Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice

Journal of Neuroscience

Volumn 21, Issue 20, 2001, Pages 8082-8090

  Sörensen, Lene ^a   Ekstrand, Mats ^a   Silva, José P ^a   Lindqvist, Eva ^b   Xu, Baoji ^c   Rustin, Pierre ^d   Olson, Lars ^b   Larsson, Nils Göran ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Apoptosis; Cre loxP; Hippocampus; MILON; Mitochondria; Mitochondrial transcription factor A; Neocortex; Neurodegeneration; Oxidative phosphorylation; Oxidative stress; OXPHOS; Reactive oxygen species; Respiratory chain; ROS; Tfam

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; KAINIC ACID; MITOCHONDRIAL DNA; MITOCHONDRIAL RNA;

ADOLESCENT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; FOREBRAIN; GENE DISRUPTION; GLIOSIS; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MITOCHONDRIAL LATE ONSET NEURODEGENERATION; MITOCHONDRIAL RESPIRATION; NEOCORTEX; NERVE CELL EXCITABILITY; NERVE FIBER DEGENERATION; NEUROTOXICITY; NEWBORN; NICK END LABELING; NONHUMAN; ONSET AGE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

EID: 0035887745     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-20-08082.2001     Document Type: Article

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