Mitochondrial DNA repair and aging

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 509, Issue 1-2, 2002, Pages 127-151

  Mandavilli, Bhaskar S ^a   Santos, Janine H ^a   Van Houten, Bennett ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Animal models; C. elegans; DNA damage; DNA repair; Drosophila; Mitochondria; Yeast

Indexed keywords

ATM PROTEIN; BRCA2 PROTEIN; DOUBLE STRANDED DNA; HISTONE H2A; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MITOCHONDRIAL DNA; NIBRIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN; PROTEIN NHEJ; RAG1 PROTEIN; RAG2 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGING; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; BASE PAIRING; BLOOM SYNDROME; CAENORHABDITIS ELEGANS; CLINICAL FEATURE; COCKAYNE SYNDROME; COMBINED IMMUNODEFICIENCY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DROSOPHILA; DYSKERATOSIS CONGENITA; ELECTRON TRANSPORT; ENERGY YIELD; ENZYME DEFICIENCY; EXCISION REPAIR; FANCONI ANEMIA; GENE CONVERSION; GENE MUTATION; HUMAN; IMMUNE RESPONSE; MISMATCH REPAIR; NONHUMAN; OMENN SYNDROME; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; ROTHMUND THOMSON SYNDROME; SIGNAL TRANSDUCTION; TRICHOTHIODYSTROPHY; WERNER SYNDROME; XERODERMA PIGMENTOSUM; YEAST;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; DNA REPAIR; DNA, MITOCHONDRIAL; DROSOPHILA MELANOGASTER; ELECTRON TRANSPORT; HUMANS; MICE; MODELS, ANIMAL; MUTATION; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA; ZIZIPHUS MAURITIANA;

EID: 0037202602     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00220-8     Document Type: Article

References (248)

1. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 2:1956;298-300.
2. Harman D. The aging process. Proc. Natl. Acad. Sci. U.S.A. 78:1981;78124-78128.
3. Harman D. Free radical theory of aging. Mutat. Res. 275:1992;257-266.
4. Beckman K.B., Ames B.N. The free radical theory of aging matures. Physiol. Rev. 78:1998;547-581.
5. Cadenas E., Davies K.J. Mitochondrial free radical generation, oxidative stress and aging. Free Radic. Biol. Med. 29:2000;222-230.
6. Boveris A., Oshino N., Chance B. The cellular production of hydrogen peroxide. Biochem. J. 128:1972;617-630.
7. Harman D. The biological clock: the mitochondria? J. Am. Geriat. Soc. 20:1972;145-147.
8. Miquel J., Economos A.C., Fleming J., Johnson J.E. Jr. Mitochondrial role in cell aging. Exp. Gerontol. 15:1980;575-591.
9. Miquel J. An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells. Arch. Gerontol. Geriatr. 12:1991;99-117.
10. Fleming J.E., Miquel J., Cottrell S.F., Yengoyan L.S., Economos A.C. Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontology. 28:1982;44-53.
11. Miquel J., Fleming J.E. A two-step hypothesis on the mechanisms of in vitro cell aging: cell differentiation followed by intrinsic mitochondrial mutagenesis. Exp. Gerontol. 19:1984;31-36.
12. Fleming J.E., Miquel J., Bensch K.G. Age-dependent changes in mitochondria. Basic Life Sci. 35:1985;143-156.
13. Richter C., Park J.W., Ames B.N. Normal oxidative damage to the mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. U.S.A. 85:1988;6465-6467.
14. Bandy B., Davison A.J. Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic. Biol. Med. 8:1990;523-539.
15. Hayakawa M., Hattori K., Sugiyama S., Ozawa T. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem. Biophys. Res. Commun. 189:1992;979-985.
16. Mecocci P., MacGarvey U., Kaufman A.E., Koontz D., Schoffner J.M., Wallace D.C., Beal M.F. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34:1993;609-616.
17. Mecocci P., MacGarvey U., Beal M.F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36:1994;747-751.
18. Tanhauser S.M., Laipis P.J. Multiple deletions are detectable in mitochondrial DNA of aging mice. J. Biol. Chem. 270:1995;24769-24775.
19. Schapira A.H. Mitochondrial complex I deficiency in Parkinson's disease. Lancet I. 8649:1989;1269.
20. Schapira A.H. Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary splastic paraplegia and Friedrich's ataxia. Biochim. Biophys. Acta. 1410:1999;99-102.
21. Nikoskelainen E.K., Savontaus M.L., Wanne O.P., Katilda M.J., Nummelin K.U. Leber's hereditary optic neuropathy, a maternally inherited disease: a genealogic study on four pedigrees. Arch. Opthalmol. 105:1987;665-671.
22. Wallace D.C., Singh G., Lott M.T., Hodge J.A., Schurr T.G., Lezza A.M., Elsas L.J. II, Nikoskelainen E.K. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science. 242:1988;1427.
23. Holt I.J., Cooper J.M., Morgan-Hughes J.A. Deletions of muscle mitochondrial DNA. Lancet. 1:1988;1462.
24. Tanaka M., Kovalenko S.A., Gong J.S., Borgeld H.J., Katsumata K., Hayakawa M., Yoneda M., Ozawa T. Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases. Ann. N. Y. Acad. Sci. 786:1996;102-111.
25. Melov S., Schneider J.A., Coskun P.E., Bennett D.A., Wallace D.C. Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA. Neurobiol. Aging. 20:1999;565-571.
26. Ozawa T. Mitochondrial genome mutation in cell death and aging. J. Bioenerg. Biomembr. 31:1999;377-390.
27. Wallace D.C. Diseases of the mitochondrial DNA. Ann. Rev. Biochem. 61:1992;1175-1212.
28. Turrens J.F., Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191:1980;421-427.
29. Chung M.A., Kasai H., Nishimura S., Yu B.P. Protection of DNA damage by dietary restriction. Free Radic. Biol. Med. 12:1992;523-525.
30. Cortopassi G.A., Shibata D., Soong N.W., Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7370-7374.
31. Wei Y.H., Kao S.H., Lee H.C. Simultaneous increase of mitochondrial DNA shows marked age-dependent increases in human brain. Ann. N. Y. Acad. Sci. 786:1996;24-43.
32. Rhee S.G., Kim K.H., Chae H.Z., Yim M.B., Uchida K., Netto L.E., Stadtman E.R. Antioxidant defense mechanisms: a new thiol-specific antioxidant enzyme. Ann. N. Y. Acad. Sci. 738:1994;86-92.
33. Wunderlich V., Schutt M., Bottger M., Graffi A. Preferential alkylation of mitochondrial deoxyribonucleic acid by N-methyl-N-nitrosourea. Biochem. J. 118:1970;99-109.
34. Allen J.A., Coombs M.M. Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA. Nature. 287:1980;244-245.
35. Nagatani Y. Cytological studies on the affinity of the carcinogenic azo dyes for cytoplasmic components. Int. Rev. Cytol. 10:1960;243-313.
36. Takayama S., Murumatsu M. Incorporation of tritiated dimethylnitrosoamine into subcellular fractions of mouse liver after long-term administration of dimethylnitrosoamine. Z. Krebsforsch. 73:1969;172-180.
37. Backer J.M., Weinstein I.B. Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene. Science. 209:1980;297-299.
38. Miyaki M., Yatagai K., Ono T. Strand breaks of mammalian mitochondrial DNA caused by carcinogens. Chem. Biol. Interact. 17:1977;321-329.
39. Neubert D., Hopfenmuller W., Fuchs G. Manifestation of carcinogenesis as a stochastic process on the basis of an altered mitochondrial genome. Arch. Toxicol. 48:1981;89-125.
40. Niranjan B.G., Bhat N.K., Avadhani N.G. Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis. Science. 215:1982;73-75.
41. Rossi S.C., Gorman N., Wetterhahn K.E. Mitochondrial reduction of carcinogen chromate: formation of chromium(V). Chem. Res. Toxicol. 1:1988;101-107.
42. Tomasi A., Albano E., Banni S., Botti B., Corongiu F., Dessi M.A., Iannone A., Vannini V., Dianzani M.U. Free radical metabolism of carbon tetrachloride in rat liver mitochondria. Biochem. J. 246:1987;313-317.
43. Penta J.S., Johnson F.M., Wachsman J.T., Copeland W.C. Mitochondrial DNA in human malignancy. Mutat. Res. 488:2001;119-133.
44. Gutteridge J.M., Halliwell B. Iron toxicity and oxygen radicals. Baillieres Clin. Haematol. 2:1989;195-256.
45. Wiseman H., Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J. 313:1996;17-29.
46. Hayakawa M., Ogawa T., Sugiyama S., Tanaka M., Ozawa T. Massive conversion of guanine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine. Biochem. Biophys. Res. Commun. 176:1991;87-93.
47. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U.S.A. 90:1993;7915-7922.
48. Suter M., Richter C. Fragmented mitochondrial DNA is the predominant carrier of oxidized DNA bases. Biochemistry. 38:1999;459-464.
49. Fraga C.G., Shigenaga M.K., Park J.W., Degan P., Ames B.N. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. U.S.A. 87:1990;4533-4537.
50. Ozawa T. Genetic and functional changes in mitochondria with aging. Physiol. Rev. 77:1997;425-464.
51. Zorov D.B. Mitochondrial damage as a source of diseases and aging: a strategy of how to fight these. Biochim. Biophys. Acta. 1275:1996;10-15.
52. Anson R.M., Senturker S., Dizdaroglu M., Bohr V.A. Measurement of oxidatively induced base lesions in liver of Wistar rats of different ages. Free Radic. Biol. Med. 27:1999;456-462.
53. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P.W., Woodall A.A., Yeo H.C., Ames B.N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. U.S.A. 95:1998;288-293.
54. Beckman K.B., Ames B.N. Endogenous oxidative damage to the mtDNA. Mutat. Res. 424:1999;51-58.
55. Beckman K.B., Ames B.N. Detection and quantitation of oxidative adducts of mitochondrial DNA. Methods Enzymol. 264:1996;442-453.
56. Anson R.M., Hudson E., Bohr V.A. Mitochondrial endogenous oxidative damage has been overestimated. FASEB J. 14:2000;355-360.
57. Hamilton M.L., Van Rammen H., Drake J.A., Yang H., Guo Z.M., Kewitt K., Walter C.A., Richrdson A. Does oxidative damage to DNA increase with age? Proc. Natl. Acad. Sci. U.S.A. 98:2001;10469-10474.
58. S. Ayala-Torres, Y. Chen, T. Svoboda, J. Rosenblatt, B. Van Houten, Analysis of gene-specific DNA damage and repair using quantitative PCR, in: P.W. Doetsch (Ed.) Methods. A Companion to Methods in Enzymology, vol. 22, Academic Press, New York, NY, 2000, pp. 135-147.
59. Santos J.H., Mandavilli B.S., Van Houten B. Measuring oxidative mitochondrial DNA damage and repair using quantitative PCR. Methods Mol. Biol. 197:2002;159-176.
60. Yakes F.M., Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 94:1997;514-519.
61. Salazar J.J., Van Houten B. Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator for hydrogen peroxide in human fibroblasts. Mutat. Res. 385:1997;139-149.
62. Mandavilli B.S., Ali S.F., Van Houten B. DNA damage in brain mitochondria caused by aging and MPTP treatment. Brain Res. 885:2000;45-52.
63. Moon S.K., Thompson L.J., Madamanchi N., Ballinger S.W., Papaconstantinou J., Horaist C., Runge M.S., Patterson C. Aging, oxidative stress, and proliferative capacity in cultured mouse aortic smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 280:2001;H2779-H2788.
64. Ballinger S.W., Van Houten B., Coklin C.A., Jin A., Godley B. Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells. Exp. Eye Res. 68:1999;765-772.
65. Ballinger S.W., Patterson C., Yan C.N., Doan R., Burow D.L., Young C.G., Yakes F.M., Van Houten B., Ballinger C.A., Freeman B.A., Runge M.S. Hydrogen peroxide and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ. Res. 86:2000;960-966.
66. Deng G., Su J.H., Ivins K.J., Van Houten B., Cottman C. Bcl-2 facilitates recovery from DNA damage after oxidative stress. Exp. Neurol. 159:1999;309-318.
67. Sawyer D.E., Van Houten B. Repair of DNA damage in mitochondria. Mutat. Res. 434:1999;161-176.
68. Sawyer D.E., Roman S.D., Aitken R.J. Relative susceptibilities of nuclear and mitochondrial DNA to damage induced by hydrogen peroxide in two mouse germ cell lines. Redox Rep. 6:2001;182-184.
69. F Jin G., Hurst J.S., Godley B.F. Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium. Curr. Eye Res. 23:2001;11-19.
70. Wallace D.C. Mouse models for mitochondrial disease. Am. J. Med. Genet. 106:2001;71-93.
71. DiMauro S., Schon E.A. Mitochondrial DNA mutations in human disease. Am. J. Med. Genet. 106:2001;18-26.
72. Wallace D.C. Mitochondrial diseases in man and mouse. Science. 283:1999;1482-1488.
73. Orth M., Schapira A.H. Mitochondria and degenerative disorders. Am. J. Med. Genet. 106:2001;27-36.
74. Shoubridge E.A. Nuclear genetic defects of oxidative phosphorylation. Hum. Mol. Genet. 10:2001;2277-2284.
75. Suomalainen A., Kaukonen J. Diseases caused by nuclear genes affecting mtDNA stability. Am. J. Med. Genet. 106:2001;53-61.
76. Triepels R.H., van den Heuvel L.P., Sundell L., Marusich M.F., Smeitink J.A. Respiratory chain complex I deficiency. Am. J. Med. Genet. 106:2001;37-45.
77. Tanaka M., Nishikimi M., Suzuki H., Ozawa T., Nishizawa M., Tanaka K., Miyatake T. Deficiency of subunits in heart mitochondrial NADH-ubiquinone oxidoreductase of a patient with mitochondrial encephalopathy and cardiomyopathy. Bichem. Biophys. Res. Commun. 140:1986;88-93.
78. Tanaka M., Nishikimi M., Suzuki H., Ozawa T., Koga Y., Nonaka I. Partial deficiency of subunits in complex I or IV of patients with mitochondrial myopathies. Biochem. Int. 14:1987;525-530.
79. Holt I.J., Cooper J.M., Morgan-Hughes J.A. Deletions of muscle mitochondrial DNA. Lancet. 1:1988;1462.
80. Ozawa T., Yoneda M., Tanaka M., Ohno K., Sato W., Suzuki H., Nishikimi M., Yamamoto M., Nonaka I., Horai S. Maternal inheritance of deleted mitochondrial DNA in a family with mitochondrial myopathy. Biochem. Biophys. Res. Commun. 154:1988;1240-1247.
81. Rotig A., Cormier V., Blanche S., Bonnefont J.P., Ledeist F., Romero N., Scmitz J., Rustin P., Fischer A., Sausubray J.M. Pearson's marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy. J. Clin. Invest. 86:1990;1601-1608.
82. Linnane A.W., Zhang C., Baumer A., Nagley P. Mitochondrial DNA mutation and the aging process: bioenergy and pharmacological intervention. Mutat. Res. 275:1992;195-208.
83. Arnheim N., Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat. Res. 275:1992;157-167.
84. Yen T.C., Su J.H., King K.L., Wei Y.H. Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem. Biophys. Res. Commun. 178:1991;124-131.
85. Kopsidas G., Kovalenko S.A., Kelso J.M., Linnane A.W. Age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle. Mutat. Res. 421:1998;27-36.
86. Kajander O.A., Rovio A.T., Majamaa K., Poulton J., Spelbrink J.N., Holt I.J., Karhunen P.J., Jacobs H.T. Human mtDNA sublimons resemble rearranged mitochondrial genomes found in pathological states. Hum. Mol. Genet. 9:2000;2821-2835.
87. Kajander O.A., Karhunen P.J., Jacobs H.T. The relationship between somatic mtDNA rearrangements. Hum. Mol. Genet. 11:2002;317-324.
88. Moraes C.T., Shanske S., Tritschler H.J., Aprille J.R., Andreetta F., Bonilla E., Schon E.A., DiMauro S. mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am. J. Hum. Genet. 48:1991;492-501.
89. Tritschler H.J., Andreetta F., Moraes C.T., Bonilla E., Arnaudo E., Danon M.J., Glass S., Zelaya B.M., Vamos E., Telerman-Toppet N. Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA. Neurology. 42:1992;209-217.
90. Spelbrink J.N., Li F.Y., Tiranti V., Nikali K., Yuan Q.P., Tariq M., Wanrooij S., Garrido N., Comi G., Morandi L., Santoro L., Toscano A., Fabrizi G.M., Somer H., Croxen R., Beeson D., Poulton J., Suomalainen A., Jacobs H.T., Zeviani M., Larsson C. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nature. 28:2001;223-231.
91. Linnane A.W., Marzuki S., Ozawa T., Tanaka M. Mitochondrial DNA mutations as an important contributor to aging and degenerative diseases. Lancet. 1(8639):1989;642-645.
92. Servidei S. Mitochondrial encephalopathies: gene mutation. Neuromuscul. Disord. 10(10):2000;X-XV.
93. Lin M.T., Simon D.K., Ahn C.H., Kim L.M., Beal M.F. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11:2002;133-145.
94. Fliss M.S., Usadel H., Caballero O.L., Wu L., Buta M.R., Eleff S.M., Jen J., Sdransky D. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science. 287:2000;2017-2019.
95. Richard S.M., Bailliet G., Paez G.L., Bianchi M.S., Peltomaki P., Bianchi N.O. Nuclear and mitochondrial genome instability in human breast cancer. Cancer Res. 60:2000;4231-4237.
96. Polyak K., LI Y., Zhu H., Lengauer C., Wilson J.K., Markovitz S.D., Trush M.A., Kinzler K.W., Vogelstein B. Somatic mutations of the mitochondrial genome in human colorectal tumors. Nat. Genet. 20:1998;291-293.
97. Habano W., Nakamura S., Sugai T. Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome. Oncogene. 17:1998;1931-1937.
98. Coller H.A., Khrapko K., Bodyak N.D., Nekhaeva E., Herrero-Jimenez P., Thilly W.G. High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nature. 28:2001;147-150.
99. Inoue K., Nakada K., Ogura A., Isobe K., Goto Y., Nonaka I., Hayashi J-I. Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes. Nature. 26:2000;176-181.
100. Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M. Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains. J. Hered. 92:2001;352-355.
101. Wei Y.H., Lee C.F., Lee H.C., Ma Y.S., Wang C.W., Lu C.Y., Pang C.Y. Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4977 bp-deleted mitochondrial DNA. Ann. N. Y. Acad. Sci. 28:2001;97-112.
102. Clayton D.A., Doda J.N., Friedberg E.C. The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc. Natl. Acad. Sci. U.S.A. 71:1974;2777-2781.
103. Prakash L. Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet light. J. Mol. Biol. 98:1975;781-795.
104. LeDoux S.P., Driggers W.J., Hollensworth S.B., Wilson G.L. Repair of alkylation and oxidative damage in mitochondrial DNA. Mutat. Res. 434:1999;149-159.
105. Croteau D.L., Stierum R.H., Bohr V.A. Mitochondrial DNA repair pathways. Mutat. Res. 434:1999;137-148.
106. Bogenhagen D.F. Repair of mtDNA in vertebrates. Am. J. Hum. Genet. 64:1999;1276-1281.
107. Bogenhagen D.F., Pinz K.G., Perez-Jannotti R.M. Enzymology of mitochondrial base excision repair. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;257-271.
108. Dianov G.L., de Souza-Pinto N., Nyaga S.G., Thybo T., Stevnsner T., Bohr V.A. Base excision repair in nuclear and mitochondrial DNA. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;285-297.
109. LeDoux S.P., Wison G.L. Base excision repair of mitochondrial DNA damage in mammalian cells. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;273-284.
110. Nakabeppu Y. Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;75-92.
111. V.A. Bohr, D.S. Okumoto, in: E.C. Friedberg, P.C. Hanawalt (Eds.), DNA Repair: A Laboratory Manual of Research Procedures, vol. 3, Marcel Dekker, New York, 1988, pp. 347-366.
112. Rodriguez H., Akman S.A., Holmquist G.P., Wilson G.L., Driggers W.J., LeDoux S.P. Mapping oxidative DNA damage using ligation-mediated polymerase chain reaction technology. Methods. 22:2000;148-156.
113. Pettepher C.C., LeDoux S.P., Bohr V.A., Wilson G.L. Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J. Biol. Chem. 266:1991;3113-3117.
114. LeDoux S.P., Wilson G.L., Beecham E.J., Stevnsner T., Wassermann K., Bohr V.A. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis. 13:1992;1967-1973.
115. Laval F., Wink D.A., Laval J. A discussion of mechanisms of NO genotoxicity: implication of inhibition of DNA repair proteins. Rev. Physiol. Biochem. Pharmacol. 131:1997;175-191.
116. Hollensworth S.B., Shen C., Sim J.E., Spitz D.R., Wilson G.L., LeDoux S.P. Glial cell type-specific responses to menadione induced oxidative stress. Free Radic. Biol. Med. 28:2000;1161-1174.
117. LeDoux S.P., Shen C., Grishko V.I., Fields P.A., Grad A.L., Wilson G.L. Glial cell-specific differences in response to alkylation damage. Glia. 24:1998;304-312.
118. Pinz K.G., Bogenhagen D.F. Efficient repair of abasic sites in DNA by mitochondrial enzymes. Mol. Cell. Biol. 18:1998;1257-1265.
119. Lim S.E., Longley M.J., Copeland W.C. The mitochondrial p55 accessory subunit of human DNA polymerase γ enhances DNA binding, promotes processive DNA synthesis and confers N-ethylmaleimide resistance. J. Biol. Chem. 274:1999;38197-38203.
120. Longley M.J., Prasad R., Srivastava D.K., Wilson S.H., Copeland W.C. Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair. Proc. Natl. Acad. Sci. U.S.A. 95:1998;12244-12248.
121. Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxoG. Nature. 349:1991;431-434.
122. Grollman A.P., Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9:1993;246-249.
123. Krokan H.E., Standal R., Slupphaug G. DNA glycosylases in the base excision repair of DNA. Biochem. J. 325:1997;1-15.
124. Demple B., Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63:1994;915-948.
125. Hazra T.K., Hill J.W., Isumi T., Mitra S. Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;193-204.
126. Taffe B.G., Larminat F., Laval J., Croteau D.L., Anson R.M., Bohr V.A. Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells. Mutat. Res. 364:1996;183-192.
127. Nishioka K., Ohtsubo T., Oda H., Fujiwara T., Kang D., Sugimachi K., Nakabeppu Y. Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol. Biol. Cell. 10:1999;1637-1652.
128. Klungland A., Rosewell J., Hollenbach S., Larsen E., Daly G., Epe B., Seeberg E., Lindahl T., Barnes D.E. Accumulation of premutagenic lesions in mice defective in removal of oxidative base damage. Proc. Natl. Acad. Sci. U.S.A. 96:1999;13300-13305.
129. Nishimura S. Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;107-123.
130. Osterod M., Hollenbach S., Hengstler J.G., Barnes D.E., Lindahl T., Epe B. Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis. 22:2001;1459-1463.
131. de Souza-Pinto N.C., Eide L., Hogue B.A., Thybo T., Stevnsner T., Klungland A., Bohr V.A. Repair of 8-oxodeoxyguanosine lesions in mitochondrial DNA depends on the oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1-defective mice. Cancer Res. 61:2001;5378-5381.
132. de Souza-Pinto N.C., Hogue B.A., Bohr V.A. DNA repair and aging in mouse liver: 8-oxoG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radic. Biol. Med. 30:2001;916-923.
133. Dobson A.W., Xu Y., Kelley M.R., LeDoux S.P., Wilson G.L. Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to the mitochondria. J. Biol. Chem. 275:2000;37518-37523.
134. Stedeford T., Cardozo-Pelaez F., Nemeth N., Song S., Harbison R.D., Sanchez-Ramos J. Comparison of base excision repair capacity in proliferating and differentiated PC12 cells. Free Radic. Biol. Med. 31:2001;1272-1278.
135. Anderson C.T., Friedberg E.C. The presence of nuclear and mitochondrial uracil DNA glycosylase in extracts of human KB cells. Nucleic Acids Res. 8:1980;875-888.
136. Domena J.D., Timmer R.T., Dicharry S.A., Mosbaugh D.W. Purification and properties of mitochondrial uracil DNA glycosylase from rat liver. Biochemistry. 27:1988;6742-6751.
137. Caradonna S., Ladner R., Hansbury M., Kosciuk M., Lynch F., Muller S. Affinity purification and comparative analysis of two distinct human uracil DNA glycosylases. Exp. Cell Res. 222:1996;345-359.
138. Haug T., Skorpen F., Aas P.A., Malm V., Skjelbred C., Kroken H.E. Regulation of expression of nuclear and mitochondrial forms of human uracil DNA glycosylase. Nucleic Acids Res. 26:1998;1449-1457.
139. Bharati S., Krokan H.E., Kristiansen L., Otterlei M., Slupphaug G. Human mitochondrial uracil glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Res. 26:1998;4953-4959.
140. Otterlei M., Haug T., Nagelhus T.A., Slupphaug G., Lindmo T., Krokan H.E. Nuclear and mitochondrial splice forms of human uracil DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localization signal, respectively. Nucleic Acids Res. 26:1998;4611-4617.
141. Takao M., Aburatani H., Kobayashi K., Yasui A. Mitochondrial targeting of human DNA glycosylases for repair of oxidative damage. Nucleic Acids Res. 26:1998;2917-2922.
142. Tomkinson A.E., Bonk R.T., Linn S. Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells. J. Biol. Chem. 263:1988;12532-12537.
143. Tsuchimoto D., Sakai Y., Sakumi K., Nishioka K., Sasaki M., Fujiwara T., Nakabeppu Y. Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria while nuclear APE2 is partly associated with proliferating cell nuclear antigen. Nucleic Acids Res. 29:2001;2349-2360.
144. Tell G., Crivellato E., Pines A., Paron I., Pucillo C., Manzini G., Bandiera A., Kelley M.R., DiLoreto C., Damante G. Mitochondrial localization of APE/Ref-1 in thyroid cells. Mutat. Res. 485:2001;143-152.
145. Xanthoudakis S., Miao G.G., Curran T. The redox and DNA repair activities of Ref-1 are encoded by overlapping domains. Proc. Natl. Acad. Sci. U.S.A. 91:1994;23-27.
146. Ramana C.V., Boldogh I., Izumi T., Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc. Natl. Acad. Sci. U.S.A. 95:1998;5061-5066.
147. Edwards M., Rassin D.K., Izumi T., Mitra S., Perez-Polo J.G. APE/Ref-1 responses to oxidative stress in aged rats. Cancer Res. 54:1998;635-638.
148. Carrodegaus J.A., Kobayashi R., Lim S.E., Copeland W.C., Bogenhagen D.F. The accessory subunit of Xenopus laevis mitochondrial DNA polymerase γ and is related to class II aminoacyl-tRNA synthetases. Mol. Cell. Biol. 19:1999;4039-4046.
149. Pinz K.G., Bogenhagen D.F. Characterization of a catalytically slow AP lyase activity in DNA polymerase γ and other family A DNA polymerases. J. Biol. Chem. 275:2000;12509-12514.
150. Van Goethen G., Dermaut B., Lofgren A., Martin J.-J., Van Broeckhoven C. Mutation of POL G is associated with progressive external opthalmoplegia characterised by mtDNA mutations. Nat. Genet. 28:2001;211-212.
151. Rovio A.T., Marchington D.R., Donat S., Schuppe H.C., Abel J., Fritsche E., Elliott D.J., Laippala P., Ahola A.L., McNay D., Harrison R.F., Hughes B., Barrett T., Bailey D.M., Mehmet D., Jequier A.M., Hargreave T.B., Kao S.H., Cummins J.M., Barton D.E., Cooke H.J., Wei Y.H., Wichmann L., Poulton J., Jacobs H.T. Mutations at the mitochondrial DNA polymerase (Pol γ) locus associated with male infertility. Nat. Genet. 29:2001;261-262.
152. Levin C.J., Zimmerman S.B. A DNA ligase from mitochondria of rat liver. Biochem. Biophys. Res. Commun. 69:1976;514-520.
153. Lakshmipathy U., Campbell C. The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol. Cell. Biol. 19:1999;3869-3876.
154. Lakshmipathy U., Campbell C. Antisense-mediated decrease in DNA ligase III expression results in reduction in mitochondrial DNA integrity. Nucleic Acids Res. 29:2001;668-676.
155. Caldecott K.W., McKeown C.K., Tucker J.D., Ljunquist S., Thompson L.H. An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Mol. Cell. Biol. 14:1994;68-76.
156. Ljunquist S., Keene K., Olsson L., Sandstrom M. Altered DNA ligase III activity in the CHO EM9 mutant. Mutat. Res. 314:1994;117-186.
157. Lakshmipathy U., Campbell C. Mitochondrial DNA ligase III function is independent of XRCC1. Nucleic Acids Res. 28:2000;3880-3886.
158. Perez-Jannotti R.M., Klein S.M., Bogenhagen D.F. Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. J. Biol. Chem. 276:2001;48978-48987.
159. Weisiger R.A., Fridovich I. Mitochondrial superoxide dismutase. Site of synthesis and mitochondrial localization. J. Biol. Chem. 248:1973;4793-4796.
160. Fridovich I. Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64:1995;97-112.
161. Carlsson L.M., Jonsson J., Edlund T., Marklund S.L. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc. Natl. Acad. Sci. U.S.A. 92:1995;6264-6268.
162. Manabe Y., Warita H., Murakami T., Shiote M., Hayashi T., Nagano I., Shoji M., Abe K. Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene. Brain Res. 915:2001;104-107.
163. Nagai M., Aoki M., Miyoshi I., Kato M., Pasinelli P., Kasai N., Brown R.H. Jr., Itoyama Y. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J. Neurosci. 21:2001;9246-9254.
164. Cluskey S., Ramsden D.B. Mechanism of neurodegeneration in amyotrophic lateral sclerosis. Mol. Pathol. 54:2001;386-392.
165. Deng H.X., Hentati A., Tainer J.A., Iqbal Z., Cayabyab A., Hung W.Y., Getzoff E.D., Hu P., Herxfeldt B., Roos R.P. Amyotrophic lateral sclerosis and structural defects in Cu/Zn superoxide dismutase. Science. 261:1993;986.
166. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng H.X. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362:1993;59-62.
167. Gurney M.E., Liu R., Althaus J.S., Hall E.D., Becker D.A. Mutant Cu/Zn superoxide dismutase in motor neuron disease. J. Inherit. Metab. Dis. 21:1998;587-597.
168. Hall E.D., Oostveen J.A., Gurney M.E. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia. 23:1998;249-256.
169. Ferri A., Gabbianelli R., Casciati A., Celsi F., Rotilio G., Carri M.T. Oxidative inactivation of calcineurin by Cu/Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis. J. Neurochem. 79:2001;531-538.
170. Andreasson O.A., Ferrante R.J., Dedeoglu A., Albers D.W., Klivenyi P., Carlson E.J., Epstein C.J., Beal M.F. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate. Exp. Neurol. 167:2001;189-195.
171. Li Y., Huang T.T., Carlson E.J., Melov S., Ursell P.C., Olson J.L., Noble L.J., Yoshimura M.P., Berger C., Chan P.H. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11:1995;376-381.
172. Melov S., Coskun P., Patel M., Tuinstra R., Cottrell B., Jun A.S., Zastawny T.H., Dizdaroglu M., Goodman S.I., Huang T.T., Miziorka H., Epstein C.J., Wallace D.C. Mitochondrial disease in superoxide dismutase 2 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 96:1999;846-851.
173. Lebovitz R.M., Zhang H., Vogel H., Cartwright J. Jr., Dionne L., Liu N., Huang S., Matzuk M.M. Neurodegeneration, myocardial injury and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 93:1996;9782-9787.
174. Melov S., Schneider J.A., Day B.J., Hinerfeld D., Coskun P., Mirra S.S., Crapo J.D., Wallace D.C. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat. Genet. 18:1998;99-100.
175. Melov S., Doctrow S.R., Schneider J.A., Haberson J., Patel M., Coskun P.E., Huffman K., Wallace D.C., Malfroy B. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21:2001;8348-8353.
176. +/- mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. U.S.A. 98:2001;2278-2283.
177. Asikainen T.M., Huang T.T., Taskinen E., Levonen A.L., Carlson E., Lapatto R., Epstein C.J., Raivio K.O. Increased sensitivity of homozygous SOD2 mutant mice to oxygen toxicity. Free Radic. Biol. Med. 32:2002;175-186.
178. Ho Y.S., Magnenat J.L., Bronson R.T., Cao J., Gargano M., Sugawara M., Funk C.D. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J. Biol. Chem. 272:1997;16644-16651.
179. Esposito L.A., Kokoszka J.E., Waymire K.G., Cottrell B., MacGregor
180. Graham B.H., Waymire K.G., Cottrell B., Trounce I.A., MacGregor G.R., Wallace D.C. A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat. Genet. 16:1997;226-234.
181. Murdock D.G., Boone B.E., Esposito L.A., Wallace D.C. Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J. Biol. Chem. 274:1999;14429-14433.
182. Esposito L.A., Melov S., Panov A., Cottrell B.A., Wallace D.C. Mitochondrial disease in mouse results in increased oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 96:1999;4820-4825.
183. W.E. Wood, Community of C. elegans Researchers, The Nematode Caenorhabditis elegans. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1988.
184. D.L. Riddle, T. Blumenthal, B.J. Meyer, J.R. Priess, C. elegans, II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1997.
185. Hekimi S., Lakowski B., Barnes T.M., Ewbank J.J. Molecular genetics of the life span of C. elegans: how much does it teach us? Trends Genet. 14:1998;14-20.
186. Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf2 an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 277:1997;942-946.
187. Morris J.Z., Tissenbaum H.A., Rukvun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 382:1996;536-539.
188. Ishii N., Fujii M., Hartman P.S., Tsuda M., Yasuda K., Senoo-Masuda N., Yanase S., Ayusawa D., Suzuki K. A mutation in succinate dehydrogenase cytochrome b cause oxidative stress and aging in nematodes. Nature. 394:1998;694-697.
189. Hartman P.S., Ishii N., Kayser E.B., Morgan P.G., Sedensky M.M. Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans. Mech. Ageing Dev. 122:2001;1187-1201.
190. Larsen P.L., Clarke C.F. Extension of life-span in Caenorhabditis elegans by diet lacking coenzyme Q. Science. 295:2002;120-123.
191. Takahashi M., Asaumi S., Honda S., Suzuki Y., Nakai D., Kuroyanagi H., Shimizu T., Honda Y., Shirasawa T. Mouse coq7/clk1 orthologue rescued slowed rhythmic behavior and extended life span of clk1 longevity mutant in Caenorhabditis elegans. Biochem. Biophys. Res. Comm. 286:2001;534-540.
192. Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 90:1993;8905-8909.
193. Honda Y., Honda S. The daf2 gene network for longevity regulates oxidative stress resistance and MN superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13:1999;1385-1393.
194. Kayser E.B., Morgan P.G., Sedensky M.M. GAS-1: a mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. Anesthesiology. 90:1999;545-554.
195. Kayser E.B., Morgan P.G., Hoppel C.L., Sedensky M.M. Mitochondrial expression and function of gas1 in Caenorhabditis elegans. J Biol. Chem. 276:2001;20551-20558.
196. Echtay K.S., Winkler E., Klingenberg M. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature. 408:2000;609-613.
197. Jonassen T., Larsen P.L., Clarke C.F. A dietary source of coenzyme Q is essential for growth and long-lived Caenorhabditis elegans clk1 mutants. Proc. Natl. Acad. Sci. U.S.A. 98:2001;421-426.
198. Stenmark P. A new member of the family of di-iron carboxylate proteins. Coq7 (clk1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis. J. Biol. Chem. 276:2001;33297-33300.
199. Miyadera H., Amino H., Hiraishi A., Taka H., Murayama K., Miyoshi H., Sakamoto K., Ishii N., Hekimi S., Kita K. Altered quinone biosynthesis in the long-lived clk1 mutant of Caenorhabditis elegans. J. Biol. Chem. 276:2001;7713-7716.
200. Morgan P.G., Sedensky M.M. Mutations conferring new patterns of sensitivity to volatile anesthetics in Caenorhabditis elegans. Anesthesiology. 81:1994;888-898.
201. Senoo-Matsuda N., Yasuda K., Tsuda M., Ohkubo T., Yoshimura S., Nakazawa H., Hartman P.S., Ishii N. A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caernohabditis elegans. J. Biol. Chem. 276:2001;41553-41558.
202. Hekimi S., Boutis P., Lakowski B. Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Genetics. 141:1995;1351-1364.
203. Branicky R., Bernard C., Hekimi S. clk1, mitochondria, and physiological rates. Bioessays. 22:2000;48-56.
204. Wong A., Boutis P., Hekimi S. Mutations in the clk1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics. 139:1995;1247-1259.
205. Ewbank J.J., Barnes T.M., Lakowski B., Lussier M., Bussey H., Hekimi S. Structural and functional conservation of the Caenorhabditis elegans timing gene clk1. Science. 275:1997;980-983.
206. Marbois B.N., Clarke C.F. The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis. J. Biol. Chem. 271:1996;2995-3004.
207. Braeckman B.P., Houthoofd K., De Vreese A., Vanfleteren J.R. Apparent uncoupling of energy production and consumption in long-lived clk mutants of Caenorhabditis elegans. Curr. Biol. 9:1999;493-496.
208. Felkai S., Ewbank J.J., Lemieux J., Labbe J.-C., Brown G.G., Hekimi S. Clk-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18:1999;1783-1792.
209. Vajo Z., King L.M., Jonassen T., Wilkin D.J., Ho N., Munnich A., Clarke C.F., Francomano C.A. Conservation of the Caenorhabditis elegans timing gene clk1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. Mamm. Genome. 10:1999;1000-1004.
210. Jonassen T., Proft M., Randez-Gil F., Schultz J.R., Marbois B.N., Entian K.D., Clarke C.F. Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. J. Biol. Chem. 273:1998;3351-3357.
211. Nakai D., Yuasa S., Takahashi M., Shimizu T., Asaumi S., Isono K., Takao T., Suzuki Y., Kuroyanagi H., Hirokawa K., Koseki H., Shirsawa T. Mouse homologue of coq7/clk1, longevity gene in Caenorhabditis elegans is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis. Biochem. Biophys. Res. Commun. 289:2001;463-471.
212. Melov S., Hertz G.Z., Stormo G.D., Johnson T.E. Detection of deletions in the mitochondrial genome of Caenorhabditis elegans. EMBO J. 22:1994;1075-1078.
213. Melov S., Lithgow G.J., Fischer D.R., Tedesco P.M., Johnson T.E. Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. EMBO J. 23:1995;1419-1425.
214. Vlafeteren J.R. Oxidative stress and aging in Caenorhabditis elegans. Biochem. J. 292:1993;605-608.
215. Hunter T., Bannister W.H., Hunter G.J. Cloning, expression and characterization of two manganese superoxide dismutases from Caenorhabditis elegans. J. Biol. Chem. 272:1997;28652-28659.
216. Melov S., Ravenscroft J., Malik S., Gill M.S., Walker D.W., Clayton P.E., Wallace D.C., Malfroy B., Doctrow S.R., Lithgow G.J. Extension of life-span with superoxide dismutase/catalase mimetics. Science. 289:2000;1567-1569.
217. Calleja M., Pena P., Ugalse C., Ferreiro C., Marco F., Garesse R. Mitochondrial DNA remains intact during Drosophila aging but the levels of mitochondrial transcripts are significantly reduced. J. Biol. Chem. 268:1993;18891-18897.
218. Schwarze S.R., Weindruch R., Aiken J.M. Decreased mitochondrial RNA levels without the accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat. Res. 382:1998;99-107.
219. Sohal R.S., Sohal B.H., Orr W.C. Mitochondrial superoxide, hydrogen peroxide generation, protein oxidative damage and longevity in different species of flies. Free Radic. Biol. Med. 19:1995;499-504.
220. Das N., Levine R.L., Orr W.C., Sohal R.S. Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Biochem. J. 360:2001;209-216.
221. Ross R.E. Age-specific decrease in aerobic efficiency associated with increase in oxygen free radical production in Drosophila melanogaster. J. Insect Phys. 46:2000;1477-1480.
222. Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130.
223. Mockett R.J., Orr W.C., Rahmandar J.J., Benes J.J., Radyuk S.N., Klichko V.I., Sohal R.S. Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Arch. Biochem. Biophys. 371:1999;260-269.
224. Toivonen J.M., O'Dell K.M., Petit N., Irvine S.C., Knight G.K., Lehtonen M., Longmuir M., Luoto K., Touraille S., Wang Z., Alziari S., Shah Z.H., Jacobs H.T. Technical knockout, a Drosophila model of mitochondrial deafness. Genetics. 159:2001;241-254.
225. Muller I., Zimmermann M., Becker D., Flomer M. Calendar life span versus budding life span of Saccharomyces cerevisiae. Mech. Ageing Dev. 12:1980;47-52.
226. Longo V.D., Gralla E.B., Silverstone J.V. Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. J. Biol. Chem. 271:1996;12275-12280.
227. Jazwinski S.M. Metabolic control and gene dysregulation in yeast aging. Ann. N. Y. Acad. Sci. 908:2000;21-30.
228. Longo V.D., Liou L.-L., Silverstone J.V., Gralla E.B. Mitochondrial superoxide decreases yeast survival in stationary phase. Arch. Biochem. Biophys. 365:1999;131-142.
229. Barker M.G., Brimage L.J., Smart K.A. Effect of Cu/Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 177:1999;199-204.
230. Wawryn J., Krzepilko A., Myszka A., Bilinski T. Deficiency in superoxide dismutases shortens life span of yeast cells. Acta Biochim. Pol. 46:1999;249-253.
231. Laun P., Pichova A., Madeo F., Fuchs J., Ellinger A., Kohlwein S., Dawes I., Frohlich K.U., Breitenbach M. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol. Microbiol. 39:2001;1166-1173.
232. Alseth I., Eide L., Pirovano M., Rognes T., Seeberg E., Bjoras M. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2 are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol. Cell. Biol. 19:1999;3779-3787.
233. You H.J., Swanson R.L., Harrington C., Corbett A.H., Jinks-Robertson S., Senturker S., Wallace S.S., Boiteux S., Dizdaroglu M., Doetsch P. Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and in the mitochondria. Biochemistry. 38:1999;11298-11306.
234. Singh K.K., Sigala B., Sikder H.A., Schwimmer C. Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res. 29:2001;1381-1388.
235. Foury F., Vanderstraeten S. Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity. EMBO J. 11:1992;2717-2726.
236. Goffrini P., Algeri A.A., Donnini C., Wesolowski-Louvel M., Ferrero I. RAG1 and RAG2: nuclear genes involved in the dependence/independence on mitochondrial respiratory function for growth on sugars. Yeast. 5:1989;99-106.
237. Parikh V.S., Morgan M.M., Scott R., Clements L.S., Butow R.A. The mitochondrial genotype can influence nuclear gene expression in yeast. Science. 235:1987;576-580.
238. Liao X., Butow R.A. RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell. 72:1993;61-71.
239. Jia Y., Rothermel B., Thornton J., Butow R.A. A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol. Cell. Biol. 17:1997;1110-1117.
240. Small W.C., Brodeur R.D., Sandor A., Fedorova N., Li G., Butow R.A., Srere P.A. Enzymatic and metabolic studies on retrograde regulation mutants of yeast. Biochemistry. 34:1995;5569-5576.
241. Chelstowska A., Butow R.A. RTG genes in yeast that function in communication between mitochondria and the nucleus are also required for expression of genes encoding peroxisomal proteins. J. Biol. Chem. 270:1995;18141-18146.
242. Kirchman P.A., Kim S., Lai C.Y., Jazwinski S.M. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics. 152:1999;179-190.
243. Jha N., Jurma O., Lalli G., Liu Y., Pettus E.H., Greenamyre J.T., Liu R.M., Forman H.J., Andersen J.K. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. J. Biol. Chem. 275:2000;26096-26101.
244. Lee C.K., Klopp R.G., Weindruch R., Prolla T.A. Gene expression profile in aging and its retardation by caloric restriction. Science. 285:1999;1390-1393.
245. Lee C.K., Weindruch R., Prolla T.A. Gene expression profile of ageing brain in mice. Nat. Genet. 25:2000;294-297.
246. Zou S., Meadows S., Sharp L., Jan L.Y., Jan Y.N. Genome wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97:2000;13726-13731.
247. Epstein C.B., Waddle J.A., Hale W. IV, Dave V., Thornton J., Macatee T.L., Garner H.R., Butow R.A. Genome-wide responses to mitochondrial dysfunction. Mol. Biol. Cell. 12:2001;297-308.
248. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3:2000;1301-1306.