Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

Journal of Biological Chemistry

Volumn 284, Issue 32, 2009, Pages 21446-21457

  Pohjoismäki, Jaakko L O ^a,b,c   Goffart, Steffi ^a,b   Tyynismaa, Henna ^d   Willcox, Smaranda ^e   Ide, Tomomi ^f   Kang, Dongchon ^f   Suomalainen, Anu ^d   Karhunen, Pekka J ^c   Griffith, Jack D ^e   Holt, Ian J ^g   Jacobs, Howard T ^a,b  

^a UNIVERSITY OF TAMPERE   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f KYUSHU UNIVERSITY   (Japan)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE GEL ELECTROPHORESIS; DNA HELICASE; GENOME EQUIVALENT; HUMAN BRAIN; HUMAN HEART; LINEAR FRAGMENTS; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA (MTDNA); MITOCHONDRIAL TRANSCRIPTION FACTOR; MOUSE BRAIN; OVER-EXPRESSION; REPLICATION FORK; RESTRICTION DIGESTION; SKELETAL MUSCLE; T7 ENDONUCLEASE; TOPOISOMERASES; TRANSGENIC MICE;

ELECTROPHORESIS; GELATION; GENES; MAMMALS; MITOCHONDRIA; NUCLEIC ACIDS; OLIGOMERS; TRANSCRIPTION FACTORS;

DNA;

CATENATED DNA; DEOXYRIBONUCLEASE I; DNA TOPOISOMERASE IV; HELICASE; MITOCHONDRIAL DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR A; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL JUNCTION; CONTROLLED STUDY; DNA DETERMINATION; ELECTRON MICROSCOPY; GENE OVEREXPRESSION; HEART; HEART MITOCHONDRION; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRIAL DNA REPLICATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ADULT; AGED; ANIMALS; BRAIN; CHILD, PRESCHOOL; DNA, MITOCHONDRIAL; FEMALE; HEART; HUMANS; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; NUCLEIC ACID CONFORMATION; RABBITS; SPECIES SPECIFICITY; SWINE; TISSUE DISTRIBUTION;

MAMMALIA; MUS MUSCULUS; ORYCTOLAGUS CUNICULUS; SUIDAE;

EID: 69249158083     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.016600     Document Type: Article

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