The mitochondrial p55 accessory subunit of human DNA polymerase γ enhances DNA binding, promotes processive DNA synthesis, and confers N- ethylmaleimide resistance

Journal of Biological Chemistry

Volumn 274, Issue 53, 1999, Pages 38197-38203

  Lim, Susan E ^a   Longley, Matthew J ^a   Copeland, William C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; N ETHYLMALEIMIDE; PROTEIN P55;

ARTICLE; CATALYSIS; COMPLEX FORMATION; DNA BINDING; DNA REPAIR; DNA SYNTHESIS; DNA TEMPLATE; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE DELETION; MITOCHONDRIAL MEMBRANE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PURIFICATION; RECEPTOR AFFINITY;

BASE SEQUENCE; CATALYTIC DOMAIN; DIMERIZATION; DNA; DNA PRIMERS; DNA REPLICATION; DNA, COMPLEMENTARY; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ETHYLMALEIMIDE; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECOMBINANT PROTEINS; SODIUM CHLORIDE;

ESCHERICHIA COLI;

EID: 0033621374     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.53.38197     Document Type: Article

References (31)

1. Shoffner, J. M., and Wallace, D. C. (1994) Anna. Rev. Nutr. 14, 535-568
2. Bourgeron, T., Rustin, P., Chretien, D., Birch-Machin, M., Bourgeois, M., Viegas-Pequignot, E., Munnich, A., and Rotig, A. (1995) Nat. Genet. 11, 144-149
3. Wallace, D. C. (1999) Science 283, 1482-1488
4. Clayton, D. A. (1982) Cell 28, 693-705
5. Kornberg, A., and Baker, T. A. (1992) DNA Replication, 2nd Ed., pp. 209-210, W. H. Freeman and Co., New York
6. Wernette, C. M., and Kaguni, L. S. (1986) J. Biol. Chem. 261, 14764-14770
7. Insdorf, N. F., and Bogenhagen, D. F. (1989) J. Biol. Chem. 264, 21491-21497
8. Gray, H., and Wong, T. W. (1992) J. Biol. Chem. 267, 5835-5841
9. Ropp, P. A., and Copeland, W. C. (1995) Gene (Amst.) 165, 103-107
10. Ropp, P. A., and Copeland, W. C. (1996) Genomics 36, 449-458
11. Longley, M. J., Ropp, P. A., Lim, S. E., and Copeland, W. C. (1998) Biochemistry 37, 10529-10539
12. Longley, M. J., Prasad, R., Srivastava, D. K., Wilson, S. H., and Copeland, W. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12244-12248
13. Williams, A. J., Wernette, C. M., and Kaguni, L. S. (1993) J. Biol. Chem. 268, 24855-24862
14. Wang, Y., Farr, C. L., and Kaguni, L. S. (1997) J. Biol. Chem. 272, 13640-13646
15. Carrodeguas, J. A., Kobayashi, R., Lim, S. E., Copeland, W. C., and Bogenhagen, D F. (1999) Mol. Cell. Biol. 19, 4039-4046
16. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., pp. 18.17-18.18, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
17. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
18. Hughes, M. J., and Jiricny, J. (1992) J. Biol. Chem. 267, 23876-23882
19. Martin, R. G., and Ames, B. N. (1961) J. Biol. Chem. 236, 1372-1379
20. Siegel, L. M., and Monty, K. J. (1966) Biochim. Biophvs. Acta 112, 346-362
21. Longley, M. J., and Mosbaugh, D. W. (1991) J. Biol. Chem. 266, 24702-24711
22. Olson, M. W., and Kaguni, L. S. (1992) J. Biol. Chem. 267, 23136-23142
23. Wang, T. S.-F. (1991) Annu. Rev. Biochem. 60, 513-552
24. Mosbaugh, D. W. (1988) Nucleic Acids Res. 16, 5645-5659
25. Wyman, C., and Botchan, M. (1995) Curr. Biol. 5, 334-337
26. Kelman, Z., and O'Donnell, M. (1995) Nucleic Acids Res. 23, 3613-3620
27. Jonsson, Z. O., and Hubscher, U. (1997) Bioessays 19, 967-975
28. Doublie, S., Tabor, S., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998) Nature 391, 251-258
29. Huber, H. E., Tabor, S., and Richardson, C. C. (1987) J. Biol. Chem. 262, 16224-16232
30. Tabor, S., Huber, H. E., and Richardson, C. C. (1987) J. Biol. Chem. 262, 16212-16223
31. Kunkel, T. A., Patel, S. S., and Johnson, K. A. (1994) Prof. Natl. Acad. Sci. U. S. A. 91, 6830-6834