Selective mtDNA mutation accumulation results in β-cell apoptosis and diabetes development

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 4, 2009, Pages

  Bensch, Kenneth G ^a   Mott, Justin L ^a,c   Chang, Shin Wen ^a   Hansen, Polly A ^b   Moxley, Michael A ^a   Chambers, Kari T ^a   De Graaf, Wieke ^b   Zassenhaus, H Peter ^a   Corbett, John A ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Insulin; Islet; Mitochondrial deoxyribonucleic acid

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; GLUCOSE; INSULIN; MITOCHONDRIAL DNA; DNA DIRECTED DNA POLYMERASE; POLG PROTEIN, MOUSE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DISEASE COURSE; FEMALE; GENE MUTATION; GLUCOSE TOLERANCE; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEFICIENCY; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PREVALENCE; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE; ANIMAL; CYTOLOGY; GENETICS; HOMEOSTASIS; METABOLISM; MUTATION; ORGAN SIZE; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PROMOTER REGION; TRANSGENE;

ANIMALS; APOPTOSIS; DIABETES MELLITUS; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FEMALE; GLUCOSE; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, TRANSGENIC; MUTATION; ORGAN SIZE; PROMOTER REGIONS, GENETIC; TRANSGENES;

EID: 65649145174     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90839.2008     Document Type: Article

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