Medicine: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Science

Volumn 309, Issue 5733, 2005, Pages 481-484

  Kujoth, C C ^a   Hiona, A ^b   Pugh, T D ^c   Someya, S ^d   Panzer, K ^a   Wohlgemuth, S E ^b   Hofer, T ^b   Seo, A Y ^b   Sullivan, R ^e   Jobling, W A ^f   Morrow, J D ^g   Van Remmen, H ^h   Sedivy, J M ^f   Yamasoba, T ^d   Tanokura, M ^d   Weindruch, R ^c   Leeuwenburgh, C ^b   Prolla, T A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f BROWN UNIVERSITY   (United States)

^g VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORRELATION METHODS; DNA; LIVING SYSTEMS STUDIES; POLYMERS; TISSUE;

APOPTOTIC MARKERS; MITOCHONDRIAL DNA (MTDNA); POLYMERASE Γ (POLG);

GENETIC ENGINEERING;

BIOCHEMICAL MARKER; DNA POLYMERASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; DNA DIRECTED DNA POLYMERASE; DNA FRAGMENT; HYDROGEN PEROXIDE; POLG PROTEIN, HUMAN; POLG PROTEIN, MOUSE;

DNA;

AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL PROLIFERATION; FATTY ACID OXIDATION; GENE MUTATION; GENE TARGETING; MAMMAL CELL; MOUSE; MUTATOR GENE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; AMINO ACID SUBSTITUTION; ANIMAL; DNA DAMAGE; GENETICS; HEART MITOCHONDRION; HEART MUSCLE; HUMAN; LIPID PEROXIDATION; LIVER; LIVER MITOCHONDRION; METABOLISM; MOLECULAR CLONING; MUTATION; PHENOTYPE; PHYSIOLOGY; PRESBYACUSIS; SKELETAL MUSCLE;

ANIMALIA; MAMMALIA;

AGING; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CLONING, MOLECULAR; DNA DAMAGE; DNA FRAGMENTATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; GENE TARGETING; HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; LIVER; MICE; MITOCHONDRIA, HEART; MITOCHONDRIA, LIVER; MUSCLE, SKELETAL; MUTATION; MYOCARDIUM; OXIDATIVE STRESS; PHENOTYPE; PRESBYCUSIS; REACTIVE OXYGEN SPECIES;

EID: 22344456832     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112125     Document Type: Article

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25. We thank J. Warren for stem cell injections, S. Kinoshita for histological processing, and D. Carlson for support in mouse colony management. Supported by NIH grants AG021905 (T.A.P.), AG18922 (R.W.), AG17994 (C.L.), AG21042 (C.L.), DK48831, GM15431, and RR00095 (J.D.M.), and AG16694 (J.M.S.); by NIH training grants T32 AG00213 (G.C.K.) and T32 GM07601 (W.A.J.); and by American Heart Association predoctoral fellowship 0415166B (A.H.). R.W. and TAP. are founders and members of the board of LifeGen Technologies, a company focused on nutritional genomics, including the impact of nutrients and caloric restriction on the aging process.