Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 48, 2013, Pages 19408-19413

  Pohjoismäki, Jaakko L O ^a,b   Williams, Siôn L ^c   Boettger, Thomas ^a   Goffart, Steffi ^a,b   Kim, Johnny ^a   Suomalainen, Anu ^d   Moraes, Carlos T ^c   Braun, Thomas ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

MtDNA mutations; Recombination; Repair

Indexed keywords

DNA POLYMERASE; DNA TOPOISOMERASE IV; HELICASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TWINKLE HELICASE; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DNA REPLICATION; DNA REPLICATION ORIGIN; GENE LOCUS; GENOTOXICITY; HEART MUSCLE CELL; HEART PROTECTION; HYPERTROPHIC CARDIOMYOPATHY; IN VITRO STUDY; MITOCHONDRIAL GENOME; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; UPREGULATION; WILD TYPE;

MTDNA MUTATIONS; RECOMBINATION; REPAIR;

ADAPTATION, BIOLOGICAL; ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHWESTERN; BLOTTING, WESTERN; DNA HELICASES; DNA REPLICATION; DNA, MITOCHONDRIAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION PROFILING; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84888380368     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303046110     Document Type: Article

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