A new generation of human artificial chromosomes for functional genomics and gene therapy

Cellular and Molecular Life Sciences

Volumn 70, Issue 7, 2013, Pages 1135-1148

  Kouprina, Natalay ^a   Earnshaw, William C ^b   Masumoto, Hiroshi ^c   Larionov, Vladimir ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c KAZUSA DNA RESEARCH INSTITUTE   (Japan)

Author keywords

Gene delivery vector; Gene expression; HAC; Human artificial chromosomes

Indexed keywords

POLYCLONAL ANTIBODY; SYNTHETIC DNA;

ARTIFICIAL CHROMOSOME; BIOSAFETY; CELL TYPE; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME 21; CHROMOSOME ARM; CHROMOSOME SEGREGATION; CHROMOSOME SIZE; DNA DETERMINATION; DOWN REGULATION; FUNCTIONAL GENOMICS; GENE CONTROL; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE ISOLATION; GENE LOCUS; GENE TARGETING; GENE THERAPY; GENE VECTOR; GENETIC COMPLEMENTATION; GENETIC MANIPULATION; GENETIC RECOMBINATION; GENETIC SELECTION; HETEROZYGOTE; HUMAN; MOLECULAR CLONING; MONOGENIC DISORDER; NONHUMAN; PROTEIN SYNTHESIS; REVIEW; TRANSGENICS; UPREGULATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHROMOSOMES, ARTIFICIAL, HUMAN; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GENETIC DISEASES, INBORN; GENETIC THERAPY; GENOMICS; HUMANS; MODELS, BIOLOGICAL;

EID: 84876675718     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1113-3     Document Type: Review

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