Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 269-273

  Cassano, P ^a   Lezza, A M S ^a   Leeuwenburgh, C ^b   Cantatore, P ^a,c   Gadaleta, M N ^a,c  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF FLORIDA   (United States)

^c CNR   (Italy)

Author keywords

Caloric restriction; Mitochondrial DNA; Rat brain; Rat liver; Skeletal muscle

Indexed keywords

DNA; MITOCHONDRIAL DNA;

AGING; CALORIC RESTRICTION; CONFERENCE PAPER; DIET; GENE DELETION; HUMAN; MITOCHONDRION; NONHUMAN; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

EID: 3242714939     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.045     Document Type: Conference Paper

References (10)

1. ASPNES, L., C.M. LEE, R. WEINDRUCH, et al. 1997. Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J. 11: 573-581.
2. GADALETA, M.N., G. RAINALDI, A.M.S. LEZZA, et al. 1992. Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rat. Mutat. Res. 275: 181-193.
3. GADALETA, M.N., G. RAINALDI, A.M.S. LEZZA, et al. 1995. Structure and expression of mitochondrial DNA in aging rat: DNA deletions and protein synthesis. In Progress in Cell Research. Vol. 5. F. Palmieri et al., Eds.: 231-235. Elsevier Science. Amsterdam.
4. YOWE, D.L. & B.N. AMES. 1998. Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans. Gene 209: 23-30.
5. KANG, C.M., B.S. KRISTAL & B.P. YU. 1998. Age-related mitochondrial DNA deletions: effect of dietary restriction. Free Radic. Biol. Med. 24: 148-154.
6. 2 production and oxidative DNA damage in rat liver mitochondria and location of the free radical source. J. Bioenerg. Biomembr. 33: 279-287.
7. LEE, C.-K., R. WEINDRUCH & T.A. PROLLA. 2000. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25: 294-297.
8. RICHTER, C., J.W. PARK & B.N. AMES. 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85: 6465-6467.
9. 8dG levels correlate in old subjects but not in Alzheimer's disease patients brain. FASEB J. 13: 1083-1088.
10. DREW, B.R. & C. LEEUWENBURGH. 2003. Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R1259-R1267 (July 10 [Epub ahead of print]).