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9:765-775. (Pubitemid 29024456)
9. Takemoto N, et al. (1998) Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int Immunol 10:1981-1985. (Pubitemid 28566060)
10. Guo L, et al. (2002) In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc Natl Acad Sci USA 99:10623-10628.
11. Avni O, et al. (2002) T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol 3:643-651. (Pubitemid 34752473)
12. Fields PE, Kim ST, Flavell RA (2002) Cutting edge: Changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J Immunol 169:647-650.
13. Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA (2004) Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21:865-876.
14. Kaneko T, et al. (2007) Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Mol Immunol 44:2249-2256. (Pubitemid 46110908)
15. Messi M, et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 4:78-86. (Pubitemid 36104711)
16. Yamashita M, et al. (2002) Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem 277:42399-42408. (Pubitemid 35257563)
17. Yamashita M, et al. (2004) Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J Biol Chem 279:39454-39464. (Pubitemid 39258211)
18. Kim ST, Fields PE, Flavell RA (2007) Demethylation of a specific hypersensitive site in the Th2 locus control region. Proc Natl Acad Sci USA 104:17052-17057.
19. Lee DU, Agarwal S, Rao A (2002) Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16:649-660. (Pubitemid 34626686)
20. Lee GR, Fields PE, Flavell RA (2001) Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14:447-459.
21. Loots GG, et al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288:136-140.
22. Mohrs M, et al. (2001) Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol 2:842-847.
23. Agarwal S, Avni O, Rao A (2000) Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12:643-652.
24. Ansel KM, et al. (2004) Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol 5:1251-1259.
25. Lee GR, Fields PE, Griffin TJ, IV, Flavell RA (2003) Regulation of the Th2 cytokine locus by a locus control region. Immunity 19:145-153.
26. Lee DU, Rao A (2004) Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3. Proc Natl Acad Sci USA 101:16010-16015.
27. Lee GR, Spilianakis CG, Flavell RA (2005) Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol 6:42-48.
28. Spilianakis CG, Flavell RA (2004) Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol 5:1017-1027.
29. Kinoshita E, van der Linden E, Sanchez H, Wyman C (2009) RAD50, an SMC family member with multiple roles in DNA break repair: How does ATP affect function? Chromosome Res 17:277-288.
30. Williams RS, Williams JS, Tainer JA (2007) Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem Cell Biol 85:509-520.
31. Luo G, et al. (1999) Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci USA 96:7376-7381.
32. Rose S, Lichtenheld M, Foote MR, Adkins B (2007) Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function. J Immunol 178:2667-2678. (Pubitemid 46333143)
33. Busse WW, Lemanske RF, Jr, (2001) Asthma. N Engl J Med 344:350-362.
34. Galli SJ, Tsai M, Piliponsky AM (2008) The development of allergic inflammation. Nature 454:445-454.
35. Holgate ST (1999) The epidemic of allergy and asthma. Nature 402 (6760, Suppl) B2-B4.
36. Wurster AL, Pazin MJ (2008) BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. Mol Cell Biol 28:7274-7285.
37. Cai S, Lee CC, Kohwi-Shigematsu T (2006) SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet 38:1278-1288. (Pubitemid 44646290)
38. Jacob E, Hod-Dvorai R, Schif-Zuck S, Avni O (2008) Unconventional association of the polycomb group proteins with cytokine genes in differentiated T helper cells. J Biol Chem 283:13471-13481.
39. Bank A (2006) Regulation of human fetal hemoglobin: New players, new complexities. Blood 107:435-443.
40. Dean A (2006) On a chromosome far, far away: LCRs and gene expression. Trends Genet 22:38-45. (Pubitemid 43011996)
41. Li Q, Peterson KR, Fang X, Stamatoyannopoulos G (2002) Locus control regions. Blood 100:3077-3086.
42. Mahajan MC, Weissman SM (2006) Multi-protein complexes at the β-globin locus. Brief Funct Genomic Proteomic 5:62-65.
43. Barnes PJ (2004) New drugs for asthma. Nat Rev Drug Discov 3:831-844.