Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

Science

Volumn 286, Issue 5440, 1999, Pages 774-779

  Michikawa, Yuichi ^a   Mazzucchelli, Franca ^b   Bresolin, Nereo ^b   Scarlato, Guglielmo ^b   Attardi, Giuseppe ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

AGED; AGING; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; POINT MUTATION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CELL LINE; CHILD; CHILD, PRESCHOOL; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA, MITOCHONDRIAL; FETUS; FIBROBLASTS; HUMANS; INFANT; INFANT, NEWBORN; LONGITUDINAL STUDIES; MIDDLE AGED; MITOCHONDRIA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; POINT MUTATION; POLYMERASE CHAIN REACTION; PSEUDOGENES;

EID: 0033595684     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5440.774     Document Type: Article

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47. Supported by National Institute on Aging (NIH) grant AG12117-03 (to G.A.). We thank A. Chomyn and G. Villani for valuable discussions, M. Lai for support, A. Aman, R. Steinberger, and M. Scott for their help with experiments, and A. Drew, B. Keeley, R. Zedan, and C. Lin for expert technical assistance.