Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

Ageing Research Reviews

Volumn 33, Issue , 2017, Pages 89-104

  DeBalsi, Karen L ^a   Hoff, Kirsten E ^a   Copeland, William C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Age related diseases; Aging; DNA polymerase gamma; Mitochondrial DNA mutations; MtDNA replication; POLG

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; EXONUCLEASE; HELICASE; MITOCHONDRIAL DNA; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; MITOCHONDRIAL TRANSCRIPTION FACTOR A; POLG2 PROTEIN; PROTEIN; REACTIVE OXYGEN METABOLITE; RIBONUCLEASE H; TWINKLE PROTEIN; UNCLASSIFIED DRUG;

AGING; CELL RESPIRATION; CLONAL VARIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA SYNTHESIS; ENZYME ACTIVITY; GENE DELETION; GERIATRIC DISORDER; HUMAN; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL GENETICS; MOLECULAR BIOLOGY; MUTAGENESIS; NONHUMAN; RESPIRATORY CHAIN; REVIEW; DNA REPLICATION; GENETICS; METABOLISM; MITOCHONDRIAL GENE; MITOCHONDRION; MUTATION; PHYSIOLOGY;

AGING; DNA REPLICATION; DNA, MITOCHONDRIAL; GENES, MITOCHONDRIAL; HUMANS; MITOCHONDRIA; MUTAGENESIS; MUTATION; REACTIVE OXYGEN SPECIES;

EID: 84966655463     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2016.04.006     Document Type: Review

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