High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Nature Genetics

Volumn 38, Issue 5, 2006, Pages 515-517

  Bender, Andreas ^a,c   Krishnan, Kim J ^a   Morris, Christopher M ^b   Taylor, Geoffrey A ^a   Reeve, Amy K ^a   Perry, Robert H ^b   Jaros, Evelyn ^b   Hersheson, Joshua S ^a   Betts, Joanne ^a   Klopstock, Thomas ^c   Taylor, Robert W ^a   Turnbull, Douglass M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE DELETION; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRIAL GENETICS; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SOMATIC MUTATION; SUBSTANTIA NIGRA;

AGING; BASE SEQUENCE; DNA, MITOCHONDRIAL; HUMANS; PARKINSON DISEASE; SEQUENCE DELETION; SUBSTANTIA NIGRA;

EID: 33646375711     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1769     Document Type: Article

References (15)

1. Taylor, R.W. & Turnbull, D.M. Nat. Rev. Genet. 6, 389-402 (2005).
2. Johnson, M.A., Turnbull, D.M., Dick, D.J. & Sherratt, H.S. J. Neurol. Sci. 60, 31-53 (1983).
3. Sciacco, M., Bonilla, E., Schon, E.A., DiMauro, S. & Moraes, C.T. Hum. Mol. Genet. 3, 13-19 (1994).
4. Cortopassi, G.A. & Arnheim, N. Nucleic Acids Res. 18, 6927-6933 (1990).
5. Müller-Höcker, J. Am. J. Pathol. 134, 1167-1173 (1989).
6. Taylor, R.W. et al. J. Clin. Invest. 112, 1351-1360 (2003).
7. Fearnley, J.M. & Lees, A.J. Brain 114, 2283-2301 (1991).
8. Greene, J.G., Dingledine, R. & Greenamyre, J.T. Neurobiol. Dis. 18, 19-31 (2005).
9. Smeyne, R.J. & Jackson-Lewis, V. Brain Res. Mol. Brain Res. 134, 57-66 (2005).
10. Itoh, K., Weis, S., Mehraein, P. & Muller-Hocker, J. Neurobiol. Aging 17, 843-848 (1996).
11. Cottrell, D.A. et al. Neurobiol. Aging 22, 265-272 (2001).
12. He, L. et al. Nucleic Acids Res. 30, e68 (2002).
13. Trifunovic, A. et al. Nature 429, 417-423 (2004).
14. Kraytsberg, Y. et al. Nat. Genet., advance online publication 9 April 2006 (doi: 10.1038/ng1778).
15. Luoma, P. et al. Lancet 364, 875-882 (2004).