The systems biology of mitochondrial fission and fusion and implications for disease and aging

Biogerontology

Volumn 15, Issue 1, 2014, Pages 1-12

  Chauhan, Anuradha ^a   Vera, Julio ^a   Wolkenhauer, Olaf ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Adaptation; Aging; Antagonistic interactions; Fission; Fusion; Mitochondria

Indexed keywords

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; CELLULAR MICROENVIRONMENT; DISEASE; DNA, MITOCHONDRIAL; ENERGY METABOLISM; HUMANS; MITOCHONDRIAL DYNAMICS; SYSTEMS BIOLOGY;

EID: 84893847881     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-013-9474-z     Document Type: Review

References (95)

1. Alon U (2007) Network motifs: theory and experimental approaches. Nat Rev Genet 8(6):450-461 (Pubitemid 46789247)
2. Aon MA, Cortassa S, O'Rourke B (2006) The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys J 91(11):4317-4327 (Pubitemid 44887289)
3. Aon MA, Cortassa S, O'Rourke B (2008) Mitochondrial oscillations in physiology and pathophysiology. Adv Exp Med Biol 641:98-117
4. Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJC, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon EA (2012) Upregulated function of mitochondria-associated er membranes in alzheimer disease. EMBO J 31(21):4106-4123
5. Arnheim N, Cortopassi G (1992) Deleterious mitochondrial dna mutations accumulate in aging human tissues. Mutat Res 275(3-6):157-167
6. BalÅosi G, van Oudenaarden A, Collins JJ (2011) Cellular decision making and biological noise: from microbes to mammals. Cell 144(6):910-925
7. Bandy B, Davison AJ (1990) Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic Biol Med 8(6):523-539 (Pubitemid 20204417)
8. Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM (2006) High levels of mitochondrial dna deletions in substantia nigra neurons in aging and parkinson disease. Nat Genet 38(5):515-517
9. Berman SB, Pineda FJ, Hardwick JM (2008) Mitochondrial fission and fusion dynamics: the long and short of it. Cell Death Differ 15(7):1147-1152 (Pubitemid 351850967)
10. Blackstone C, Chang CR (2011) Mitochondria unite to survive. Nat Cell Biol 13(5):521-522
11. Bogenhagen DF (2010) Does mtdna nucleoid organization impact aging. Exp Gerontol 45(7-8):473-477
12. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA (2003) Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol 15(6):706-716 (Pubitemid 37487964)
13. Cartoni R, Lger B, Hock MB, Praz M, Crettenand A, Pich S, Ziltener JL, Luthi F, Driaz O, Zorzano A, Gobelet C, Kralli A, Russell AP (2005) Mitofusins 1/2 and erralpha expression are increased in human skeletal muscle after physical exercise. J Physiol 567(Pt 1):349-358 (Pubitemid 41167327)
14. Cereghetti GM, Stangherlin A, Martinsde Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L (2008) Dephosphorylation by calcineurin regulates translocation of drp1 to mitochondria. Proc Natl Acad Sci USA 105(41):15,803-15,808
15. Chan DC (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125(7):1241-1252 (Pubitemid 43929096)
16. Chang CR, Blackstone C (2010) Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein drp1. Ann N Y Acad Sci 1201:34-39
17. Chauhan A, Lorenzen S, Herzel H, Bernard S (2011) Regulation of mammalian cell cycle progression in the regenerating liver. J Theor Biol 283(1):103-112
18. Chen H, Chomyn A, Chan DC (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280(28):26,185-26,192 (Pubitemid 41022214)
19. Collins TJ, Berridge MJ, Lipp P, Bootman MD (2002) Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J 21(7):1616-1627 (Pubitemid 34614618)
20. Comet JP, Noual M, Richard A, Aracena J, Calzone L, Demongeot J, Kaufman M, Naldi A, Snoussi EH, Thieffry D (2013) On circuit functionality in boolean networks. Bull Math Biol 75(6):906-919
21. Cortassa S, Aon MA, Winslow RL, O'Rourke B (2004) A mitochondrial oscillator dependent on reactive oxygen species. Biophys J 87(3):2060-2073 (Pubitemid 39167059)
22. Cribbs JT, Strack S (2007) Reversible phosphorylation of drp1 by cyclic amp-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 8(10):939-944 (Pubitemid 47500477)
23. de Jong H (2002) Modeling and simulation of genetic regulatory systems: a literature review. J Comput Biol 9(1):67-103 (Pubitemid 34264287)
24. Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS (2006) Proteolytic processing of opa1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J Biol Chem 281(49):37,972-37,979 (Pubitemid 46042101)
25. Escobar-Henriques M, Langer T (2006) Mitochondrial shaping cuts. Biochim Biophys Acta 1763(5-6):422-429 (Pubitemid 44015945)
26. Ferrell JE Jr (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14(2):140-148 (Pubitemid 34219501)
27. Figge MT, Reichert AS, Meyer-Hermann M, Osiewacz HD (2012) Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PLoS Comput Biol 8(6):e1002,576
28. Figueiredo PA, Mota MP, Appell HJ, Duarte JA (2008) The role of mitochondria in aging of skeletal muscle. Biogerontology 9(2):67-84
29. Finkel T, Serrano M, Blasco MA (2007) The common biology of cancer and ageing. Nature 448(7155):767-774 (Pubitemid 47266334)
30. Fridlyand LE, Philipson LH (2010) Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theor Biol Med Model 7:15
31. Fudenberg D, Tirole J (1991) Game theory. The MIT Press, Cambridge
32. Galloway CA, Lee H, Yoon Y (2012) Mitochondrial morphology-emerging role in bioenergetics. Free Radic Biol Med 53(12):2218-2228
33. Gao CL, Liu GL, Liu S, Chen XH, Ji CB, Zhang CM, Xia ZK, Guo XR (2011) Overexpression of pgc-1 improves insulin sensitivity and mitochondrial function in 3t3-l1 adipocytes. Mol Cell Biochem 353(1-2):215-223
34. Giedt RJ, Pfeiffer DR, Matzavinos A, Kao CY, Alevriadou BR (2012) Mitochondrial dynamics and motility inside living vascular endothelial cells: role of bioenergetics. Ann Biomed Eng 40(9):1903-1916
35. Goldbeter A (1991) A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Proc Natl Acad Sci USA 88(20):9107-9111 (Pubitemid 21915578)
36. Gomes LC, Di Benedetto G, Scorrano L (2011) During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 13(5):589-598
37. Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H (2005) Spontaneous synchronization of coupled circadian oscillators. Biophys J 89(1):120-129 (Pubitemid 41098269)
38. Harman D (1972) The biologic clock: The mitochondria?. J Am Geriatr Soc 20(4):145-147
39. Hekimi S, Lapointe J, Wen Y (2011) Taking a "good" look at free radicals in the aging process. Trends Cell Biol 21(10):569-576
40. Heuett WJ, Periwal V (2010) Autoregulation of free radicals via uncoupling protein control in pancreatic beta-cell mitochondria. Biophys J 98(2):207-217
41. Huang P, Galloway CA, Yoon Y (2011) Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. PLoS One 6(5):e20,655
42. Ishihara N, Fujita Y, Oka T, Mihara K (2006) Regulation of mitochondrial morphology through proteolytic cleavage of opa1. EMBO J 25(13):2966-2977 (Pubitemid 44106750)
43. Izhikevich EM (2003) Simple model of spiking neurons. IEEE Trans Neural Netw 14(6):1569-1572
44. Jahani-Asl A, Slack RS (2007) The phosphorylation state of drp1 determines cell fate. EMBO Rep 8(10):912-913 (Pubitemid 47500472)
45. Jendrach M, Pohl S, Vth M, Kowald A, Hammerstein P, Bereiter-Hahn J (2005) Morpho-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev 126(6-7):813-821 (Pubitemid 40693304)
46. Jeneson JAL, Schmitz JPJ, van den Broek NMA, van Riel NAW, Hilbers PAJ, Nicolay K, Prompers JJ (2009) Magnitude and control of mitochondrial sensitivity to adp. Am J Physiol Endocrinol Metab 297(3):E774-E784
47. Johnston IG, Gaal B, Neves RPd, Enver T, Iborra FJ, Jones NS (2012) Mitochondrial variability as a source of extrinsic cellular noise. PLoS Comput Biol 8(3):e1002,416
48. Kaplan D, Glass L (1995) Understanding nonlinear dynamics. Springer, New York
49. Kirkwood TBL (2005) Understanding the odd science of aging. Cell 120(4):437-447 (Pubitemid 40269759)
50. Kowald A, Kirkwood TB (2000) Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. J Theor Biol 202(2):145-160 (Pubitemid 30088466)
51. Kowald A, Kirkwood TBL (2011) Evolution of the mitochondrial fusion-fission cycle and its role in aging. Proc Natl Acad Sci USA 108(25):10,237-10,242
52. Kowald A, Lehrach H, Klipp E (2006) Alternative pathways as mechanism for the negative effects associated with overexpression of superoxide dismutase. J Theor Biol 238(4):828-840 (Pubitemid 43175833)
53. Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA (2005) Mitochondrial dna mutations, oxidative stress, and apoptosis in mammalian aging. Science 309(5733):481-484 (Pubitemid 40994689)
54. Kurz FT, Aon MA, O'Rourke B, Armoundas AA (2010) Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci USA 107(32):14,315-14,320
55. Legewie S, Blüthgen N, Herzel H (2006) Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Comput Biol 2(9):e120 (Pubitemid 44495720)
56. Liu X, Weaver D, Shirihai O, Hajnczky G (2009) Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J 28(20):3074-3089
57. Ma W, Trusina A, El-Samad H, Lim WA, Tang C (2009) Defining network topologies that can achieve biochemical adaptation. Cell 138(4):760-773
58. Martinez-Outschoorn UE, Pestell RG, Howell A, Tykocinski ML, Nagajyothi F, Machado FS, Tanowitz HB, Sotgia F, Lisanti MP (2011) Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and achilles' heel of tumor cells. Cell Cycle 10(24):4208-4216
59. Mazzoni C, Falcone C (2011) The importance of mitochondrial fusion in aging. Cell Cycle 10(21):3631
60. McBride HM, Neuspiel M, Wasiak S (2006) Mitochondria: more than just a powerhouse. Curr Biol 16(14):R551-R560 (Pubitemid 44066793)
61. McCarthy N (2012) Mitochondria: getting together. Nat Rev Cancer 12(10):661
62. McDougal DB, Osborn LA (1976) Post-tetanic hyperpolarization, sodium-potassium-activated adenosine triphosphatase and high energy phosphate levels in garfish olfactory nerve. J Physiol 256(1):41-60
63. Meinhardt H (2009) Models for the generation and interpretation of gradients. Cold Spring Harb Perspect Biol 1(4):a001,362
64. Miquel J (1991) An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells. Arch Gerontol Geriatr 12(2-3):99-117
65. Mouli PK, Twig G, Shirihai OS (2009) Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J 96(9):3509-3518
66. Novák B, Tyson JJ (2008) Design principles of biochemical oscillators. Nat Rev Mol Cell Biol 9(12):981-991
67. Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148(6):1145-1159
68. Passarino G, Rose G, Bellizzi D (2010) Mitochondrial function, mitochondrial dna and ageing: a reappraisal. Biogerontology 11(5):575-588
69. Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TBL, von Zglinicki T (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5(5):e110 (Pubitemid 46790403)
70. Pellegrini L, Scorrano L (2007) A cut short to death: parl and opa1 in the regulation of mitochondrial morphology and apoptosis. Cell Death Differ 14(7):1275-1284 (Pubitemid 46969865)
71. Pomerening JR, Kim SY, Ferrell JE Jr (2005) Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 122(4):565-578 (Pubitemid 41191155)
72. Poovathingal SK, Gruber J, Halliwell B, Gunawan R (2009) Stochastic drift in mitochondrial dna point mutations: a novel perspective ex silico. PLoS Comput Biol 5(11):e1000,572
73. Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P (2009) Ca(2+) transfer from the er to mitochondria: when, how and why. Biochim Biophys Acta 1787(11):1342-1351
74. Savageau MA, Fasani RA (2009) Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Lett 583(24):3914-3922
75. Savageau MA, Coelho PMBM, Fasani RA, Tolla DA, Salvador A (2009) Phenotypes and tolerances in the design space of biochemical systems. Proc Natl Acad Sci U S A 106(16):6435-6440
76. Seo AY, Joseph AM, Dutta D, Hwang JCY, Aris JP, Leeuwenburgh C (2010) New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123(Pt 15):2533-2542
77. Serasinghe MN, Yoon Y (2008) The mitochondrial outer membrane protein hfis1 regulates mitochondrial morphology and fission through self-interaction. Exp Cell Res 314(19):3494-3507
78. Shutt T, Geoffrion M, Milne R, McBride HM (2012) The intracellular redox state is a core determinant of mitochondrial fusion. EMBO Rep 13(10):909-915
79. Spencer SL, Sorger PK (2011) Measuring and modeling apoptosis in single cells. Cell 144(6):926-939
80. Strauss W (1992) Partial differential equations: an introduction. Wiley, New York
81. Suen DF, Norris KL, Youle RJ (2008) Mitochondrial dynamics and apoptosis. Genes Dev 22(12):1577-1590 (Pubitemid 351846838)
82. Sukhorukov VM, Dikov D, Reichert AS, Meyer-Hermann M (2012) Emergence of the mitochondrial reticulum from fission and fusion dynamics. PLoS Comput Biol 8(10):e1002,745
83. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K (2007) Mitotic phosphorylation of dynamin-related gtpase drp1 participates in mitochondrial fission. J Biol Chem 282(15):11,521-11,529 (Pubitemid 47100787)
84. Tretter L, Chinopoulos C, Adam-Vizi V (1997) Enhanced depolarization-evoked calcium signal and reduced [atp]/[adp] ratio are unrelated events induced by oxidative stress in synaptosomes. J Neurochem 69(6):2529-2537 (Pubitemid 27495440)
85. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlf S, Oldfors A, Wibom R, Trnell J, Jacobs HT, Larsson NG (2004) Premature ageing in mice expressing defective mitochondrial-DNA polymerase. Nature 429(6990):417-423 (Pubitemid 38715133)
86. Turing AM (1990) The chemical basis of morphogenesis. 1953. Bull Math Biol 52(1-2):153-97; discussion 119-52
87. Twig G, Elorza A, Molina AJA, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27(2):433-446 (Pubitemid 351161653)
88. Tyson JJ, Albert R, Goldbeter A, Ruoff P, Sible J (2008) Biological switches and clocks. J R Soc Interface 5(Suppl 1):S1-S8 (Pubitemid 351915282)
89. Ullah M, Wolkenhauer O (2011) Stochastic approaches for systems biology. Springer, New York
90. Veening JW, Smits WK, Kuipers OP (2008) Bistability, epigenetics, and bet-hedging in bacteria. Annu Rev Microbiol 62:193-210
91. Wallace DC (1999) Mitochondrial diseases in man and mouse. Science 283(5407):1482-1488 (Pubitemid 29133350)
92. Wallach A, Eytan D, Marom S, Meir R (2008) Selective adaptation in networks of heterogeneous populations: model, simulation, and experiment. PLoS Comput Biol 4(2):e29 (Pubitemid 351328505)
93. Westermann B (2010) Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11(12):872-884
94. Youle RJ, van der Bliek AM (2012) Mitochondrial fission, fusion, and stress. Science 337(6098):1062-1065
95. Zorzano A, Liesa M, Palacn M (2009) Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. Int J Biochem Cell Biol 41(10):1846-1854