PDX1 Deficiency Causes Mitochondrial Dysfunction and Defective Insulin Secretion through TFAM Suppression

Cell Metabolism

Volumn 10, Issue 2, 2009, Pages 110-118

  Gauthier, Benoit R ^a   Wiederkehr, Andreas ^a   Baquié, Mathurin ^a   Dai, Chunhua ^b   Powers, Alvin C ^b,c   Kerr Conte, Julie ^d   Pattou, François ^d   MacDonald, Raymond J ^e   Ferrer, Jorge ^f   Wollheim, Claes B ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b VANDERBILT UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIV LILLE   (France)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f HOSPITAL CLÍNIC   (Spain)

Author keywords

HUMDISEASE

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; SODIUM CALCIUM EXCHANGE PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE REPRESSION; GENE SEQUENCE; GENETIC REGULATION; HYPERGLYCEMIA; IMMUNOBLOTTING; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; RESPIRATORY CHAIN; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; DNA-BINDING PROTEINS; DOXYCYCLINE; GLUCOSE; HIGH MOBILITY GROUP PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; SODIUM-CALCIUM EXCHANGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

MUS; RATTUS;

EID: 67949115637     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2009.07.002     Document Type: Article

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